PE20080066A1 - Derivados biciclicos como inhibidores de cetp - Google Patents

Derivados biciclicos como inhibidores de cetp

Info

Publication number
PE20080066A1
PE20080066A1 PE2007000555A PE2007000555A PE20080066A1 PE 20080066 A1 PE20080066 A1 PE 20080066A1 PE 2007000555 A PE2007000555 A PE 2007000555A PE 2007000555 A PE2007000555 A PE 2007000555A PE 20080066 A1 PE20080066 A1 PE 20080066A1
Authority
PE
Peru
Prior art keywords
methyl
haloalkyl
amino
alkyl
tetrazol
Prior art date
Application number
PE2007000555A
Other languages
English (en)
Inventor
Masashi Kishida
Naoko Matsuura
Hidetomo Imase
Yuki Iwaki
Ichiro Umemura
Osamu Ohmori
Eiji Kawahara
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20080066A1 publication Critical patent/PE20080066A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS BICICLICOS DE FORMULA (I) DONDE A ES UN ANILLO CARBOCICLICO(C6-C22) O HETEROCICLICO DE 5 A 14 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON ALQUILO(C1-C7), HALOALQUILO(C1-C7), HALOGENO, ENTRE OTROS SUSTITUYENTES; Ar ES UN RADICAL AROMATICO CARBOCICLICO(C6-C22) OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C7), ALCOXILO(C1-C7), HALOGENO, ENTRE OTROS SUSTITUYENTES; R1 ES C(=O)-R3, C(=O)-O-R3, S(O)m-R3, ENTRE OTROS, DONDE R3 ES H, ALQUILO(C1-C7), HALOALQUILO(C1-C7), CICLOALQUILO(C3-C7), ENTRE OTROS; m ES DE 0 A 2; X E Y SON CADA UNO N O CR6, DONDE R6 ES H, HALOGENO, CN, OH, ALQUILO(C1-C7), ENTRE OTROS; R2 ES C(=O)R3, C(=O)-O-R3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[(3-{N'-[3,5-BIS-(TRIFLUORO-METIL)-BENCIL]-N'-(2-METIL-2H-TETRAZOL-5-IL)-AMINO}-METIL)-QUINOLIN-2-IL]-N-(CICLOPENTIL-METIL)-ETIL-AMINA, ACIDO TRANS-[4-({N-[3-({N'-[3,5-BIS-(TRIFLUORO-METIL)-BENCIL]-N'-(2-METIL-2H-TETRAZOL-5-IL)-AMINO}-METIL)-QUINOLIN-2-IL]-N-ETIL-AMINO}-METIL)-CICLOHEXIL]-ACETICO, 3-({N-[3,5-BIS-(TRIFLUORO-METIL)-BENCIL]-N-(2-METIL-2H-TETRAZOL-5-IL)-AMINO}-METIL)-2-[N'-(CICLOPENTIL-METIL)-N'-ETIL-AMINO]-QUINOLIN-7-CARBONITRILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA DE TRANSFERENCIA DE COLESTERIL-ESTER (CETP) SIENDO UTILES EN EL TRATAMIENTO DE HIPERLIPIDEMIA, ARTERIOESCLEROSIS, CARDIOPATIA CORONARIA, ANGINA
PE2007000555A 2006-05-10 2007-05-08 Derivados biciclicos como inhibidores de cetp PE20080066A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0609268.8A GB0609268D0 (en) 2006-05-10 2006-05-10 Organic compounds
US86648006P 2006-11-20 2006-11-20
US89614207P 2007-03-21 2007-03-21

Publications (1)

Publication Number Publication Date
PE20080066A1 true PE20080066A1 (es) 2008-03-17

Family

ID=36637241

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000555A PE20080066A1 (es) 2006-05-10 2007-05-08 Derivados biciclicos como inhibidores de cetp

Country Status (6)

Country Link
JP (1) JP4926241B2 (es)
CN (1) CN101622242B (es)
BR (1) BRPI0711384A2 (es)
GB (1) GB0609268D0 (es)
PE (1) PE20080066A1 (es)
RU (1) RU2430917C2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4846769B2 (ja) * 2007-07-30 2011-12-28 田辺三菱製薬株式会社 医薬組成物
JPWO2014017569A1 (ja) * 2012-07-26 2016-07-11 興和株式会社 血中ｌｄｌを低下させるための医薬
RU2015123632A (ru) * 2012-11-19 2017-01-10 Др. Редди'С Лабораторис Лтд. Фармацевтические композиции ингибиторов сетр
CN103351354B (zh) * 2013-06-09 2015-08-12 西安近代化学研究所 1-甲基-5-氨基四唑合成方法
CN103524445A (zh) * 2013-09-09 2014-01-22 南通市华峰化工有限责任公司 一种1-甲基-5氨基四氮唑的合成生产方法
CN107304174B (zh) * 2016-04-21 2019-05-10 沈阳药科大学 N,n-双取代环烯基甲胺类衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003221376A (ja) * 2001-11-21 2003-08-05 Japan Tobacco Inc Ｃｅｔｐ活性阻害剤
EP1829858A3 (en) * 2002-08-30 2007-10-03 Japan Tobacco, Inc. Dibenzylamine compounds and pharmaceutical use thereof
KR101238525B1 (ko) * 2004-12-31 2013-02-28 레디 유에스 테라퓨틱스 인코포레이티드 Ｃｅｔｐ 저해제로서의 신규 벤질아민 유도체
AU2006330072B2 (en) * 2005-12-28 2012-08-02 Dr. Reddy's Laboratories Ltd. Selective benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors
PE20071025A1 (es) * 2006-01-31 2007-10-17 Mitsubishi Tanabe Pharma Corp Compuesto amina trisustituido

Also Published As

Publication number Publication date
CN101622242A (zh) 2010-01-06
GB0609268D0 (en) 2006-06-21
RU2008148290A (ru) 2010-06-20
RU2430917C2 (ru) 2011-10-10
JP4926241B2 (ja) 2012-05-09
BRPI0711384A2 (pt) 2011-11-22
CN101622242B (zh) 2013-07-17
JP2009536172A (ja) 2009-10-08

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