SI2188258T1 - Substituirane nikotinamidne spojine in njihova uporaba v zdravilih - Google Patents
Substituirane nikotinamidne spojine in njihova uporaba v zdravilihInfo
- Publication number
- SI2188258T1 SI2188258T1 SI200830849T SI200830849T SI2188258T1 SI 2188258 T1 SI2188258 T1 SI 2188258T1 SI 200830849 T SI200830849 T SI 200830849T SI 200830849 T SI200830849 T SI 200830849T SI 2188258 T1 SI2188258 T1 SI 2188258T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pharmaceutical products
- nicotinamide compounds
- substituted nicotinamide
- substituted
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007044277A DE102007044277A1 (de) | 2007-09-17 | 2007-09-17 | Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln |
| EP08802179A EP2188258B1 (de) | 2007-09-17 | 2008-09-15 | Substituierte nicotinamid-verbindungen und deren verwendung in arzneimitteln |
| PCT/EP2008/007633 WO2009036938A1 (de) | 2007-09-17 | 2008-09-15 | Substituierte nicotinamid-verbindungen und deren verwendung in arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2188258T1 true SI2188258T1 (sl) | 2013-01-31 |
Family
ID=40347805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200830849T SI2188258T1 (sl) | 2007-09-17 | 2008-09-15 | Substituirane nikotinamidne spojine in njihova uporaba v zdravilih |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8084470B2 (sl) |
| EP (1) | EP2188258B1 (sl) |
| JP (1) | JP5539205B2 (sl) |
| KR (1) | KR20100068453A (sl) |
| CN (1) | CN101801932A (sl) |
| AR (1) | AR068467A1 (sl) |
| BR (1) | BRPI0817044A2 (sl) |
| CA (1) | CA2699689C (sl) |
| CO (1) | CO6260092A2 (sl) |
| CY (1) | CY1113551T1 (sl) |
| DE (1) | DE102007044277A1 (sl) |
| DK (1) | DK2188258T3 (sl) |
| ES (1) | ES2400407T3 (sl) |
| HK (1) | HK1144422A1 (sl) |
| HR (1) | HRP20130166T1 (sl) |
| IL (1) | IL204496A (sl) |
| MX (1) | MX2010002506A (sl) |
| NZ (1) | NZ583684A (sl) |
| PE (1) | PE20090652A1 (sl) |
| PL (1) | PL2188258T3 (sl) |
| PT (1) | PT2188258E (sl) |
| RU (1) | RU2489425C2 (sl) |
| SI (1) | SI2188258T1 (sl) |
| WO (1) | WO2009036938A1 (sl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI475020B (zh) * | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| TWI522349B (zh) * | 2010-08-27 | 2016-02-21 | 歌林達股份有限公司 | 作為ｋｃｎｑ２／３調節劑之被取代之２－氧基－喹啉－３－甲醯胺 |
| WO2012052167A1 (en) * | 2010-10-20 | 2012-04-26 | Grünenthal GmbH | Substituted 6-amino-nicotinamides as kcnq2/3 modulators |
| FR2968661B1 (fr) * | 2010-12-14 | 2016-01-01 | Oreal | Procede de depigmentation des matieres keratiniques a l'aide de composes thiopyridinones |
| EP2906217A1 (en) * | 2012-10-11 | 2015-08-19 | Grünenthal GmbH | Treatment and/or prophylaxis of tspo mediated diseases and/or disorders |
| US9248122B2 (en) | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
| BR112015012418A2 (pt) | 2012-11-28 | 2017-07-11 | Gruenenthal Gmbh | carboxamidas específicas como moduladores de kcnq2/3 |
| EP3558992A4 (en) * | 2016-12-15 | 2020-12-02 | ONO Pharmaceutical Co., Ltd. | ACTIVATOR OF TREK (TWIK-ASSOCIATED K + CHANNELS) CHANNELS |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022884A (en) * | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
| GB9919588D0 (en) * | 1999-08-18 | 1999-10-20 | Hoechst Schering Agrevo Gmbh | Fungicidal compounds |
| WO2002072088A2 (en) | 2001-02-20 | 2002-09-19 | Bristol-Myers Squibb Company | Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases |
| GB0319793D0 (en) * | 2003-08-22 | 2003-09-24 | Lilly Co Eli | Pyridinylmorpholine derivatives |
-
2007
- 2007-09-17 DE DE102007044277A patent/DE102007044277A1/de not_active Withdrawn
-
2008
- 2008-09-15 CA CA2699689A patent/CA2699689C/en not_active Expired - Fee Related
- 2008-09-15 SI SI200830849T patent/SI2188258T1/sl unknown
- 2008-09-15 KR KR1020107008408A patent/KR20100068453A/ko not_active Application Discontinuation
- 2008-09-15 JP JP2010524410A patent/JP5539205B2/ja not_active Expired - Fee Related
- 2008-09-15 NZ NZ583684A patent/NZ583684A/en not_active IP Right Cessation
- 2008-09-15 CN CN200880107279A patent/CN101801932A/zh active Pending
- 2008-09-15 RU RU2010115184/04A patent/RU2489425C2/ru not_active IP Right Cessation
- 2008-09-15 PT PT88021795T patent/PT2188258E/pt unknown
- 2008-09-15 ES ES08802179T patent/ES2400407T3/es active Active
- 2008-09-15 DK DK08802179.5T patent/DK2188258T3/da active
- 2008-09-15 BR BRPI0817044 patent/BRPI0817044A2/pt not_active IP Right Cessation
- 2008-09-15 PL PL08802179T patent/PL2188258T3/pl unknown
- 2008-09-15 MX MX2010002506A patent/MX2010002506A/es active IP Right Grant
- 2008-09-15 WO PCT/EP2008/007633 patent/WO2009036938A1/de active Application Filing
- 2008-09-15 EP EP08802179A patent/EP2188258B1/de not_active Not-in-force
- 2008-09-17 US US12/212,369 patent/US8084470B2/en not_active Expired - Fee Related
- 2008-09-17 AR ARP080104040A patent/AR068467A1/es not_active Application Discontinuation
- 2008-09-17 PE PE2008001619A patent/PE20090652A1/es not_active Application Discontinuation
-
2010
- 2010-03-12 CO CO10029446A patent/CO6260092A2/es not_active Application Discontinuation
- 2010-03-15 IL IL204496A patent/IL204496A/en not_active IP Right Cessation
- 2010-11-18 HK HK10110728.6A patent/HK1144422A1/xx not_active IP Right Cessation
-
2013
- 2013-01-15 CY CY20131100043T patent/CY1113551T1/el unknown
- 2013-02-27 HR HRP20130166AT patent/HRP20130166T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20090652A1 (es) | 2009-05-28 |
| MX2010002506A (es) | 2010-03-26 |
| NZ583684A (en) | 2011-04-29 |
| WO2009036938A1 (de) | 2009-03-26 |
| CO6260092A2 (es) | 2011-03-22 |
| CN101801932A (zh) | 2010-08-11 |
| CA2699689C (en) | 2015-03-24 |
| BRPI0817044A2 (pt) | 2015-03-24 |
| PT2188258E (pt) | 2013-01-23 |
| ES2400407T3 (es) | 2013-04-09 |
| US8084470B2 (en) | 2011-12-27 |
| IL204496A (en) | 2013-02-28 |
| RU2489425C2 (ru) | 2013-08-10 |
| DE102007044277A1 (de) | 2009-03-19 |
| EP2188258A1 (de) | 2010-05-26 |
| JP5539205B2 (ja) | 2014-07-02 |
| EP2188258B1 (de) | 2012-11-28 |
| US20090076086A1 (en) | 2009-03-19 |
| AU2008300945A1 (en) | 2009-03-26 |
| KR20100068453A (ko) | 2010-06-23 |
| PL2188258T3 (pl) | 2013-04-30 |
| HRP20130166T1 (hr) | 2013-03-31 |
| CY1113551T1 (el) | 2016-06-22 |
| JP2010539124A (ja) | 2010-12-16 |
| DK2188258T3 (da) | 2013-01-14 |
| RU2010115184A (ru) | 2011-10-27 |
| HK1144422A1 (en) | 2011-02-18 |
| CA2699689A1 (en) | 2009-03-26 |
| AR068467A1 (es) | 2009-11-18 |
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