PE20150403A1 - Pirrol carboxamidas fluorometilo sustituidas - Google Patents
Pirrol carboxamidas fluorometilo sustituidasInfo
- Publication number
- PE20150403A1 PE20150403A1 PE2015000264A PE2015000264A PE20150403A1 PE 20150403 A1 PE20150403 A1 PE 20150403A1 PE 2015000264 A PE2015000264 A PE 2015000264A PE 2015000264 A PE2015000264 A PE 2015000264A PE 20150403 A1 PE20150403 A1 PE 20150403A1
- Authority
- PE
- Peru
- Prior art keywords
- pirrol
- chlorophenyl
- trifluoromethyl
- benzyl
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Referida a un compuesto derivado de carboxamida de formula (I), donde n es 0, 1 o 2; m es 0 o 1; X es O, S, NH, entre otros; R1, R2 y R3 son H, F, Cl, Br, CF3, entre otros; R4 es CH2F, CHF2, CF3; R5 es H, alquilo C1-C6, entre otros; R6, R7 y R8 son H, F, Cl, CF3, entre otros; R9 es H, alquilo C1-C6, entre otros; R10 es H, un residuo alifatico C1-C10, entre otros. Son compuestos preferidos: [1-Bencilo-3-(4-clorofenil)-5-(trifluorometilo)-1H-pirrol-2-il]-morfolino-4-il-metano, amida del acido 1-Bencilo-3-(4-clorofenil)-N-(2,2-dimetilo-propilo)-N-metilo-5-(trifluorometilo)-1H-pirrol-2-carboxilico, entre otros. Dichos compuestos son bloqueadores de canales de calcio activados por voltaje y son utiles en el tratamiento y/o profilaxis del dolor y otras enfermedades y/o trastornos
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12006120 | 2012-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20150403A1 true PE20150403A1 (es) | 2015-04-16 |
Family
ID=46851247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015000264A PE20150403A1 (es) | 2012-08-29 | 2013-08-29 | Pirrol carboxamidas fluorometilo sustituidas |
Country Status (28)
Country | Link |
---|---|
US (1) | US9302988B2 (es) |
EP (1) | EP2906534B1 (es) |
JP (1) | JP6114392B2 (es) |
KR (1) | KR20150046321A (es) |
CN (1) | CN104755459A (es) |
AR (1) | AR092279A1 (es) |
AU (1) | AU2013307645B2 (es) |
BR (1) | BR112015004306A2 (es) |
CA (1) | CA2883242A1 (es) |
CL (1) | CL2015000460A1 (es) |
CY (1) | CY1118542T1 (es) |
DK (1) | DK2906534T3 (es) |
EA (1) | EA027640B1 (es) |
EC (1) | ECSP15007358A (es) |
ES (1) | ES2618520T3 (es) |
HK (1) | HK1212685A1 (es) |
HR (1) | HRP20170338T1 (es) |
HU (1) | HUE032691T2 (es) |
IL (1) | IL237393A (es) |
LT (1) | LT2906534T (es) |
MX (1) | MX2015002357A (es) |
PE (1) | PE20150403A1 (es) |
PL (1) | PL2906534T3 (es) |
PT (1) | PT2906534T (es) |
RS (1) | RS55702B1 (es) |
SI (1) | SI2906534T1 (es) |
TW (1) | TW201416348A (es) |
WO (1) | WO2014032801A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2015011445A (es) | 2013-03-15 | 2016-04-20 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulacion de la hemoglobina. |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
AU2014365744A1 (en) * | 2013-12-19 | 2016-05-26 | Grunenthal Gmbh | Fluoromethyl-substituted pyrrole carboxamides III |
WO2015090600A1 (en) * | 2013-12-19 | 2015-06-25 | Grünenthal GmbH | Fluoromethyl-substituted pyrrole carboxamides as cav2.2 calcium channel blockers |
EP3083613A1 (en) | 2013-12-19 | 2016-10-26 | Grünenthal GmbH | Fluoromethyl-substituted pyrrole carboxamides iv |
TW201718557A (zh) * | 2015-10-08 | 2017-06-01 | 歌林達有限公司 | 經吡唑基取代之四氫吡喃基碸 |
TW201726128A (zh) * | 2015-10-08 | 2017-08-01 | 歌林達有限公司 | 經吡唑基取代之四氫哌喃基碸 |
WO2020140957A1 (en) * | 2019-01-04 | 2020-07-09 | Ascentage Pharma (Suzhou) Co., Ltd. | Method for preparing sulfonamides drugs |
WO2020144375A1 (en) * | 2019-01-11 | 2020-07-16 | Grünenthal GmbH | Substituted pyrrolidine amides iii |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19963174A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Pyrrol-Mannichbasen |
US20050101657A1 (en) * | 2001-12-28 | 2005-05-12 | Takeda Chemical Industries Ltd. | Androgen receptor antagonists |
WO2004027042A2 (en) * | 2002-09-23 | 2004-04-01 | E. I. Du Pont De Nemours And Company | Isolation and use of ryanodine receptors |
DE10261130A1 (de) * | 2002-12-20 | 2004-07-01 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2,5-Diaminomethyl-1H-pyrrole |
DE102006027229A1 (de) | 2006-06-09 | 2007-12-20 | Grünenthal GmbH | 1,3-Disubstituierte 4-Methyl-1H-pyrrol-2-carbonsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
US9115132B2 (en) | 2010-07-09 | 2015-08-25 | Convergence Pharmaceuticals Limited | Tetrazole compounds as calcium channel blockers |
-
2013
- 2013-08-28 TW TW102130731A patent/TW201416348A/zh unknown
- 2013-08-29 SI SI201330537A patent/SI2906534T1/sl unknown
- 2013-08-29 KR KR20157008032A patent/KR20150046321A/ko not_active Application Discontinuation
- 2013-08-29 PE PE2015000264A patent/PE20150403A1/es not_active Application Discontinuation
- 2013-08-29 AR ARP130103069A patent/AR092279A1/es unknown
- 2013-08-29 RS RS20170183A patent/RS55702B1/sr unknown
- 2013-08-29 CA CA2883242A patent/CA2883242A1/en not_active Abandoned
- 2013-08-29 US US14/013,081 patent/US9302988B2/en not_active Expired - Fee Related
- 2013-08-29 JP JP2015528905A patent/JP6114392B2/ja not_active Expired - Fee Related
- 2013-08-29 PT PT137563201T patent/PT2906534T/pt unknown
- 2013-08-29 ES ES13756320T patent/ES2618520T3/es active Active
- 2013-08-29 DK DK13756320.1T patent/DK2906534T3/en active
- 2013-08-29 EP EP13756320.1A patent/EP2906534B1/en not_active Not-in-force
- 2013-08-29 MX MX2015002357A patent/MX2015002357A/es unknown
- 2013-08-29 HU HUE13756320A patent/HUE032691T2/hu unknown
- 2013-08-29 BR BR112015004306A patent/BR112015004306A2/pt not_active IP Right Cessation
- 2013-08-29 WO PCT/EP2013/002594 patent/WO2014032801A1/en active Application Filing
- 2013-08-29 LT LTEP13756320.1T patent/LT2906534T/lt unknown
- 2013-08-29 CN CN201380056094.8A patent/CN104755459A/zh active Pending
- 2013-08-29 PL PL13756320T patent/PL2906534T3/pl unknown
- 2013-08-29 EA EA201500270A patent/EA027640B1/ru not_active IP Right Cessation
- 2013-08-29 AU AU2013307645A patent/AU2013307645B2/en not_active Ceased
-
2015
- 2015-02-24 IL IL237393A patent/IL237393A/en not_active IP Right Cessation
- 2015-02-25 CL CL2015000460A patent/CL2015000460A1/es unknown
- 2015-02-27 EC ECIEPI20157358A patent/ECSP15007358A/es unknown
-
2016
- 2016-01-19 HK HK16100545.2A patent/HK1212685A1/zh not_active IP Right Cessation
-
2017
- 2017-01-30 CY CY20171100131T patent/CY1118542T1/el unknown
- 2017-03-01 HR HRP20170338TT patent/HRP20170338T1/hr unknown
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Legal Events
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