AR002251A1 - DERIVATIVES OF SULFONAMIDES, PROCEDURE FOR THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS AND USE OF THE COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR DISEASES ASSOCIATED WITH ENDOTHELINE. - Google Patents
DERIVATIVES OF SULFONAMIDES, PROCEDURE FOR THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS AND USE OF THE COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR DISEASES ASSOCIATED WITH ENDOTHELINE.Info
- Publication number
- AR002251A1 AR002251A1 ARP950100297A AR10029795A AR002251A1 AR 002251 A1 AR002251 A1 AR 002251A1 AR P950100297 A ARP950100297 A AR P950100297A AR 10029795 A AR10029795 A AR 10029795A AR 002251 A1 AR002251 A1 AR 002251A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- phenyl
- alkoxy
- alkyl
- lower alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Los compuestos de fórmula (I) en donde R1 es heterocíclilo;R2 eshidrógeno, alquilo inferior, alcoxilo inferior, alquiltio inferior, alcoxiloinferior-alquilo inferior, alquilsulfonilo inferior-alcoxilo inferior, fenilo, alquilo inferior- fenilo,alcoxilo inferior-fenilo, alquileno inferior-dioxifenilo, fenilo alquilo inferior, alquilo inferior-fenilo,alquilo inferior, alcoxilo inferior fenilo-alquilo inferior, alquileno inferior dioxifeniloalquilo inferior, heterociclilo o heterocicl o-alquilo inferior; R3 es alquilo inferior alcoxilo inferior, formilo, haloalquilo inferior, hidroxilo-alquiloinferior amino-alquilo inferior o un radical -CH2O-A-alquilo inferior,-(CH2)m-O -(CD G)nCH,-(CH2)m-O-(CD G)n OR9,-(CH2)m-O-(CD G)n NH2 ó -(CH2)m-O-(CD G)n-B-R9;R4 y R8 son hidrógeno,alcoxilo inferior o halógeno;R9 significa heterociclilo; fenilo o fenilo sustituido con alquilo inferior, alcoxilo inferior y/ohalógeno, ó alquilo inferior;D y G significan hidrógeno o alquiloinferior ; A significa un grupo 1,2 dihidroxi-etileno cetalizado; B significa -OC(O)O,O(C(O)NH, -NH(C(O)NH- e -NHC(O)O-, n es 2, 3 ó 4; y m es 0 ó 1, son sustancias que inhiben los receptores de la endotelia. Pueden utilizarse, por lo tanto,parael trata miento de enfermedades que están asociadas a las actividades de la endotelina, en particular, las enfermedades circulatorias como la hipertensión,isquemia, espasmos vasculares y angina pectoris.The compounds of formula (I) wherein R1 is heterocyclyl; R2 is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkoxy-lower alkyl, lower alkylsulfonyl-lower alkoxy, phenyl, lower alkyl-phenyl, lower alkoxy-phenyl, lower alkylene -dioxyphenyl, phenyl lower alkyl, lower alkyl-phenyl, lower alkyl, lower alkoxy phenyl-lower alkyl, lower alkylene dioxyphenyl lower alkyl, heterocyclyl or heterocyclic o-lower alkyl; R3 is lower alkyl lower alkoxy, formyl, halo lower alkyl, hydroxyl-lower alkyl amino-lower alkyl or a radical -CH2O-A-lower alkyl, - (CH2) mO - (CD G) nCH, - (CH2) mO- (CD G) n OR9, - (CH2) mO- (CD G) n NH2 or - (CH2) mO- (CD G) nB-R9, R4 and R8 are hydrogen, lower alkoxy or halogen, R9 signifies heterocyclyl; phenyl or phenyl substituted with lower alkyl, lower alkoxy and / or halogen, or lower alkyl, D and G signify hydrogen or lower alkyl; A signifies a 1,2-dihydroxy-ethylene ketalized group; B means -OC (O) O, O (C (O) NH, -NH (C (O) NH- and -NHC (O) O-, n is 2, 3 or 4; and m is 0 or 1, they are Substances that inhibit endothelial receptors They can therefore be used for the treatment of diseases that are associated with endothelin activities, in particular circulatory diseases such as hypertension, ischemia, vascular spasms and angina pectoris.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH355994 | 1994-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR002251A1 true AR002251A1 (en) | 1998-03-11 |
Family
ID=4258608
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP950100297A AR002251A1 (en) | 1994-11-25 | 1995-11-23 | DERIVATIVES OF SULFONAMIDES, PROCEDURE FOR THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS AND USE OF THE COMPOUNDS FOR THE PREPARATION OF MEDICINES FOR DISEASES ASSOCIATED WITH ENDOTHELINE. |
ARP970105148A AR010549A2 (en) | 1994-11-25 | 1997-11-04 | DERIVATIVES OF SULFONAMIDES USEFUL AS SYNTHESIS INTERMEDIARIES. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970105148A AR010549A2 (en) | 1994-11-25 | 1997-11-04 | DERIVATIVES OF SULFONAMIDES USEFUL AS SYNTHESIS INTERMEDIARIES. |
Country Status (9)
Country | Link |
---|---|
AR (2) | AR002251A1 (en) |
BR (1) | BR9505528A (en) |
CO (1) | CO4650181A1 (en) |
PE (1) | PE52496A1 (en) |
PL (1) | PL185692B1 (en) |
TR (1) | TR199501486A2 (en) |
UY (1) | UY24100A1 (en) |
WO (1) | WO1996016963A1 (en) |
ZA (1) | ZA959808B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI284642B (en) * | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
EP1345920B1 (en) * | 2000-12-18 | 2006-04-12 | Actelion Pharmaceuticals Ltd. | Novel sulfamides and their use as endothelin receptor antagonists |
EP1725540B1 (en) | 2004-03-05 | 2012-09-12 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 antagonists |
AR062501A1 (en) | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | THERAPEUTIC COMPOSITIONS |
MX2010001837A (en) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Iron with actively cooled soleplate and method for cooling the soleplate. |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2086544C1 (en) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity |
-
1995
- 1995-06-06 WO PCT/CH1995/000131 patent/WO1996016963A1/en unknown
- 1995-11-17 ZA ZA959808A patent/ZA959808B/en unknown
- 1995-11-21 PE PE1995285176A patent/PE52496A1/en not_active Application Discontinuation
- 1995-11-23 AR ARP950100297A patent/AR002251A1/en active IP Right Grant
- 1995-11-24 CO CO95055930A patent/CO4650181A1/en unknown
- 1995-11-24 TR TR95/01486A patent/TR199501486A2/en unknown
- 1995-11-24 PL PL95311487A patent/PL185692B1/en not_active IP Right Cessation
- 1995-11-24 UY UY24100A patent/UY24100A1/en not_active IP Right Cessation
- 1995-11-27 BR BR9505528A patent/BR9505528A/en not_active IP Right Cessation
-
1997
- 1997-11-04 AR ARP970105148A patent/AR010549A2/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
BR9505528A (en) | 1997-11-04 |
CO4650181A1 (en) | 1998-09-03 |
ZA959808B (en) | 1996-05-27 |
AR010549A2 (en) | 2000-06-28 |
PL311487A1 (en) | 1996-05-27 |
UY24100A1 (en) | 2000-12-29 |
TR199501486A2 (en) | 1996-07-21 |
PE52496A1 (en) | 1996-12-12 |
WO1996016963A1 (en) | 1996-06-06 |
PL185692B1 (en) | 2003-07-31 |
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