AR010549A2 - DERIVADOS DE SULFONAMIDAS uTILES COMO INTERMEDIARIOS DE SíNTESIS. - Google Patents

DERIVADOS DE SULFONAMIDAS uTILES COMO INTERMEDIARIOS DE SíNTESIS.

Info

Publication number
AR010549A2
AR010549A2 ARP970105148A ARP970105148A AR010549A2 AR 010549 A2 AR010549 A2 AR 010549A2 AR P970105148 A ARP970105148 A AR P970105148A AR P970105148 A ARP970105148 A AR P970105148A AR 010549 A2 AR010549 A2 AR 010549A2
Authority
AR
Argentina
Prior art keywords
phenyl
lower alkyl
alkoxy
alkyl
derivatives
Prior art date
Application number
ARP970105148A
Other languages
English (en)
Original Assignee
Speedel Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Pharma Ag filed Critical Speedel Pharma Ag
Publication of AR010549A2 publication Critical patent/AR010549A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Compuestos de formula (I) en donde R1 es heterociclilo; R2 es hidrogeno, alquilo inferior, alcoxilo inferior, alquiltio inferior, alcoxilo inferior-alquilo inferior, alquilsulfonilo inferior-alcoxilo inferior, fenilo, alquilo inferior-fenilo,al coxilo inferior-fenilo, alquileno inferior-dioxifenilo,fenilo-alquilo inferior-fenilo, alcoxilo inferior-fenilo, alquileno inferior- dioxifenilo, fenilo-alquilo inferior, alquilo inferior-fenilo-alquilo inferior,alcoxilo inferior, heterocicliloo h eterociclio -alquilo inferior; R4 y R8 son hidrogeno alcoxilo inferior o halogeno; R9 significa heterociclilo; fenilo ofenilo sustituído con alquilo inferiro, alcoxilo inferior y/o halogeno, o alquilo inferior, Ra y Rb significanhidrogeno o a lquilo inferior; y hal eshalogeno. Además se refiere a nuevas sulfonamidas y su utilizacion como intermediarios para la obtencion de medicamentos.
ARP970105148A 1994-11-25 1997-11-04 DERIVADOS DE SULFONAMIDAS uTILES COMO INTERMEDIARIOS DE SíNTESIS. AR010549A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH355994 1994-11-25

Publications (1)

Publication Number Publication Date
AR010549A2 true AR010549A2 (es) 2000-06-28

Family

ID=4258608

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP950100297A AR002251A1 (es) 1994-11-25 1995-11-23 Derivados de sulfonamidas, procedimiento para su obtencion, composiciones farmaceuticas y utilizacion de los compuestos para preparacion de medicamentos para enfermedades asociadas con la endotelina.
ARP970105148A AR010549A2 (es) 1994-11-25 1997-11-04 DERIVADOS DE SULFONAMIDAS uTILES COMO INTERMEDIARIOS DE SíNTESIS.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP950100297A AR002251A1 (es) 1994-11-25 1995-11-23 Derivados de sulfonamidas, procedimiento para su obtencion, composiciones farmaceuticas y utilizacion de los compuestos para preparacion de medicamentos para enfermedades asociadas con la endotelina.

Country Status (9)

Country Link
AR (2) AR002251A1 (es)
BR (1) BR9505528A (es)
CO (1) CO4650181A1 (es)
PE (1) PE52496A1 (es)
PL (1) PL185692B1 (es)
TR (1) TR199501486A2 (es)
UY (1) UY24100A1 (es)
WO (1) WO1996016963A1 (es)
ZA (1) ZA959808B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI284642B (en) * 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides
BRPI0116237B8 (pt) 2000-12-18 2021-05-25 Actelion Pharmaceuticals Ltd "composto de sulfamida, composição farmacêutica contendo o mesmo e seu uso como medicamento antagonista de receptor de endotelina".
EP1725540B1 (en) 2004-03-05 2012-09-12 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 antagonists
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
MX2010001837A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина

Also Published As

Publication number Publication date
PE52496A1 (es) 1996-12-12
CO4650181A1 (es) 1998-09-03
UY24100A1 (es) 2000-12-29
WO1996016963A1 (de) 1996-06-06
BR9505528A (pt) 1997-11-04
AR002251A1 (es) 1998-03-11
ZA959808B (en) 1996-05-27
PL185692B1 (pl) 2003-07-31
TR199501486A2 (tr) 1996-07-21
PL311487A1 (en) 1996-05-27

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