PE20060289A1 - Derivados de indazol e indolona como inhibidores selectivos del receptor de dopamina d3 - Google Patents
Derivados de indazol e indolona como inhibidores selectivos del receptor de dopamina d3Info
- Publication number
- PE20060289A1 PE20060289A1 PE2005000570A PE2005000570A PE20060289A1 PE 20060289 A1 PE20060289 A1 PE 20060289A1 PE 2005000570 A PE2005000570 A PE 2005000570A PE 2005000570 A PE2005000570 A PE 2005000570A PE 20060289 A1 PE20060289 A1 PE 20060289A1
- Authority
- PE
- Peru
- Prior art keywords
- indazole
- alkyl
- dopamine
- ethyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A COMPUESTOS DERIVADOS DE INDAZOL E INDOLONA DE FORMULA I DONDE A ES N O C=O; X ES H, METILO, ETILO, ENTRE OTROS; --- REPRESENTA UN ENLACE SENCILLO CUANDO A ES N Y ESTA AUSENTE CUANDO A ES C=O; R1 SE SELECCIONA DE (II), (III) Y (IV) EN LAS QUE Z ES O O CH2; R2 ES H O ALQUILO C1-C6, ENTRE OTROS; R3 ES H O ALQUILO C1-C6, ENTRE OTROS; R4 ES H O ALQUILO C1-C6; R5 ES H, METILO, ETILO, METOXI O ETOXI; R6 ES ALQUILO C1-C6; R7 ES H O ALQUILO C1-C6, ENTRE OTROS; R8 ES H, ALQUILO C1-C6, FENILO O (CH2)FENILO; EN LOS QUE HETEROARILO ES UN ANILLO AROMATICO DE 5 A 7 MIEMBROS QUE CONTIENE DE 1 A 4 HETEROATOMOS SELECCIONADOS DE 0, S Y N; CON LAS CONDICIONES DE QUE Z ES O CUANDO A SEA C=O Y CUANDO A ES C=O, X ES H Y R1 ES (IV), ENTONCES R5 NO PUEDE SER H. TAMBIEN ESTA REFERIDA A COMPOSICIONES QUE COMPRENDEN ESTOS COMPUESTOS CUYOS PREFERIDOS SON 4-[(2R,5S)-5-METIL-4-PROPILMORFOLIN-2-IL]-1H-INDAZOL, 4-[1-(2-ETIL)AZETIDIN-3-IL]-1H-INDAZOL, 4-[1-(3-FENILPROPIL)AZETIDIN-3-IL]-1H-INDAZOL, ENTRE OTROS. DICHOS COMPUESTOS SON AGONISTAS SELECTIVOS DE LOS RECEPTORES DE DOPAMINA D3 Y SON UTILES PARA EL TRATAMIENTO DE LA DISFUNCION SEXUAL
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0411810A GB0411810D0 (en) | 2004-05-26 | 2004-05-26 | New indazole and indolone derivatives and their use as pharmaceuticals |
| GB0415455A GB0415455D0 (en) | 2004-07-09 | 2004-07-09 | New indazole and indolone derivatives and their use as pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060289A1 true PE20060289A1 (es) | 2006-04-22 |
Family
ID=35219654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000570A PE20060289A1 (es) | 2004-05-26 | 2005-05-23 | Derivados de indazol e indolona como inhibidores selectivos del receptor de dopamina d3 |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1753763B1 (es) |
| JP (2) | JP4093588B2 (es) |
| AP (1) | AP2006003823A0 (es) |
| AR (1) | AR049191A1 (es) |
| AT (1) | ATE404560T1 (es) |
| AU (1) | AU2005247696A1 (es) |
| BR (1) | BRPI0511533A (es) |
| CA (1) | CA2568050A1 (es) |
| CR (1) | CR8772A (es) |
| DE (1) | DE602005008954D1 (es) |
| EA (1) | EA200601985A1 (es) |
| EC (1) | ECSP067024A (es) |
| ES (1) | ES2308492T3 (es) |
| GT (1) | GT200500118A (es) |
| IL (1) | IL179365A0 (es) |
| MA (1) | MA28606B1 (es) |
| MX (1) | MXPA06013759A (es) |
| NL (1) | NL1029128C2 (es) |
| NO (1) | NO20065328L (es) |
| PA (1) | PA8635001A1 (es) |
| PE (1) | PE20060289A1 (es) |
| SV (1) | SV2005002128A (es) |
| TW (1) | TW200607500A (es) |
| UY (1) | UY28918A1 (es) |
| WO (1) | WO2005116027A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR078411A1 (es) | 2009-05-07 | 2011-11-09 | Lilly Co Eli | Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende |
| US9259409B2 (en) * | 2011-01-24 | 2016-02-16 | Inceptum Research & Therapeutics, Inc. | Compositions comprising a prostaglandin for treating neuropsychiatric conditions |
| CN107108556B (zh) * | 2014-11-03 | 2020-09-29 | 艾欧米制药有限公司 | 药用化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993023035A2 (en) * | 1992-05-18 | 1993-11-25 | Smithkline Beecham Plc | Use of indolone derivatives for the treatment of memory disorders, sexual dysfunction and parkinson's disease |
| WO1998035942A1 (en) * | 1997-02-18 | 1998-08-20 | American Home Products Corporation | 4-aminoethoxyindazole derivatives |
| GB0130219D0 (en) * | 2001-12-18 | 2002-02-06 | Pfizer Ltd | Compounds for the treatment of sexual dysfunction |
| RS51442B (en) * | 2002-12-10 | 2011-04-30 | Pfizer Inc. | MORPHOLINE DERIVATIVES USED AS DOPAMINE AGONISTS IN TREATMENT I.A. SEXUAL DYSFUNCTIONS |
-
2005
- 2005-05-17 BR BRPI0511533-7A patent/BRPI0511533A/pt not_active IP Right Cessation
- 2005-05-17 AT AT05742759T patent/ATE404560T1/de not_active IP Right Cessation
- 2005-05-17 AU AU2005247696A patent/AU2005247696A1/en not_active Abandoned
- 2005-05-17 EP EP05742759A patent/EP1753763B1/en active Active
- 2005-05-17 WO PCT/IB2005/001513 patent/WO2005116027A2/en active IP Right Grant
- 2005-05-17 CA CA002568050A patent/CA2568050A1/en not_active Abandoned
- 2005-05-17 EA EA200601985A patent/EA200601985A1/ru unknown
- 2005-05-17 JP JP2007514182A patent/JP4093588B2/ja not_active Expired - Fee Related
- 2005-05-17 AP AP2006003823A patent/AP2006003823A0/xx unknown
- 2005-05-17 ES ES05742759T patent/ES2308492T3/es active Active
- 2005-05-17 DE DE602005008954T patent/DE602005008954D1/de not_active Expired - Fee Related
- 2005-05-17 MX MXPA06013759A patent/MXPA06013759A/es unknown
- 2005-05-20 GT GT200500118A patent/GT200500118A/es unknown
- 2005-05-23 PE PE2005000570A patent/PE20060289A1/es not_active Application Discontinuation
- 2005-05-24 AR ARP050102145A patent/AR049191A1/es unknown
- 2005-05-24 UY UY28918A patent/UY28918A1/es not_active Application Discontinuation
- 2005-05-25 TW TW094117076A patent/TW200607500A/zh unknown
- 2005-05-25 NL NL1029128A patent/NL1029128C2/nl not_active IP Right Cessation
- 2005-05-26 SV SV2005002128A patent/SV2005002128A/es not_active Application Discontinuation
- 2005-05-26 PA PA20058635001A patent/PA8635001A1/es unknown
-
2006
- 2006-11-16 IL IL179365A patent/IL179365A0/en unknown
- 2006-11-20 NO NO20065328A patent/NO20065328L/no unknown
- 2006-11-24 CR CR8772A patent/CR8772A/es unknown
- 2006-11-24 MA MA29487A patent/MA28606B1/fr unknown
- 2006-11-24 EC EC2006007024A patent/ECSP067024A/es unknown
-
2007
- 2007-12-11 JP JP2007320093A patent/JP2008074874A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CR8772A (es) | 2006-12-13 |
| AR049191A1 (es) | 2006-07-05 |
| BRPI0511533A (pt) | 2008-01-02 |
| TW200607500A (en) | 2006-03-01 |
| AU2005247696A1 (en) | 2005-12-08 |
| NL1029128C2 (nl) | 2006-06-14 |
| ES2308492T3 (es) | 2008-12-01 |
| CA2568050A1 (en) | 2005-12-08 |
| EA200601985A1 (ru) | 2007-04-27 |
| JP4093588B2 (ja) | 2008-06-04 |
| UY28918A1 (es) | 2005-12-30 |
| ATE404560T1 (de) | 2008-08-15 |
| WO2005116027A3 (en) | 2006-04-13 |
| IL179365A0 (en) | 2007-03-08 |
| EP1753763B1 (en) | 2008-08-13 |
| MXPA06013759A (es) | 2007-02-08 |
| AP2006003823A0 (en) | 2006-12-31 |
| WO2005116027A2 (en) | 2005-12-08 |
| NO20065328L (no) | 2006-12-18 |
| DE602005008954D1 (de) | 2008-09-25 |
| GT200500118A (es) | 2006-01-10 |
| EP1753763A2 (en) | 2007-02-21 |
| ECSP067024A (es) | 2006-12-29 |
| MA28606B1 (fr) | 2007-05-02 |
| JP2008500329A (ja) | 2008-01-10 |
| NL1029128A1 (nl) | 2005-11-30 |
| JP2008074874A (ja) | 2008-04-03 |
| SV2005002128A (es) | 2005-12-13 |
| PA8635001A1 (es) | 2006-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |