PE52496A1 - NEW SULFONAMIDE AND PROCEDURE FOR OBTAINING - Google Patents

NEW SULFONAMIDE AND PROCEDURE FOR OBTAINING

Info

Publication number
PE52496A1
PE52496A1 PE1995285176A PE28517695A PE52496A1 PE 52496 A1 PE52496 A1 PE 52496A1 PE 1995285176 A PE1995285176 A PE 1995285176A PE 28517695 A PE28517695 A PE 28517695A PE 52496 A1 PE52496 A1 PE 52496A1
Authority
PE
Peru
Prior art keywords
formula
compound
lower alkyl
halogen
reaction
Prior art date
Application number
PE1995285176A
Other languages
Spanish (es)
Inventor
Loffler Bernd-Michael
Hirth Georges
Ramuz Henri
Cassal Jean-Marie
Neidhart Werner
Muller Marcel
Clozel Martine
Breu Volker
Burri Kaspar
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE52496A1 publication Critical patent/PE52496A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A: 1) EL COMPUESTO DE FORMULA I DONDE: R1 ES HETEROCICLILO, DE PREFERENCIA PIRIDILO; R2 ES HIDROGENO, ALQUILO INFERIOR, ALCOXILO INFERIOR ENTRE OTROS, DE PREFERENCIA HIDROGENO; R3 ES ALQUILO INFERIOR, ALCOXILO INFERIOR, -CH2O-A-ALQUILO INFERIOR, -(CH2)m-O-(CRaRb)nOH ENTRE OTROS; DONDE Ra Y Rb SIGNIFICAN H o ALQUILO INFERIOR; A SIGNIFICA UN GRUPO 1,2-DIHIDROXI-ETILENO CETALIZADO; B ES -OC(O)O-, -NH(C(O)NH o -NHC(O)O-; n ES 2, 3, o 4; m ES 0 o 1; R4, R5, R6, R7, R8 SON INDEPENDIENTEMENTE HIDROGENO, ALCOXILO INFERIOR O HALOGENO; R9 ES HETEROCICLILO, FENILO NO SUSTITUIDO O SUSTITUIDO CON ALQUILO INFERIOR, ALCOXILO INFERIOR Y/O HALOGENO ENTRE OTROS; 2) EL COMPUESTO DE FORMULA II DONDE Hal SIGNIFICA HALOGENO; 3) A LOS PROCEDIMIENTO DE OBTENCION TALES COMO: a) REACCION DE UN COMPUESTO DE FORMULA II CON UN COMPUESTO DE FORMULA HO(CRaRb)nXH, DONDE n, Ra Y Rb, YA SE DEFINIERON y X SIGNIFICA O o NH, o; b) REACCION DE UN COMPUESTO DE FORMULA III CON UN COMPUESTO DE FORMULA R1SO2Z, DONDE Y ES HALOGENO Y Z AMINO, o Y REPRESENTA AMINO y Z HALOGENO, o; c) REACCION DE UN COMPUESTO DE FORMULA IV CON UN ISOCIANATO DE FORMULA R9NCO o UN CLORURO DE CARBAMOILO DE FORMULA R9NCOCl, ENTRE OTROS. ESTE COMPUESTO ES USADO EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON ACTIVIDADES DE LA ENDOTELINA TALES COMO HIPERTENSION E ISQUEMIAIT REFERS TO: 1) THE COMPOUND OF FORMULA I WHERE: R1 IS HETERO-CYCLILE, PREFERRED BY PIRIDYL; R2 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXYL AMONG OTHERS, PREFERRED HYDROGEN; R3 IS LOWER ALKYL, LOWER ALKOXYL, -CH2O-A-LOWER ALKYL, - (CH2) m-O- (CRaRb) nOH AMONG OTHERS; WHERE Ra AND Rb MEAN H or LOWER ALKYL; A MEANS A GROUP 1,2-DIHYDROXY-ETHYLENE CETALLIZED; B ES -OC (O) O-, -NH (C (O) NH or -NHC (O) O-; n ES 2, 3, or 4; m ES 0 or 1; R4, R5, R6, R7, R8 ARE INDEPENDENTLY HYDROGEN, LOWER ALKOXYL, OR HALOGEN; R9 IS HETERO CYCLYL, PHENYL NOT SUBSTITUTED OR REPLACED WITH LOWER ALKYL, LOWER ALKYL AND / OR HALOGEN, AMONG OTHER; 2) THE COMPONENT HALOGEN OF FORM. 3) A PROCEDURE FOR OBTAINING SUCH AS: a) REACTION OF A COMPOUND OF FORMULA II WITH A COMPOUND OF FORMULA HO (CRaRb) nXH, WHERE n, Ra AND Rb, ALREADY DEFINED AND X MEANS O or NH, or; b) REACTION OF A COMPOUND OF FORMULA III WITH A COMPOUND OF FORMULA R1SO2Z, WHERE Y IS HALOGEN AND Z AMINO, or Y REPRESENTS AMINO and Z HALOGEN, or; c) REACTION OF A COMPOUND OF FORMULA IV WITH AN ISOCYANATE OF FORMULA R9NCO OR A CARBAMOIL CHLORIDE OF FORMULA R9NCOCl, AMONG OTHERS. THIS COMPOUND IS USED IN THE TREATMENT OF DISEASES ASSOCIATED WITH ENDOTHELINE ACTIVITIES SUCH AS HYPERTENSION AND ISCHEMIA

PE1995285176A 1994-11-25 1995-11-21 NEW SULFONAMIDE AND PROCEDURE FOR OBTAINING PE52496A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH355994 1994-11-25

Publications (1)

Publication Number Publication Date
PE52496A1 true PE52496A1 (en) 1996-12-12

Family

ID=4258608

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995285176A PE52496A1 (en) 1994-11-25 1995-11-21 NEW SULFONAMIDE AND PROCEDURE FOR OBTAINING

Country Status (9)

Country Link
AR (2) AR002251A1 (en)
BR (1) BR9505528A (en)
CO (1) CO4650181A1 (en)
PE (1) PE52496A1 (en)
PL (1) PL185692B1 (en)
TR (1) TR199501486A2 (en)
UY (1) UY24100A1 (en)
WO (1) WO1996016963A1 (en)
ZA (1) ZA959808B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI284642B (en) * 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides
CA2431675C (en) * 2000-12-18 2011-11-08 Actelion Pharmaceuticals Ltd. Novel sulfamides and their use as endothelin receptor antagonists
CN1930135B (en) 2004-03-05 2011-12-28 弗·哈夫曼-拉罗切有限公司 Diaminopyrimidines as P2X3 and P2X2/3 antagonists
AR062501A1 (en) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd THERAPEUTIC COMPOSITIONS
MX2010001837A (en) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Iron with actively cooled soleplate and method for cooling the soleplate.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2086544C1 (en) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity

Also Published As

Publication number Publication date
AR010549A2 (en) 2000-06-28
UY24100A1 (en) 2000-12-29
CO4650181A1 (en) 1998-09-03
ZA959808B (en) 1996-05-27
AR002251A1 (en) 1998-03-11
BR9505528A (en) 1997-11-04
PL185692B1 (en) 2003-07-31
TR199501486A2 (en) 1996-07-21
PL311487A1 (en) 1996-05-27
WO1996016963A1 (en) 1996-06-06

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FG Grant, registration
FD Application declared void or lapsed