PE20110156A1 - Nuevos derivados cromenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents
Nuevos derivados cromenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienenInfo
- Publication number
- PE20110156A1 PE20110156A1 PE2010000440A PE2010000440A PE20110156A1 PE 20110156 A1 PE20110156 A1 PE 20110156A1 PE 2010000440 A PE2010000440 A PE 2010000440A PE 2010000440 A PE2010000440 A PE 2010000440A PE 20110156 A1 PE20110156 A1 PE 20110156A1
- Authority
- PE
- Peru
- Prior art keywords
- contain
- pharmaceutical compositions
- pyrrol
- trans
- ethyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical class [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000003291 dopaminomimetic effect Effects 0.000 abstract 1
- PQPFFKCJENSZKL-UHFFFAOYSA-N pentan-3-amine Chemical compound CCC(N)CC PQPFFKCJENSZKL-UHFFFAOYSA-N 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN COMPUESTO DERIVADO CROMENICO DE FORMULA (I) DONDE R1 Y R2 FORMAN LA CADENA CARBONADA 1-ETILPROPANAMINA DISUSTITUIDA EN N POR R3 Y R4; R3 ES H, ALQUILO C1-C6 LINEAL O RAMIFICADO; R4 ES H, ALQUILO C1-C6 LINEAL O RAMIFICADO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (3aS,9bR)-2-[2-(trans-4-AMINOCICLOHEXIL)ETIL]-1,2,3,3a,4,9b-HEXAHIDROCROMENO[3,4-c]PIRROL-8-CARBONITRILO; (3aS,9bR)-2-{[2-(trans-4-METILAMINO)CICLOHEXIL]ETIL}-1,2,3,3a,4,9b-HEXAHIDROCROMENO[3,4-c]PIRROL-8-CARBONITRILO; N-(trans-4-{2-[(3aS,9bR)-8-CIANO-1,3a,4,9b-TETRAHIDROCROMENO[3,4-c]PIRROL-2(3H)-IL]ETIL}CICLOHEXIL)ACETAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UN METODO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN ANTAGONISTA DE LOS RECEPTORES DOPAMINERGICOS D2 Y D3 UTIL EN EL TRATAMIENTO DE ESQUIZOFRENIA, ENFERMEDAD DE PARKINSON, DEPRESION, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0903572A FR2948372B1 (fr) | 2009-07-21 | 2009-07-21 | Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110156A1 true PE20110156A1 (es) | 2011-03-19 |
Family
ID=41856518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010000440A PE20110156A1 (es) | 2009-07-21 | 2010-07-06 | Nuevos derivados cromenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8247441B2 (es) |
| EP (1) | EP2277882A1 (es) |
| JP (1) | JP2011026319A (es) |
| KR (1) | KR20110009064A (es) |
| CN (1) | CN101962384B (es) |
| AR (1) | AR077492A1 (es) |
| AU (1) | AU2010202876A1 (es) |
| BR (1) | BRPI1002409A2 (es) |
| CA (1) | CA2709341A1 (es) |
| CL (1) | CL2010000743A1 (es) |
| CO (1) | CO6280049A1 (es) |
| CR (1) | CR11566A (es) |
| CU (1) | CU20100149A7 (es) |
| EA (1) | EA017774B1 (es) |
| EC (1) | ECSP10010357A (es) |
| FR (1) | FR2948372B1 (es) |
| GE (1) | GEP20125545B (es) |
| IL (1) | IL206885A0 (es) |
| MA (1) | MA32342B1 (es) |
| MX (1) | MX2010007799A (es) |
| NZ (1) | NZ586855A (es) |
| PE (1) | PE20110156A1 (es) |
| SG (1) | SG168482A1 (es) |
| TW (1) | TW201109337A (es) |
| UY (1) | UY32768A (es) |
| WO (1) | WO2011010014A1 (es) |
| ZA (1) | ZA201005203B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10870660B2 (en) | 2016-07-28 | 2020-12-22 | Shionogi & Co., Ltd. | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect |
| EP3744721A4 (en) | 2018-01-26 | 2021-11-10 | Shionogi & Co., Ltd | CONDENSED CYCLIC COMPOUND WITH ANTAGONISM TO DOPAMINE D3 RECEPTOR |
| WO2019146740A1 (ja) | 2018-01-26 | 2019-08-01 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する環式化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2722194B1 (fr) * | 1994-07-06 | 1996-08-23 | Adir | Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent |
| AU5272296A (en) * | 1995-04-06 | 1996-10-23 | Novo Nordisk A/S | Benzopyranopyrrole compounds, their preparation and use |
| FR2764890B1 (fr) * | 1997-06-24 | 1999-08-27 | Adir | Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
-
2009
- 2009-07-21 FR FR0903572A patent/FR2948372B1/fr not_active Expired - Fee Related
-
2010
- 2010-07-06 PE PE2010000440A patent/PE20110156A1/es not_active Application Discontinuation
- 2010-07-07 AU AU2010202876A patent/AU2010202876A1/en not_active Abandoned
- 2010-07-07 UY UY0001032768A patent/UY32768A/es unknown
- 2010-07-08 SG SG201004962-5A patent/SG168482A1/en unknown
- 2010-07-08 IL IL206885A patent/IL206885A0/en unknown
- 2010-07-12 CL CL2010000743A patent/CL2010000743A1/es unknown
- 2010-07-13 CR CR11566A patent/CR11566A/es not_active Application Discontinuation
- 2010-07-16 CU CU20100149A patent/CU20100149A7/es unknown
- 2010-07-16 GE GEAP201011892A patent/GEP20125545B/en unknown
- 2010-07-16 MX MX2010007799A patent/MX2010007799A/es unknown
- 2010-07-16 CA CA2709341A patent/CA2709341A1/fr not_active Abandoned
- 2010-07-16 CO CO10087224A patent/CO6280049A1/es active IP Right Grant
- 2010-07-16 NZ NZ586855A patent/NZ586855A/en not_active IP Right Cessation
- 2010-07-19 MA MA33038A patent/MA32342B1/fr unknown
- 2010-07-20 JP JP2010162384A patent/JP2011026319A/ja not_active Ceased
- 2010-07-20 BR BRPI1002409-3A patent/BRPI1002409A2/pt not_active Application Discontinuation
- 2010-07-20 EC EC2010010357A patent/ECSP10010357A/es unknown
- 2010-07-20 WO PCT/FR2010/000519 patent/WO2011010014A1/fr active Application Filing
- 2010-07-20 EP EP10290411A patent/EP2277882A1/fr not_active Withdrawn
- 2010-07-20 US US12/804,355 patent/US8247441B2/en not_active Expired - Fee Related
- 2010-07-20 EA EA201001041A patent/EA017774B1/ru not_active IP Right Cessation
- 2010-07-20 AR ARP100102637A patent/AR077492A1/es unknown
- 2010-07-20 TW TW099123875A patent/TW201109337A/zh unknown
- 2010-07-21 ZA ZA2010/05203A patent/ZA201005203B/en unknown
- 2010-07-21 CN CN2010102347598A patent/CN101962384B/zh not_active Expired - Fee Related
- 2010-07-21 KR KR1020100070584A patent/KR20110009064A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI1002409A2 (pt) | 2012-05-15 |
| AR077492A1 (es) | 2011-08-31 |
| ECSP10010357A (es) | 2011-02-28 |
| EA017774B1 (ru) | 2013-03-29 |
| JP2011026319A (ja) | 2011-02-10 |
| TW201109337A (en) | 2011-03-16 |
| CU20100149A7 (es) | 2012-03-15 |
| GEP20125545B (en) | 2012-05-25 |
| MX2010007799A (es) | 2011-02-03 |
| CR11566A (es) | 2010-09-13 |
| US20110021490A1 (en) | 2011-01-27 |
| US8247441B2 (en) | 2012-08-21 |
| CO6280049A1 (es) | 2011-05-20 |
| SG168482A1 (en) | 2011-02-28 |
| WO2011010014A1 (fr) | 2011-01-27 |
| NZ586855A (en) | 2011-11-25 |
| CA2709341A1 (fr) | 2011-01-21 |
| AU2010202876A1 (en) | 2011-02-10 |
| MA32342B1 (fr) | 2011-06-01 |
| UY32768A (es) | 2011-01-31 |
| FR2948372A1 (fr) | 2011-01-28 |
| ZA201005203B (en) | 2011-03-30 |
| EA201001041A1 (ru) | 2011-02-28 |
| KR20110009064A (ko) | 2011-01-27 |
| IL206885A0 (en) | 2010-12-30 |
| CN101962384A (zh) | 2011-02-02 |
| CN101962384B (zh) | 2013-04-10 |
| CL2010000743A1 (es) | 2011-07-08 |
| EP2277882A1 (fr) | 2011-01-26 |
| FR2948372B1 (fr) | 2011-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |