PE20120520A1 - Proceso para producir compuesto de acido carboxilico - Google Patents

Proceso para producir compuesto de acido carboxilico

Info

Publication number
PE20120520A1
PE20120520A1 PE2011001709A PE2011001709A PE20120520A1 PE 20120520 A1 PE20120520 A1 PE 20120520A1 PE 2011001709 A PE2011001709 A PE 2011001709A PE 2011001709 A PE2011001709 A PE 2011001709A PE 20120520 A1 PE20120520 A1 PE 20120520A1
Authority
PE
Peru
Prior art keywords
compound
methylpropan
fluorophenyl
chloro
ethyl
Prior art date
Application number
PE2011001709A
Other languages
English (en)
Inventor
Katsuya Matsumoto
Katsuyuki Yokota
Teruhiko Inoue
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of PE20120520A1 publication Critical patent/PE20120520A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DEL ACIDO 2'-((1R)-1-{(2R)-3-[1-(4-CLORO-3-FLUOROFENIL)-2-METILPROPAN-2-ILAMINO]-2-HIDROXIPROPOXI}ETIL)-3-METILBIFENIL-4-CARBOXILICO DE FORMULA (I) QUE COMPRENDE: A) SOMETER A GLICIDILACION EL COMPUESTO 3-METIL-2'-[(1R)-1-HIDROXIETIL]BIFENIL-4-CARBOXILATO DE TER-BUTILO PARA LA OBTENCION DEL COMPUESTO 3-METIL-2'-[(1R)-1-((R)-OXIRANILMETOXI)ETIL]BIFENIL-4-CARBOXILATO DE TER-BUTILO DE FORMULA (III); B) HACER REACCIONAR EL COMPUESTO DE FORMULA (III) CON EL COMPUESTO [1-(4-CLORO-3-FLUOROFENIL)-2-METILPROPAN-2-IL]AMINA PARA PREPARAR EL COMPUESTO 2'-((1R)-1-{(2R)-3-[1-(4-CLORO-3-FLUOROFENIL)-2-METILPROPAN-2-ILAMINO]-2-HIDROXIPROPOXI}ETIL)-3-METILBIFENIL-4-CARBOXILATO DE TER-BUTILO; Y C) SOMETER A TRANSESTERIFICACION Y LUEGO A HIDROLISIS CON ALCALI AL COMPUESTO OBTENIDO EN EL PASO ANTERIOR. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DE LA OSTEOPOROSIS
PE2011001709A 2009-03-26 2010-03-25 Proceso para producir compuesto de acido carboxilico PE20120520A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009077601 2009-03-26
US21171209P 2009-04-02 2009-04-02

Publications (1)

Publication Number Publication Date
PE20120520A1 true PE20120520A1 (es) 2012-05-14

Family

ID=42781045

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001709A PE20120520A1 (es) 2009-03-26 2010-03-25 Proceso para producir compuesto de acido carboxilico

Country Status (13)

Country Link
US (1) US20100286416A1 (es)
EP (1) EP2412697A1 (es)
JP (1) JP5250693B2 (es)
CN (1) CN102365261A (es)
AU (1) AU2010228194A1 (es)
CA (1) CA2756422A1 (es)
CO (1) CO6450694A2 (es)
IL (1) IL215358A0 (es)
MX (1) MX2011010031A (es)
NZ (1) NZ595513A (es)
PE (1) PE20120520A1 (es)
SG (1) SG174564A1 (es)
WO (1) WO2010110352A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY138734A (en) * 2003-04-23 2009-07-31 Japan Tobacco Inc Casr antagonist
EP1704856A4 (en) * 2003-12-26 2009-08-19 Kyowa Hakko Kirin Co Ltd PROTEIN INHIBITOR OF THE HSP90 FAMILY

Also Published As

Publication number Publication date
JPWO2010110352A1 (ja) 2012-10-04
SG174564A1 (en) 2011-10-28
IL215358A0 (en) 2011-12-29
CO6450694A2 (es) 2012-05-31
WO2010110352A1 (ja) 2010-09-30
MX2011010031A (es) 2011-10-11
JP5250693B2 (ja) 2013-07-31
US20100286416A1 (en) 2010-11-11
AU2010228194A1 (en) 2011-10-27
CA2756422A1 (en) 2010-09-30
NZ595513A (en) 2013-05-31
EP2412697A1 (en) 2012-02-01
CN102365261A (zh) 2012-02-29

Similar Documents

Publication Publication Date Title
PH12014502584A1 (en) Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
NZ739760A (en) Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same
MA31498B1 (fr) Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
NZ627274A (en) Anesthetic compounds and related methods of use
MY159924A (en) Androgen receptor modulating compounds
BR112013000920A2 (pt) compostos para a redução de produção de beta-amiloide
NZ703341A (en) Compositions comprising apomorphine and organic acids and uses thereof
WO2012024100A3 (en) Process for preparing aminocyclohexyl ether compounds
BR112015004529A2 (pt) alcóxi pirazóis como ativadores de guanilato ciclase solúvel
MX2007004560A (es) Proceso para hacer compuestos de fenoxi benzamida.
TN2013000529A1 (en) Trpm8 antagonists and their use in treatments
BR112014004210A2 (pt) processo para a preparação de derivados de diamida do ácido antranílico substituídos com tetrazole por reação de benzoxazinonas com aminas
BR112012017994A2 (pt) composição líquida, uso de uma composição líquida, e, métodos para preparar uma composição líquida e para tratamento de um distúrbio
MX2010009860A (es) Sintesis total de salinosporamida a y sus analogos.
BR112015011974A8 (pt) derivados de azaquinazolina carboxamida, seus usos e processo para sua produção, medicamento e composição farmacêutica
BR112015015035A2 (pt) processo integrado para produção de ácido acético
MX2011012479A (es) Moduladores de los receptores 5-ht y metodos de uso de los mismos.
BRPI0507352A (pt) reações de acoplamento úteis na preparação de derivados de (1h-tetrazol-5-il)-bifenila
AR072117A1 (es) Procedimiento para preparar una sal de malato 3-pirrol sustituido 2-indolinona, intermediario de sintesis y una composicion farmaceutica que la comprende.
BR112013026913A2 (pt) resinas de poliamidoamina-epialoidrina, método de fabricação, e uso das mesmas
PE20120520A1 (es) Proceso para producir compuesto de acido carboxilico
BR112014009266A8 (pt) processos encurtado, biocatalítico e para preparação de ácidos isoxazolil-metóxi-nicotínicos
MX2014013761A (es) Acidos (3r,4r,5s)-5-guanidino-4-acetamido-3-(pentan-3-iloxi)cicloh exen-1-carboxilicos fluorosustituidos, sus esteres y uso de los mismos.
BR112015015880A2 (pt) processo para a produção do composto, composto de fórmula, preparação farmacêutica e compostos, composições, métodos e utilizações substancialmente inovadores
UY34900A (es) Procedimiento de síntesis enzimática de la (7s)-1-(3,4-dimetoxibiciclo [4.2.0] octa-1,3,5-trien-7-il) n-metil metanamina, y aplicación a la síntesis de la ivabradina y de sus sales

Legal Events

Date Code Title Description
FA Abandonment or withdrawal