PE20110156A1 - Nuevos derivados cromenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents

Nuevos derivados cromenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Info

Publication number
PE20110156A1
PE20110156A1 PE2010000440A PE2010000440A PE20110156A1 PE 20110156 A1 PE20110156 A1 PE 20110156A1 PE 2010000440 A PE2010000440 A PE 2010000440A PE 2010000440 A PE2010000440 A PE 2010000440A PE 20110156 A1 PE20110156 A1 PE 20110156A1
Authority
PE
Peru
Prior art keywords
contain
pharmaceutical compositions
pyrrol
trans
ethyl
Prior art date
Application number
PE2010000440A
Other languages
English (en)
Inventor
Nanteuil Guillaume De
Anne Dekeyne
Bernard Cimetiere
Mark Millan
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41856518&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110156(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of PE20110156A1 publication Critical patent/PE20110156A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DERIVADO CROMENICO DE FORMULA (I) DONDE R1 Y R2 FORMAN LA CADENA CARBONADA 1-ETILPROPANAMINA DISUSTITUIDA EN N POR R3 Y R4; R3 ES H, ALQUILO C1-C6 LINEAL O RAMIFICADO; R4 ES H, ALQUILO C1-C6 LINEAL O RAMIFICADO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS (3aS,9bR)-2-[2-(trans-4-AMINOCICLOHEXIL)ETIL]-1,2,3,3a,4,9b-HEXAHIDROCROMENO[3,4-c]PIRROL-8-CARBONITRILO; (3aS,9bR)-2-{[2-(trans-4-METILAMINO)CICLOHEXIL]ETIL}-1,2,3,3a,4,9b-HEXAHIDROCROMENO[3,4-c]PIRROL-8-CARBONITRILO; N-(trans-4-{2-[(3aS,9bR)-8-CIANO-1,3a,4,9b-TETRAHIDROCROMENO[3,4-c]PIRROL-2(3H)-IL]ETIL}CICLOHEXIL)ACETAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UN METODO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN ANTAGONISTA DE LOS RECEPTORES DOPAMINERGICOS D2 Y D3 UTIL EN EL TRATAMIENTO DE ESQUIZOFRENIA, ENFERMEDAD DE PARKINSON, DEPRESION, ENTRE OTROS
PE2010000440A 2009-07-21 2010-07-06 Nuevos derivados cromenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen PE20110156A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0903572A FR2948372B1 (fr) 2009-07-21 2009-07-21 Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
PE20110156A1 true PE20110156A1 (es) 2011-03-19

Family

ID=41856518

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2010000440A PE20110156A1 (es) 2009-07-21 2010-07-06 Nuevos derivados cromenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Country Status (27)

Country Link
US (1) US8247441B2 (es)
EP (1) EP2277882A1 (es)
JP (1) JP2011026319A (es)
KR (1) KR20110009064A (es)
CN (1) CN101962384B (es)
AR (1) AR077492A1 (es)
AU (1) AU2010202876A1 (es)
BR (1) BRPI1002409A2 (es)
CA (1) CA2709341A1 (es)
CL (1) CL2010000743A1 (es)
CO (1) CO6280049A1 (es)
CR (1) CR11566A (es)
CU (1) CU20100149A7 (es)
EA (1) EA017774B1 (es)
EC (1) ECSP10010357A (es)
FR (1) FR2948372B1 (es)
GE (1) GEP20125545B (es)
IL (1) IL206885A0 (es)
MA (1) MA32342B1 (es)
MX (1) MX2010007799A (es)
NZ (1) NZ586855A (es)
PE (1) PE20110156A1 (es)
SG (1) SG168482A1 (es)
TW (1) TW201109337A (es)
UY (1) UY32768A (es)
WO (1) WO2011010014A1 (es)
ZA (1) ZA201005203B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3495363B1 (en) 2016-07-28 2023-08-23 Shionogi & Co., Ltd Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect
JPWO2019146739A1 (ja) 2018-01-26 2021-01-07 塩野義製薬株式会社 ドーパミンd3受容体拮抗作用を有する縮環化合物
WO2019146740A1 (ja) 2018-01-26 2019-08-01 塩野義製薬株式会社 ドーパミンd3受容体拮抗作用を有する環式化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2722194B1 (fr) * 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
WO1996031512A1 (en) * 1995-04-06 1996-10-10 Novo Nordisk A/S Benzopyranopyrrole compounds, their preparation and use
FR2764890B1 (fr) * 1997-06-24 1999-08-27 Adir Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives

Also Published As

Publication number Publication date
IL206885A0 (en) 2010-12-30
US20110021490A1 (en) 2011-01-27
AR077492A1 (es) 2011-08-31
EA017774B1 (ru) 2013-03-29
AU2010202876A1 (en) 2011-02-10
GEP20125545B (en) 2012-05-25
CN101962384A (zh) 2011-02-02
CA2709341A1 (fr) 2011-01-21
JP2011026319A (ja) 2011-02-10
CN101962384B (zh) 2013-04-10
US8247441B2 (en) 2012-08-21
KR20110009064A (ko) 2011-01-27
CL2010000743A1 (es) 2011-07-08
CU20100149A7 (es) 2012-03-15
FR2948372B1 (fr) 2011-07-22
MX2010007799A (es) 2011-02-03
UY32768A (es) 2011-01-31
SG168482A1 (en) 2011-02-28
EP2277882A1 (fr) 2011-01-26
MA32342B1 (fr) 2011-06-01
TW201109337A (en) 2011-03-16
FR2948372A1 (fr) 2011-01-28
CR11566A (es) 2010-09-13
NZ586855A (en) 2011-11-25
BRPI1002409A2 (pt) 2012-05-15
ECSP10010357A (es) 2011-02-28
CO6280049A1 (es) 2011-05-20
WO2011010014A1 (fr) 2011-01-27
ZA201005203B (en) 2011-03-30
EA201001041A1 (ru) 2011-02-28

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