PE20080066A1 - BICYCLE DERIVATIVES AS CETP INHIBITORS - Google Patents

BICYCLE DERIVATIVES AS CETP INHIBITORS

Info

Publication number
PE20080066A1
PE20080066A1 PE2007000555A PE2007000555A PE20080066A1 PE 20080066 A1 PE20080066 A1 PE 20080066A1 PE 2007000555 A PE2007000555 A PE 2007000555A PE 2007000555 A PE2007000555 A PE 2007000555A PE 20080066 A1 PE20080066 A1 PE 20080066A1
Authority
PE
Peru
Prior art keywords
methyl
haloalkyl
amino
alkyl
tetrazol
Prior art date
Application number
PE2007000555A
Other languages
Spanish (es)
Inventor
Masashi Kishida
Naoko Matsuura
Hidetomo Imase
Yuki Iwaki
Ichiro Umemura
Osamu Ohmori
Eiji Kawahara
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20080066A1 publication Critical patent/PE20080066A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

SE REFIERE A COMPUESTOS BICICLICOS DE FORMULA (I) DONDE A ES UN ANILLO CARBOCICLICO(C6-C22) O HETEROCICLICO DE 5 A 14 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON ALQUILO(C1-C7), HALOALQUILO(C1-C7), HALOGENO, ENTRE OTROS SUSTITUYENTES; Ar ES UN RADICAL AROMATICO CARBOCICLICO(C6-C22) OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C7), ALCOXILO(C1-C7), HALOGENO, ENTRE OTROS SUSTITUYENTES; R1 ES C(=O)-R3, C(=O)-O-R3, S(O)m-R3, ENTRE OTROS, DONDE R3 ES H, ALQUILO(C1-C7), HALOALQUILO(C1-C7), CICLOALQUILO(C3-C7), ENTRE OTROS; m ES DE 0 A 2; X E Y SON CADA UNO N O CR6, DONDE R6 ES H, HALOGENO, CN, OH, ALQUILO(C1-C7), ENTRE OTROS; R2 ES C(=O)R3, C(=O)-O-R3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[(3-{N'-[3,5-BIS-(TRIFLUORO-METIL)-BENCIL]-N'-(2-METIL-2H-TETRAZOL-5-IL)-AMINO}-METIL)-QUINOLIN-2-IL]-N-(CICLOPENTIL-METIL)-ETIL-AMINA, ACIDO TRANS-[4-({N-[3-({N'-[3,5-BIS-(TRIFLUORO-METIL)-BENCIL]-N'-(2-METIL-2H-TETRAZOL-5-IL)-AMINO}-METIL)-QUINOLIN-2-IL]-N-ETIL-AMINO}-METIL)-CICLOHEXIL]-ACETICO, 3-({N-[3,5-BIS-(TRIFLUORO-METIL)-BENCIL]-N-(2-METIL-2H-TETRAZOL-5-IL)-AMINO}-METIL)-2-[N'-(CICLOPENTIL-METIL)-N'-ETIL-AMINO]-QUINOLIN-7-CARBONITRILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA DE TRANSFERENCIA DE COLESTERIL-ESTER (CETP) SIENDO UTILES EN EL TRATAMIENTO DE HIPERLIPIDEMIA, ARTERIOESCLEROSIS, CARDIOPATIA CORONARIA, ANGINAREFERS TO BICYCLE COMPOUNDS OF FORMULA (I) WHERE A IS A CARBOCYCLIC RING (C6-C22) OR HETEROCYCLIC RING OF 5 TO 14 MEMBERS OPTIONALLY SUBSTITUTED WITH ALKYL (C1-C7), HALOALKYL (C1-CENTOS), HALOALKYL (C1-CENTOS), HALOALKyl ; Ar IS A CARBOCYCLIC AROMATIC RADICAL (C6-C22) OPTIONALLY SUBSTITUTED WITH ALKYL (C1-C7), ALCOXYL (C1-C7), HALOGEN, AMONG OTHER SUBSTITUENTS; R1 IS C (= O) -R3, C (= O) -O-R3, S (O) m-R3, AMONG OTHERS, WHERE R3 IS H, ALKYL (C1-C7), HALOALKYL (C1-C7), CYCLOALKYL (C3-C7), AMONG OTHERS; m IS 0 TO 2; X AND Y ARE EACH N O CR6, WHERE R6 IS H, HALOGEN, CN, OH, ALKYL (C1-C7), AMONG OTHERS; R2 IS C (= O) R3, C (= O) -O-R3, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N - [(3- {N '- [3,5-BIS- (TRIFLUORO-METHYL) -BENZYL] -N' - (2-METHYL-2H-TETRAZOL-5-IL) -AMINE} - METHYL) -QUINOLIN-2-IL] -N- (CYCLOPENTIL-METHYL) -ETHYL-AMINE, TRANS- [4 - ({N- [3 - ({N '- [3,5-BIS- (TRIFLUORO- METHYL) -BENZYL] -N '- (2-METHYL-2H-TETRAZOL-5-IL) -AMINO} -MEthyl) -QUINOLIN-2-IL] -N-ETHYL-AMINO} -MEthyl) -CYCLOHEXIL] -ACETIC , 3 - ({N- [3,5-BIS- (TRIFLUORO-METHYL) -BENZYL] -N- (2-METHYL-2H-TETRAZOL-5-IL) -AMINO} -MEthyl) -2- [N ' - (CYCLOPENTIL-METHYL) -N'-ETHYL-AMINO] -QUINOLIN-7-CARBONITRILE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITORS OF CHOLESTERYL-ESTER TRANSFER PROTEIN (CETP), BEING USEFUL IN THE TREATMENT OF HYPERLIPIDEMIA, ARTERIOSCLEROSIS, CORONARY CARDIOPATIA, ANGINA

PE2007000555A 2006-05-10 2007-05-08 BICYCLE DERIVATIVES AS CETP INHIBITORS PE20080066A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0609268.8A GB0609268D0 (en) 2006-05-10 2006-05-10 Organic compounds
US86648006P 2006-11-20 2006-11-20
US89614207P 2007-03-21 2007-03-21

Publications (1)

Publication Number Publication Date
PE20080066A1 true PE20080066A1 (en) 2008-03-17

Family

ID=36637241

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000555A PE20080066A1 (en) 2006-05-10 2007-05-08 BICYCLE DERIVATIVES AS CETP INHIBITORS

Country Status (6)

Country Link
JP (1) JP4926241B2 (en)
CN (1) CN101622242B (en)
BR (1) BRPI0711384A2 (en)
GB (1) GB0609268D0 (en)
PE (1) PE20080066A1 (en)
RU (1) RU2430917C2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4846769B2 (en) * 2007-07-30 2011-12-28 田辺三菱製薬株式会社 Pharmaceutical composition
JPWO2014017569A1 (en) * 2012-07-26 2016-07-11 興和株式会社 Medicine for lowering blood LDL
EP2919765A2 (en) * 2012-11-19 2015-09-23 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions of cetp inhibitors
CN103351354B (en) * 2013-06-09 2015-08-12 西安近代化学研究所 1-methyl-5-amino tetrazole synthetic method
CN103524445A (en) * 2013-09-09 2014-01-22 南通市华峰化工有限责任公司 Method for synthetic production of 1-methyl-5-aminotetrazole
CN107304174B (en) * 2016-04-21 2019-05-10 沈阳药科大学 Disubstituted cycloalkenyl methylamine like derivative of N, N- and its preparation method and application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003221376A (en) * 2001-11-21 2003-08-05 Japan Tobacco Inc Cept activity inhibitor
BR0306208A (en) * 2002-08-30 2004-10-13 Japan Tobacco Inc Dibenzylamine compounds and their pharmaceutical use
DK1848430T3 (en) * 2004-12-31 2017-11-06 Dr Reddys Laboratories Ltd NEW BENZYLAMINE DERIVATIVES AS CETP INHIBITORS
WO2007075194A1 (en) * 2005-12-28 2007-07-05 Reddy Us Therapeutics, Inc. Selective benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors
UY30118A1 (en) * 2006-01-31 2007-06-29 Tanabe Seiyaku Co AMIS TRISUSTITUDE COMPUTER

Also Published As

Publication number Publication date
BRPI0711384A2 (en) 2011-11-22
GB0609268D0 (en) 2006-06-21
JP2009536172A (en) 2009-10-08
RU2008148290A (en) 2010-06-20
CN101622242B (en) 2013-07-17
RU2430917C2 (en) 2011-10-10
JP4926241B2 (en) 2012-05-09
CN101622242A (en) 2010-01-06

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