PE20170294A1 - Inhibidores de aldosterona sintasa - Google Patents
Inhibidores de aldosterona sintasaInfo
- Publication number
- PE20170294A1 PE20170294A1 PE2017000086A PE2017000086A PE20170294A1 PE 20170294 A1 PE20170294 A1 PE 20170294A1 PE 2017000086 A PE2017000086 A PE 2017000086A PE 2017000086 A PE2017000086 A PE 2017000086A PE 20170294 A1 PE20170294 A1 PE 20170294A1
- Authority
- PE
- Peru
- Prior art keywords
- aldosterone synthase
- synthase inhibitors
- pyrano
- difluorophenyl
- imidazol
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Se refiere a un compuesto de formula I, donde: Cy es un sistema de anillos monociclicos o biciclicos tales como C3-C10cicloalquilo, heterociclilo, entre otros; R1 y R2 son H, C1-C3-alquilo, entre otros o R1 y R2 forman un C3-C6cicloalquilo o C3-C6-heterociclilo. Son compuestos preferidos: N-{[3-(3,4-difluorofenil)-6-metil-4-oxo-3H,4H,6H,7H-pirano[3,4-d]imidazol-6-il]metil}carbamato de ter-butilo; 3-(3,4-difluorofenil)-6,6-dimetil-3H,4H,6H,7H-pirano[3,4-d]imidazol-4-ona; entre otros. Tambien se refiere a una composicion y un metodo. Dichos compuestos inhiben la aldosterona sintasa siendo utiles en el tratamiento de nefropatia diabetica, glomerulosclerosis, entre otras
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462028556P | 2014-07-24 | 2014-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20170294A1 true PE20170294A1 (es) | 2017-04-12 |
Family
ID=53761616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017000086A PE20170294A1 (es) | 2014-07-24 | 2015-07-23 | Inhibidores de aldosterona sintasa |
Country Status (34)
Country | Link |
---|---|
US (1) | US9334285B2 (es) |
EP (1) | EP3172212B1 (es) |
JP (1) | JP6250862B2 (es) |
KR (1) | KR102378648B1 (es) |
CN (1) | CN106488921B (es) |
AP (1) | AP2016009616A0 (es) |
AR (1) | AR101290A1 (es) |
AU (1) | AU2015292632B2 (es) |
BR (1) | BR112017000584B1 (es) |
CA (1) | CA2956118C (es) |
CL (1) | CL2017000040A1 (es) |
CO (1) | CO2017000443A2 (es) |
CY (1) | CY1121063T1 (es) |
DK (1) | DK3172212T3 (es) |
EA (1) | EA031105B1 (es) |
ES (1) | ES2684050T3 (es) |
HR (1) | HRP20181441T1 (es) |
HU (1) | HUE039981T2 (es) |
IL (1) | IL249665B (es) |
LT (1) | LT3172212T (es) |
MX (1) | MX368093B (es) |
MY (1) | MY191352A (es) |
NZ (1) | NZ727188A (es) |
PE (1) | PE20170294A1 (es) |
PH (1) | PH12017500089B1 (es) |
PL (1) | PL3172212T3 (es) |
PT (1) | PT3172212T (es) |
RS (1) | RS57570B1 (es) |
SG (1) | SG11201700595RA (es) |
SI (1) | SI3172212T1 (es) |
TW (1) | TWI600658B (es) |
UA (1) | UA118801C2 (es) |
UY (1) | UY36228A (es) |
WO (1) | WO2016014736A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX369025B (es) * | 2014-10-15 | 2019-10-25 | Boehringer Ingelheim Int | Inhibidores de aldosterona sintasa. |
WO2016089800A1 (en) * | 2014-12-02 | 2016-06-09 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors |
US10858342B2 (en) | 2016-06-28 | 2020-12-08 | Boehringer Ingelheim International Gmbh | Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases |
SG10201610038SA (en) * | 2016-07-29 | 2017-12-28 | Apple Inc | Systems and methods for management of asymmetrical multi-tapped battery packs |
US11958818B2 (en) | 2019-05-01 | 2024-04-16 | Boehringer Ingelheim International Gmbh | (R)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate |
WO2023114170A1 (en) | 2021-12-14 | 2023-06-22 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors for treating chronic kidney disease |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100703068B1 (ko) * | 2003-12-30 | 2007-04-05 | 에스케이케미칼주식회사 | 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물 |
CN101410389A (zh) * | 2006-03-29 | 2009-04-15 | 诺瓦提斯公司 | 有机化合物 |
TW200808813A (en) * | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
AR092289A1 (es) * | 2011-11-14 | 2015-04-15 | Sunshine Lake Pharma Co Ltd | Derivados de aminoquinazolina y sus sales y metodos de uso |
US8912341B2 (en) * | 2013-01-16 | 2014-12-16 | Northwestern University | Enantioselective N-heterocyclic carbene-catalyzed annulation reactions with imidazolidinones |
-
2015
- 2015-07-23 JP JP2017503920A patent/JP6250862B2/ja active Active
- 2015-07-23 ES ES15744459.7T patent/ES2684050T3/es active Active
- 2015-07-23 HU HUE15744459A patent/HUE039981T2/hu unknown
- 2015-07-23 LT LTEP15744459.7T patent/LT3172212T/lt unknown
- 2015-07-23 KR KR1020177005181A patent/KR102378648B1/ko active IP Right Grant
- 2015-07-23 AR ARP150102340A patent/AR101290A1/es unknown
- 2015-07-23 PE PE2017000086A patent/PE20170294A1/es unknown
- 2015-07-23 PT PT15744459T patent/PT3172212T/pt unknown
- 2015-07-23 DK DK15744459.7T patent/DK3172212T3/en active
- 2015-07-23 EA EA201790253A patent/EA031105B1/ru not_active IP Right Cessation
- 2015-07-23 PL PL15744459T patent/PL3172212T3/pl unknown
- 2015-07-23 BR BR112017000584-0A patent/BR112017000584B1/pt active IP Right Grant
- 2015-07-23 MX MX2017000929A patent/MX368093B/es active IP Right Grant
- 2015-07-23 CN CN201580036596.3A patent/CN106488921B/zh active Active
- 2015-07-23 MY MYPI2016002216A patent/MY191352A/en unknown
- 2015-07-23 NZ NZ727188A patent/NZ727188A/en unknown
- 2015-07-23 SI SI201530354T patent/SI3172212T1/sl unknown
- 2015-07-23 EP EP15744459.7A patent/EP3172212B1/en active Active
- 2015-07-23 WO PCT/US2015/041648 patent/WO2016014736A1/en active Application Filing
- 2015-07-23 RS RS20180970A patent/RS57570B1/sr unknown
- 2015-07-23 UA UAA201701595A patent/UA118801C2/uk unknown
- 2015-07-23 AP AP2016009616A patent/AP2016009616A0/en unknown
- 2015-07-23 CA CA2956118A patent/CA2956118C/en active Active
- 2015-07-23 US US14/806,706 patent/US9334285B2/en active Active
- 2015-07-23 TW TW104123931A patent/TWI600658B/zh active
- 2015-07-23 SG SG11201700595RA patent/SG11201700595RA/en unknown
- 2015-07-23 AU AU2015292632A patent/AU2015292632B2/en active Active
- 2015-07-24 UY UY0001036228A patent/UY36228A/es active IP Right Grant
-
2016
- 2016-12-20 IL IL249665A patent/IL249665B/en active IP Right Grant
-
2017
- 2017-01-06 CL CL2017000040A patent/CL2017000040A1/es unknown
- 2017-01-13 PH PH12017500089A patent/PH12017500089B1/en unknown
- 2017-01-19 CO CONC2017/0000443A patent/CO2017000443A2/es unknown
-
2018
- 2018-09-04 CY CY181100920T patent/CY1121063T1/el unknown
- 2018-09-07 HR HRP20181441TT patent/HRP20181441T1/hr unknown
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