PE20071043A1 - FORMULACIONES FARMACEUTICAS ACUOSAS QUE COMPRENDE LIGANDOS SELECTIVOS DEL RECEPTOR DE ESTROGENO ERß - Google Patents
FORMULACIONES FARMACEUTICAS ACUOSAS QUE COMPRENDE LIGANDOS SELECTIVOS DEL RECEPTOR DE ESTROGENO ERßInfo
- Publication number
- PE20071043A1 PE20071043A1 PE2007000155A PE2007000155A PE20071043A1 PE 20071043 A1 PE20071043 A1 PE 20071043A1 PE 2007000155 A PE2007000155 A PE 2007000155A PE 2007000155 A PE2007000155 A PE 2007000155A PE 20071043 A1 PE20071043 A1 PE 20071043A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- aqueous pharmaceutical
- erß
- alcoxy
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA ACUOSA QUE COMPRENDE: A) UN LIGANDO SELECTIVO DEL RECEPTOR ESTROGENICO ER DE FORMULA (I) DONDE R1 ES H, OH, HALOGENO, ALQUILO(C1-C6), CICLOALQUILO(C3-C8), ENTRE OTROS; R2 Y R2a SON CADA UNO H, OH, ALQUILO(C1-C6), ALCOXI(C1-C4), ALQUENILO(C2-C7), ENTRE OTROS; R3, R3a Y R4 SON CADA UNO H, ALQUILO(C1-C6), ALQUENILO(C2-C7), HALOGENO, ALCOXI(C1-C4), ENTRE OTROS; X ES O, S O NR7, DONDE R7 ES H, ALQUILO(C1-C6), ARILO(C6-C10), ENTRE OTROS; O DE FORMULA (III) DONDE R11, R12, R13 O R14 SON CADA UNO H, OH, ALQUILO(C1-C6), ALCOXI(C1-C6) O HALOGENO; R15, R16, R17, R18, R19 Y R20 SON CADA UNO H, ALQUILO(C1-C6), ALQUENILO(C2-C7), HALOGENO, CN, ENTRE OTROS; SIENDO COMPUESTOS PREFERIDOS: 2-(3-FLUOR-4-HIDROXIFENIL)-7-VINIL-1,3-BENZOXAZOL-5-OL Y 3-(3-FLUOR-4-HIDROXI-FENIL)-7-HIDROXI-NAFTALEN-1-CARBONITRILO; B) UN SOLUBILIZANTE COMPLEJANTE TAL COMO HIDROXIPROPIL BETA-CICLODEXTRINA Y SULFOBUTIL ETER BETA-CICLODEXTRINA QUE SE ENCUENTRAN EN UNA CANTIDAD DE 0,00021% A 60% P/V DE LA COMPOSICION; C) UN COMPUESTO PARA AJUSTAR EL pH TAL COMO NaOH O KOH. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION. DICHA COMPOSICION ES UTIL PARA EL TRATAMIENTO DE ARTRITIS, ENDOMETRIOSIS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77302806P | 2006-02-14 | 2006-02-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20071043A1 true PE20071043A1 (es) | 2007-10-23 |
Family
ID=38225453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000155A PE20071043A1 (es) | 2006-02-14 | 2007-02-13 | FORMULACIONES FARMACEUTICAS ACUOSAS QUE COMPRENDE LIGANDOS SELECTIVOS DEL RECEPTOR DE ESTROGENO ERß |
Country Status (10)
Country | Link |
---|---|
US (1) | US20070191442A1 (es) |
EP (1) | EP1984028A2 (es) |
JP (1) | JP2009526851A (es) |
AR (1) | AR059574A1 (es) |
AU (1) | AU2007215131A1 (es) |
BR (1) | BRPI0707655A2 (es) |
CA (1) | CA2641116A1 (es) |
PE (1) | PE20071043A1 (es) |
TW (1) | TW200800177A (es) |
WO (1) | WO2007095286A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20080117A1 (es) * | 2006-03-06 | 2008-02-22 | Wyeth Corp | Formulaciones farmaceuticas de una forma cristalina anhidra de 2-(3-fluor-4-hidroxifenil)-7-vinil-1,3-benzoxazol-5-ol |
PE20071019A1 (es) * | 2006-03-06 | 2007-10-29 | Wyeth Corp | Formulaciones farmaceuticas liquidas y semi-solidas que comprenden un modulador de receptores estrogenicos |
TW200800178A (en) * | 2006-03-06 | 2008-01-01 | Wyeth Corp | Pharmaceutical formulations of a monohydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20080241234A1 (en) * | 2006-11-21 | 2008-10-02 | Wyeth | Pharmaceutical formulations of an anhydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20090239920A1 (en) * | 2006-11-21 | 2009-09-24 | Wyeth | Pharmaceutical formulations of an anhydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20080175900A1 (en) * | 2006-11-21 | 2008-07-24 | Wyeth | Pharmaceutical formulations of an anhydrate crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
US20080175901A1 (en) * | 2006-11-21 | 2008-07-24 | Wyeth | Pharmaceutical formulations of a crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
AU2008210528A1 (en) * | 2007-01-31 | 2008-08-07 | Wyeth | Use of estrogen receptor beta selective ligands for treating acute lung injuries |
DE102007015169A1 (de) * | 2007-03-27 | 2008-10-02 | Universität des Saarlandes Campus Saarbrücken | 17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020198174A1 (en) * | 2001-05-07 | 2002-12-26 | Allergan Sales, Inc. | Disinfecting and solubilizing steroid compositions |
BR0113625A (pt) * | 2000-09-08 | 2003-07-22 | Pharmacia Italia Spa | Exemestano como agente de quimioprevenção |
FR2817750B1 (fr) * | 2000-12-11 | 2003-02-21 | Sanofi Synthelabo | Composition pharmaceutique de dronedarone pour administration parenterale |
UA83620C2 (ru) * | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
US6914074B2 (en) * | 2001-12-13 | 2005-07-05 | Wyeth | Substituted phenyl naphthalenes as estrogenic agents |
US6960607B2 (en) * | 2001-12-13 | 2005-11-01 | Wyeth | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents |
US6884814B2 (en) * | 2001-12-13 | 2005-04-26 | Wyeth | Phenyl benzisoxazoles as estrogenic agents |
US6903238B2 (en) * | 2001-12-13 | 2005-06-07 | Wyeth | Substituted indenones as estrogenic agents |
TW200301107A (en) * | 2001-12-13 | 2003-07-01 | Wyeth Corp | Substituted 6H-dibenzo[c,h]chromenes as estrogenic agents |
US6774248B2 (en) * | 2001-12-18 | 2004-08-10 | Wyeth | Substituted 2-phenyl benzofurans as estrogenic agents |
US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
TW200500065A (en) * | 2003-05-21 | 2005-01-01 | Wyeth Corp | Antiarthritic combinations |
WO2006007503A1 (en) * | 2004-07-01 | 2006-01-19 | Wyeth | Tetracyclic compounds as estrogen ligands |
AU2005282554A1 (en) * | 2004-09-07 | 2006-03-16 | Wyeth | 6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents |
EP1819321A2 (en) * | 2004-12-02 | 2007-08-22 | Wyeth, A Corporation of the State of Delaware | Formulations of substituted benzoxazoles |
AR053653A1 (es) * | 2004-12-02 | 2007-05-16 | Wyeth Corp | Formulaciones de benzoxazoles substituidos |
MX2007007347A (es) * | 2004-12-17 | 2007-07-13 | Wyeth Corp | Usos nevodosos para agonistas de estrogeno beta. |
JP2008530210A (ja) * | 2005-02-16 | 2008-08-07 | ワイス | 放射線または化学療法誘発粘膜炎および放射線膀胱炎のためのエストロゲン受容体−β選択性アゴニストの使用 |
-
2007
- 2007-02-13 AR ARP070100594A patent/AR059574A1/es not_active Application Discontinuation
- 2007-02-13 CA CA002641116A patent/CA2641116A1/en not_active Abandoned
- 2007-02-13 JP JP2008555324A patent/JP2009526851A/ja active Pending
- 2007-02-13 BR BRPI0707655-0A patent/BRPI0707655A2/pt not_active Application Discontinuation
- 2007-02-13 WO PCT/US2007/003901 patent/WO2007095286A2/en active Application Filing
- 2007-02-13 EP EP07750722A patent/EP1984028A2/en not_active Withdrawn
- 2007-02-13 TW TW096105215A patent/TW200800177A/zh unknown
- 2007-02-13 US US11/674,496 patent/US20070191442A1/en not_active Abandoned
- 2007-02-13 AU AU2007215131A patent/AU2007215131A1/en not_active Abandoned
- 2007-02-13 PE PE2007000155A patent/PE20071043A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2007095286A3 (en) | 2007-12-13 |
AU2007215131A1 (en) | 2007-08-23 |
WO2007095286A2 (en) | 2007-08-23 |
BRPI0707655A2 (pt) | 2011-05-10 |
AR059574A1 (es) | 2008-04-16 |
EP1984028A2 (en) | 2008-10-29 |
JP2009526851A (ja) | 2009-07-23 |
US20070191442A1 (en) | 2007-08-16 |
CA2641116A1 (en) | 2007-08-23 |
TW200800177A (en) | 2008-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |