PE20070017A1 - Derivados n-amida de 8-azabiciclo[3.2.1]oct-3-ilo como antagonistas de ccr1 - Google Patents
Derivados n-amida de 8-azabiciclo[3.2.1]oct-3-ilo como antagonistas de ccr1Info
- Publication number
- PE20070017A1 PE20070017A1 PE2006000656A PE2006000656A PE20070017A1 PE 20070017 A1 PE20070017 A1 PE 20070017A1 PE 2006000656 A PE2006000656 A PE 2006000656A PE 2006000656 A PE2006000656 A PE 2006000656A PE 20070017 A1 PE20070017 A1 PE 20070017A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- alcoxy
- octan
- azabicyclo
- Prior art date
Links
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 title abstract 2
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- CIEWGZJDEDBECJ-UHFFFAOYSA-N 1-chloro-4-methylbenzene Chemical class [CH2]C1=CC=C(Cl)C=C1 CIEWGZJDEDBECJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 ALCOXY (C1-C4) Chemical class 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- LKJPYSCBVHEWIU-UHFFFAOYSA-N N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide Chemical compound C=1C=C(C#N)C(C(F)(F)F)=CC=1NC(=O)C(O)(C)CS(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 101100054666 Streptomyces halstedii sch3 gene Chemical group 0.000 abstract 1
- 201000009961 allergic asthma Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Abstract
SE REFIERE A COMPUESTOS N-AMIDA DE 8-AZABICICLO[3.2.1]OCT-3-ILO DE FORMULA (I) DONDE n ES DE 1 A 4; m ES DE 1 A 3; p ES DE 0 A 2; R1, R2 Y R3 SON H O ALQUILO(C1-C4); Q ES UN ENLACE DIRECTO, CONR9, OCONR9, NR9, ENTRE OTROS, DONDE R9 ES H O ALQUILO(C1-C4); R4 ES H, ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO CON COOH, FENILO O SCH3; R5 Y R6 SON H, ALQUILO(C1-C4), FENILO O R5 Y R6 JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN CICLOALQUILO(C3-C8); R7 Y R8 SON H, HALOGENO O ALCOXI(C1-C4); A ES UN COMPUESTO DE FORMULA (i) O (ii), DONDE D ES UN ENLACE DIRECTO, O U CH2CH2; R11 ES H, HALOGENO, ALCOXI(C1-C4), NITRO, ENTRE OTROS; R12 ES CIANO, ALQUILO(C1-C4), ALCOXI(C1-C4), HALOGENO O CF3; q ES DE 0 A 2; R13 ES H O ALQUILO(C1-C4); R14 ES H O HALOGENO. SON COMPUESTOS PREFERIDOS: 5-CLORO-2-(3-((3-ENDO)-8-(4-CLOROBENCIL)-8-AZABICICLO[3.2.1]OCTAN-3-ILAMINO)-3-OXOPROPOXI)-N-METILBENZAMIDA, 3-(4-CLORO-2-UREIDOFENOXI)-N-((3-ENDO)-8-(4-CLOROBENCIL)-8-AZABICICLO[3.2.1]OCTAN-3-IL)PROPANAMIDA, 5-CLORO-2-(4-((3-ENDO)-8-(4-CLOROBENCIL)-8-AZABICICLO[3.2.1]OCTAN-3-ILAMINO)-4-OXOBUTOXI)-N-METILBENZAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE QUIMIOQUINA CCR1 SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ASMA ALERGICA, FIBROSIS PULMONAR, GLOMERULONEFRITIS, ATEROSCLEROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200501431A ES2277745B1 (es) | 2005-06-14 | 2005-06-14 | Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070017A1 true PE20070017A1 (es) | 2007-02-05 |
Family
ID=35740673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000656A PE20070017A1 (es) | 2005-06-14 | 2006-06-12 | Derivados n-amida de 8-azabiciclo[3.2.1]oct-3-ilo como antagonistas de ccr1 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090130090A1 (es) |
| EP (1) | EP1891064B1 (es) |
| JP (1) | JP2008543795A (es) |
| CN (1) | CN101228158A (es) |
| AR (1) | AR057651A1 (es) |
| AT (1) | ATE441647T1 (es) |
| DE (1) | DE602006008937D1 (es) |
| ES (2) | ES2277745B1 (es) |
| PE (1) | PE20070017A1 (es) |
| TW (1) | TW200716626A (es) |
| UY (1) | UY29572A1 (es) |
| WO (1) | WO2006133802A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007102768A1 (en) * | 2006-03-07 | 2007-09-13 | Astrazeneca Ab | Piperidine derivatives, their process for preparation, their use as therapeutic agents and pharmaceutical compositions containing them . |
| NZ599853A (en) | 2008-04-11 | 2012-08-31 | Janssen Pharmaceutica Nv | Process for the preparation of meso-N-[(3-endo)-8-benzyl-8-azabicyclo[3.2.1]oct-3-yl]acetamide and its derivatives |
| WO2010091104A1 (en) * | 2009-02-06 | 2010-08-12 | Exelixis, Inc. | Glucosylceramide synthase inhibitors |
| EP2430019B1 (en) | 2009-05-14 | 2013-09-18 | Janssen Pharmaceutica, N.V. | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase |
| US8697691B2 (en) * | 2009-12-21 | 2014-04-15 | Vanderbilt University | Alkyl 3-((2-amidoethyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate analogs as selective M1 agonists and methods of making and using same |
| EP2771484A1 (en) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| EP2875023B1 (en) * | 2012-07-19 | 2017-04-05 | Janssen Pharmaceutica NV | Octahydro-cyclopentapyrrolyl antagonists of ccr2 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6140338A (en) * | 1996-07-29 | 2000-10-31 | Banyu Pharmaceutical, Co., Ltd. | Chemokine receptor antagonists |
| PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
| SE0200919D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Chemical compounds |
| BR0312699A (pt) * | 2002-07-18 | 2005-04-26 | Pfizer Prod Inc | Derivados de piperidina bicìclica como antagonistas de receptor de quimiocina ccr1 |
| SE0301369D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
-
2005
- 2005-06-14 ES ES200501431A patent/ES2277745B1/es not_active Expired - Fee Related
-
2006
- 2006-05-30 UY UY29572A patent/UY29572A1/es unknown
- 2006-05-30 WO PCT/EP2006/005129 patent/WO2006133802A1/en active Application Filing
- 2006-05-30 DE DE602006008937T patent/DE602006008937D1/de active Active
- 2006-05-30 CN CNA2006800266367A patent/CN101228158A/zh active Pending
- 2006-05-30 US US11/921,961 patent/US20090130090A1/en not_active Abandoned
- 2006-05-30 EP EP06753965A patent/EP1891064B1/en active Active
- 2006-05-30 ES ES06753965T patent/ES2332819T3/es active Active
- 2006-05-30 JP JP2008516161A patent/JP2008543795A/ja not_active Withdrawn
- 2006-05-30 AT AT06753965T patent/ATE441647T1/de not_active IP Right Cessation
- 2006-06-12 PE PE2006000656A patent/PE20070017A1/es not_active Application Discontinuation
- 2006-06-12 AR ARP060102442A patent/AR057651A1/es not_active Application Discontinuation
- 2006-06-13 TW TW095121003A patent/TW200716626A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008543795A (ja) | 2008-12-04 |
| CN101228158A (zh) | 2008-07-23 |
| ES2277745A1 (es) | 2007-07-16 |
| EP1891064B1 (en) | 2009-09-02 |
| DE602006008937D1 (de) | 2009-10-15 |
| UY29572A1 (es) | 2006-12-29 |
| ATE441647T1 (de) | 2009-09-15 |
| US20090130090A1 (en) | 2009-05-21 |
| ES2332819T3 (es) | 2010-02-12 |
| AR057651A1 (es) | 2007-12-12 |
| WO2006133802A1 (en) | 2006-12-21 |
| EP1891064A1 (en) | 2008-02-27 |
| ES2277745B1 (es) | 2008-06-01 |
| TW200716626A (en) | 2007-05-01 |
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