PE52399A1 - Metodo para usar compuestos neurotroficos de sulfonamida - Google Patents

Metodo para usar compuestos neurotroficos de sulfonamida

Info

Publication number
PE52399A1
PE52399A1 PE1998000096A PE00009698A PE52399A1 PE 52399 A1 PE52399 A1 PE 52399A1 PE 1998000096 A PE1998000096 A PE 1998000096A PE 00009698 A PE00009698 A PE 00009698A PE 52399 A1 PE52399 A1 PE 52399A1
Authority
PE
Peru
Prior art keywords
alkyl
members
rent
compound
formula
Prior art date
Application number
PE1998000096A
Other languages
English (en)
Inventor
Gregory Scott Hamilton
Jia-He Li
Joseph P Steiner
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25175836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE52399(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of PE52399A1 publication Critical patent/PE52399A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE; "A" ES CH2, O, NH o N-ALQUILO C1-C4; "B" Y "D" SON Ar, H, ALQUILO C1-C6, ALQUENILO C1-C6 OPCIONALMENTE SUSTITUIDOS Y CARACTERIZADOS PORQUE UNO O DOS CH2 DEL ALQUILO O ALQUENILO PUEDE CONTENER O, S, SO, SO2 o -C(Q)=C(T); "Q" ES H, ALQUILO C1-C6 O ALQUENILO C1-C6; "T" ES Ar o CICLOALQUILO DE 5 A 7 MIEMBROS CON H, OH, O(C1-C4)ALQUILO, O(C1-C4)ALQUENILO O CARBONILO EN LAS POSICIONES 3 Y 4; Ar ES FENILO, NAFTILO, FURILO, TIENILO, PIRIDILO, HETEROCICLOS MONO O BICICLICOS DE 5-6 MIEMBROS CADA CICLO CON 1-4 O, N, S; "E" ES ALQUILO C1-C6, ALQUENILO C1-C6, CICLOALQUILO C5-C7, ENTRE OTROS; "J" ES H, ALQUILO O BENCILO; "K" ES ALQUILO, BENCILO, CICLOHEXILMETILO(C1-C4); "J" Y "K" PUEDEN FORMAR UN ANILLO HETEROCICLO DE 5-7 MIEMBROS CON O o S o SO o SO2; n ES 0 o 3; LOS CARBONOS 1 Y 2 TIENEN CONFIGURACION R o S. EL COMPUESTO DE FORMULA (I) IMPULSA LA ACTIVIDAD NEURONAL, PROMOCIONA LA REGENERACION NEURONAL, PREVIENE LA NEURODEGENERACION POR LO QUE PUEDE SER UTIL EN EL TRATAMIENTO DE UN TRASTORNO NEUROLOGICO
PE1998000096A 1997-02-12 1998-02-10 Metodo para usar compuestos neurotroficos de sulfonamida PE52399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/799,407 US5721256A (en) 1997-02-12 1997-02-12 Method of using neurotrophic sulfonamide compounds

Publications (1)

Publication Number Publication Date
PE52399A1 true PE52399A1 (es) 1999-05-27

Family

ID=25175836

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000096A PE52399A1 (es) 1997-02-12 1998-02-10 Metodo para usar compuestos neurotroficos de sulfonamida

Country Status (12)

Country Link
US (4) US5721256A (es)
EP (1) EP1014978A4 (es)
JP (1) JP2001511806A (es)
AR (1) AR011660A1 (es)
AU (1) AU6268898A (es)
CA (1) CA2280742A1 (es)
CR (1) CR5720A (es)
GT (1) GT199800024A (es)
PA (1) PA8446601A1 (es)
PE (1) PE52399A1 (es)
WO (1) WO1998035675A1 (es)
ZA (1) ZA98824B (es)

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US5935989A (en) 1996-12-31 1999-08-10 Gpi Nil Holdings Inc. N-linked ureas and carbamates of heterocyclic thioesters
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US5846979A (en) 1997-02-28 1998-12-08 Gpi Nil Holdings, Inc. N-oxides of heterocyclic esters, amides, thioesters, and ketones
US6268384B1 (en) * 1997-08-29 2001-07-31 Vertex Pharmaceuticals Incorporated Compounds possessing neuronal activity
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US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
AU1708099A (en) 1998-06-03 1999-12-20 Amgen, Inc. N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
SI20638A (sl) 1998-07-17 2002-02-28 Agouron Pharmaceuticals, Inc. Spojine, sestavki in metode za stimulacijo rasti in podaljševanja nevronov
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US7338976B1 (en) * 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6339101B1 (en) * 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6333340B1 (en) * 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US7265150B1 (en) * 1998-08-14 2007-09-04 Gpi Nil Holdings Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders
US6337340B1 (en) * 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6376517B1 (en) * 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
US6228872B1 (en) 1998-11-12 2001-05-08 Bristol-Myers Squibb Company Neurotrophic diamide and carbamate agents
WO2000046193A2 (en) * 1999-02-03 2000-08-10 Schering Aktiengesellschaft Ether derivatives having neuronal activity
US6284779B1 (en) 1999-02-03 2001-09-04 Schering Aktiiengesellschaft Heteroaromatic compounds
AU3221300A (en) * 1999-02-03 2000-08-25 Schering Aktiengesellschaft Carboxylic acid derivatives, process for their preparation and their use as rotamase enzyme activity inhibitors
WO2001004090A2 (en) 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods
JP2003504367A (ja) 1999-07-09 2003-02-04 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 神経栄養性ピロリジン類およびピペリジン類、並びに関連組成物および方法
AU5483500A (en) 1999-07-09 2001-01-30 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods
US6495549B1 (en) * 1999-07-15 2002-12-17 Pfizer Inc FKBP inhibitors
WO2001008685A1 (en) * 1999-07-30 2001-02-08 Vertex Pharmaceuticals Incorporated Acyclic and cyclic amine derivatives
AU6388500A (en) * 1999-08-05 2001-03-05 Procter & Gamble Company, The Multivalent sulfonamides
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EP1214293A1 (en) * 1999-09-08 2002-06-19 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
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US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
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US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
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IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
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Also Published As

Publication number Publication date
AU6268898A (en) 1998-09-08
ZA98824B (en) 1998-10-30
US5721256A (en) 1998-02-24
JP2001511806A (ja) 2001-08-14
AR011660A1 (es) 2000-08-30
WO1998035675A1 (en) 1998-08-20
CA2280742A1 (en) 1998-08-20
US5968957A (en) 1999-10-19
EP1014978A1 (en) 2000-07-05
EP1014978A4 (en) 2003-05-28
CR5720A (es) 2001-01-25
PA8446601A1 (es) 2000-05-24
US6245783B1 (en) 2001-06-12
US20030114492A1 (en) 2003-06-19
GT199800024A (es) 1999-07-23

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