PE20211410A1 - Formas farmaceuticas orales biodisponibles - Google Patents
Formas farmaceuticas orales biodisponiblesInfo
- Publication number
- PE20211410A1 PE20211410A1 PE2021000157A PE2021000157A PE20211410A1 PE 20211410 A1 PE20211410 A1 PE 20211410A1 PE 2021000157 A PE2021000157 A PE 2021000157A PE 2021000157 A PE2021000157 A PE 2021000157A PE 20211410 A1 PE20211410 A1 PE 20211410A1
- Authority
- PE
- Peru
- Prior art keywords
- oral pharmaceutical
- pharmaceutical forms
- available oral
- solid dispersion
- bio available
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen una forma de un compuesto lipofilo util en una composicion farmaceutica y un metodo para formar una dispersion solida, tal como un producto intermedio secado por pulverizacion, con la forma del compuesto. Tambien se describe el uso de la dispersion solida para proporcionar una forma farmaceutica oral biodisponible que tenga una mayor carga de dosis y una mejor disolucion menos sujeta a un efecto de la comida. Estas composiciones se emplean en el tratamiento de la leucemia, artritis reumatoide, esclerosis multiple, entre otras
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862714182P | 2018-08-03 | 2018-08-03 | |
PCT/US2019/044853 WO2020028778A1 (en) | 2018-08-03 | 2019-08-02 | Bioavailable oral dosage forms |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20211410A1 true PE20211410A1 (es) | 2021-08-02 |
Family
ID=67766269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021000157A PE20211410A1 (es) | 2018-08-03 | 2019-08-02 | Formas farmaceuticas orales biodisponibles |
Country Status (23)
Country | Link |
---|---|
US (1) | US20210205225A1 (es) |
EP (1) | EP3829544A1 (es) |
JP (1) | JP2021532193A (es) |
KR (1) | KR20210041589A (es) |
CN (1) | CN112752570A (es) |
AR (1) | AR115913A1 (es) |
AU (1) | AU2019316036A1 (es) |
BR (1) | BR112021001859A2 (es) |
CA (1) | CA3107737A1 (es) |
CL (1) | CL2021000271A1 (es) |
CO (1) | CO2021001979A2 (es) |
CR (1) | CR20210093A (es) |
EA (1) | EA202190429A1 (es) |
EC (1) | ECSP21011795A (es) |
IL (1) | IL280471A (es) |
MX (1) | MX2021001364A (es) |
NI (1) | NI202100006A (es) |
PE (1) | PE20211410A1 (es) |
PH (1) | PH12021550237A1 (es) |
SG (1) | SG11202100984VA (es) |
TN (1) | TN2021000021A1 (es) |
TW (1) | TW202019414A (es) |
WO (1) | WO2020028778A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3080983C (en) | 2009-05-27 | 2023-02-28 | Pct Therapeutics, Inc. | Method of inhibiting and reducing a viral infection |
WO2019028171A1 (en) | 2017-08-01 | 2019-02-07 | Ptc Therapeutics, Inc. | DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS |
CN112028888B (zh) * | 2020-09-11 | 2021-08-20 | 中国药科大学 | 一种化合物及其制备方法和用途 |
US20220151938A1 (en) * | 2022-01-28 | 2022-05-19 | Ptc Therapeutics, Inc. | Tablet for use in treating huntington's disease and method of making the same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007526341A (ja) | 2004-03-03 | 2007-09-13 | スフェリックス, インコーポレイテッド | 疎水性薬物のためのポリマー薬物送達システム |
SG184755A1 (en) | 2004-03-15 | 2012-10-30 | Ptc Therapeutics Inc | Carboline derivatives useful in the inhibition of angiogenesis |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
WO2008127714A1 (en) | 2007-04-13 | 2008-10-23 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
WO2009040818A1 (en) | 2007-09-25 | 2009-04-02 | Solubest Ltd | Compositions comprising lipophilic active compounds and method for their preparation |
WO2009100176A2 (en) * | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor |
CA3080983C (en) * | 2009-05-27 | 2023-02-28 | Pct Therapeutics, Inc. | Method of inhibiting and reducing a viral infection |
WO2010138706A1 (en) * | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating breast cancer |
WO2017091373A1 (en) * | 2015-11-25 | 2017-06-01 | Patheon Development Services Inc. | Amorphous dispersion granules and oral dosage forms |
-
2019
- 2019-08-02 EA EA202190429A patent/EA202190429A1/ru unknown
- 2019-08-02 EP EP19759102.7A patent/EP3829544A1/en active Pending
- 2019-08-02 PE PE2021000157A patent/PE20211410A1/es unknown
- 2019-08-02 KR KR1020217006355A patent/KR20210041589A/ko unknown
- 2019-08-02 BR BR112021001859-0A patent/BR112021001859A2/pt unknown
- 2019-08-02 SG SG11202100984VA patent/SG11202100984VA/en unknown
- 2019-08-02 CR CR20210093A patent/CR20210093A/es unknown
- 2019-08-02 CN CN201980065062.1A patent/CN112752570A/zh active Pending
- 2019-08-02 MX MX2021001364A patent/MX2021001364A/es unknown
- 2019-08-02 US US17/264,940 patent/US20210205225A1/en not_active Abandoned
- 2019-08-02 CA CA3107737A patent/CA3107737A1/en active Pending
- 2019-08-02 WO PCT/US2019/044853 patent/WO2020028778A1/en active Application Filing
- 2019-08-02 JP JP2021529250A patent/JP2021532193A/ja active Pending
- 2019-08-02 TN TNP/2021/000021A patent/TN2021000021A1/en unknown
- 2019-08-02 AU AU2019316036A patent/AU2019316036A1/en active Pending
- 2019-08-05 AR ARP190102223A patent/AR115913A1/es unknown
- 2019-08-05 TW TW108127793A patent/TW202019414A/zh unknown
-
2021
- 2021-01-28 IL IL280471A patent/IL280471A/en unknown
- 2021-02-01 PH PH12021550237A patent/PH12021550237A1/en unknown
- 2021-02-02 CL CL2021000271A patent/CL2021000271A1/es unknown
- 2021-02-03 NI NI202100006A patent/NI202100006A/es unknown
- 2021-02-18 CO CONC2021/0001979A patent/CO2021001979A2/es unknown
- 2021-02-19 EC ECSENADI202111795A patent/ECSP21011795A/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2020028778A1 (en) | 2020-02-06 |
EA202190429A1 (ru) | 2021-06-15 |
CR20210093A (es) | 2021-05-28 |
PH12021550237A1 (en) | 2021-10-11 |
TW202019414A (zh) | 2020-06-01 |
AU2019316036A1 (en) | 2021-03-04 |
EP3829544A1 (en) | 2021-06-09 |
SG11202100984VA (en) | 2021-02-25 |
MX2021001364A (es) | 2021-04-13 |
CO2021001979A2 (es) | 2021-03-08 |
CN112752570A (zh) | 2021-05-04 |
AR115913A1 (es) | 2021-03-10 |
US20210205225A1 (en) | 2021-07-08 |
NI202100006A (es) | 2021-05-21 |
TN2021000021A1 (en) | 2022-10-03 |
ECSP21011795A (es) | 2021-03-31 |
IL280471A (en) | 2021-03-25 |
BR112021001859A2 (pt) | 2021-04-27 |
KR20210041589A (ko) | 2021-04-15 |
CA3107737A1 (en) | 2020-02-06 |
JP2021532193A (ja) | 2021-11-25 |
CL2021000271A1 (es) | 2021-08-20 |
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