PE20060307A1 - Proceso de amonolisis enzimatica para preparacion de compuestos intermediarios para inhibidores de dipeptidilo peptidasa iv - Google Patents
Proceso de amonolisis enzimatica para preparacion de compuestos intermediarios para inhibidores de dipeptidilo peptidasa ivInfo
- Publication number
- PE20060307A1 PE20060307A1 PE2005000497A PE2005000497A PE20060307A1 PE 20060307 A1 PE20060307 A1 PE 20060307A1 PE 2005000497 A PE2005000497 A PE 2005000497A PE 2005000497 A PE2005000497 A PE 2005000497A PE 20060307 A1 PE20060307 A1 PE 20060307A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- intermediary
- amonolysis
- dipeptidyl peptidase
- ester
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UN PROCESO DE PREPARACION DE UN COMPUESTO INTERMEDIARIO (A) ESTER 1-(1,1-DIMETIL ETILICO) DEL ACIDO (5S)-5-AMINOCARBONIL-4,5-DIHIDRO-1H-PIRROLO-1-CARBOXILICO TAMBIEN REFERIDO COMO ESTER 1-(1,1-DIMETIL ETILICO) DEL ACIDO (2S)-2-AMINOCARBONIL-2,3-DIHIDRO-1H-PIRROLO-1-CARBOXILICO, QUE CONSISTE EN SOMETER UN COMPUESTO (B) ESTER 1-(1,1-DIMETILETIL)-5-ETILICO O METILICO DEL ACIDO (5S)-4,5-DIHIDRO-1H-PIRROLO-1,5-CARBOXILICO A UNA AMONOLISIS ENZIMATICA EN LA PRESENCIA DE UNA FUENTE DE AMONIACO COMO CARBAMATO DE AMONIO, GAS DE AMONIACO, ENTRE OTROS PARA PRODUCIR EL INTERMEDIARIO (A), EMPLEANDOSE LA ENZIMA HIDROLASA LA CUAL ES DERIVADA DEL MICROORGANISMO CANDIDA ANTARCTICA LIPASA-B. ESTE INTERMEDIARIO (A) ES UTIL EN LA PREPARACION DE UN INHIBIDOR DE DIPEPTIDILO PEPTIDASA IV (1S,3S,5S)-2-[(2S)-2-AMINO-2-(3-HIDROXITRICICLO[3.3.1.1(3.7)]-DEC-1-IL)-1-OXOETIL]-2-AZABICICLO{3.1.0}HEXANO-3-CARBONITRILO, EL CUAL ES UTIL PARA EL TRATAMIENTO DE DIABETES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56809704P | 2004-05-04 | 2004-05-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060307A1 true PE20060307A1 (es) | 2006-04-20 |
Family
ID=35320243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000497A PE20060307A1 (es) | 2004-05-04 | 2005-05-04 | Proceso de amonolisis enzimatica para preparacion de compuestos intermediarios para inhibidores de dipeptidilo peptidasa iv |
Country Status (5)
Country | Link |
---|---|
US (2) | US7223573B2 (es) |
AR (1) | AR048651A1 (es) |
PE (1) | PE20060307A1 (es) |
TW (1) | TW200536827A (es) |
WO (1) | WO2005108594A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7420079B2 (en) * | 2002-12-09 | 2008-09-02 | Bristol-Myers Squibb Company | Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof |
US7741082B2 (en) | 2004-04-14 | 2010-06-22 | Bristol-Myers Squibb Company | Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor |
KR20110135411A (ko) * | 2009-03-27 | 2011-12-16 | 브리스톨-마이어스 스큅 컴퍼니 | Dpp-iv 억제제로 주요 유해 심장혈관 이벤트를 예방하는 방법 |
US8501960B2 (en) | 2010-05-05 | 2013-08-06 | Assia Chemical Industries Ltd. | Saxagliptin intermediates, saxagliptin polymorphs, and processes for preparation thereof |
EP2608788A1 (en) | 2010-10-04 | 2013-07-03 | Assia Chemical Industries Ltd. | Polymorphs of saxagliptin hydrochloride and processes for preparing them |
CN104098481B (zh) * | 2013-04-10 | 2016-05-11 | 浙江九洲药物科技有限公司 | 一种沙格列汀中间体的制备方法 |
CN103951588B (zh) * | 2014-04-30 | 2016-10-05 | 淮海工学院 | 一种合成沙格列汀中间体n-叔丁氧羰基-3-羟基-1-金刚烷基-d-甘氨酸的方法 |
CN105315189A (zh) * | 2014-05-29 | 2016-02-10 | 上海医药工业研究院 | 一种制备(5s)-5-氨基羰基-4,5-二氢-1h-吡咯-1-羧酸-1(1,1-二甲基乙基)酯的方法 |
EA201791982A1 (ru) | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
MX2019011867A (es) | 2017-04-03 | 2020-01-09 | Coherus Biosciences Inc | Agonista de ppary para el tratamiento de la paralisis supranuclear progresiva. |
KR20210158587A (ko) | 2020-06-24 | 2021-12-31 | 삼성전자주식회사 | 반도체 패키지 및 반도체 패키지의 제조 방법 |
CN114369061B (zh) * | 2022-01-28 | 2024-05-03 | 济南同路医药科技发展有限公司 | 一种氯硝西泮有关物质b的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL120873A0 (en) | 1996-05-24 | 1997-09-30 | Tanabe Seiyaku Co | Process for preparing optically active 2-halogen-3-hydroxypropionic acid ester |
US6068991A (en) * | 1997-12-16 | 2000-05-30 | Bristol-Myers Squibb Company | High expression Escherichia coli expression vector |
WO2000004179A1 (en) | 1998-07-15 | 2000-01-27 | Bristol-Myers Squibb Company | Stereoselective reductive amination of ketones |
US6395767B2 (en) * | 2000-03-10 | 2002-05-28 | Bristol-Myers Squibb Company | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
US7420079B2 (en) | 2002-12-09 | 2008-09-02 | Bristol-Myers Squibb Company | Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof |
-
2005
- 2005-04-28 TW TW094113728A patent/TW200536827A/zh unknown
- 2005-05-02 US US11/119,552 patent/US7223573B2/en active Active
- 2005-05-03 WO PCT/US2005/015199 patent/WO2005108594A1/en active Application Filing
- 2005-05-03 AR ARP050101778A patent/AR048651A1/es not_active Application Discontinuation
- 2005-05-04 PE PE2005000497A patent/PE20060307A1/es not_active Application Discontinuation
-
2007
- 2007-04-18 US US11/736,786 patent/US7611880B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
TW200536827A (en) | 2005-11-16 |
US20050256019A1 (en) | 2005-11-17 |
US7223573B2 (en) | 2007-05-29 |
US7611880B2 (en) | 2009-11-03 |
AR048651A1 (es) | 2006-05-10 |
WO2005108594A1 (en) | 2005-11-17 |
US20070207527A1 (en) | 2007-09-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20060307A1 (es) | Proceso de amonolisis enzimatica para preparacion de compuestos intermediarios para inhibidores de dipeptidilo peptidasa iv | |
WO2005106011A3 (en) | Process for preparing dipeptidyl iv inhibitors and intermediates therefor | |
DK1633779T3 (da) | Oxidoreduktase fra Pichia capsulata | |
NO20064307L (no) | Inhibitorer av dipeptidylpeptidase IV for regulering av glukose metabolisme | |
WO2003092605A3 (en) | Protease inhibitors | |
MY141797A (en) | Biochemical synthesis of 6-amino caproic acid | |
UA93533C2 (en) | Insecticidal composition | |
PT1851322E (pt) | Processo para a redução enzimática enantiosselectiva de compostos cetónicos | |
EA200970050A1 (ru) | Ингибиторы пролилгидроксилаз | |
MX2008000529A (es) | Planta de produccion y metodo para convertir biomasa. | |
TW200712048A (en) | Process for the production of alkyl (meth)acrylates | |
NZ603236A (en) | Boronate ester compounds and pharmaceutical compositions thereof | |
HK1106518A1 (en) | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds | |
MX2009005391A (es) | Proceso para elaborar (met) acrilatos de alquilo utilizando una hidrolisis de cianohidrina enzimatica. | |
PE20070603A1 (es) | COMPOSICION FARMACEUTICA QUE COMPRENDE UN INHIBIDOR DE ESCUALENO SINTASA Y UN INHIBIDOR DE 3-HIDROXI-3-METILGLUTARIL-CoA-REDUCTASA (HMG-CoA) | |
MY139322A (en) | Method for producing 2-azetidinone derivative | |
TW200706951A (en) | Emireflective display and method thereof | |
DE602007010812D1 (de) | Mandelsäurederivate und deren herstellung | |
BRPI0418664A (pt) | método para produzir um derivado de ácido (met) acrìlico | |
DK1893633T3 (da) | Inhibitorer for det angiotensin I-omdannende enzym (ACE) | |
EP1884565A4 (en) | NOVEL MICROORGANISM, LIPID IMPROVEMENT AGENT AND PROCESS FOR PRODUCING 2-ACYL-LYSOPHOSPHOLIPID | |
GB2486113A (en) | An improved process for the synthesis of alkyl/aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof | |
SI2069517T1 (sl) | Postopek za proizvodnjo optiäśno aktivnega 2-benziloksicikloheksilamina | |
WO2008014811A8 (en) | PROCESS FOR THE PREPARATION OF ε-ALKOXYCARBONYLLYSINES AND THEIR ANALOGUES | |
TW200602496A (en) | Enzymatic process for deacetylation of a phenoxy-alkynyl acetate to the corresponding alcohol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |