PE20080187A1 - Agonistas receptores de eritropoietina - Google Patents
Agonistas receptores de eritropoietinaInfo
- Publication number
- PE20080187A1 PE20080187A1 PE2007000455A PE2007000455A PE20080187A1 PE 20080187 A1 PE20080187 A1 PE 20080187A1 PE 2007000455 A PE2007000455 A PE 2007000455A PE 2007000455 A PE2007000455 A PE 2007000455A PE 20080187 A1 PE20080187 A1 PE 20080187A1
- Authority
- PE
- Peru
- Prior art keywords
- receptor agonists
- erythropoietin receptor
- antibody
- erythropoyetin
- erythroblasts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
SE REFIERE A UN ANTICUERPO HUMANIZADO CON LA SIGUIENTE SECUENCIA AMINOACIDICA ID NO.1, EL CUAL COMPRENDE UNA REGION VARIABLE DE CADENA SIMPLE QUE PUEDE SER SEC ID NO.3,4,5,6, 68, 90, 112, ENTRE OTROS, O FUSIONADO A UN Fc QUE PUEDE SER IgG1, IgG2, IgG3, IgG4. DICHO ANTICUERPO SE UNE AL RECEPTOR DE ERITROPOYETINA HUMANO, SIENDO UTILES EN LA ESTIMULACION Y DIFERENCIACION DE ERITROBLASTOS E INHIBICION DE LA APOPTOSIS DE EN LAS CELULAS PROGENITORAS DE LA ERITRO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79217406P | 2006-04-14 | 2006-04-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080187A1 true PE20080187A1 (es) | 2008-03-10 |
Family
ID=38610179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000455A PE20080187A1 (es) | 2006-04-14 | 2007-04-13 | Agonistas receptores de eritropoietina |
Country Status (10)
Country | Link |
---|---|
US (1) | US20080124340A1 (es) |
EP (1) | EP2007812A2 (es) |
JP (1) | JP2009533057A (es) |
AR (1) | AR060440A1 (es) |
AU (1) | AU2007238704A1 (es) |
CA (1) | CA2649384A1 (es) |
MX (1) | MX2008013201A (es) |
PE (1) | PE20080187A1 (es) |
TW (1) | TW200808822A (es) |
WO (1) | WO2007120766A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2614260T3 (es) | 2000-05-26 | 2017-05-30 | Immunex Corporation | Uso de anticuerpos contra el receptor de interleuquina-4 y composiciones de los mismos |
US20100203047A1 (en) * | 2007-10-05 | 2010-08-12 | University Of Maryland, Baltimore | Novel Compositions And Methods For Stimulating Erythropoiesis In A Mammal |
SG172927A1 (en) * | 2009-01-15 | 2011-08-29 | Hoffmann La Roche | Antibodies against human epo receptor |
WO2010111282A1 (en) * | 2009-03-24 | 2010-09-30 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Anti-mesothelin antibodies |
US9738719B2 (en) * | 2012-08-31 | 2017-08-22 | The Scripps Research Institute | Methods and compositions related to modulators of eukaryotic cells |
SG11201503567SA (en) | 2012-12-05 | 2015-06-29 | Novartis Ag | Compositions and methods for antibodies targeting epo |
EP3122371A4 (en) * | 2014-03-28 | 2017-09-06 | New York University | Fgf23 fusion proteins |
WO2016018883A1 (en) * | 2014-07-29 | 2016-02-04 | The Board Of Trustees Of The Leland Stanford Junior University | Tuning dimeric receptor signaling with extracellular ligands that alter receptor orientation and proximity upon binding |
ES2913530T3 (es) | 2015-08-12 | 2022-06-02 | Novartis Ag | Métodos para tratar trastornos oftálmicos |
CA3002602C (en) * | 2015-10-23 | 2021-11-02 | Apogenix Ag | Single-chain cd27-receptor agonist proteins |
TW201800418A (zh) * | 2016-04-25 | 2018-01-01 | 索倫多醫療公司 | 結合stat3之抗體治療劑 |
KR20230107301A (ko) * | 2020-11-10 | 2023-07-14 | 더 스크립스 리서치 인스티튜트 | 오피오이드 치료들을 위한 항체들 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5885574A (en) * | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
US6103879A (en) * | 1996-06-21 | 2000-08-15 | Axys Pharmaceuticals, Inc. | Bivalent molecules that form an activating complex with an erythropoietin receptor |
US6998124B1 (en) * | 1999-04-14 | 2006-02-14 | Smithkline Beecham Corporation | Erythropoietin receptor antibodies |
US20050227289A1 (en) * | 2004-04-09 | 2005-10-13 | Reilly Edward B | Antibodies to erythropoietin receptor and uses thereof |
US20080102065A1 (en) * | 2006-04-14 | 2008-05-01 | Borges Luis G | Erythropoietin receptor extended duration limited agonists |
-
2007
- 2007-04-13 WO PCT/US2007/009030 patent/WO2007120766A2/en active Application Filing
- 2007-04-13 PE PE2007000455A patent/PE20080187A1/es not_active Application Discontinuation
- 2007-04-13 MX MX2008013201A patent/MX2008013201A/es not_active Application Discontinuation
- 2007-04-13 US US11/786,879 patent/US20080124340A1/en not_active Abandoned
- 2007-04-13 EP EP07755338A patent/EP2007812A2/en not_active Withdrawn
- 2007-04-13 CA CA002649384A patent/CA2649384A1/en not_active Abandoned
- 2007-04-13 JP JP2009505478A patent/JP2009533057A/ja not_active Withdrawn
- 2007-04-13 AU AU2007238704A patent/AU2007238704A1/en not_active Abandoned
- 2007-04-13 TW TW096113045A patent/TW200808822A/zh unknown
- 2007-04-13 AR ARP070101570A patent/AR060440A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2007120766A2 (en) | 2007-10-25 |
TW200808822A (en) | 2008-02-16 |
EP2007812A2 (en) | 2008-12-31 |
WO2007120766A3 (en) | 2008-05-29 |
AU2007238704A1 (en) | 2007-10-25 |
US20080124340A1 (en) | 2008-05-29 |
JP2009533057A (ja) | 2009-09-17 |
AR060440A1 (es) | 2008-06-18 |
CA2649384A1 (en) | 2007-10-25 |
MX2008013201A (es) | 2008-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |