PE52496A1 - Nueva sulfonamida y procedimiento de obtencion - Google Patents
Nueva sulfonamida y procedimiento de obtencionInfo
- Publication number
- PE52496A1 PE52496A1 PE1995285176A PE28517695A PE52496A1 PE 52496 A1 PE52496 A1 PE 52496A1 PE 1995285176 A PE1995285176 A PE 1995285176A PE 28517695 A PE28517695 A PE 28517695A PE 52496 A1 PE52496 A1 PE 52496A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- compound
- lower alkyl
- halogen
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
SE REFIERE A: 1) EL COMPUESTO DE FORMULA I DONDE: R1 ES HETEROCICLILO, DE PREFERENCIA PIRIDILO; R2 ES HIDROGENO, ALQUILO INFERIOR, ALCOXILO INFERIOR ENTRE OTROS, DE PREFERENCIA HIDROGENO; R3 ES ALQUILO INFERIOR, ALCOXILO INFERIOR, -CH2O-A-ALQUILO INFERIOR, -(CH2)m-O-(CRaRb)nOH ENTRE OTROS; DONDE Ra Y Rb SIGNIFICAN H o ALQUILO INFERIOR; A SIGNIFICA UN GRUPO 1,2-DIHIDROXI-ETILENO CETALIZADO; B ES -OC(O)O-, -NH(C(O)NH o -NHC(O)O-; n ES 2, 3, o 4; m ES 0 o 1; R4, R5, R6, R7, R8 SON INDEPENDIENTEMENTE HIDROGENO, ALCOXILO INFERIOR O HALOGENO; R9 ES HETEROCICLILO, FENILO NO SUSTITUIDO O SUSTITUIDO CON ALQUILO INFERIOR, ALCOXILO INFERIOR Y/O HALOGENO ENTRE OTROS; 2) EL COMPUESTO DE FORMULA II DONDE Hal SIGNIFICA HALOGENO; 3) A LOS PROCEDIMIENTO DE OBTENCION TALES COMO: a) REACCION DE UN COMPUESTO DE FORMULA II CON UN COMPUESTO DE FORMULA HO(CRaRb)nXH, DONDE n, Ra Y Rb, YA SE DEFINIERON y X SIGNIFICA O o NH, o; b) REACCION DE UN COMPUESTO DE FORMULA III CON UN COMPUESTO DE FORMULA R1SO2Z, DONDE Y ES HALOGENO Y Z AMINO, o Y REPRESENTA AMINO y Z HALOGENO, o; c) REACCION DE UN COMPUESTO DE FORMULA IV CON UN ISOCIANATO DE FORMULA R9NCO o UN CLORURO DE CARBAMOILO DE FORMULA R9NCOCl, ENTRE OTROS. ESTE COMPUESTO ES USADO EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON ACTIVIDADES DE LA ENDOTELINA TALES COMO HIPERTENSION E ISQUEMIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH355994 | 1994-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE52496A1 true PE52496A1 (es) | 1996-12-12 |
Family
ID=4258608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1995285176A PE52496A1 (es) | 1994-11-25 | 1995-11-21 | Nueva sulfonamida y procedimiento de obtencion |
Country Status (9)
Country | Link |
---|---|
AR (2) | AR002251A1 (es) |
BR (1) | BR9505528A (es) |
CO (1) | CO4650181A1 (es) |
PE (1) | PE52496A1 (es) |
PL (1) | PL185692B1 (es) |
TR (1) | TR199501486A2 (es) |
UY (1) | UY24100A1 (es) |
WO (1) | WO1996016963A1 (es) |
ZA (1) | ZA959808B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI284642B (en) * | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
NZ525614A (en) * | 2000-12-18 | 2005-03-24 | Actelion Pharmaceuticals Ltd | Novel sulfamides and their use as endothelin receptor antagonists |
EP2343282B1 (en) | 2004-03-05 | 2015-07-22 | F. Hoffmann-La Roche AG | Diaminopyrimidines as P2X3 and P2X2/3 antagonists |
AR062501A1 (es) | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | Composiciones terapeuticas |
MX2010001837A (es) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
-
1995
- 1995-06-06 WO PCT/CH1995/000131 patent/WO1996016963A1/de unknown
- 1995-11-17 ZA ZA959808A patent/ZA959808B/xx unknown
- 1995-11-21 PE PE1995285176A patent/PE52496A1/es not_active Application Discontinuation
- 1995-11-23 AR ARP950100297A patent/AR002251A1/es active IP Right Grant
- 1995-11-24 TR TR95/01486A patent/TR199501486A2/xx unknown
- 1995-11-24 CO CO95055930A patent/CO4650181A1/es unknown
- 1995-11-24 UY UY24100A patent/UY24100A1/es not_active IP Right Cessation
- 1995-11-24 PL PL95311487A patent/PL185692B1/pl not_active IP Right Cessation
- 1995-11-27 BR BR9505528A patent/BR9505528A/pt not_active IP Right Cessation
-
1997
- 1997-11-04 AR ARP970105148A patent/AR010549A2/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
WO1996016963A1 (de) | 1996-06-06 |
BR9505528A (pt) | 1997-11-04 |
CO4650181A1 (es) | 1998-09-03 |
AR002251A1 (es) | 1998-03-11 |
PL185692B1 (pl) | 2003-07-31 |
PL311487A1 (en) | 1996-05-27 |
UY24100A1 (es) | 2000-12-29 |
TR199501486A2 (tr) | 1996-07-21 |
AR010549A2 (es) | 2000-06-28 |
ZA959808B (en) | 1996-05-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20030809A1 (es) | Derivados de piperidina como antagonistas de la hormona concentradora de la melanina (mch) | |
PE106499A1 (es) | Antagonistas del receptor ccr-3 | |
PE20011047A1 (es) | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas | |
PE20021005A1 (es) | Quinazolinas como inhibidores de mmp-13 | |
AR006720A1 (es) | Un compuesto derivado de azahexano heterociclico, su uso para la preparacion de una composicion farmaceutica, procedimiento para prepararlo y una composicion farmaceutica que lo comprende | |
PE115999A1 (es) | Secretagogos de la hormona del crecimiento | |
PE20020061A1 (es) | Fenil sulfamoil carboxamidas sustituidas | |
PE20051039A1 (es) | [1,8] naftiridin-2-onas y compuestos relacionados | |
CO5200785A1 (es) | Uso terapeutico de quinazolina | |
AR042461A1 (es) | Analogos 2-sustituidos de quinazolin-4-il - amina. composiciones farmaceuticas | |
PE20020657A1 (es) | Derivados de amida de piperidinas 1,4-disustituidas de formula (i) | |
EA200300428A1 (ru) | Антагонисты метаботропных рецепторов глутамата | |
AR038341A1 (es) | Compuestos que son agonistas de receptores alfa-1 preferentemente agonistas de receptores alfa-1a/l | |
UY25873A1 (es) | Derivados de 3-azabiciclo [3.1.0] hexano útiles en terapia en afecciones mediadas por receptores opiáceos | |
ATE201867T1 (de) | N-aminoalkylfluorencarboxamide, neue klasse von dopaminerezeptor subtype spezifische liganden | |
PE91798A1 (es) | Pirrolicarboxanilidas condensadas: utiles como ligandos receptores | |
NO972841D0 (no) | Aryl- og heteroaryl-sulfonamidderivater, deres fremstilling og anvendelse som endotelinantagonister | |
PE20040757A1 (es) | Derivados de benzoxazina | |
FI935517A0 (fi) | Fenoxi- och fenoxialkylpiperidiner som virusmotverkande medel | |
PA8575001A1 (es) | Fluorobenzamidas como inhibidores de maob | |
PE14696A1 (es) | Derivado de fenetanolamina | |
AR015964A1 (es) | Compuestos de isoquinolina, su uso, procedimiento para tratar una afeccion, procedimiento de preparacion del compuesto, composicion farmaceutica que locontiene y compuesto util en dicho procedimiento | |
AR042362A1 (es) | Derivados de 3h-quinazolin-4-ona, proceso de obtencion y composiciones farmaceuticas que los contienen | |
PE52496A1 (es) | Nueva sulfonamida y procedimiento de obtencion | |
PE20030705A1 (es) | Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |