PE20230486A1 - Polipeptidos y sus usos - Google Patents
Polipeptidos y sus usosInfo
- Publication number
- PE20230486A1 PE20230486A1 PE2022001740A PE2022001740A PE20230486A1 PE 20230486 A1 PE20230486 A1 PE 20230486A1 PE 2022001740 A PE2022001740 A PE 2022001740A PE 2022001740 A PE2022001740 A PE 2022001740A PE 20230486 A1 PE20230486 A1 PE 20230486A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- amino acid
- acid sequence
- polypeptide
- present
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/20—Protein or domain folding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
Abstract
Referido a un polipeptido que comprende o consiste en: (a) una secuencia de aminoacidos al menos 75 %, 80 %, o hasta 99 % identica a la secuencia de aminoacidos de la SEQ ID NO:1 (I3-01 de tipo silvestre), en donde 1, 2, 3, 4, 5, 6, 7, 8, 9 o las 10 mutaciones siguientes con relacion a la SEQ ID NO:1 estan presentes en el polipeptido: F32Y, H37D/E/K/N/Q/R, F43Q, entre otros; (b) una secuencia de aminoacidos al menos 75 %, 80 %, o hasta 99 % identica a la secuencia de aminoacidos de la SEQ ID NO: 2 (tetramero O43-38 de tipo silvestre), en donde 1, 2, 3, 4, 5, 6, 7, 8 o las 9 de las siguientes mutaciones con relacion a la SEQ ID NO:2 estan presentes en el polipeptido: M138D/E/K/N/Q/R/S/T, L139D/N/S, A141S, entre otros; (c) una secuencia de aminoacidos al menos 75 %, 80 %, o hasta 99 % identica a la secuencia de aminoacidos de la SEQ ID NO:3 (trimero O43-38 de tipo silvestre), en donde 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 o las 21 de las siguientes mutaciones con relacion a la SEQ ID NO:3 estan presentes en el polipeptido: R17D/E/K/N/Q/S/T, N19D/E, S20D/E/K/N, entre otros; (d) una secuencia de aminoacidos al menos 75 %, 80 %, o hasta 99 % identica a la secuencia de aminoacidos de la SEQ ID NO:4 (I53_dn5A de tipo silvestre), en donde 1, 2, 3, 4, 5, 6, 7, 8, 9 o las 10 de las siguientes mutaciones con relacion a la SEQ ID NO:4 estan presentes en el polipeptido: R17T, W18D/E/K/N/Q/R/S/T/Y, N19E, E21D, entre otros; o (e) una secuencia de aminoacidos al menos 75 %, 80 %, o hasta 99 % identica a la secuencia de aminoacidos de la SEQ ID NO:5 o 6 (hMPV de tipo silvestre), en donde 1, 2, 3, 4 o las 5 de las siguientes mutaciones con relacion a la SEQ ID NO:5 o 6 estan presentes en el polipeptido: A107D, V112R, T114E, V118R y/o G264D; en donde los residuos entre parentesis son opcionales y pueden estar presentes o pueden estar ausentes en su totalidad o en parte. Tambien se refiere a una proteina de fusion que comprende dicho polipeptido, nanoparticulas y una composicion que comprende dichos polipeptidos, metodos para disenarlos, acido nucleico que codifica dicho polipeptido, vector de expresion, celula hospedera, y metodos para disenar tales polipeptidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062977036P | 2020-02-14 | 2020-02-14 | |
PCT/US2021/017856 WO2021163481A1 (en) | 2020-02-14 | 2021-02-12 | Polypeptides and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20230486A1 true PE20230486A1 (es) | 2023-03-21 |
Family
ID=77292738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022001740A PE20230486A1 (es) | 2020-02-14 | 2021-02-12 | Polipeptidos y sus usos |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230075095A1 (es) |
EP (1) | EP4103586A4 (es) |
JP (1) | JP2023513592A (es) |
KR (1) | KR20220142471A (es) |
AU (1) | AU2021220958A1 (es) |
BR (1) | BR112022016197A2 (es) |
CL (1) | CL2022002215A1 (es) |
CO (1) | CO2022011395A2 (es) |
PE (1) | PE20230486A1 (es) |
WO (1) | WO2021163481A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023196871A2 (en) * | 2022-04-07 | 2023-10-12 | University Of Washington | Secretion-optimized de novo designed protein nanoparticles for eukaryotic expression and genetic delivery |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2568788A1 (en) * | 2004-06-16 | 2005-12-29 | Dsm Ip Assets B.V. | Production of polypeptides by improved secretion |
US9630994B2 (en) * | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
WO2016138525A1 (en) * | 2015-02-27 | 2016-09-01 | University Of Washington | Polypeptide assemblies and methods for the production thereof |
CN115947873A (zh) * | 2017-04-04 | 2023-04-11 | 华盛顿大学 | 显示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途 |
-
2021
- 2021-02-12 BR BR112022016197A patent/BR112022016197A2/pt unknown
- 2021-02-12 PE PE2022001740A patent/PE20230486A1/es unknown
- 2021-02-12 KR KR1020227031325A patent/KR20220142471A/ko unknown
- 2021-02-12 EP EP21753413.0A patent/EP4103586A4/en active Pending
- 2021-02-12 US US17/760,180 patent/US20230075095A1/en active Pending
- 2021-02-12 WO PCT/US2021/017856 patent/WO2021163481A1/en active Application Filing
- 2021-02-12 AU AU2021220958A patent/AU2021220958A1/en active Pending
- 2021-02-12 JP JP2022549070A patent/JP2023513592A/ja active Pending
-
2022
- 2022-08-12 CO CONC2022/0011395A patent/CO2022011395A2/es unknown
- 2022-08-12 CL CL2022002215A patent/CL2022002215A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2023513592A (ja) | 2023-03-31 |
AU2021220958A1 (en) | 2022-09-01 |
US20230075095A1 (en) | 2023-03-09 |
EP4103586A4 (en) | 2024-05-15 |
CL2022002215A1 (es) | 2023-05-05 |
CO2022011395A2 (es) | 2023-01-16 |
WO2021163481A1 (en) | 2021-08-19 |
KR20220142471A (ko) | 2022-10-21 |
BR112022016197A2 (pt) | 2022-10-25 |
EP4103586A1 (en) | 2022-12-21 |
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