PE20131351A1 - Formas en estado solido de un potente inhibidor del vch - Google Patents
Formas en estado solido de un potente inhibidor del vchInfo
- Publication number
- PE20131351A1 PE20131351A1 PE2013000628A PE2013000628A PE20131351A1 PE 20131351 A1 PE20131351 A1 PE 20131351A1 PE 2013000628 A PE2013000628 A PE 2013000628A PE 2013000628 A PE2013000628 A PE 2013000628A PE 20131351 A1 PE20131351 A1 PE 20131351A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- methyl
- mixture obtained
- inhibitor
- refers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UNA SAL CRISTALINA DE SODIO DEL COMPUESTO DE FORMULA (1) QUE ES EL ACIDO (E)-3-[2-(1-{[2-(5-BROMO-PIRIMIDIN-2-IL)-3-CICLOPENTIL-1-METIL-1H-INDOL-6-CARBONIL]-AMINO}-CICLOBUTIL)-3-METIL-3H-BENCIMIDAZOL-5-IL]-ACRILICO CUYO MODELO DE DIFRACCION DE RAYOS X EN POLVO COMPRENDE PICOS DE 5.2, 7.5, 8.4, 13.1, 18.3, 20.0, 20.4, 21.4, 23.1 Y 25.4 GRADOS 2O QUE SE MIDE USANDO RADIACION CuKa. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION QUE COMPRENDE: i) HACER REACCIONAR EL COMPUESTO (1) CON UNA DISOLUCION DE NaOH ACUOSA EN UN DISOLVENTE ADECUADO, ii) ANADIR METIL-ETILCETONA A LA MEZCLA OBTENIDA EN LA ETAPA (i) MIENTRAS SE CALIENTA LA MEZCLA A UNA TEMPERATURA DE 50 A 60 °C, iii) ANADIR METIL-ETILCETONA ADICIONAL A LA MEZCLA OBTENIDA A UNA TEMPERATURA DE 50 °C, Y iv) ENFRIAR LA MEZCLA OBTENIDA A 25 °C, DANDO COMO RESULTADO LA PRECIPITACION DE CRISTALES DE LA SAL DE SODIO DEL COMPUESTO (1). DICHO COMPUESTO ES UN INHIBIDOR DE LA ARN POLIMERASA DEPENDIENTE DEL ARN DE NS5B DEL VIRUS DE LA HEPATITIS C (VHC) SIENDO UTIL EN EL TRATAMIENTO DE LA INFECCION POR VHC
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38824210P | 2010-09-30 | 2010-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20131351A1 true PE20131351A1 (es) | 2013-12-04 |
Family
ID=44759789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013000628A PE20131351A1 (es) | 2010-09-30 | 2011-09-23 | Formas en estado solido de un potente inhibidor del vch |
Country Status (21)
Country | Link |
---|---|
US (2) | US8598183B2 (es) |
EP (1) | EP2621921A1 (es) |
JP (1) | JP2013543495A (es) |
KR (1) | KR20130108326A (es) |
CN (1) | CN103153987A (es) |
AP (1) | AP2013006733A0 (es) |
AR (1) | AR083256A1 (es) |
AU (1) | AU2011307346A1 (es) |
BR (1) | BR112013007700A2 (es) |
CA (1) | CA2813179A1 (es) |
CL (1) | CL2013000578A1 (es) |
CO (1) | CO6700844A2 (es) |
EA (1) | EA201300422A1 (es) |
EC (1) | ECSP13012552A (es) |
MA (1) | MA34548B1 (es) |
MX (1) | MX2013003551A (es) |
PE (1) | PE20131351A1 (es) |
SG (1) | SG188376A1 (es) |
TW (1) | TW201307327A (es) |
UY (1) | UY33632A (es) |
WO (1) | WO2012044520A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112013007700A2 (pt) * | 2010-09-30 | 2019-09-24 | Boehringer Ingelheim Int | formas em estado sólido de um potente inibidor de hcv |
AR089078A1 (es) * | 2011-12-06 | 2014-07-30 | Sanofi Sa | Formas cristalinas de [(s)-1-carbamoil-2-(fenil-pirimidin-2-il-amino)-etil]-amida de acido 2-(2-metilamino-pirimidin-4-il)-1h-indol-5-carboxilico |
US20130261134A1 (en) * | 2012-03-30 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Mesylate salt forms of a potent hcv inhibitor |
WO2014138374A1 (en) | 2013-03-08 | 2014-09-12 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69426408T2 (de) | 1993-09-28 | 2001-07-12 | Scherer Gmbh R P | Herstellung von Weichgelatinekapseln |
US5821242A (en) * | 1996-06-06 | 1998-10-13 | Eli Lilly And Company | Anti-viral compounds |
EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
ES2431314T3 (es) | 2004-02-20 | 2013-11-26 | Boehringer Ingelheim International Gmbh | Inhibidores de polimerasa vírica |
AU2006213769B2 (en) | 2005-02-11 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Process for preparing 2,3-disubstituted indoles |
JP5284101B2 (ja) | 2005-11-09 | 2013-09-11 | ノバルティス アーゲー | 一時可塑剤を用いる医薬組成物の製造法 |
BR112013007700A2 (pt) * | 2010-09-30 | 2019-09-24 | Boehringer Ingelheim Int | formas em estado sólido de um potente inibidor de hcv |
-
2011
- 2011-09-23 BR BR112013007700A patent/BR112013007700A2/pt not_active IP Right Cessation
- 2011-09-23 MX MX2013003551A patent/MX2013003551A/es not_active Application Discontinuation
- 2011-09-23 SG SG2013015854A patent/SG188376A1/en unknown
- 2011-09-23 US US13/241,551 patent/US8598183B2/en active Active
- 2011-09-23 KR KR1020137008249A patent/KR20130108326A/ko not_active Application Discontinuation
- 2011-09-23 PE PE2013000628A patent/PE20131351A1/es not_active Application Discontinuation
- 2011-09-23 CN CN2011800471790A patent/CN103153987A/zh active Pending
- 2011-09-23 AP AP2013006733A patent/AP2013006733A0/xx unknown
- 2011-09-23 WO PCT/US2011/052869 patent/WO2012044520A1/en active Application Filing
- 2011-09-23 MA MA35773A patent/MA34548B1/fr unknown
- 2011-09-23 AU AU2011307346A patent/AU2011307346A1/en not_active Abandoned
- 2011-09-23 EP EP11764925.1A patent/EP2621921A1/en not_active Withdrawn
- 2011-09-23 JP JP2013531669A patent/JP2013543495A/ja active Pending
- 2011-09-23 EA EA201300422A patent/EA201300422A1/ru unknown
- 2011-09-23 CA CA2813179A patent/CA2813179A1/en not_active Abandoned
- 2011-09-29 AR ARP110103617A patent/AR083256A1/es unknown
- 2011-09-29 TW TW100135337A patent/TW201307327A/zh unknown
- 2011-09-29 UY UY0001033632A patent/UY33632A/es unknown
-
2013
- 2013-02-28 CL CL2013000578A patent/CL2013000578A1/es unknown
- 2013-03-22 CO CO13057890A patent/CO6700844A2/es unknown
- 2013-04-15 EC ECSP13012552 patent/ECSP13012552A/es unknown
- 2013-10-30 US US14/067,218 patent/US20140057928A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA201300422A1 (ru) | 2013-09-30 |
CA2813179A1 (en) | 2012-04-05 |
WO2012044520A1 (en) | 2012-04-05 |
CL2013000578A1 (es) | 2013-08-02 |
EP2621921A1 (en) | 2013-08-07 |
AR083256A1 (es) | 2013-02-13 |
SG188376A1 (en) | 2013-04-30 |
UY33632A (es) | 2012-04-30 |
CN103153987A (zh) | 2013-06-12 |
JP2013543495A (ja) | 2013-12-05 |
ECSP13012552A (es) | 2013-06-28 |
TW201307327A (zh) | 2013-02-16 |
KR20130108326A (ko) | 2013-10-02 |
US8598183B2 (en) | 2013-12-03 |
US20140057928A1 (en) | 2014-02-27 |
AU2011307346A1 (en) | 2013-02-21 |
US20120122887A1 (en) | 2012-05-17 |
MA34548B1 (fr) | 2013-09-02 |
CO6700844A2 (es) | 2013-06-28 |
AP2013006733A0 (en) | 2013-02-28 |
MX2013003551A (es) | 2013-05-01 |
BR112013007700A2 (pt) | 2019-09-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |