SI2188258T1 - Substituirane nikotinamidne spojine in njihova uporaba v zdravilih - Google Patents

Substituirane nikotinamidne spojine in njihova uporaba v zdravilih

Info

Publication number
SI2188258T1
SI2188258T1 SI200830849T SI200830849T SI2188258T1 SI 2188258 T1 SI2188258 T1 SI 2188258T1 SI 200830849 T SI200830849 T SI 200830849T SI 200830849 T SI200830849 T SI 200830849T SI 2188258 T1 SI2188258 T1 SI 2188258T1
Authority
SI
Slovenia
Prior art keywords
pharmaceutical products
nicotinamide compounds
substituted nicotinamide
substituted
compounds
Prior art date
Application number
SI200830849T
Other languages
English (en)
Inventor
Beatrix Merla
Sven Kuhnert
Robert Frank
Dagmar Kaulartz
Wolfgang Schroder
Gregor Bahrenberg
Klaus Schiene
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of SI2188258T1 publication Critical patent/SI2188258T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
SI200830849T 2007-09-17 2008-09-15 Substituirane nikotinamidne spojine in njihova uporaba v zdravilih SI2188258T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007044277A DE102007044277A1 (de) 2007-09-17 2007-09-17 Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln
PCT/EP2008/007633 WO2009036938A1 (de) 2007-09-17 2008-09-15 Substituierte nicotinamid-verbindungen und deren verwendung in arzneimitteln
EP08802179A EP2188258B1 (de) 2007-09-17 2008-09-15 Substituierte nicotinamid-verbindungen und deren verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
SI2188258T1 true SI2188258T1 (sl) 2013-01-31

Family

ID=40347805

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200830849T SI2188258T1 (sl) 2007-09-17 2008-09-15 Substituirane nikotinamidne spojine in njihova uporaba v zdravilih

Country Status (24)

Country Link
US (1) US8084470B2 (sl)
EP (1) EP2188258B1 (sl)
JP (1) JP5539205B2 (sl)
KR (1) KR20100068453A (sl)
CN (1) CN101801932A (sl)
AR (1) AR068467A1 (sl)
BR (1) BRPI0817044A2 (sl)
CA (1) CA2699689C (sl)
CO (1) CO6260092A2 (sl)
CY (1) CY1113551T1 (sl)
DE (1) DE102007044277A1 (sl)
DK (1) DK2188258T3 (sl)
ES (1) ES2400407T3 (sl)
HK (1) HK1144422A1 (sl)
HR (1) HRP20130166T1 (sl)
IL (1) IL204496A (sl)
MX (1) MX2010002506A (sl)
NZ (1) NZ583684A (sl)
PE (1) PE20090652A1 (sl)
PL (1) PL2188258T3 (sl)
PT (1) PT2188258E (sl)
RU (1) RU2489425C2 (sl)
SI (1) SI2188258T1 (sl)
WO (1) WO2009036938A1 (sl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI475020B (zh) * 2009-03-12 2015-03-01 The substituted nicotine amide as a KCNQ2 / 3 modifier
ES2537628T3 (es) * 2010-08-27 2015-06-10 Grünenthal GmbH 2-Oxiquinolin-3-carboxamidas sustituidas como moduladores de KCNQ2/3
KR101820645B1 (ko) * 2010-10-20 2018-01-22 그뤼넨탈 게엠베하 Ｋｃｎｑ２／３ 조절제로서의 치환된 ６­아미노­니코틴아미드
FR2968661B1 (fr) * 2010-12-14 2016-01-01 Oreal Procede de depigmentation des matieres keratiniques a l'aide de composes thiopyridinones
WO2014056620A1 (en) * 2012-10-11 2014-04-17 Grünenthal GmbH Treatment and/or prophylaxis of tspo mediated diseases and/or disorders
WO2014082737A1 (en) 2012-11-28 2014-06-05 Grunenthal Gmbh Specific carboxamides as kcnq2/3 modulators
US9248122B2 (en) 2012-11-28 2016-02-02 Grünenthal GmbH Heteroquinoline-3-carboxamides as KCNQ2/3 modulators
JP7120549B2 (ja) * 2016-12-15 2022-08-17 小野薬品工業株式会社 Ｔｒｅｋ（ｔｗｉｋ関連ｋチャネル）チャネルのアクチベータ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
GB9919588D0 (en) * 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
WO2002072088A2 (en) 2001-02-20 2002-09-19 Bristol-Myers Squibb Company Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases
GB0319793D0 (en) * 2003-08-22 2003-09-24 Lilly Co Eli Pyridinylmorpholine derivatives

Also Published As

Publication number Publication date
EP2188258A1 (de) 2010-05-26
IL204496A (en) 2013-02-28
NZ583684A (en) 2011-04-29
JP2010539124A (ja) 2010-12-16
EP2188258B1 (de) 2012-11-28
KR20100068453A (ko) 2010-06-23
US20090076086A1 (en) 2009-03-19
JP5539205B2 (ja) 2014-07-02
PL2188258T3 (pl) 2013-04-30
AR068467A1 (es) 2009-11-18
CA2699689A1 (en) 2009-03-26
HK1144422A1 (en) 2011-02-18
PT2188258E (pt) 2013-01-23
RU2489425C2 (ru) 2013-08-10
ES2400407T3 (es) 2013-04-09
PE20090652A1 (es) 2009-05-28
CA2699689C (en) 2015-03-24
HRP20130166T1 (hr) 2013-03-31
CY1113551T1 (el) 2016-06-22
CO6260092A2 (es) 2011-03-22
WO2009036938A1 (de) 2009-03-26
CN101801932A (zh) 2010-08-11
AU2008300945A1 (en) 2009-03-26
DK2188258T3 (da) 2013-01-14
BRPI0817044A2 (pt) 2015-03-24
DE102007044277A1 (de) 2009-03-19
MX2010002506A (es) 2010-03-26
US8084470B2 (en) 2011-12-27
RU2010115184A (ru) 2011-10-27

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