PE14696A1 - PHENETHANOLAMINE DERIVATIVE - Google Patents
PHENETHANOLAMINE DERIVATIVEInfo
- Publication number
- PE14696A1 PE14696A1 PE1995270670A PE27067095A PE14696A1 PE 14696 A1 PE14696 A1 PE 14696A1 PE 1995270670 A PE1995270670 A PE 1995270670A PE 27067095 A PE27067095 A PE 27067095A PE 14696 A1 PE14696 A1 PE 14696A1
- Authority
- PE
- Peru
- Prior art keywords
- carbon atoms
- alkyl
- compounds
- preferred
- replaced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I DONDE: R1 REPRESENTA UN GRUPO ARILO OPCIONALMENTE SUSTITUIDO POR UNO O MAS SUSTITUYENTES, SELECCIONADO DE HALO, HIDROXI, ALCOXI DE 1 A 6 ATOMOS DE CARBONO, ENTRE OTROS; DE PREFERENCIA ES UN GRUPO FENILO SUSTITUIDO POR UN ATOMO DE CLORO EN POSICION META; R2 REPRESENTA H o ALQUILO DE 1 A 6 ATOMOS DE CARBONO, DE PREFERENCIA ES METILO o H; R3 ES UN GRUPO FENILO O HETEROARILO SUSTITUIDO CON R6 Y R7; R4 y R5 CADA UNO REPRESENTA INDEPENDIENTEMENTE H o ALQUILO DE 1 A 6 ATOMOS DE CARBONO O R4 Y R5 CONJUNTAMENTE FORMAN UN GRUPO CICLOALQUILO DE 3 A 6 ATOMOS DE CARBONO; X ES (CH2)n DONDE n ES 1 o 2, DE PREFERENCIA 2. ESTOS COMPUESTOS SE CARACTERIZAN POR ACTUAR COMO AGONISTAS EN LOS BETA-ADRENORECEPTORES ATIPICOS , SIENDO UTILES EN EL TRATAMIENTO DE DESORDENES GASTROINTESTINALES EN PARTICULAR LOS ASOCIADOS CON LA INFLAMACION Y ULCERACIONIT REFERS TO FORMULA I COMPOUNDS WHERE: R1 REPRESENTS AN ARILO GROUP OPTIONALLY REPLACED BY ONE OR MORE SUBSTITUTES, SELECTED FROM HALO, HIDROXI, ALCOXI FROM 1 TO 6 CARBON ATOMS, AMONG OTHERS; OF PREFERENCE IS A PHENYLUS GROUP REPLACED BY A CHLORINE ATOME IN GOAL POSITION; R2 REPRESENTS H or ALKYL FROM 1 TO 6 CARBON ATOMS, PREFERRED IS METHYL or H; R3 IS A PHENYL OR HETEROARYL GROUP REPLACED WITH R6 AND R7; R4 and R5 EACH ONE INDEPENDENTLY REPRESENTS H or ALKYL FROM 1 TO 6 CARBON ATOMS OR R4 AND R5 TOGETHER FORM A CYCLOALKYL GROUP OF 3 TO 6 CARBON ATOMS; X IS (CH2) n WHERE n IS 1 or 2, PREFERRED 2. THESE COMPOUNDS ARE CHARACTERIZED BY ACTING AS AGONISTS IN THE BETA-ADRENORECEPTORS ATYPICAL, BEING USEFUL IN THE TREATMENT OF GASTROINTESTINAL DISORDERS AND ASSOCIATED WITH ULCH
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9411589A GB9411589D0 (en) | 1994-06-09 | 1994-06-09 | Chemical compounds |
GBGB9504169.5A GB9504169D0 (en) | 1995-03-02 | 1995-03-02 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE14696A1 true PE14696A1 (en) | 1996-05-13 |
Family
ID=26305035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1995270670A PE14696A1 (en) | 1994-06-09 | 1995-06-07 | PHENETHANOLAMINE DERIVATIVE |
Country Status (5)
Country | Link |
---|---|
AU (1) | AU2737295A (en) |
CO (1) | CO4410319A1 (en) |
IL (1) | IL114059A0 (en) |
PE (1) | PE14696A1 (en) |
WO (1) | WO1995033724A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9525121D0 (en) * | 1995-12-08 | 1996-02-07 | Glaxo Group Ltd | Chemical compounds |
GB9525177D0 (en) * | 1995-12-08 | 1996-02-07 | Glaxo Group Ltd | Chemical compounds |
US5914339A (en) * | 1996-05-14 | 1999-06-22 | American Home Products Corporation | Substituted 1,3-benzodioxoles |
FR2751646B1 (en) * | 1996-07-23 | 1999-01-22 | Sanofi Sa | PHENOXYPROPANOLAMINE WITH ANTAGONIST BETA3-ADRENERGIC ACTION |
GB9706707D0 (en) * | 1997-04-02 | 1997-05-21 | Glaxo Group Ltd | Chemical compounds |
GB9812709D0 (en) * | 1998-06-13 | 1998-08-12 | Glaxo Group Ltd | Chemical compounds |
GB9929118D0 (en) * | 1999-12-10 | 2000-02-02 | Glaxo Group Ltd | Chemical compounds |
US7709677B2 (en) | 2001-01-31 | 2010-05-04 | Glaxosmithkline Llc | Process of preparing arylethanoldiamines |
GB0102408D0 (en) * | 2001-01-31 | 2001-03-14 | Glaxo Group Ltd | Chemical compounds |
GB0102407D0 (en) | 2001-01-31 | 2001-03-14 | Glaxo Group Ltd | Process |
US7034053B2 (en) | 2001-01-31 | 2006-04-25 | Smithkline Beecham Corporation | Phenethanolamine derivatives, compositions, and their use as agonists at atypical beta-adrenoreceptors |
DE60315892T2 (en) | 2002-12-24 | 2008-08-14 | Astrazeneca Ab | PHOSPHONO-OXY-CHINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE |
EP1595873A1 (en) * | 2004-05-13 | 2005-11-16 | Boehringer Ingelheim Pharma GmbH & Co.KG | Substituted cycloalkyl derivatives for the treatment of respiratory diseases |
US7423035B2 (en) | 2004-05-13 | 2008-09-09 | Boehringer Ingelheim International Gmbh | Substituted cycloalkyl derivatives, process for the manufacture thereof and use thereof as medicament |
ATE529111T1 (en) | 2005-12-07 | 2011-11-15 | Basilea Pharmaceutica Ag | USEFUL MONOBACTAM ANTIBIOTICS |
US9522129B2 (en) | 2010-08-03 | 2016-12-20 | Velicept Therapeutics, Inc. | Pharmaceutical Combination |
US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
CN107205964A (en) | 2014-12-03 | 2017-09-26 | 威力塞帕特治疗股份有限公司 | It is used for the composition and method of lower urinary tract symptom using regulation release Suo Labeilong |
US10065922B2 (en) | 2015-10-23 | 2018-09-04 | Velicept Therapeutics, Inc. | Solabegron zwitterion and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4154761A (en) * | 1976-02-09 | 1979-05-15 | Allen & Hanburys Limited | Pharmacologically active compounds |
DK31578A (en) * | 1977-02-03 | 1978-08-04 | Allen & Hanburys Ltd | PROCEDURE FOR THE PRODUCTION OF BENZENE DERIVATIVES |
US5061727A (en) * | 1990-05-04 | 1991-10-29 | American Cyanamid Company | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles |
NO179246C (en) * | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatic amino-alcohol derivatives and intermediates for their preparation |
GB9207964D0 (en) * | 1992-04-10 | 1992-05-27 | Ici Plc | Chemical compounds |
-
1995
- 1995-06-06 AU AU27372/95A patent/AU2737295A/en not_active Abandoned
- 1995-06-06 WO PCT/EP1995/002133 patent/WO1995033724A1/en active Application Filing
- 1995-06-07 PE PE1995270670A patent/PE14696A1/en not_active Application Discontinuation
- 1995-06-08 CO CO95024914A patent/CO4410319A1/en unknown
- 1995-06-08 IL IL11405995A patent/IL114059A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL114059A0 (en) | 1995-10-31 |
CO4410319A1 (en) | 1997-01-09 |
AU2737295A (en) | 1996-01-04 |
WO1995033724A1 (en) | 1995-12-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FX | Voluntary withdrawal |