PE20090652A1 - Compuestos de nicotinamida sustituida y sus usos en medicamentos - Google Patents

Compuestos de nicotinamida sustituida y sus usos en medicamentos

Info

Publication number
PE20090652A1
PE20090652A1 PE2008001619A PE2008001619A PE20090652A1 PE 20090652 A1 PE20090652 A1 PE 20090652A1 PE 2008001619 A PE2008001619 A PE 2008001619A PE 2008001619 A PE2008001619 A PE 2008001619A PE 20090652 A1 PE20090652 A1 PE 20090652A1
Authority
PE
Peru
Prior art keywords
nicotinamide
phenylsulfonil
alkyl
compounds
medicines
Prior art date
Application number
PE2008001619A
Other languages
English (en)
Inventor
Beatrix Merla
Sven Kuhnert
Robert Frank
Dagmar Kaulartz
Wolfgang Schroder
Gregor Bahrenberg
Klaus Schiene
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20090652A1 publication Critical patent/PE20090652A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE NICOTINAMIDA DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C6), ARILO, HETEROARILO OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; R2 ES H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO; R3 ES CICLOALQUILO(C3-C10), ARILO, HETEROARILO OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; R4, R5, R6 Y R7 SON CADA UNO H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO; R8, R9 Y R10 SON CADA UNO H, F, Cl, Br, CF3, ENTRE OTROS; n ES DE 0 A 2; p Y q SON CADA UNO 0 O 1. SON COMPUESTOS PREFERIDOS: 2-(2-(FENILSULFONIL)ETILTIO)-N-(PIRIDIN-2-ILMETIL)NICOTINAMIDA, 2-(2-(FENILSULFONIL)ETILTIO)-N-(PIRIDIN-4-ILMETIL)NICOTINAMIDA, N-METIL-N-(3-METILBENCIL)-2-(2-(FENILSULFONIL)ETILTIO)NICOTINAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DE LOS CANALES DE KCNQ2/3 K+ SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR NEUROPATICO, EPILEPSIA, INCONTINENCIA URINARIA
PE2008001619A 2007-09-17 2008-09-17 Compuestos de nicotinamida sustituida y sus usos en medicamentos PE20090652A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007044277A DE102007044277A1 (de) 2007-09-17 2007-09-17 Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln

Publications (1)

Publication Number Publication Date
PE20090652A1 true PE20090652A1 (es) 2009-05-28

Family

ID=40347805

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001619A PE20090652A1 (es) 2007-09-17 2008-09-17 Compuestos de nicotinamida sustituida y sus usos en medicamentos

Country Status (24)

Country Link
US (1) US8084470B2 (es)
EP (1) EP2188258B1 (es)
JP (1) JP5539205B2 (es)
KR (1) KR20100068453A (es)
CN (1) CN101801932A (es)
AR (1) AR068467A1 (es)
BR (1) BRPI0817044A2 (es)
CA (1) CA2699689C (es)
CO (1) CO6260092A2 (es)
CY (1) CY1113551T1 (es)
DE (1) DE102007044277A1 (es)
DK (1) DK2188258T3 (es)
ES (1) ES2400407T3 (es)
HK (1) HK1144422A1 (es)
HR (1) HRP20130166T1 (es)
IL (1) IL204496A (es)
MX (1) MX2010002506A (es)
NZ (1) NZ583684A (es)
PE (1) PE20090652A1 (es)
PL (1) PL2188258T3 (es)
PT (1) PT2188258E (es)
RU (1) RU2489425C2 (es)
SI (1) SI2188258T1 (es)
WO (1) WO2009036938A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI475020B (zh) * 2009-03-12 2015-03-01 The substituted nicotine amide as a KCNQ2 / 3 modifier
WO2012025236A1 (en) * 2010-08-27 2012-03-01 Grünenthal GmbH Substituted 2-oxy-quinoline-3-carboxamides as kcnq2/3 modulators
NZ628871A (en) * 2010-10-20 2015-07-31 Gruenenthal Chemie Substituted 6-amino-nicotinamides as kcnq2/3 modulators
FR2968661B1 (fr) * 2010-12-14 2016-01-01 Oreal Procede de depigmentation des matieres keratiniques a l'aide de composes thiopyridinones
US9775843B2 (en) 2012-10-11 2017-10-03 Grünenthal GmbH Treatment and/or prophylaxis of TSPO mediated diseases and/or disorders
BR112015012418A2 (pt) 2012-11-28 2017-07-11 Gruenenthal Gmbh carboxamidas específicas como moduladores de kcnq2/3
US9248122B2 (en) 2012-11-28 2016-02-02 Grünenthal GmbH Heteroquinoline-3-carboxamides as KCNQ2/3 modulators
WO2018110669A1 (en) 2016-12-15 2018-06-21 Ono Pharmaceutical Co., Ltd. Activator of trek (twik related k+ channels) channels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
GB9919588D0 (en) * 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
IL157313A0 (en) 2001-02-20 2004-02-19 Bristol Myers Squibb Co Modulators of kcnq potassium channels and uses thereof
GB0319793D0 (en) * 2003-08-22 2003-09-24 Lilly Co Eli Pyridinylmorpholine derivatives

Also Published As

Publication number Publication date
US20090076086A1 (en) 2009-03-19
MX2010002506A (es) 2010-03-26
CA2699689C (en) 2015-03-24
US8084470B2 (en) 2011-12-27
ES2400407T3 (es) 2013-04-09
CN101801932A (zh) 2010-08-11
WO2009036938A1 (de) 2009-03-26
KR20100068453A (ko) 2010-06-23
HK1144422A1 (en) 2011-02-18
DE102007044277A1 (de) 2009-03-19
EP2188258B1 (de) 2012-11-28
PL2188258T3 (pl) 2013-04-30
JP5539205B2 (ja) 2014-07-02
SI2188258T1 (sl) 2013-01-31
HRP20130166T1 (hr) 2013-03-31
BRPI0817044A2 (pt) 2015-03-24
EP2188258A1 (de) 2010-05-26
DK2188258T3 (da) 2013-01-14
IL204496A (en) 2013-02-28
AU2008300945A1 (en) 2009-03-26
JP2010539124A (ja) 2010-12-16
AR068467A1 (es) 2009-11-18
RU2010115184A (ru) 2011-10-27
CO6260092A2 (es) 2011-03-22
RU2489425C2 (ru) 2013-08-10
CY1113551T1 (el) 2016-06-22
PT2188258E (pt) 2013-01-23
CA2699689A1 (en) 2009-03-26
NZ583684A (en) 2011-04-29

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