PE20070820A1 - Derivados de triazolopiridina en calidad de inhibidores de lipasas y fosfolipasas - Google Patents

Derivados de triazolopiridina en calidad de inhibidores de lipasas y fosfolipasas

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Publication number
PE20070820A1
PE20070820A1 PE2006001256A PE2006001256A PE20070820A1 PE 20070820 A1 PE20070820 A1 PE 20070820A1 PE 2006001256 A PE2006001256 A PE 2006001256A PE 2006001256 A PE2006001256 A PE 2006001256A PE 20070820 A1 PE20070820 A1 PE 20070820A1
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PE
Peru
Prior art keywords
lipase
methanone
triazolo
pyridin
quality
Prior art date
Application number
PE2006001256A
Other languages
English (en)
Inventor
Hubert Heuer
Stefan Petry
Karl-Heinz Baringhaus
Gunter Muller
Gerhard Zoller
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20070820A1 publication Critical patent/PE20070820A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE X =C(-R)-, =N-, EN LA QUE AL MENOS 1 O A LO SUMO 2 X ES/SON =N-; W ES -(C=O)-, -(S=O)-, -(SO2)-; R ES H, HALOGENO, HALOALQUILO C1-C3, ALQUILOXI C1-C3, ENTRE OTROS; R1 ES ALQUILO C5-C16, CICLOALQUILO C5-C12, BICICLO, TRIFLUOROMETOXI, ENTRE OTROS; R2 ES H, ALQUILO C4-C12, O R1 Y R2 PUEDEN FORMAR UN SISTEMA DE ANILLO DE 4 A 7 MIEMBROS, MONOCICLICO, SATURADO O PARCIALMENTE INSATURADO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (5-CLORO-[1,2,3]TRIAZOLO[4,5-b]PIRIDIN-1-IL)-(3,4-DIHIDRO-1H-ISOQUINOLIN-2-IL)-METANONA; (5-CLORO-[1,2,3]TRIAZOLO[4,5-b]PIRIDIN-1-IL)-(3,4-DIHIDRO-1H-ISOQUINOLIN-2-IL)-METANONA; (4-METILPIPERIDIN-1-IL)-[1,2,3]TRIAZOLO[4,5-c]PIRIDIN-1-IL-METANONA. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LIPASA SENSIBLE A HORMONAS O DE LIPASA ENDOTELIAL UTILES EN TRASTORNOS DEL METABOLISMO DE LOS ACIDOS GRASOS Y TRASTORNOS DE UTILIZACION DE GLUCOSA, SINDROME METABOLICO, DIABETES, ENTRE OTROS
PE2006001256A 2005-10-19 2006-10-17 Derivados de triazolopiridina en calidad de inhibidores de lipasas y fosfolipasas PE20070820A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005049954A DE102005049954A1 (de) 2005-10-19 2005-10-19 Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen

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PE20070820A1 true PE20070820A1 (es) 2007-09-04

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PE2006001256A PE20070820A1 (es) 2005-10-19 2006-10-17 Derivados de triazolopiridina en calidad de inhibidores de lipasas y fosfolipasas

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US (2) US7718669B2 (es)
EP (1) EP1940838B1 (es)
JP (1) JP2009512649A (es)
KR (1) KR20080057299A (es)
CN (1) CN101291932A (es)
AR (1) AR058095A1 (es)
AU (1) AU2006303551A1 (es)
BR (1) BRPI0617712A2 (es)
CA (1) CA2625442A1 (es)
CR (1) CR9851A (es)
DE (1) DE102005049954A1 (es)
DO (1) DOP2006000227A (es)
EC (1) ECSP088376A (es)
HN (1) HN2006035237A (es)
IL (1) IL190715A0 (es)
MA (1) MA29857B1 (es)
MY (1) MY140514A (es)
NO (1) NO20082159L (es)
NZ (1) NZ567574A (es)
PE (1) PE20070820A1 (es)
RU (1) RU2008119435A (es)
TN (1) TNSN08178A1 (es)
TW (1) TW200800987A (es)
UY (1) UY29878A1 (es)
WO (1) WO2007045392A1 (es)
ZA (1) ZA200802369B (es)

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FR2915199B1 (fr) * 2007-04-18 2010-01-22 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
FR2915197B1 (fr) 2007-04-18 2009-06-12 Sanofi Aventis Sa Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AR072707A1 (es) 2008-07-09 2010-09-15 Sanofi Aventis Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos
EP2351744B1 (en) * 2008-10-17 2015-01-07 Shionogi & Co., Ltd. Acetic acid amide derivative having inhibitory activity on vascular endothelial lipase
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JP5791150B2 (ja) 2009-12-15 2015-10-07 塩野義製薬株式会社 血管内皮リパーゼ阻害活性を有するオキサジアゾール誘導体
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WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
EP2968359B1 (en) 2013-03-12 2021-01-20 Celltaxis, LLC Methods of inhibiting leukotriene a4 hydrolase
US9637450B2 (en) 2013-03-14 2017-05-02 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, their preparation and use
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
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KR20150127245A (ko) 2013-03-14 2015-11-16 켈탁시스, 인코퍼레이티드 류코트라이엔 a4 가수분해효소의 저해제
EP3495357B1 (en) 2013-03-14 2021-05-05 The Trustees of Columbia University in the City of New York 4-phenylpiperidines, their preparation and use
MX2015011678A (es) 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
US9944644B2 (en) 2013-03-14 2018-04-17 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles their preparation and use
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CA2947174C (en) * 2014-04-30 2023-02-28 The Trustees Of Columbia University In The City Of New York Substituted 4-phenylpiperidines, their preparaiton and use
KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
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CN117126134A (zh) * 2022-05-20 2023-11-28 中国科学院上海药物研究所 新型四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途

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AR058095A1 (es) 2008-01-23
AU2006303551A1 (en) 2007-04-26
MA29857B1 (fr) 2008-10-03
UY29878A1 (es) 2007-05-31
HN2006035237A (es) 2010-03-11
RU2008119435A (ru) 2009-11-27
US20090030011A1 (en) 2009-01-29
DOP2006000227A (es) 2007-05-15
NZ567574A (en) 2010-03-26
WO2007045392A1 (de) 2007-04-26
ECSP088376A (es) 2008-05-30
EP1940838B1 (de) 2012-08-22
ZA200802369B (en) 2009-01-28
IL190715A0 (en) 2008-11-03
US20100190801A1 (en) 2010-07-29
CN101291932A (zh) 2008-10-22
TNSN08178A1 (en) 2009-10-30
US7718669B2 (en) 2010-05-18
JP2009512649A (ja) 2009-03-26
CR9851A (es) 2008-07-29
NO20082159L (no) 2008-05-08
BRPI0617712A2 (pt) 2011-08-02
EP1940838A1 (de) 2008-07-09
MY140514A (en) 2009-12-31
DE102005049954A1 (de) 2007-05-31
KR20080057299A (ko) 2008-06-24
TW200800987A (en) 2008-01-01
CA2625442A1 (en) 2007-04-26

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