PE20151652A1 - Proceso e intermedios para preparar un medicamento - Google Patents
Proceso e intermedios para preparar un medicamentoInfo
- Publication number
- PE20151652A1 PE20151652A1 PE2015001956A PE2015001956A PE20151652A1 PE 20151652 A1 PE20151652 A1 PE 20151652A1 PE 2015001956 A PE2015001956 A PE 2015001956A PE 2015001956 A PE2015001956 A PE 2015001956A PE 20151652 A1 PE20151652 A1 PE 20151652A1
- Authority
- PE
- Peru
- Prior art keywords
- intermediates
- prepare
- medicinal product
- preparing
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se divulga un proceso para preparar los siguientes compuestos (I) y (II): donde R1, R1a y R2a son como se han definido en la memoria descriptiva, asi como tambien un proceso para preparar otros intermedios que pueden ser utiles para sintetizar productos posteriores, especialmente compuestos que son utiles como medicamentos, por ejemplo, inhibidores de la tirosina-cinasa de Bruton (Btk) tal como ibrutinib. Tambien se divulgan otros procesos, otros intermedios compuestos per se
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361786842P | 2013-03-15 | 2013-03-15 | |
EP13159470 | 2013-03-15 | ||
EP13197813 | 2013-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20151652A1 true PE20151652A1 (es) | 2015-11-12 |
Family
ID=51535892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015001956A PE20151652A1 (es) | 2013-03-15 | 2014-03-11 | Proceso e intermedios para preparar un medicamento |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP2970291B1 (es) |
JP (1) | JP6777398B2 (es) |
KR (2) | KR102311329B1 (es) |
CN (2) | CN105026400A (es) |
AU (2) | AU2014230935A1 (es) |
BR (1) | BR112015021856A2 (es) |
CA (1) | CA2901510C (es) |
DK (1) | DK2970291T3 (es) |
EA (1) | EA201591685A1 (es) |
ES (1) | ES2924193T3 (es) |
HR (1) | HRP20220628T1 (es) |
HU (1) | HUE058914T2 (es) |
LT (1) | LT2970291T (es) |
MX (2) | MX2015012731A (es) |
MY (1) | MY194905A (es) |
PE (1) | PE20151652A1 (es) |
SG (2) | SG11201507595XA (es) |
SI (1) | SI2970291T1 (es) |
WO (1) | WO2014139970A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2751109T3 (en) | 2011-09-02 | 2017-01-23 | Incyte Holdings Corp | HETEROCYCLYLAMINES AS PI3K INHIBITORS |
US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
CN105884747B (zh) * | 2014-08-28 | 2021-01-05 | 首药控股(北京)有限公司 | 一种制备布鲁顿酪氨酸激酶(btk)激酶抑制剂的制备方法 |
CN104447761A (zh) * | 2014-11-27 | 2015-03-25 | 广东东阳光药业有限公司 | 一种吡唑衍生物的制备方法 |
WO2016115869A1 (zh) * | 2015-01-21 | 2016-07-28 | 中国科学院合肥物质科学研究院 | Flt3激酶的新型抑制剂及其用途 |
CN105481862B (zh) * | 2015-01-21 | 2018-08-21 | 中国科学院合肥物质科学研究院 | Flt3激酶的新型抑制剂及其用途 |
TWI748941B (zh) * | 2015-02-27 | 2021-12-11 | 美商英塞特公司 | Pi3k抑制劑之鹽及製備方法 |
LV15201B (lv) | 2015-08-31 | 2017-07-20 | Latvijas Organiskās Sintēzes Institūts | Ibrutiniba izejvielas iegūšanas paņēmiens |
CN106608877B (zh) * | 2015-10-21 | 2018-11-13 | 新发药业有限公司 | 一种依鲁替尼中间体4-氨基-3-(4-苯氧基)苯基-1H-吡唑并[3,4-d]嘧啶的制备方法 |
JO3793B1 (ar) | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | مثبطات تيروزين كاينيز بروتون وأساليب استخدامها |
JO3794B1 (ar) | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون |
WO2018103058A1 (en) * | 2016-12-09 | 2018-06-14 | Janssen Pharmaceutica Nv | Inhibitors of bruton's tyrosine kinase and methods of their use |
CN109311883B (zh) * | 2017-02-09 | 2021-03-19 | 合肥合源药业有限公司 | Flt3激酶抑制剂或其盐的晶型及其制备方法 |
CN107383017B (zh) * | 2017-07-20 | 2020-01-14 | 河南师范大学 | 依鲁替尼高效制备方法 |
US20200369611A1 (en) * | 2017-08-01 | 2020-11-26 | Boehringer Ingelheim International Gmbh | Intermediate compounds and methods |
EP3972956A1 (en) * | 2019-05-21 | 2022-03-30 | Janssen Pharmaceutica NV | Processes and intermediates for preparing a btk inhibitor |
JP2022533747A (ja) * | 2019-05-21 | 2022-07-25 | ヤンセン ファーマシューティカ エヌ.ベー. | Btk阻害剤を調製するためのプロセス及び中間体 |
CN113200987A (zh) * | 2021-04-29 | 2021-08-03 | 湖南华腾制药有限公司 | 一种伊布替尼的制备方法 |
CN115322226B (zh) * | 2022-08-17 | 2023-08-11 | 厦门大学 | 一种共价靶向砷抑制剂及其制备方法和应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK3812002A3 (en) * | 1999-09-17 | 2003-09-11 | Abbott Gmbh & Co Kg | Pyrazolopyrimidines as therapeutic agents |
EP2532235A1 (en) * | 2006-09-22 | 2012-12-12 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
ES2403546T3 (es) * | 2006-11-03 | 2013-05-20 | Pharmacyclics, Inc. | Sonda de actividad de la tirosina-cinasa de Bruton y procedimiento de utilización |
MX2009010284A (es) * | 2007-03-28 | 2010-01-29 | Pharmacyclics Inc | Inhibidores de la tirosina-cinasa de bruton. |
UA105362C2 (en) * | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
MX2011010184A (es) | 2009-03-31 | 2011-10-28 | Boehringer Ingelheim Int | Derivados de 1-heterociclil-1,5-dihidro-pirazolo[3,4-d]pirimidin-4 -ona y su uso como moduladores de pde9a. |
US7741330B1 (en) * | 2009-10-12 | 2010-06-22 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase |
WO2012003544A1 (en) * | 2010-07-09 | 2012-01-12 | The Walter And Eliza Hall Institute Of Medical Research | Protein kinase inhibitors and methods of treatment |
EP2632898A4 (en) * | 2010-10-29 | 2014-04-02 | Biogen Idec Inc | HETEROCYCLIC TYROSINE KINASE HEMMER |
US9376438B2 (en) * | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
CA2841080A1 (en) * | 2011-07-13 | 2013-01-17 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
CA2881519A1 (en) * | 2012-08-10 | 2014-02-13 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
US20150291554A1 (en) * | 2012-11-02 | 2015-10-15 | Pfizer Inc. | Bruton's Tyrosine Kinase Inhibitors |
CN103848810A (zh) * | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
-
2014
- 2014-03-11 JP JP2015562078A patent/JP6777398B2/ja active Active
- 2014-03-11 CN CN201480015131.5A patent/CN105026400A/zh active Pending
- 2014-03-11 WO PCT/EP2014/054621 patent/WO2014139970A1/en active Application Filing
- 2014-03-11 KR KR1020157025525A patent/KR102311329B1/ko active IP Right Grant
- 2014-03-11 HU HUE14708885A patent/HUE058914T2/hu unknown
- 2014-03-11 EA EA201591685A patent/EA201591685A1/ru unknown
- 2014-03-11 SI SI201431956T patent/SI2970291T1/sl unknown
- 2014-03-11 CA CA2901510A patent/CA2901510C/en active Active
- 2014-03-11 HR HRP20220628TT patent/HRP20220628T1/hr unknown
- 2014-03-11 LT LTEPPCT/EP2014/054621T patent/LT2970291T/lt unknown
- 2014-03-11 PE PE2015001956A patent/PE20151652A1/es unknown
- 2014-03-11 SG SG11201507595XA patent/SG11201507595XA/en unknown
- 2014-03-11 MY MYPI2015002280A patent/MY194905A/en unknown
- 2014-03-11 ES ES14708885T patent/ES2924193T3/es active Active
- 2014-03-11 SG SG10201809696UA patent/SG10201809696UA/en unknown
- 2014-03-11 CN CN202011305518.8A patent/CN112608298A/zh active Pending
- 2014-03-11 KR KR1020217031854A patent/KR102377688B1/ko active IP Right Grant
- 2014-03-11 EP EP14708885.0A patent/EP2970291B1/en active Active
- 2014-03-11 AU AU2014230935A patent/AU2014230935A1/en not_active Abandoned
- 2014-03-11 MX MX2015012731A patent/MX2015012731A/es unknown
- 2014-03-11 BR BR112015021856A patent/BR112015021856A2/pt not_active Application Discontinuation
- 2014-03-11 DK DK14708885.0T patent/DK2970291T3/da active
-
2015
- 2015-09-14 MX MX2020012596A patent/MX2020012596A/es unknown
-
2018
- 2018-06-08 AU AU2018204086A patent/AU2018204086B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BR112015021856A2 (pt) | 2017-07-18 |
CA2901510C (en) | 2022-11-29 |
SG11201507595XA (en) | 2015-10-29 |
CN112608298A (zh) | 2021-04-06 |
MX2015012731A (es) | 2016-02-18 |
CN105026400A (zh) | 2015-11-04 |
KR20210123429A (ko) | 2021-10-13 |
LT2970291T (lt) | 2022-06-10 |
KR102311329B1 (ko) | 2021-10-14 |
SG10201809696UA (en) | 2018-11-29 |
HRP20220628T1 (hr) | 2022-06-24 |
JP6777398B2 (ja) | 2020-10-28 |
SI2970291T1 (sl) | 2022-07-29 |
AU2018204086B2 (en) | 2020-03-12 |
EA201591685A1 (ru) | 2016-01-29 |
ES2924193T3 (es) | 2022-10-05 |
KR20150132172A (ko) | 2015-11-25 |
CA2901510A1 (en) | 2014-09-18 |
MX2020012596A (es) | 2021-02-09 |
HUE058914T2 (hu) | 2022-09-28 |
KR102377688B1 (ko) | 2022-03-22 |
WO2014139970A1 (en) | 2014-09-18 |
EP2970291A1 (en) | 2016-01-20 |
DK2970291T3 (da) | 2022-08-01 |
JP2016510779A (ja) | 2016-04-11 |
MY194905A (en) | 2022-12-22 |
AU2018204086A1 (en) | 2018-06-28 |
EP2970291B1 (en) | 2022-05-11 |
AU2014230935A1 (en) | 2015-09-03 |
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