PE59699A1 - 2,4 diaminopirimidina sustituida - Google Patents

2,4 diaminopirimidina sustituida

Info

Publication number
PE59699A1
PE59699A1 PE1998000142A PE00014298A PE59699A1 PE 59699 A1 PE59699 A1 PE 59699A1 PE 1998000142 A PE1998000142 A PE 1998000142A PE 00014298 A PE00014298 A PE 00014298A PE 59699 A1 PE59699 A1 PE 59699A1
Authority
PE
Peru
Prior art keywords
alkyl
alcoxyl
aryl
compound
formula
Prior art date
Application number
PE1998000142A
Other languages
English (en)
Inventor
Pierre-Charles Wyss
Philippe Guerry
Christian Hubschwerlen
Synese Jolidon
Jean-Luc Specklin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE59699A1 publication Critical patent/PE59699A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) O SUS SALES DONDE, R1 ES ALCOXILO, R2 ES OH O ALCOXILO; R3 ES CN, H, ALQUILO, ALQUENILO, CICLOALQUILO, ARILO, HETEROCICLO, ARIL-Q-ALQUILO, -CR4R4`COR5; ENTRE OTROS; Q ES SO o SO2; R4 Y R4' SON H, ALQUILO, ARILO, HETEROCICLO; R5 ES H, ALQUILO, ALCOXILO, ENTRE OTROS; o R4 Y R5 FORMAN JUNTOS UN GRUPO CR4R4'COR5, n ES 2-5. SON COMPUESTOS PREFERIDOS (E)-(RS)-3-[5-(2,4-DIAMINO-PIRIMIDIN-5-ILMETIL)-2,3-DIMETOXIFENIL]-1-(1-FENIL-1H-FTALAZIN-2-IL)PROPENONA; (E)-(RS)-3-[5-(2,4-DIAMINO-PIRIMIDIN-5-ILMETIL)-2,3-DIMETOXI-FENIL]-1-(1-FURAN-2-IL-1H-FTALAZIN-2-IL)-PROPENONA; ENTRE OTROS. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA SU OBTENCION Y A UNA PREPARACION FARMACEUTICA QUE CONTIENE UN COMPUESTO DE FORMULA (I) Y UNA SULFONAMIDA, EN UNA PROPORCION PREFERIDA DE 1:10 A 1:2 PARTES EN PESO. EL COMPUESTO DE FORMULA (I) PUEDE SER UTIL PARA EL TRATAMIENTO DE INFECCIONES
PE1998000142A 1997-03-03 1998-02-27 2,4 diaminopirimidina sustituida PE59699A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97103436 1997-03-03

Publications (1)

Publication Number Publication Date
PE59699A1 true PE59699A1 (es) 1999-06-16

Family

ID=8226543

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000142A PE59699A1 (es) 1997-03-03 1998-02-27 2,4 diaminopirimidina sustituida

Country Status (21)

Country Link
US (1) US6114330A (es)
JP (1) JP4174077B2 (es)
KR (1) KR20000075888A (es)
CN (1) CN1091109C (es)
AR (1) AR011879A1 (es)
AT (1) ATE241618T1 (es)
AU (1) AU726836B2 (es)
BR (1) BR9808135A (es)
CA (1) CA2281642C (es)
CO (1) CO4940508A1 (es)
DE (1) DE69815072T2 (es)
DK (1) DK0966464T3 (es)
ES (1) ES2198705T3 (es)
HR (1) HRP980110A2 (es)
MA (1) MA26475A1 (es)
PE (1) PE59699A1 (es)
PT (1) PT966464E (es)
TR (1) TR199902140T2 (es)
TW (1) TW464648B (es)
UY (1) UY24913A1 (es)
ZA (1) ZA981529B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040162333A1 (en) * 2003-02-19 2004-08-19 Naima Mezaache Rapid absorption selective 5-HT agonist formulations
US8268825B2 (en) * 2005-09-26 2012-09-18 The Board Of Regents For Oklahoma State University Method for the treatment of anthrax infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ296532A (en) * 1994-11-24 2000-02-28 F Substituted 5-benzyl-2,4,-diaminopyrimidines
TW438796B (en) * 1996-05-15 2001-06-07 Hoffmann La Roche 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same

Also Published As

Publication number Publication date
TW464648B (en) 2001-11-21
ATE241618T1 (de) 2003-06-15
CN1249751A (zh) 2000-04-05
TR199902140T2 (en) 2000-04-21
BR9808135A (pt) 2000-03-28
CA2281642A1 (en) 1998-09-11
AR011879A1 (es) 2000-09-13
ES2198705T3 (es) 2004-02-01
KR20000075888A (ko) 2000-12-26
AU726836B2 (en) 2000-11-23
JP2001513791A (ja) 2001-09-04
MA26475A1 (fr) 2004-12-20
US6114330A (en) 2000-09-05
DE69815072D1 (de) 2003-07-03
ZA981529B (en) 1998-09-03
CN1091109C (zh) 2002-09-18
JP4174077B2 (ja) 2008-10-29
PT966464E (pt) 2003-09-30
AU6823198A (en) 1998-09-22
CA2281642C (en) 2008-02-05
UY24913A1 (es) 2001-01-31
DE69815072T2 (de) 2004-04-01
CO4940508A1 (es) 2000-07-24
HRP980110A2 (en) 1998-12-31
DK0966464T3 (da) 2003-09-22

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed