PE20191303A1 - Compuestos con actividad antitumoral contra celulas cancerosas que tienen mutaciones en el exon 20 de egfr o her2 - Google Patents
Compuestos con actividad antitumoral contra celulas cancerosas que tienen mutaciones en el exon 20 de egfr o her2Info
- Publication number
- PE20191303A1 PE20191303A1 PE2019001033A PE2019001033A PE20191303A1 PE 20191303 A1 PE20191303 A1 PE 20191303A1 PE 2019001033 A PE2019001033 A PE 2019001033A PE 2019001033 A PE2019001033 A PE 2019001033A PE 20191303 A1 PE20191303 A1 PE 20191303A1
- Authority
- PE
- Peru
- Prior art keywords
- mutations
- compounds
- egfr
- exon
- her2
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 title abstract 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 title abstract 2
- 230000035772 mutation Effects 0.000 title abstract 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 title abstract 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- LPFWVDIFUFFKJU-UHFFFAOYSA-N 1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one Chemical compound C=12C=C(OC3CCN(CC3)C(=O)C=C)C(OC)=CC2=NC=NC=1NC1=CC=C(Cl)C(Cl)=C1F LPFWVDIFUFFKJU-UHFFFAOYSA-N 0.000 abstract 1
- ULXXDDBFHOBEHA-CWDCEQMOSA-N afatinib Chemical compound N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 0.000 abstract 1
- 229960001686 afatinib Drugs 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 229950009876 poziotinib Drugs 0.000 abstract 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662423732P | 2016-11-17 | 2016-11-17 | |
| US201662427692P | 2016-11-29 | 2016-11-29 | |
| US201762572716P | 2017-10-16 | 2017-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20191303A1 true PE20191303A1 (es) | 2019-09-23 |
Family
ID=62146809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019001033A PE20191303A1 (es) | 2016-11-17 | 2017-11-17 | Compuestos con actividad antitumoral contra celulas cancerosas que tienen mutaciones en el exon 20 de egfr o her2 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11446302B2 (enExample) |
| EP (1) | EP3541832A4 (enExample) |
| JP (2) | JP7265985B2 (enExample) |
| KR (2) | KR102585006B1 (enExample) |
| CN (2) | CN117599061A (enExample) |
| AU (2) | AU2017363199B2 (enExample) |
| BR (1) | BR112019010020A2 (enExample) |
| CA (1) | CA3044432A1 (enExample) |
| CL (1) | CL2019001353A1 (enExample) |
| CO (1) | CO2019006218A2 (enExample) |
| CU (1) | CU20190051A7 (enExample) |
| EC (1) | ECSP19043254A (enExample) |
| MA (1) | MA46852A (enExample) |
| MX (1) | MX2019005834A (enExample) |
| PE (1) | PE20191303A1 (enExample) |
| PH (1) | PH12019501116A1 (enExample) |
| TW (1) | TWI782931B (enExample) |
| WO (1) | WO2018094225A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111527103A (zh) * | 2017-09-08 | 2020-08-11 | 科罗拉多大学董事会,法人团体 | 用于治疗或预防her驱动的抗药性癌症的化合物、组合物和方法 |
| CA3094108A1 (en) * | 2018-03-27 | 2019-10-03 | Board Of Regents, The University Of Texas Systems | Compounds with anti-tumor activity against cancer cells bearing her2 exon 19 mutations |
| CA3101657A1 (en) * | 2018-06-25 | 2020-01-02 | Spectrum Pharmaceuticals, Inc. | Combination of poziotinib with cytotoxic agent and/or other molecularly targeted agent and use thereof |
| SG11202012067YA (en) * | 2018-06-25 | 2021-01-28 | Spectrum Pharmaceuticals Inc | Poziotinib combinations with an anti-her1, her2 or her4 antibody and methods of use thereof |
| TW202012391A (zh) * | 2018-07-04 | 2020-04-01 | 日商第一三共股份有限公司 | 二芳基醚型喹唑啉衍生物 |
| BR112021004527A2 (pt) * | 2018-09-14 | 2021-06-08 | Spectrum Pharmaceuticals, Inc. | kits e métodos para tratamento contra câncer |
| CN113056272A (zh) * | 2018-09-21 | 2021-06-29 | 光谱医药公司 | 新的喹唑啉egfr抑制剂 |
| CN113271948B (zh) * | 2018-12-21 | 2024-08-16 | 得克萨斯大学体系董事会 | 治疗癌症的联合疗法 |
| SG11202108311RA (en) | 2019-02-26 | 2021-09-29 | Janssen Biotech Inc | Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies |
| PH12021552110A1 (en) * | 2019-03-29 | 2022-06-06 | Univ Texas | Compounds with anti-tumor activity against cancer cells bearing her2 exon 21 insertions |
| AU2020254499A1 (en) * | 2019-03-29 | 2021-10-28 | Board Of Regents, The University Of Texas System | Compounds with anti-tumor activity against cancer cells bearing EGFR or HER2 exon 20 insertions |
| CN113784718A (zh) * | 2019-04-17 | 2021-12-10 | 得克萨斯大学体系董事会 | 对携带酪氨酸激酶抑制剂抗性egfr突变的癌细胞具有抗肿瘤活性的化合物 |
| SG11202111120VA (en) * | 2019-04-17 | 2021-11-29 | Univ Texas | Compounds against cancer bearing tyrosine kinase inhibitor resistant egfr mutations |
| PH12021552798A1 (en) | 2019-05-14 | 2022-09-19 | Janssen Biotech Inc | Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
| US20220296598A1 (en) * | 2019-08-23 | 2022-09-22 | Spectrum Pharmaceuticals, Inc. | Poziotinib Combination with VEGFR2 Inhibitors and Methods of Use Thereof |
| US20230069749A1 (en) * | 2020-01-29 | 2023-03-02 | Board Of Regents, The University Of Texas System | Use of poziotinib for the treatment of cancers with nrg1 fusions |
| CN115427456A (zh) * | 2020-01-29 | 2022-12-02 | 得克萨斯州大学系统董事会 | 基于喹唑啉的酪氨酸激酶抑制剂在具有nrg1融合的癌症的治疗中的用途 |
| JP7783182B2 (ja) | 2020-02-12 | 2025-12-09 | ヤンセン バイオテツク，インコーポレーテツド | ｃ－ＭＥＴエクソン１４スキッピング変異を有する患者の治療 |
| CN111658650B (zh) * | 2020-05-28 | 2022-05-06 | 南通大学 | Mln4924在制备脉络膜新生血管治疗药物中的应用 |
| UY39342A (es) * | 2020-07-27 | 2022-02-25 | Spectrum Pharmaceuticals Inc | Tratamiento con poziotinib para el cáncer de pulmón de células no pequeñas |
| US12528869B2 (en) | 2020-08-25 | 2026-01-20 | Janssen Biotech, Inc. | Treatment of non-small cell lung cancer with EGFR mutations |
| CA3196712A1 (en) | 2020-09-23 | 2022-03-31 | Scorpion Therapeutics, Inc. | Pyrrolo[3,2-c]pyridin-4-one derivatives useful in the treatment of cancer |
| WO2022072632A1 (en) | 2020-09-30 | 2022-04-07 | Scorpion Therapeutics, Inc. | Bicyclic compounds for use in the treatment cancer |
| WO2022072634A1 (en) | 2020-09-30 | 2022-04-07 | Scorpion Therapeutics, Inc. | Bicyclic compounds for use in the treatment cancer |
| WO2022072645A2 (en) | 2020-09-30 | 2022-04-07 | Scorpion Therapeutics, Inc. | Methods for treating cancer |
| WO2022094271A1 (en) | 2020-10-30 | 2022-05-05 | Scorpion Therapeutics, Inc. | Methods for treating cancer |
| WO2022098992A1 (en) | 2020-11-05 | 2022-05-12 | Scorpion Therapeutics, Inc. | Use of macrocyclic compounds in methods of treating cancer |
| JP2024505056A (ja) * | 2021-01-29 | 2024-02-02 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ポジオチニブを用いてがんを処置する方法 |
| JP2024509920A (ja) | 2021-03-09 | 2024-03-05 | ヤンセン バイオテツク，インコーポレーテツド | Ｅｇｆｒ活性化変異を欠くがんの治療 |
| WO2022197913A1 (en) | 2021-03-18 | 2022-09-22 | Scorpion Therapeutics, Inc. | Bicyclic derivatives which can be used to treat cancer |
| WO2023015149A1 (en) * | 2021-08-02 | 2023-02-09 | Spectrum Pharmaceuticals, Inc. | Treatment of non-small cell lung cancer with poziotinib |
| TW202342057A (zh) | 2022-02-07 | 2023-11-01 | 美商健生生物科技公司 | 用於減少用ｅｇｆｒ／ｍｅｔ雙特異性抗體治療之患者的輸注相關反應之方法 |
| WO2023173083A1 (en) | 2022-03-11 | 2023-09-14 | Scorpion Therapeutics, Inc. | Tetrahydroindole derivatives as egfr and/or her2 inhibtors useful for the treatment of cancer |
| JP2026508945A (ja) | 2023-03-13 | 2026-03-13 | ヤンセン バイオテツク，インコーポレーテツド | 二重特異性抗ＥＧＦＲ／ｃ－Ｍｅｔ抗体と抗ＰＤ－１抗体との併用療法 |
| CN121712773A (zh) | 2023-06-08 | 2026-03-20 | 安塔列斯疗法股份有限公司 | 1,5-二氢-4h-吡咯并[3,2-c]吡啶-4-酮用于癌症治疗 |
| WO2025101809A1 (en) * | 2023-11-08 | 2025-05-15 | Fate Therapeutics, Inc. | Ipsc-derived t cells for solid tumor treatment |
| CN117587111A (zh) * | 2023-11-30 | 2024-02-23 | 苏州拓维生物技术有限公司 | 一种快速批量筛选化合物在激酶细胞系中活性的方法 |
| WO2026038160A1 (en) | 2024-08-13 | 2026-02-19 | Janssen Biotech, Inc. | Methods for reducing infusion-related reactions in patients treated with egfr/met bispecific antibodies |
| CA3278557A1 (en) | 2024-08-13 | 2026-03-01 | Janssen Biotech, Inc. | Methods for reducing dermatologic adverse events in patients treated with egfr/met bispecific antibodies |
| WO2026086737A1 (en) | 2024-10-21 | 2026-04-30 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Uses and methods of bispecific antibody-drug conjugates for treating tumor diseases |
| WO2026086740A1 (en) | 2024-10-21 | 2026-04-30 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Use and method of bispecific antibody-drug conjugates for treating tumor diseases |
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2017
- 2017-11-17 MA MA046852A patent/MA46852A/fr unknown
- 2017-11-17 CU CU2019000051A patent/CU20190051A7/es unknown
- 2017-11-17 US US16/461,992 patent/US11446302B2/en active Active
- 2017-11-17 WO PCT/US2017/062326 patent/WO2018094225A1/en not_active Ceased
- 2017-11-17 JP JP2019526282A patent/JP7265985B2/ja active Active
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- 2017-11-17 MX MX2019005834A patent/MX2019005834A/es unknown
- 2017-11-17 AU AU2017363199A patent/AU2017363199B2/en not_active Ceased
- 2017-11-17 BR BR112019010020A patent/BR112019010020A2/pt not_active Application Discontinuation
- 2017-11-17 EP EP17871141.2A patent/EP3541832A4/en active Pending
- 2017-11-17 TW TW106139967A patent/TWI782931B/zh not_active IP Right Cessation
- 2017-11-17 CN CN201780083541.7A patent/CN110291104B/zh not_active Expired - Fee Related
- 2017-11-17 KR KR1020197017346A patent/KR102585006B1/ko active Active
- 2017-11-17 KR KR1020237033201A patent/KR102771603B1/ko active Active
- 2017-11-17 PE PE2019001033A patent/PE20191303A1/es unknown
- 2017-11-17 CA CA3044432A patent/CA3044432A1/en active Pending
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2019
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- 2019-06-14 CO CONC2019/0006218A patent/CO2019006218A2/es unknown
- 2019-06-17 EC ECSENADI201943254A patent/ECSP19043254A/es unknown
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2022
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2023
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| US20200316071A1 (en) | 2020-10-08 |
| AU2023266384A1 (en) | 2023-12-07 |
| MX2019005834A (es) | 2019-10-14 |
| KR102585006B1 (ko) | 2023-10-05 |
| CO2019006218A2 (es) | 2020-01-17 |
| JP7685550B2 (ja) | 2025-05-29 |
| CL2019001353A1 (es) | 2019-11-08 |
| PH12019501116A1 (en) | 2019-11-25 |
| KR20190085980A (ko) | 2019-07-19 |
| CN117599061A (zh) | 2024-02-27 |
| TWI782931B (zh) | 2022-11-11 |
| CU20190051A7 (es) | 2020-01-03 |
| KR102771603B1 (ko) | 2025-02-24 |
| WO2018094225A1 (en) | 2018-05-24 |
| EP3541832A4 (en) | 2020-09-30 |
| CN110291104A (zh) | 2019-09-27 |
| ECSP19043254A (es) | 2019-09-30 |
| US11446302B2 (en) | 2022-09-20 |
| KR20230145496A (ko) | 2023-10-17 |
| US20230233563A1 (en) | 2023-07-27 |
| MA46852A (fr) | 2019-09-25 |
| JP2020502059A (ja) | 2020-01-23 |
| AU2017363199B2 (en) | 2023-08-17 |
| EP3541832A1 (en) | 2019-09-25 |
| TW201825098A (zh) | 2018-07-16 |
| CN110291104B (zh) | 2023-11-03 |
| AU2017363199A1 (en) | 2019-07-04 |
| BR112019010020A2 (pt) | 2019-08-20 |
| JP2023100682A (ja) | 2023-07-19 |
| JP7265985B2 (ja) | 2023-04-27 |
| CA3044432A1 (en) | 2018-05-24 |
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