PE20080744A1 - IMIDAZOL AMINAS COMO INHIBIDORES DE LA ß-SECRETASA - Google Patents

IMIDAZOL AMINAS COMO INHIBIDORES DE LA ß-SECRETASA

Info

Publication number
PE20080744A1
PE20080744A1 PE2007001049A PE2007001049A PE20080744A1 PE 20080744 A1 PE20080744 A1 PE 20080744A1 PE 2007001049 A PE2007001049 A PE 2007001049A PE 2007001049 A PE2007001049 A PE 2007001049A PE 20080744 A1 PE20080744 A1 PE 20080744A1
Authority
PE
Peru
Prior art keywords
som
pyrimidin
halogen
amine
phenyl
Prior art date
Application number
PE2007001049A
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Keith Douglas Barnes
Matthew Robert Johnson
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20080744A1 publication Critical patent/PE20080744A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN DERIVADO DE IMIDAZOL DE FORMULA (I), DONDE Q ES O, S O CH2; W ES O, S O CH2; X ES N, NO, SOm, O O CH; Y ES N, NO, SOm, O, CR10; Z ES N, NO, O, SOm O CR11; m ES 0, 1 O 2; n ES 0 O 1; R1 Y R2 SON H, ALQUILO C1-C4, ENTRE OTROS; R3 Y R4 SON H, ALQUILO C1-C4, ENTRE OTROS; R5 Y R6 SON H, HALOGENO, NO2, ENTRE OTROS; R7 Y R8 SON H, HALOGENO, NO2, CN, ENTRE OTROS; R9 ES H, HALOGENO, NO2, CN, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 8-[3-(2-FLUOROPIRIDIN-3-IL)-FENIL]-8-PIRIDIN-4-IL-2,3,4,8-TETRAHIDROIMIDAZO[1,5-a]PIRIMIDIN-6-AMINA, 8-(2,6-DIETILPIRIDIN-4-IL)-8-[3-(2-FLUROPIRIDIN-3-IL)-FENIL]-2,3,4,8-TETRAHIDRO-IMIDAZO[1,5-a]PIRIMIDIN-6-AMINA, 8-(1-ETIL-1H-PIRAZOL-4-IL)-8-[3-(2-FLUOROPIRIDIN-3-IL)FENIL]-2,3,4,8-TETRAHIDRO-IMIDAZOL[1,5-a]PIRIMIDIN-6-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y UN PROCESO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA ß-SECRETASA Y SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, SINDROME DE DOWN, HEMORRAGIA CEREBRAL HEREDITARIA CON AMILOIDOSIS DEL TIPO DUTCH, ENTRE OTROS
PE2007001049A 2006-08-17 2007-08-07 IMIDAZOL AMINAS COMO INHIBIDORES DE LA ß-SECRETASA PE20080744A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83835706P 2006-08-17 2006-08-17

Publications (1)

Publication Number Publication Date
PE20080744A1 true PE20080744A1 (es) 2008-05-24

Family

ID=38988046

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001049A PE20080744A1 (es) 2006-08-17 2007-08-07 IMIDAZOL AMINAS COMO INHIBIDORES DE LA ß-SECRETASA

Country Status (9)

Country Link
EP (1) EP2054414A2 (es)
JP (1) JP2010500999A (es)
AR (1) AR062409A1 (es)
CA (1) CA2660441A1 (es)
CL (1) CL2007002288A1 (es)
MX (1) MX2009001699A (es)
PE (1) PE20080744A1 (es)
TW (1) TW200817406A (es)
WO (1) WO2008022024A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
EP1896478B1 (en) 2005-06-14 2014-05-21 Merck Sharp & Dohme Corp. Aspartyl protease inhibitors
AR056865A1 (es) 2005-06-14 2007-10-31 Schering Corp Heterociclos nitrogenados y su uso como inhibidores de proteasas, composiciones farmaceuticas
RU2416603C9 (ru) 2005-10-25 2012-06-20 Сионоги Энд Ко., Лтд. Производные аминодигидротиазина
AR061264A1 (es) 2006-06-12 2008-08-13 Schering Corp Inhibidores de aspartil-proteasas derivados de pirimidina, composiciones farmaceuticas que los contienen y usos para tratar enfermedades cognitivas o neurodegenerativas, y como inhibidores del virus vih.
WO2008133273A1 (ja) 2007-04-24 2008-11-06 Shionogi & Co., Ltd. アルツハイマー症治療用医薬組成物
ES2476605T3 (es) 2007-04-24 2014-07-15 Shionogi & Co., Ltd. Derivados de aminohidrotiazina sustituidos con grupos cíclicos
JP2011518224A (ja) 2008-04-22 2011-06-23 シェーリング コーポレイション Ｂａｃｅ−１阻害剤としてのチオフェニル置換２−イミノ−３−メチルピロロピリミジノン化合物、組成物、およびそれらの使用
NZ589590A (en) 2008-06-13 2012-05-25 Shionogi & Co Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity
WO2010047372A1 (ja) 2008-10-22 2010-04-29 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２－アミノピリミジン－４－オンおよび２－アミノピリジン誘導体
UA108363C2 (uk) 2009-10-08 2015-04-27 Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
RU2012129168A (ru) 2009-12-11 2014-01-20 Сионоги Энд Ко. Лтд. Производные оксазина
AU2011321427A1 (en) 2010-10-29 2013-05-02 Shionogi & Co., Ltd. Naphthyridine derivative
EP2634188A4 (en) * 2010-10-29 2014-05-07 Shionogi & Co FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE
EP2694521B1 (en) 2011-04-07 2015-11-25 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
WO2012138734A1 (en) 2011-04-07 2012-10-11 Merck Sharp & Dohme Corp. C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
EP2703399A4 (en) 2011-04-26 2014-10-15 Shionogi & Co OXAZINE DERIVATIVE AND BACE-1 HEMMER THEREOF
EP2747769B1 (en) 2011-08-22 2017-08-02 Merck Sharp & Dohme Corp. 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use
EP2912035A4 (en) 2012-10-24 2016-06-15 Shionogi & Co DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1758907B1 (en) * 2004-06-16 2009-02-18 Wyeth Diphenylimidazopyrimidine and -imidazole amines as inhibitors of b-secretase
BRPI0512213A (pt) * 2004-06-16 2008-02-19 Wyeth Corp método para tratamento, prevenção ou melhora de uma doença ou distúrbio; composição farmacêutica; processo para a preparação de um composto; e uso de um composto
JP2008526966A (ja) * 2005-01-14 2008-07-24 ワイス β−セクレターゼの阻害のためのアミノ−イミダゾロン
AU2006266167A1 (en) * 2005-06-30 2007-01-11 Wyeth Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation
TW200738683A (en) * 2005-06-30 2007-10-16 Wyeth Corp Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation

Also Published As

Publication number Publication date
JP2010500999A (ja) 2010-01-14
WO2008022024A3 (en) 2008-05-22
CL2007002288A1 (es) 2008-02-08
EP2054414A2 (en) 2009-05-06
WO2008022024A2 (en) 2008-02-21
MX2009001699A (es) 2009-02-25
CA2660441A1 (en) 2008-02-21
TW200817406A (en) 2008-04-16
AR062409A1 (es) 2008-11-05

Similar Documents

Publication Publication Date Title
PE20080744A1 (es) IMIDAZOL AMINAS COMO INHIBIDORES DE LA ß-SECRETASA
PE20120121A1 (es) Derivados de imidazopirazina como inhibidores de syk
PE20060299A1 (es) DIFENILIMIDAZOPIRIMIDINA E -IMIDAZOL AMINAS COMO INHIBIDORES DE ß-SECRETASA
PE20211001A1 (es) Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b
PE20170003A1 (es) Compuestos heterociclicos y usos de los mismos
MY152386A (en) Substituted 6a,7,8,9-tetrahydropyrido[3,2-e] pyrrolo[1,2-a]pyrazin-6(5h)-ones
PE20060842A1 (es) Amino-imidazolonas para la inhibicion de b-secretasa
PE20120534A1 (es) PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt
PE20120575A1 (es) Derivados de pirazolopirimidina como inhibidores de jak quinasas
PE20090049A1 (es) Derivados de piridopirimidina como moduladores de la actividad de pde 4
CO6321259A2 (es) Compuestos de 3h-[1,2,3]triazolo[4,5-d]pirimidina su uso como inhibidores de mtor quinasa y pi3 quinasa y su sintesis
PE20040197A1 (es) Pirazolopiridinas sustituidas con carbamato
PE20140407A1 (es) Nuevos compuestos triciclicos
CR20120389A (es) COMPUESTOS SUSTITUIDOS DE N-(1H-INDAZOL-4-IL)IMIDAZO[1,2-a] PIRIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE cFMS
PE20120058A1 (es) Derivados de imidazopirazina como inhibidores de syk
PE20091315A1 (es) Ciclopentanos de pirimidilo como inhibidores de la proteina cinasa akt
PE20091712A1 (es) Derivados de azetidina y ciclobutano como inhibidores de jak
PE20121150A1 (es) Inhibidores de jak2 y su uso en el tratamiento de enfermedades mieloproliferativas y cancer
PE20090370A1 (es) Derivados de heterociclo fusionado como inhibidores de quinasa
AR060984A1 (es) Derivados de imidazo[1,5-a]pirido[3,2-e]pirazinas,y su uso en el sistema nervioso central como inhibidores de la fosfodiesterasa 10.
PE20140390A1 (es) Derivados de imidazo[1,2-b]piridazina e imidazo[4,5-b]piridina como inhibidores de jak
EP2586780A4 (en) 2-ARYL-IMIDAZO- [1,2-A] -PYRIDINE-3-ACETAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE
AR077463A1 (es) Derivados de imidazo[1, 2 - a]pirazina y su uso en medicamentos para el tratamiento de enfermedades parasitarias
RU2008148607A (ru) Соединения и композиции в качестве ингибиторов протеинкиназы
EA200800992A1 (ru) 2-амино-7,8-дигидро-6н-пиридо[4,3-d]пиримидин-5-оны, способ их получения, способ терапии с их помощью, компонент композиции и композиция на их основе, 2,4-диоксопиперидиновые соединения для их получения

Legal Events

Date Code Title Description
FD Application declared void or lapsed