PE20080655A1 - Proceso para preparar derivados de indolinona fenilaminopropanol - Google Patents

Proceso para preparar derivados de indolinona fenilaminopropanol

Info

Publication number
PE20080655A1
PE20080655A1 PE2007001138A PE2007001138A PE20080655A1 PE 20080655 A1 PE20080655 A1 PE 20080655A1 PE 2007001138 A PE2007001138 A PE 2007001138A PE 2007001138 A PE2007001138 A PE 2007001138A PE 20080655 A1 PE20080655 A1 PE 20080655A1
Authority
PE
Peru
Prior art keywords
formula
compound
hydroxy
alkyl
solvent
Prior art date
Application number
PE2007001138A
Other languages
English (en)
Inventor
Anita Wai-Yin Chan
Zhixian Ding
Mousumi Ghosh
Mahmut Levent
Panolil Raveendranath
Jianxin Ren
Maotang Zhou
Asaf Alimardanov
Alexander V Gontcharov
Antonia A Nikitenko
John R Potoski
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20080655A1 publication Critical patent/PE20080655A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN PROCESO DE PREPARACION DE DERIVADOS DE INDOLINONA FENILAMINOPROPANOL DE FORMULA (I) QUE COMPRENDE: A) ACOPLAR UN COMPUESTO DE FORMULA (IV) CON UN COMPUESTO DE FORMULA (II) EN PRESENCIA DE UN CATALIZADOR DE ACIDO DE LEWIS TAL COMO ISOPROPOXIDO DE TITANIO, UNA COMPOSICION DE DISOLVENTES QUE CONTIENE UN DISOLVENTE APROTICO POLAR TAL COMO DIMETILFORMAMIDA Y TETRAHIDROFURANO, Y UNA BASE FUERTE TAL COMO HEXAMETILDISILAZIDA DE LITIO (LHMDS), PARA FORMAR UN COMPUESTO DE DIOL DE FORMULA (V) DONDE R1 ES HALO, CF3, OCF3, HIDROXI, ENTRE OTROS; R2 ES ARILO O HETEROARILO; R5 ES H, ALQUILO(C1-C4), CN, ENTRE OTROS; R8, R9 Y R10 SON CADA UNO H O ALQUILO (C1-C4); n ES DE 0 A 4; B) TRATAR EL COMPUESTO DE FORMULA (V) CON FOSFINA Y AZODICARBOXILATO DE DIALQUILO EN UN DISOLVENTE INERTE PARA FORMAR UN COMPUESTO DE FORMULA (VI); C) HACER REACCIONAR EL COMPUESTO DE FORMULA (VI) CON NH2CH3 Y UN CATALIZADOR DE ACIDO DE LEWIS OPCIONAL EN UN DISOLVENTE POLAR PARA FORMAR UN COMPUESTO DE FORMULA (I), DONDE R4 ES H, ALQUILO(C1-C4), CICLOHEPTILMETILO, ENTRE OTROS. LOS COMPUESTOS PREFERIDOS DE FORMULA (I) SON: 7-FLUORO-1-[(1S,2R)-1-(3-FLUOROFENIL)-2-HIDROXI-3-(METILAMINO)PROPIL]-3,3-DIMETIL-1,3-DIHIDRO-2H-INDOL-2-ONA, 7-FLUORO-1-[(1S,2R)-1-(3,5-DIFLUOROFENIL)-2-HIDROXI-3-(METILAMINO)PROPIL]-3,3-DIMETIL-1,3-DIHIDRO-2H-INDOL-2-ONA, ENTRE OTROS
PE2007001138A 2006-08-24 2007-08-22 Proceso para preparar derivados de indolinona fenilaminopropanol PE20080655A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83997806P 2006-08-24 2006-08-24

Publications (1)

Publication Number Publication Date
PE20080655A1 true PE20080655A1 (es) 2008-07-14

Family

ID=38961789

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001138A PE20080655A1 (es) 2006-08-24 2007-08-22 Proceso para preparar derivados de indolinona fenilaminopropanol

Country Status (7)

Country Link
US (1) US20080146645A1 (es)
AR (1) AR062481A1 (es)
CL (1) CL2007002449A1 (es)
PA (1) PA8743601A1 (es)
PE (1) PE20080655A1 (es)
TW (1) TW200817382A (es)
WO (1) WO2008024492A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019299221A1 (en) 2018-07-03 2021-02-04 The Board Of Trustees Of The University Of Illinois Activators of the unfolded protein response

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517899B2 (en) * 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
US7414052B2 (en) * 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
PE20070462A1 (es) * 2005-09-29 2007-06-05 Wyeth Corp Compuestos derivados de fenilaminopropanol

Also Published As

Publication number Publication date
PA8743601A1 (es) 2009-02-09
WO2008024492A3 (en) 2008-05-15
CL2007002449A1 (es) 2008-03-07
WO2008024492A2 (en) 2008-02-28
TW200817382A (en) 2008-04-16
AR062481A1 (es) 2008-11-12
US20080146645A1 (en) 2008-06-19

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