PE20070825A1 - Nuevo derivado de pleuromutilina y su uso - Google Patents

Nuevo derivado de pleuromutilina y su uso

Info

Publication number
PE20070825A1
PE20070825A1 PE2006001467A PE2006001467A PE20070825A1 PE 20070825 A1 PE20070825 A1 PE 20070825A1 PE 2006001467 A PE2006001467 A PE 2006001467A PE 2006001467 A PE2006001467 A PE 2006001467A PE 20070825 A1 PE20070825 A1 PE 20070825A1
Authority
PE
Peru
Prior art keywords
salt
isopropanol
pleuromutilin
skin
additional
Prior art date
Application number
PE2006001467A
Other languages
English (en)
Inventor
Ann Marie Diederich
Joseph Sisko
Frederick G Vogt
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20070825A1 publication Critical patent/PE20070825A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/66—Y being a hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A LA SAL SOLIDA DE (1S,2R,3S,4S,6R,7R,8R,14R)-4-ETENIL-3-HIDROXI-2,4,7,14-TETRAMETIL-9-OXOTRICICLO[5.4.3.01,8]TETRADEC-6-IL IMIDODICARBONATO DE TRANS-4-AMINOICICLOHEXILO. DICHA SAL PUEDE CONTENER HASTA 0,9 EQUIVALENTES MOLARES DE ACIDO SUCCINICO ADICIONAL CARACTERIZADA POR UN PATRON DE DIFRACCION DE POLVO DE RAYOS X QUE TIENE UN PICO CARACTERISTICO EN 10,8 +-0,2 (GRADOS 2THETA) Y AL MENOS 3 PICOS CARACTERISTICOS ADICIONALES SELECCIONADOS ENTRE LOS PICOS DE LAS SIGUIENTES POSICIONES: 11,3+-0,2; 12,9+-0,2; 13,1+-0,2; ENTRE OTROS O UNA SAL DE SOLVATO DE ISOPROPANOL NO ESTEQUIOMETRICO QUE CONTIENE HASTA APROXIMADAMENTE 6% DE ISOPROPANOL. DICHA SAL ES UTIL EN EL TRATAMIENTO DE INFECCIONES DE LA PIEL Y DE ESTRUCTURAS CUTANEAS
PE2006001467A 2005-11-18 2006-11-17 Nuevo derivado de pleuromutilina y su uso PE20070825A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73820305P 2005-11-18 2005-11-18

Publications (1)

Publication Number Publication Date
PE20070825A1 true PE20070825A1 (es) 2007-08-05

Family

ID=38068018

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001467A PE20070825A1 (es) 2005-11-18 2006-11-17 Nuevo derivado de pleuromutilina y su uso

Country Status (3)

Country Link
PE (1) PE20070825A1 (es)
TW (1) TW200738599A (es)
WO (2) WO2007062335A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101671367B (zh) * 2008-09-12 2012-09-05 中国科学院上海药物研究所 截短侧耳素磷酸酯类化合物、其药物组合物及其制备方法和用途
JP2010100582A (ja) * 2008-10-24 2010-05-06 Kyorin Pharmaceut Co Ltd １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
CN103641702B (zh) * 2013-11-18 2015-11-18 宁夏泰瑞制药股份有限公司 一种截短侧耳素的水解方法
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
EP4338732A1 (en) 2022-09-16 2024-03-20 Nabriva Therapeutics GMBH Lefamulin and its derivatives for use in the treatment of tularemia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060542A (en) * 1969-07-25 1977-11-29 Biochemie Gesellschaft M.B.H. 14-Desoxy-14 thiocyanato-acetoxy-mutilin
US4086359A (en) * 1975-09-30 1978-04-25 E. R. Squibb & Sons, Inc. Derivatives of pleuromutilin and compositions
US20030219461A1 (en) * 2000-09-12 2003-11-27 Britten Nancy J. Parenteral combination therapy for infective conditions
GB0024811D0 (en) * 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
US6750064B2 (en) * 2000-12-28 2004-06-15 S.S.C.I. Inc. Methods of screening for possible solid forms

Also Published As

Publication number Publication date
WO2007062334A8 (en) 2007-12-21
TW200738599A (en) 2007-10-16
WO2007062335A3 (en) 2007-11-29
WO2007062335A2 (en) 2007-05-31
WO2007062335A8 (en) 2008-07-10
WO2007062334A3 (en) 2007-11-08
WO2007062334A2 (en) 2007-05-31

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