PE20120807A1 - Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wnt - Google Patents
Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wntInfo
- Publication number
- PE20120807A1 PE20120807A1 PE2011001829A PE2011001829A PE20120807A1 PE 20120807 A1 PE20120807 A1 PE 20120807A1 PE 2011001829 A PE2011001829 A PE 2011001829A PE 2011001829 A PE2011001829 A PE 2011001829A PE 20120807 A1 PE20120807 A1 PE 20120807A1
- Authority
- PE
- Peru
- Prior art keywords
- wnt
- antagonists
- diagnosis
- treatment
- seq
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title 1
- 102000018152 Frizzled domains Human genes 0.000 abstract 1
- 108050007261 Frizzled domains Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
REFERIDA A UN ANTAGONISTA DE Wnt QUE COMPRENDE: A) UN COMPONENTE DEL DOMINIO FRIZZLED QUE COMPRENDE UN DOMINIO CDR MINIMO (ECD) DE hFrz1 (SEQ ID. Nº:25); B) UN DOMINIO Fc DE UNA INMUNOGLUBULINA SELECCIONADA A PARTIR DEL GRUPO IgG1, IgG2, IgG3, IgG4 MOSTRADA EN LA SEQ ID Nº:67, SEQ ID. Nº:68. COMPRENDE ADEMAS UN ENLAZADOR QUE CONECTA LOS DOS COMPONENTES. DICHO ANTAGONISTA PERMANECE ACTIVO IN VIVO DURANTE AL MENOS 1 HORA Y TIENE UNA VIDA MEDIA DE AL MENOS 1 DIA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82506306P | 2006-09-08 | 2006-09-08 | |
US95117507P | 2007-07-20 | 2007-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120807A1 true PE20120807A1 (es) | 2012-07-26 |
Family
ID=39092004
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001209A PE20081217A1 (es) | 2006-09-08 | 2007-09-07 | Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wnt |
PE2011001828A PE20120806A1 (es) | 2006-09-08 | 2007-09-07 | Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wnt |
PE2011001829A PE20120807A1 (es) | 2006-09-08 | 2007-09-07 | Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wnt |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001209A PE20081217A1 (es) | 2006-09-08 | 2007-09-07 | Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wnt |
PE2011001828A PE20120806A1 (es) | 2006-09-08 | 2007-09-07 | Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wnt |
Country Status (19)
Country | Link |
---|---|
US (5) | US7947277B2 (es) |
EP (1) | EP2061495A2 (es) |
JP (1) | JP2010504081A (es) |
KR (1) | KR20090060334A (es) |
AR (1) | AR062709A1 (es) |
AU (1) | AU2007292242A1 (es) |
BR (1) | BRPI0714751A2 (es) |
CA (1) | CA2662041A1 (es) |
CL (1) | CL2007002609A1 (es) |
CR (1) | CR10699A (es) |
IL (1) | IL197240A0 (es) |
MA (1) | MA31135B1 (es) |
MX (1) | MX2009002522A (es) |
NO (1) | NO20091413L (es) |
PE (3) | PE20081217A1 (es) |
RU (1) | RU2009113023A (es) |
SG (2) | SG174100A1 (es) |
TW (1) | TW200819463A (es) |
WO (1) | WO2008031009A2 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
JP5368798B2 (ja) | 2005-10-31 | 2013-12-18 | オンコメッド ファーマシューティカルズ インコーポレイテッド | 癌を診断し処置するための組成物および方法 |
JP2009065938A (ja) * | 2007-09-14 | 2009-04-02 | Matsumoto Shika Univ | タンパク質、破骨細胞分化阻害剤、炎症性骨破壊治療薬、遺伝子、組み替えベクター、及びタンパク質の製造方法 |
US20100260785A1 (en) * | 2007-12-13 | 2010-10-14 | Gabriela Saborio | SARP-1 Fusion Proteins and Uses Thereof |
WO2009132815A1 (en) | 2008-04-30 | 2009-11-05 | Roche Diagnostics Gmbh | Use of sfrp-3 in the assessment of heart failure |
ES2334092B1 (es) * | 2008-07-02 | 2011-01-24 | Proyecto De Biomedicina Cima, S.L. | Agentes antiangiogenicos. |
SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
US8551789B2 (en) | 2010-04-01 | 2013-10-08 | OncoMed Pharmaceuticals | Frizzled-binding agents and their use in screening for WNT inhibitors |
WO2010038756A1 (ja) | 2008-09-30 | 2010-04-08 | 協和発酵キリン株式会社 | Frizzled1、Frizzled2又はFrizzled7細胞外システインリッチドメインを含む蛋白質を含有する骨疾患治療用医薬組成物 |
AU2010238723A1 (en) | 2009-04-23 | 2011-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-human ROR1 antibodies |
US8877199B2 (en) | 2009-05-15 | 2014-11-04 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | B cell surface reactive antibodies |
US20110189097A1 (en) * | 2009-11-09 | 2011-08-04 | Dritan Agalliu | Use of WNT inhibitor to inhibit angiogenesis in the CNS |
TWI535445B (zh) * | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
EP2585098B1 (en) | 2010-06-28 | 2014-08-27 | Five Prime Therapeutics, Inc. | Fzd8 extracellular domains and fzd8 extracellular domain fusion molecules for use in treating obesity and obesity-related disorders |
UY33469A (es) * | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
MX2013004315A (es) | 2010-10-20 | 2013-07-17 | Genentech Inc | Metodos y composiciones para modular la ruta wnt. |
AU2011329854B2 (en) | 2010-11-16 | 2017-03-30 | University Of Southern California | CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells |
ES2657970T3 (es) | 2010-12-01 | 2018-03-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anticuerpos contra ROR1 de conejo/ser humano quiméricos |
AU2012271413B2 (en) | 2011-06-17 | 2017-07-13 | President And Fellows Of Harvard College | Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer |
JP6121902B2 (ja) | 2011-06-21 | 2017-04-26 | 協和発酵キリン株式会社 | Frizzled2の細胞外領域蛋白質のトランケート体を含む蛋白質、および該蛋白質を含有する骨疾患治療用医薬組成物 |
KR20140048276A (ko) | 2011-07-15 | 2014-04-23 | 온코메드 파마슈티칼스, 인크. | Rspo 결합제 및 이의 용도 |
US20130216546A1 (en) * | 2012-01-10 | 2013-08-22 | Ngm Biopharmaceuticals, Inc. | Methods of Treating Glucose Metabolism Disorders |
AU2013216753B2 (en) | 2012-02-11 | 2017-09-21 | Genentech, Inc. | R-spondin translocations and methods using the same |
WO2013126006A1 (en) * | 2012-02-20 | 2013-08-29 | Swedish Orphan Biovitrum Ab (Publ) | Polypeptides binding to human complement c5 |
EP2911691B1 (en) * | 2012-10-23 | 2018-10-10 | OncoMed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
US9957330B2 (en) * | 2012-12-19 | 2018-05-01 | Affibody Ab | Polypeptides |
JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路インヒビターによる処置の方法およびモニタリング |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
CA2931975A1 (en) | 2013-12-02 | 2015-06-11 | Oncomed Pharmaceuticals, Inc. | Identification of predictive biomarkers associated with wnt pathway inhibitors |
CA2952315A1 (en) | 2014-07-11 | 2016-01-14 | Genentech, Inc. | Notch pathway inhibition |
KR101572606B1 (ko) * | 2014-11-24 | 2015-11-27 | 강원대학교산학협력단 | Sfrp5 유래의 펩타이드 및 이를 포함하는 피부 미백용 화장료 조성물 |
WO2016126054A1 (ko) | 2015-02-04 | 2016-08-11 | (주)메드팩토 | 변형된 dkk2 단백질 또는 그 유전자를 포함하는 발기부전 예방 또는 치료용 조성물 및 이를 이용한 방법 |
CA3014498A1 (en) * | 2016-03-21 | 2017-09-28 | Children's Medical Center Corporation | Compositions and methods for inhibiting wnt signaling |
CN108310366A (zh) * | 2017-01-15 | 2018-07-24 | 复旦大学附属华山医院 | 重组sfrp5蛋白在制备治疗非酒精性脂肪性肝炎药物中的用途 |
WO2021102055A1 (en) * | 2019-11-18 | 2021-05-27 | The Regents Of The University Of California | Anti-ror-2 antibodies and methods of use |
JP2023503615A (ja) * | 2019-11-26 | 2023-01-31 | シーダーズ-サイナイ メディカル センター | 循環からミトコンドリアdna又はゲノムdnaを枯渇させることにより疾患及び症状を治療する組成物及び方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997039357A1 (en) | 1996-04-12 | 1997-10-23 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt RECEPTOR COMPOSITIONS AND METHODS |
JP4299886B2 (ja) | 1996-09-24 | 2009-07-22 | タノックス インコーポレイテッド | アポトーシス関連ペプチドをコードする遺伝子ファミリー、それによってコードされるペプチド、およびそれらの使用方法 |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
EP1252192B1 (en) | 2000-02-11 | 2006-08-16 | MERCK PATENT GmbH | Enhancing the circulating half-life of antibody-based fusion proteins |
WO2001098354A2 (en) | 2000-06-21 | 2001-12-27 | Incyte Genomics, Inc. | Human receptors |
US7413873B2 (en) | 2001-01-30 | 2008-08-19 | The Regents Of The University Of California | Method of detection and treatment of colon cancer |
US20030044409A1 (en) | 2001-05-01 | 2003-03-06 | Carson Dennis A. | Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens |
US7682607B2 (en) | 2001-05-01 | 2010-03-23 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
US7713526B2 (en) | 2001-05-01 | 2010-05-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
WO2003004045A2 (en) | 2001-07-05 | 2003-01-16 | Xenon Genetics, Inc. | Methods for identifying therapeutic agents for treating diseases involving wnt polypeptides and wnt receptors |
WO2003009814A2 (en) | 2001-07-25 | 2003-02-06 | Millennium Pharmaceuticals, Inc. | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of prostate cancer |
US20040247593A1 (en) * | 2002-10-04 | 2004-12-09 | Regents Of The University Of California, | Methods for treating cancer by inhibiting Wnt signaling |
WO2004053069A2 (en) * | 2002-12-06 | 2004-06-24 | The Board Of Trustees Of The Leland Stanford Junior University | PROTECTION OF STEM CELLS FROM CYTOTOXIC AGENTS BY MODULATION OF β-CATENIN SIGNALING PATHWAYS |
US7803783B2 (en) | 2002-12-06 | 2010-09-28 | The Board Of Trustees Of The Leland Stanford Junior University | Use of WNT inhibitors to augment therapeutic index of chemotherapy |
US20050096263A1 (en) | 2003-10-30 | 2005-05-05 | Keay Susan K. | Novel antiproliferative factor and methods of use |
WO2006036175A2 (en) | 2004-09-21 | 2006-04-06 | Rhode Island Hospital, A Lifespan-Partner | Wnt proteins and detection and treatment of cancer |
CA2580780A1 (en) | 2004-09-21 | 2006-04-06 | Rhode Island Hospital, A Lifespan-Partner | Frizzled proteins and detection and treatment of cancer |
CA2580803C (en) | 2004-09-21 | 2016-06-14 | Rhode Island Hospital, A Lifespan-Partner | Wnt proteins and detection and treatment of cancer |
JP2008520583A (ja) | 2004-11-15 | 2008-06-19 | マウント シナイ スクール オブ メディスン オブ ニューヨーク ユニバーシティー | Wnt自己分泌シグナル伝達を改変するための組成物および方法 |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
-
2007
- 2007-09-07 CA CA002662041A patent/CA2662041A1/en not_active Abandoned
- 2007-09-07 KR KR1020097007144A patent/KR20090060334A/ko not_active Application Discontinuation
- 2007-09-07 PE PE2007001209A patent/PE20081217A1/es not_active Application Discontinuation
- 2007-09-07 PE PE2011001828A patent/PE20120806A1/es not_active Application Discontinuation
- 2007-09-07 EP EP07814736A patent/EP2061495A2/en not_active Ceased
- 2007-09-07 WO PCT/US2007/077845 patent/WO2008031009A2/en active Application Filing
- 2007-09-07 PE PE2011001829A patent/PE20120807A1/es not_active Application Discontinuation
- 2007-09-07 MX MX2009002522A patent/MX2009002522A/es unknown
- 2007-09-07 BR BRPI0714751-1A2A patent/BRPI0714751A2/pt not_active IP Right Cessation
- 2007-09-07 SG SG2011061421A patent/SG174100A1/en unknown
- 2007-09-07 TW TW096133617A patent/TW200819463A/zh unknown
- 2007-09-07 US US11/851,596 patent/US7947277B2/en not_active Expired - Fee Related
- 2007-09-07 AR ARP070103967A patent/AR062709A1/es not_active Application Discontinuation
- 2007-09-07 RU RU2009113023/15A patent/RU2009113023A/ru not_active Application Discontinuation
- 2007-09-07 CL CL200702609A patent/CL2007002609A1/es unknown
- 2007-09-07 AU AU2007292242A patent/AU2007292242A1/en not_active Abandoned
- 2007-09-07 JP JP2009527577A patent/JP2010504081A/ja active Pending
- 2007-09-07 SG SG2011061439A patent/SG174101A1/en unknown
-
2009
- 2009-02-25 IL IL197240A patent/IL197240A0/en unknown
- 2009-03-31 CR CR10699A patent/CR10699A/es unknown
- 2009-04-06 MA MA31763A patent/MA31135B1/fr unknown
- 2009-04-07 NO NO20091413A patent/NO20091413L/no not_active Application Discontinuation
-
2010
- 2010-06-29 US US12/826,194 patent/US20100266593A1/en not_active Abandoned
-
2011
- 2011-05-23 US US13/113,211 patent/US20110311534A1/en not_active Abandoned
-
2012
- 2012-02-07 US US13/367,760 patent/US20120141481A1/en not_active Abandoned
-
2016
- 2016-12-20 US US15/385,528 patent/US20170349639A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7947277B2 (en) | 2011-05-24 |
AR062709A1 (es) | 2008-11-26 |
SG174101A1 (en) | 2011-09-29 |
MX2009002522A (es) | 2009-06-19 |
MA31135B1 (fr) | 2010-02-01 |
US20100266593A1 (en) | 2010-10-21 |
PE20120806A1 (es) | 2012-07-25 |
PE20081217A1 (es) | 2008-09-24 |
US20080299136A1 (en) | 2008-12-04 |
CL2007002609A1 (es) | 2008-04-18 |
BRPI0714751A2 (pt) | 2014-06-24 |
CA2662041A1 (en) | 2008-03-13 |
NO20091413L (no) | 2009-06-08 |
SG174100A1 (en) | 2011-09-29 |
WO2008031009A2 (en) | 2008-03-13 |
CR10699A (es) | 2009-07-10 |
IL197240A0 (en) | 2011-08-01 |
AU2007292242A1 (en) | 2008-03-13 |
US20120141481A1 (en) | 2012-06-07 |
US20170349639A1 (en) | 2017-12-07 |
KR20090060334A (ko) | 2009-06-11 |
EP2061495A2 (en) | 2009-05-27 |
JP2010504081A (ja) | 2010-02-12 |
US20110311534A1 (en) | 2011-12-22 |
RU2009113023A (ru) | 2010-10-20 |
TW200819463A (en) | 2008-05-01 |
WO2008031009A3 (en) | 2009-07-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20120807A1 (es) | Antagonistas del gen wnt y su uso en el diagnostico y tratamiento de trastornos mediados por el wnt | |
RS53750B1 (en) | NOTCH1 RECEPTOR BINDING AGENTS AND APPLICATION PROCEDURES | |
DE602007008524D1 (de) | Spiroimidazol-derivate als ppar-modulatoren | |
EA200870193A1 (ru) | Цитотоксические агенты, включающие новые производные томаймицина, и их терапевтическое применение | |
DE602006006712D1 (de) | Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren | |
PE20110771A1 (es) | Anticuerpos monoclonales contra el inhibidor de la via del factor tisular (tfpi) | |
GT200900137A (es) | Fusiones fc con receptor para fgf soluble modificaciones, con actividad biologica mejorada. | |
EA200701439A1 (ru) | Pyy-агонисты и их применение | |
EA202091999A3 (ru) | Применение ингибиторов dpp iv | |
IL215026A (en) | 1r7zb antagonist, methods and compounds @ which include @ the same | |
TW200740773A (en) | Diaminopyrimidines as P2X3 and P2X2/3 modulators | |
ATE502633T1 (de) | Cyclosporins zur behandlung und vorbeugung von augenerkrankungen | |
EA200870197A1 (ru) | Новые 2-замещённые бензимидазолы в качестве селективных модуляторов рецептора андрогена (sarms) | |
CR9393A (es) | Anticuerpos anti-ccr5 y usos de los mismos | |
BRPI0518228B8 (pt) | inibidores de cinesina mitótica e uso dos mesmos | |
CR10694A (es) | Compuestos antagonistas del receptor de glucagon, composiciones que contienen dichos compuestos y procedimientos de uso | |
DE602007002792D1 (de) | Verbindungen und zusammensetzungen als ppar-modulatoren | |
EA200801997A1 (ru) | Новые соединения | |
EA200900831A1 (ru) | Модуляторы никотиновых ацетилхолиновых рецепторов | |
PE20061197A1 (es) | Aminoalcoholes triciclicos, como inhibidores de la secresion de citoquina il-8 | |
ATE467632T1 (de) | Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors | |
ATE484505T1 (de) | 5-sulfanylmethylä1,2,4ütriazolä1,5-aüpyrimidin- - olderivate als cxcr2-antagonisten | |
ATE466854T1 (de) | 1h-indol-6-ylpiperazin-1-ylmethanonderivate zur verwendung als h3-rezeptormodulatoren | |
ECSP10010379A (es) | Derivados de oxindol sustituido y su uso para el tratamiento de enfermedades dependientes de la vasopresina | |
ATE519498T1 (de) | Kombination aus somatostatin-analoga unterschiedlicher selektivität für humane somatostatin-rezeptor-subtypen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |