PE20091310A1 - Nueva forma cristalina b del acido (2r)-(3-amino-2-fluoropropil)fosfinico - Google Patents
Nueva forma cristalina b del acido (2r)-(3-amino-2-fluoropropil)fosfinicoInfo
- Publication number
- PE20091310A1 PE20091310A1 PE2008002133A PE2008002133A PE20091310A1 PE 20091310 A1 PE20091310 A1 PE 20091310A1 PE 2008002133 A PE2008002133 A PE 2008002133A PE 2008002133 A PE2008002133 A PE 2008002133A PE 20091310 A1 PE20091310 A1 PE 20091310A1
- Authority
- PE
- Peru
- Prior art keywords
- fluoropropyl
- amino
- crystalline
- phosphinic acid
- new crystalline
- Prior art date
Links
- WVTGPBOMAQLPCP-GSVOUGTGSA-O [(2r)-3-amino-2-fluoropropyl]-hydroxy-oxophosphanium Chemical compound NC[C@@H](F)C[P+](O)=O WVTGPBOMAQLPCP-GSVOUGTGSA-O 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- KFZMGEQAYNKOFK-YZRHJBSPSA-N (214C)propan-2-ol Chemical compound [14CH](C)(C)O KFZMGEQAYNKOFK-YZRHJBSPSA-N 0.000 abstract 1
- -1 (2R) - (3-AMINO-2-FLUOROPROPYL) Chemical class 0.000 abstract 1
- LFQSCWFLJHTTHZ-HQMMCQRPSA-N Ethanol-14C Chemical compound C[14CH2]O LFQSCWFLJHTTHZ-HQMMCQRPSA-N 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
REFERIDA A UNA FORMA CRISTALINA B DEL ACIDO (2R)-(3-AMINO-2-FLUOROPROPIL)FOSFINICO QUE TIENE UN PATRON DE DIFRACCION DE RAYOS X EN POLVOS QUE PRESENTA PICOS CON VALORES d: 6,2 Å, 4,10 Å, 4,05 Å, 2,87 Å, 2,60 Å Y 2,47 Å. TAMBIEN ESTA REFERIDA A UN PROCESO DE PREPARACION DE DICHA FORMA CRISTALINA B QUE CONSISTE EN DISOLVER LA FORMA CRISTALINA A DEL ACIDO (2R)-(3-AMINO-2-FLUOROPROPIL)FOSFINICO EN UN SOLVENTE POLAR TAL COMO METANOL O AGUA, AGREGAR UN ANTI-SOLVENTE TAL COMO ACETONITRILO, ACETONA, ETANOL, ISOPROPANOL, ACETATO DE ETILO O UNA MEZCLA DE ELOS Y AGITAR A UNA TEMPERATURA DE 40 ºC DURANTE UN PERIODO DE 33 HORAS. LA FORMA CRISTALINA B ES UTIL EN EL TRATAMIENTO DE TRANSTORNOS GASTROINTESTINALES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1576607P | 2007-12-21 | 2007-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091310A1 true PE20091310A1 (es) | 2009-09-30 |
Family
ID=40801457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008002133A PE20091310A1 (es) | 2007-12-21 | 2008-12-18 | Nueva forma cristalina b del acido (2r)-(3-amino-2-fluoropropil)fosfinico |
Country Status (8)
Country | Link |
---|---|
US (1) | US20110034420A1 (es) |
EP (1) | EP2235027A4 (es) |
AR (1) | AR070045A1 (es) |
CL (1) | CL2008003841A1 (es) |
PE (1) | PE20091310A1 (es) |
TW (1) | TW200940559A (es) |
UY (1) | UY31558A1 (es) |
WO (1) | WO2009082345A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009082344A1 (en) * | 2007-12-21 | 2009-07-02 | Astrazeneca Ab | Novel process for making (2r)-(3-amino-2-fluoropropyl)phosphinic acid form a |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9904507D0 (sv) * | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
SE9904508D0 (sv) * | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
FR2810824B1 (fr) * | 2000-06-26 | 2003-01-17 | Cit Alcatel | Dispositif de fixation pour appareil de telecommunication mobile |
SE0102057D0 (sv) * | 2001-06-08 | 2001-06-08 | Astrazeneca Ab | New Salts I |
WO2009014491A1 (en) * | 2007-07-25 | 2009-01-29 | Astrazeneca Ab | The use of (3-amino-2-fluoropropyl) phosphinic acid for treatment of nerd |
WO2009014490A1 (en) * | 2007-07-25 | 2009-01-29 | Astrazeneca Ab | Combination of (3-amino-2-fluoropropyl)phosphinic acid and omeprazole for treating tlesr, gerd, and nerd |
WO2009145716A1 (en) * | 2008-05-28 | 2009-12-03 | Astrazeneca Ab | New pharmaceutical formulation useful in gerd therapy |
-
2008
- 2008-12-18 US US12/922,477 patent/US20110034420A1/en not_active Abandoned
- 2008-12-18 PE PE2008002133A patent/PE20091310A1/es not_active Application Discontinuation
- 2008-12-18 WO PCT/SE2008/051492 patent/WO2009082345A1/en active Application Filing
- 2008-12-18 EP EP08865586A patent/EP2235027A4/en not_active Withdrawn
- 2008-12-19 AR ARP080105598A patent/AR070045A1/es unknown
- 2008-12-19 TW TW097149861A patent/TW200940559A/zh unknown
- 2008-12-19 UY UY31558A patent/UY31558A1/es unknown
- 2008-12-19 CL CL2008003841A patent/CL2008003841A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20110034420A1 (en) | 2011-02-10 |
EP2235027A4 (en) | 2011-06-22 |
CL2008003841A1 (es) | 2010-04-16 |
AR070045A1 (es) | 2010-03-10 |
EP2235027A1 (en) | 2010-10-06 |
WO2009082345A1 (en) | 2009-07-02 |
UY31558A1 (es) | 2009-08-03 |
TW200940559A (en) | 2009-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |