PH12014500887A1 - Aminoalkyl-substituted n-thienyl benzamide derivative - Google Patents
Aminoalkyl-substituted n-thienyl benzamide derivativeInfo
- Publication number
- PH12014500887A1 PH12014500887A1 PH1/2014/500887A PH12014500887A PH12014500887A1 PH 12014500887 A1 PH12014500887 A1 PH 12014500887A1 PH 12014500887 A PH12014500887 A PH 12014500887A PH 12014500887 A1 PH12014500887 A1 PH 12014500887A1
- Authority
- PH
- Philippines
- Prior art keywords
- aminoalkyl
- substituted
- npt
- inhibitory action
- iib
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 201000005991 hyperphosphatemia Diseases 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- VLLGHDRJSXCFJL-UHFFFAOYSA-N n-thiophen-2-ylbenzamide Chemical class C=1C=CC=CC=1C(=O)NC1=CC=CS1 VLLGHDRJSXCFJL-UHFFFAOYSA-N 0.000 abstract 2
- 108010092528 Phosphate Transport Proteins Proteins 0.000 abstract 1
- 102000016462 Phosphate Transport Proteins Human genes 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
- C07F9/655354—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011236533 | 2011-10-27 | ||
| PCT/JP2012/077660 WO2013062065A1 (ja) | 2011-10-27 | 2012-10-25 | アミノアルキル置換n-チエニルベンズアミド誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12014500887A1 true PH12014500887A1 (en) | 2019-06-03 |
Family
ID=48167891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2014/500887A PH12014500887A1 (en) | 2011-10-27 | 2012-10-25 | Aminoalkyl-substituted n-thienyl benzamide derivative |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9062032B2 (https=) |
| EP (1) | EP2772490B1 (https=) |
| JP (2) | JP2013107880A (https=) |
| KR (1) | KR101941048B1 (https=) |
| CN (1) | CN103906741B (https=) |
| AR (1) | AR088563A1 (https=) |
| AU (1) | AU2012329913A1 (https=) |
| BR (1) | BR112014010169B1 (https=) |
| CA (1) | CA2853688C (https=) |
| EA (1) | EA023955B1 (https=) |
| ES (1) | ES2585415T3 (https=) |
| IL (1) | IL232230A0 (https=) |
| IN (1) | IN2014CN03130A (https=) |
| MX (1) | MX342521B (https=) |
| PH (1) | PH12014500887A1 (https=) |
| PL (1) | PL2772490T3 (https=) |
| TW (1) | TW201323419A (https=) |
| WO (1) | WO2013062065A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS55764B1 (sr) * | 2012-10-02 | 2017-07-31 | Gilead Sciences | Inhibitori histonskih demetilaza |
| PT2975030T (pt) | 2013-03-13 | 2020-09-28 | Chugai Pharmaceutical Co Ltd | Derivado de di-hidropiridazina-3,5-diona |
| US9499553B2 (en) | 2013-03-13 | 2016-11-22 | Chugai Seiyaku Kabushiki Kaisha | Dihydropyridazine-3,5-dione derivative and pharmaceuticals containing the same |
| TWI594975B (zh) * | 2013-04-24 | 2017-08-11 | 第一三共股份有限公司 | 二羧酸化合物 |
| PT3030568T (pt) | 2013-08-08 | 2018-12-24 | Galapagos Nv | Tieno[2,3-c]piranos como moduladores de cftr |
| WO2015064532A1 (ja) * | 2013-10-30 | 2015-05-07 | 第一三共株式会社 | モルホリン化合物 |
| EP3126345A1 (en) * | 2014-03-31 | 2017-02-08 | Gilead Sciences, Inc. | Inhibitors of histone demethylases |
| WO2016026372A1 (zh) * | 2014-08-22 | 2016-02-25 | 江苏恒瑞医药股份有限公司 | 噻吩并环烷基或噻吩并杂环基类衍生物、其制备方法及其在医药上的应用 |
| NZ729640A (en) * | 2014-09-12 | 2022-04-29 | Chugai Pharmaceutical Co Ltd | Pharmaceutical containing sodium-dependent phosphate transporter inhibitor |
| BR112017005694A2 (pt) | 2014-09-26 | 2017-12-12 | Daiichi Sankyo Co Ltd | cristais de um sal, ou hidrato do mesmo, cristais de um trihidrato de sal dissódico, composição farmacêutica, uso dos cristais, e, método para prevenção ou tratamento de hiperfosfatemia. |
| CN105524053B (zh) * | 2014-10-19 | 2020-06-05 | 广东东阳光药业有限公司 | 四氢苯并噻吩化合物 |
| TW201700458A (zh) | 2015-04-24 | 2017-01-01 | 第一三共股份有限公司 | 二羧酸化合物之製法 |
| CN107082773B (zh) * | 2016-02-16 | 2020-07-28 | 江苏恒瑞医药股份有限公司 | 一种肠2b型磷酸钠协同转运蛋白抑制剂的硫酸盐及其结晶形式 |
| SI3497091T1 (sl) * | 2016-08-15 | 2020-11-30 | Eli Lilly And Company | Kondenzirani derivati tiofena uporabni kot inhibitorji NAPI-IIB |
| JOP20190080A1 (ar) | 2016-10-14 | 2019-04-11 | Bayer Pharma AG | مركبات مشتقة من 6-(1h-بيرازول-1-يل) بيريميدين-4- أمين مستبدل واستخداماتها |
| CN109422723B (zh) * | 2017-08-25 | 2021-02-23 | 江苏恒瑞医药股份有限公司 | 一种肠2b型磷酸钠协同转运蛋白抑制剂的晶型及其制备方法 |
| AR126060A1 (es) | 2021-06-08 | 2023-09-06 | Chugai Pharmaceutical Co Ltd | Método para producir derivado de dihidropiridazin-3,5-diona |
| KR20240018523A (ko) | 2021-06-08 | 2024-02-13 | 추가이 세이야쿠 가부시키가이샤 | 다이하이드로피리다진-3,5-다이온 유도체를 함유하는 제제 |
| WO2023203254A2 (en) | 2022-04-22 | 2023-10-26 | Fundamental Pharma Gmbh | Effective means to modulate nmda receptor-mediated toxicity |
| WO2023219127A1 (ja) | 2022-05-11 | 2023-11-16 | 中外製薬株式会社 | 嚢胞性疾患を治療または予防するための医薬組成物 |
| WO2024223617A1 (en) | 2023-04-24 | 2024-10-31 | Fundamental Pharma Gmbh | Effective means to modulate nmda receptor-mediated toxicity |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002213048A1 (en) * | 2000-10-05 | 2002-04-15 | Smith Kline Beecham Corporation | Phosphate transport inhibitors |
| JP2007131532A (ja) | 2001-09-28 | 2007-05-31 | Kirin Brewery Co Ltd | 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬 |
| AU2002354410A1 (en) * | 2001-12-05 | 2003-06-17 | Japan Tobacco Inc. | Triazole compound and medicinal use thereof |
| WO2004085382A1 (ja) | 2003-03-27 | 2004-10-07 | Kirin Beer Kabushiki Kaisha | 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬 |
| WO2006093518A2 (en) * | 2004-06-25 | 2006-09-08 | Apath, Llc | Thienyl compounds for treating virus-related conditions |
| AU2005279845A1 (en) * | 2004-08-30 | 2006-03-09 | Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Inhibition of viruses using RNase H inhibitors |
| JP2008517061A (ja) | 2004-10-20 | 2008-05-22 | コンパス ファーマシューティカルズ リミティド ライアビリティ カンパニー | 抗腫瘍剤としての化合物及びそれらの使用 |
| AU2009203549B2 (en) * | 2008-01-08 | 2013-03-07 | Purdue Pharma L.P. | Proline Analogs as ligands for cannabinoid receptors for the treatment of pain |
| PL2565190T3 (pl) | 2010-04-28 | 2015-10-30 | Astellas Pharma Inc | Związek tetrahydrobenzotiofenowy |
| JP5827327B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス，インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
| WO2012006475A1 (en) | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| JP5823514B2 (ja) | 2010-07-07 | 2015-11-25 | アーデリクス，インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
| WO2012006477A1 (en) | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP2590655B1 (en) | 2010-07-07 | 2015-06-24 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
-
2012
- 2012-10-25 ES ES12844048.4T patent/ES2585415T3/es active Active
- 2012-10-25 IN IN3130CHN2014 patent/IN2014CN03130A/en unknown
- 2012-10-25 CA CA2853688A patent/CA2853688C/en not_active Expired - Fee Related
- 2012-10-25 EP EP12844048.4A patent/EP2772490B1/en active Active
- 2012-10-25 US US14/354,086 patent/US9062032B2/en active Active
- 2012-10-25 JP JP2012236135A patent/JP2013107880A/ja active Pending
- 2012-10-25 CN CN201280053147.6A patent/CN103906741B/zh not_active Expired - Fee Related
- 2012-10-25 MX MX2014005090A patent/MX342521B/es active IP Right Grant
- 2012-10-25 JP JP2013540835A patent/JP6020460B2/ja not_active Expired - Fee Related
- 2012-10-25 AU AU2012329913A patent/AU2012329913A1/en not_active Abandoned
- 2012-10-25 PH PH1/2014/500887A patent/PH12014500887A1/en unknown
- 2012-10-25 PL PL12844048.4T patent/PL2772490T3/pl unknown
- 2012-10-25 WO PCT/JP2012/077660 patent/WO2013062065A1/ja not_active Ceased
- 2012-10-25 TW TW101139423A patent/TW201323419A/zh unknown
- 2012-10-25 EA EA201490875A patent/EA023955B1/ru not_active IP Right Cessation
- 2012-10-25 KR KR1020147014256A patent/KR101941048B1/ko not_active Expired - Fee Related
- 2012-10-25 BR BR112014010169-8A patent/BR112014010169B1/pt not_active IP Right Cessation
- 2012-10-26 AR ARP120104035A patent/AR088563A1/es unknown
-
2014
- 2014-04-24 IL IL232230A patent/IL232230A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2853688C (en) | 2018-06-12 |
| EP2772490A4 (en) | 2015-01-21 |
| PL2772490T3 (pl) | 2016-11-30 |
| EP2772490A1 (en) | 2014-09-03 |
| MX342521B (es) | 2016-10-03 |
| WO2013062065A1 (ja) | 2013-05-02 |
| CA2853688A1 (en) | 2013-05-02 |
| CN103906741B (zh) | 2016-01-20 |
| TW201323419A (zh) | 2013-06-16 |
| CN103906741A (zh) | 2014-07-02 |
| EA201490875A1 (ru) | 2014-09-30 |
| BR112014010169B1 (pt) | 2021-12-07 |
| JP6020460B2 (ja) | 2016-11-02 |
| EA023955B1 (ru) | 2016-07-29 |
| BR112014010169A2 (pt) | 2017-04-25 |
| KR20140096322A (ko) | 2014-08-05 |
| EP2772490B1 (en) | 2016-04-06 |
| IL232230A0 (en) | 2014-06-30 |
| MX2014005090A (es) | 2015-02-12 |
| AU2012329913A1 (en) | 2014-05-22 |
| US20150031727A1 (en) | 2015-01-29 |
| ES2585415T3 (es) | 2016-10-05 |
| JP2013107880A (ja) | 2013-06-06 |
| JPWO2013062065A1 (ja) | 2015-04-02 |
| IN2014CN03130A (https=) | 2015-07-03 |
| KR101941048B1 (ko) | 2019-01-22 |
| US9062032B2 (en) | 2015-06-23 |
| AR088563A1 (es) | 2014-06-18 |
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