PE20230732A1 - Derivados de dioxoloisoquinolinona novedosos y uso de los mismos - Google Patents
Derivados de dioxoloisoquinolinona novedosos y uso de los mismosInfo
- Publication number
- PE20230732A1 PE20230732A1 PE2023000179A PE2023000179A PE20230732A1 PE 20230732 A1 PE20230732 A1 PE 20230732A1 PE 2023000179 A PE2023000179 A PE 2023000179A PE 2023000179 A PE2023000179 A PE 2023000179A PE 20230732 A1 PE20230732 A1 PE 20230732A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- dimethyl
- derivatives
- dioxolisoquinolinone
- novel
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003623 enhancer Substances 0.000 abstract 2
- QTTMOCOWZLSYSV-QWAPEVOJSA-M equilin sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 QTTMOCOWZLSYSV-QWAPEVOJSA-M 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- AIFGDRAXMCFCSA-VOSQCMCKSA-N C[C@@]([C@H](CC1)CC[C@@H]1N(C)C)(OC1=C2C)OC1=C(C1=CC=CO1)C(CCN1CC3=C(C)C=C(C)NC3=O)=C2C1=O Chemical compound C[C@@]([C@H](CC1)CC[C@@H]1N(C)C)(OC1=C2C)OC1=C(C1=CC=CO1)C(CCN1CC3=C(C)C=C(C)NC3=O)=C2C1=O AIFGDRAXMCFCSA-VOSQCMCKSA-N 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- YIOFGHHAURBGSJ-UHFFFAOYSA-N isoquinoline-1,3,4-trione Chemical class C1=CC=C2C(=O)C(=O)NC(=O)C2=C1 YIOFGHHAURBGSJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
Abstract
Esta referido a derivados de dioxoisoquinolinona de Formula Ia, en donde: R1 es H, halogeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, entre otras opciones; L es un enlace o alquileno C1-6; Ra es un bicicloalquilo C5-9 sustituido; R2 es H o alquilo C1-6; R3 es H, halogeno o alquilo C1-6; y, R4 es alquilo C1-6, alcoxi C1-6 o tio-alquilo C1-6. Entre los compuestos preferidos tenemos los siguientes: (R)-6-((4,6-dimetil-2-oxo-1,2-dihidropiridin-3-il)metil)-2-(trans-4- (dimetilamino)ciclohexil)-9-(furan-2-il)-2,4-dimetil-7,8-dihidro-[1,3]dioxolo[4,5- g]isoquinolin-5(6H)-ona; (R)-6-((4,6-dimetil-2-oxo-1,2-dihidropiridin-3-il)metil)-2-(trans-4- (dimetilamino)ciclohexil)-2,4-dimetil-9-(piridin-4-il)-7,8-dihidro-[1,3]dioxolo[4,5- 20 g]isoquinolin-5(6H)-ona; entre otros. Estos compuestos son inhibidores de de la actividad de EZH1 (potenciador del homologo de zeste 1) y/o EZH2 (potenciador del homologo de zeste 2), empleandose en la prevencion o tratamiento del cancer o tumores.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020200102034A KR102386403B1 (ko) | 2020-08-13 | 2020-08-13 | 신규한 디옥솔로이소퀴놀린온 유도체 화합물 및 이의 용도 |
| PCT/KR2021/095037 WO2022035303A1 (en) | 2020-08-13 | 2021-05-20 | Novel dioxoloisoquinolinone derivatives and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20230732A1 true PE20230732A1 (es) | 2023-05-03 |
Family
ID=77746355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023000179A PE20230732A1 (es) | 2020-08-13 | 2021-05-20 | Derivados de dioxoloisoquinolinona novedosos y uso de los mismos |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11535629B2 (es) |
| EP (1) | EP4196483A1 (es) |
| JP (2) | JP7387907B2 (es) |
| CN (1) | CN116194108A (es) |
| AU (1) | AU2021203261B1 (es) |
| BR (1) | BR112023002077A2 (es) |
| CA (1) | CA3165787C (es) |
| IL (1) | IL300577A (es) |
| MX (1) | MX2023001603A (es) |
| PE (1) | PE20230732A1 (es) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013067302A1 (en) | 2011-11-04 | 2013-05-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Method of treatment |
| UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
| SI3121175T1 (sl) | 2014-03-17 | 2020-07-31 | Daiichi Sankyo Company, Limited | Derivati 1,3-benzodioksola kot EZH1 in/ali EZH2 inhibitorji |
| US20190255041A1 (en) | 2016-10-28 | 2019-08-22 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating ezh2-mediated cancer |
| CN112262143A (zh) | 2018-05-21 | 2021-01-22 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| KR20200101219A (ko) | 2019-02-19 | 2020-08-27 | 한미약품 주식회사 | 신규한 헤테로트리시클릭 유도체 화합물 및 이의 용도 |
-
2021
- 2021-05-20 JP JP2022543435A patent/JP7387907B2/ja active Active
- 2021-05-20 US US17/605,883 patent/US11535629B2/en active Active
- 2021-05-20 BR BR112023002077A patent/BR112023002077A2/pt unknown
- 2021-05-20 MX MX2023001603A patent/MX2023001603A/es unknown
- 2021-05-20 EP EP21856309.6A patent/EP4196483A1/en active Pending
- 2021-05-20 IL IL300577A patent/IL300577A/en unknown
- 2021-05-20 PE PE2023000179A patent/PE20230732A1/es unknown
- 2021-05-20 CA CA3165787A patent/CA3165787C/en active Active
- 2021-05-20 CN CN202180055369.0A patent/CN116194108A/zh active Pending
- 2021-05-20 AU AU2021203261A patent/AU2021203261B1/en active Active
-
2023
- 2023-08-30 JP JP2023140549A patent/JP2023155432A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3165787C (en) | 2023-06-06 |
| CA3165787A1 (en) | 2022-02-17 |
| JP2023155432A (ja) | 2023-10-20 |
| IL300577A (en) | 2023-04-01 |
| EP4196483A1 (en) | 2023-06-21 |
| US20220275000A1 (en) | 2022-09-01 |
| JP7387907B2 (ja) | 2023-11-28 |
| JP2023517272A (ja) | 2023-04-25 |
| AU2021203261B1 (en) | 2021-09-23 |
| CN116194108A (zh) | 2023-05-30 |
| MX2023001603A (es) | 2023-03-07 |
| US11535629B2 (en) | 2022-12-27 |
| BR112023002077A2 (pt) | 2023-02-28 |
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