PE20081633A1 - Derivados de piridina como antagonistas del receptor p2y12 - Google Patents
Derivados de piridina como antagonistas del receptor p2y12Info
- Publication number
- PE20081633A1 PE20081633A1 PE2008000130A PE2008000130A PE20081633A1 PE 20081633 A1 PE20081633 A1 PE 20081633A1 PE 2008000130 A PE2008000130 A PE 2008000130A PE 2008000130 A PE2008000130 A PE 2008000130A PE 20081633 A1 PE20081633 A1 PE 20081633A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- carbamoil
- hydroxyalkyl
- cycloalkyl
- halogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRIDINA DE FORMULA (I) DONDE R1 ES R6OC(O), R7C(O), ENTRE OTROS, DONDE R6 ES ALQUILO(C1-C12), CICLOALQUILO(C3-C6), HIDROXIALQUILO(C2-C12), ENTRE OTROS; R7 ES ALQUILO(C1-C12), HIDROXIALQUILO(C1-C12), ENTRE OTROS; R2 ES CN, HALOGENO, ALQUILO(C4-C8), ALCOXI(C1-C12), ENTRE OTROS; R4 ES H, CN, HALOGENO, ALQUILO(C1-C12), ENTRE OTROS; R14 ES H, OH, ALQUILO(C1-C8), CICLOALQUILO(C3-C6), ENTRE OTROS; R15 ES H, ARILO, HALOGENO, HIDROXIALQUILO(C1-C12), ENTRE OTROS; Rc ES UN ENLACE DIRECTO, ALQUILENO(C1-C4), ALQUILENOXI(C1-C4), ENTRE OTROS; Rd ES ALQUILO(C1-C12), CICLOALQUILO(C3-C8), ARILO, ENTRE OTROS; X ES UN ENLACE SIMPLE, IMINO, METILENO, IMINOMETILENO, ENTRE OTROS; B ES UN ANILLO MONOCICLICO O BICICLICO DE 4 A 11 MIEMBROS QUE COMPRENDE UNO O MAS NITROGENOS, Y OPCIONALMENTE O U S. SON COMPUESTOS PREFERIDOS: 6-{4-[(BENCILSULFONIL)CARBAMOIL]PIPERIDIN-1-IL}-5-CIANO-2-METOXINICOTINATO DE ETILO, 6-{3-[(BENCILSULFONIL)CARBAMOIL]AZETIDIN-1-IL}-5-CIANO-2-METOXINICOTINATO DE ETILO, 6-{4-[(BENCILSULFONIL)CARBAMOIL]PIPERIDIN-1-IL}-5-CIANO-2-ETOXINICOTINATO DE ETILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR P2Y12 SIENDO UTILES EN EL TRATAMIENTO DE LA AGREGACION PLAQUETARIA, ANGINA INESTABLE, INFARTO DE MIOCARDIO, COMPLICACIONES TROMBOTICAS ARTERIALES PRIMARIAS DE LA ATEROSCLEROSIS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88465807P | 2007-01-12 | 2007-01-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081633A1 true PE20081633A1 (es) | 2009-01-18 |
Family
ID=39608896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000130A PE20081633A1 (es) | 2007-01-12 | 2008-01-11 | Derivados de piridina como antagonistas del receptor p2y12 |
Country Status (18)
Country | Link |
---|---|
US (2) | US20080171732A1 (es) |
EP (1) | EP2111400A4 (es) |
JP (1) | JP2010515728A (es) |
KR (1) | KR20090096742A (es) |
AR (1) | AR064866A1 (es) |
AU (1) | AU2008203953A1 (es) |
BR (1) | BRPI0806529A2 (es) |
CA (1) | CA2674998A1 (es) |
CL (1) | CL2008000091A1 (es) |
CO (1) | CO6190618A2 (es) |
EC (1) | ECSP099481A (es) |
IL (1) | IL199439A0 (es) |
MX (1) | MX2009007429A (es) |
PE (1) | PE20081633A1 (es) |
RU (1) | RU2009123928A (es) |
TW (1) | TW200833335A (es) |
UY (1) | UY30866A1 (es) |
WO (1) | WO2008085117A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2655628A1 (en) * | 2006-07-04 | 2008-01-10 | Astrazeneca Ab | New pyridine analogues |
WO2010005384A1 (en) * | 2008-07-07 | 2010-01-14 | Astrazeneca Ab | Ketone pyridine analogues and their use in the treatment of cardiovascular disorders |
JP2014051434A (ja) * | 2010-12-28 | 2014-03-20 | Dainippon Sumitomo Pharma Co Ltd | 二環性ピリミジン誘導体 |
EP2750676B1 (en) | 2011-08-30 | 2018-01-10 | University of Utah Research Foundation | Methods and compositions for treating nephrogenic diabetes insipidus |
RU2602456C1 (ru) * | 2015-10-20 | 2016-11-20 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" | Способ оценки активности ароматазы овариальных фолликулов |
WO2017153235A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung |
KR102435080B1 (ko) | 2016-07-19 | 2022-08-22 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 해충 방제제로서의 축합 바이시클릭 헤테로사이클 유도체 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6156758A (en) * | 1999-09-08 | 2000-12-05 | Isis Pharmaceuticals, Inc. | Antibacterial quinazoline compounds |
US6906063B2 (en) * | 2000-02-04 | 2005-06-14 | Portola Pharmaceuticals, Inc. | Platelet ADP receptor inhibitors |
CA2400479C (en) * | 2000-02-04 | 2010-10-05 | Millennium Pharmaceuticals, Inc. | Platelet adp receptor inhibitors |
US7452870B2 (en) * | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
US7132408B2 (en) * | 2000-08-21 | 2006-11-07 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
US7018985B1 (en) * | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
JP3500429B2 (ja) * | 2000-11-01 | 2004-02-23 | 現代自動車株式会社 | ポリプロピレン樹脂組成物 |
FR2820057A1 (fr) * | 2001-01-30 | 2002-08-02 | Ct De Transfert De Technologie | Membrane pour chambre d'encapsulation de cellules produisant au moins une substance biologiquement active et organe bio-artificiel comprenant une telle membrane |
US7504497B2 (en) * | 2003-10-21 | 2009-03-17 | Inspire Pharmaceuticals, Inc. | Orally bioavailable compounds and methods for inhibiting platelet aggregation |
US7749981B2 (en) * | 2003-10-21 | 2010-07-06 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound |
US7335648B2 (en) * | 2003-10-21 | 2008-02-26 | Inspire Pharmaceuticals, Inc. | Non-nucleotide composition and method for inhibiting platelet aggregation |
KR20070032648A (ko) * | 2004-05-12 | 2007-03-22 | 브리스톨-마이어스 스큅 컴퍼니 | 혈전 상태의 치료에 유용한 p2y1 수용체의 우레아길항제 |
NZ551603A (en) * | 2004-06-24 | 2010-11-26 | Incyte Corp | N-substituted piperidines and their use as pharmaceuticals |
CN101107004A (zh) * | 2004-10-04 | 2008-01-16 | 韦恩州立大学 | 芳香酶抑制剂在子宫内膜腔和子宫手术前的子宫薄化中的应用 |
EP1836189A1 (en) * | 2005-01-06 | 2007-09-26 | AstraZeneca AB | Novel pyridine compounds |
CA2614726A1 (en) * | 2005-07-13 | 2007-01-18 | Astrazeneca Ab | New pyridine analogues |
EP2044024A4 (en) * | 2006-07-04 | 2011-06-29 | Astrazeneca Ab | NEW ANALOGUES OF PYRIDINE |
JP2009542642A (ja) * | 2006-07-04 | 2009-12-03 | アストラゼネカ アクチボラグ | 新規ピリジン類似体 |
CA2655628A1 (en) * | 2006-07-04 | 2008-01-10 | Astrazeneca Ab | New pyridine analogues |
-
2008
- 2008-01-11 PE PE2008000130A patent/PE20081633A1/es not_active Application Discontinuation
- 2008-01-11 RU RU2009123928/04A patent/RU2009123928A/ru not_active Application Discontinuation
- 2008-01-11 WO PCT/SE2008/000017 patent/WO2008085117A1/en active Application Filing
- 2008-01-11 MX MX2009007429A patent/MX2009007429A/es not_active Application Discontinuation
- 2008-01-11 CA CA002674998A patent/CA2674998A1/en not_active Abandoned
- 2008-01-11 EP EP08705190A patent/EP2111400A4/en not_active Withdrawn
- 2008-01-11 AR ARP080100131A patent/AR064866A1/es unknown
- 2008-01-11 CL CL200800091A patent/CL2008000091A1/es unknown
- 2008-01-11 BR BRPI0806529-2A2A patent/BRPI0806529A2/pt not_active IP Right Cessation
- 2008-01-11 US US11/972,831 patent/US20080171732A1/en not_active Abandoned
- 2008-01-11 JP JP2009545521A patent/JP2010515728A/ja active Pending
- 2008-01-11 US US12/522,724 patent/US20100137277A1/en not_active Abandoned
- 2008-01-11 KR KR1020097015870A patent/KR20090096742A/ko not_active Application Discontinuation
- 2008-01-11 AU AU2008203953A patent/AU2008203953A1/en not_active Abandoned
- 2008-01-11 TW TW097101297A patent/TW200833335A/zh unknown
- 2008-01-11 UY UY30866A patent/UY30866A1/es unknown
-
2009
- 2009-06-18 IL IL199439A patent/IL199439A0/en unknown
- 2009-07-02 EC EC2009009481A patent/ECSP099481A/es unknown
- 2009-07-13 CO CO09072491A patent/CO6190618A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ECSP099481A (es) | 2009-08-28 |
KR20090096742A (ko) | 2009-09-14 |
AR064866A1 (es) | 2009-04-29 |
EP2111400A1 (en) | 2009-10-28 |
JP2010515728A (ja) | 2010-05-13 |
MX2009007429A (es) | 2009-07-17 |
CL2008000091A1 (es) | 2008-09-05 |
IL199439A0 (en) | 2010-03-28 |
US20080171732A1 (en) | 2008-07-17 |
BRPI0806529A2 (pt) | 2014-04-22 |
CO6190618A2 (es) | 2010-08-19 |
RU2009123928A (ru) | 2011-02-20 |
UY30866A1 (es) | 2008-09-02 |
CA2674998A1 (en) | 2008-07-17 |
AU2008203953A1 (en) | 2008-07-17 |
EP2111400A4 (en) | 2010-07-07 |
TW200833335A (en) | 2008-08-16 |
WO2008085117A1 (en) | 2008-07-17 |
US20100137277A1 (en) | 2010-06-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |