PE20050473A1 - Nuevos derivados de pirimidin-2-amina - Google Patents
Nuevos derivados de pirimidin-2-aminaInfo
- Publication number
- PE20050473A1 PE20050473A1 PE2004000948A PE2004000948A PE20050473A1 PE 20050473 A1 PE20050473 A1 PE 20050473A1 PE 2004000948 A PE2004000948 A PE 2004000948A PE 2004000948 A PE2004000948 A PE 2004000948A PE 20050473 A1 PE20050473 A1 PE 20050473A1
- Authority
- PE
- Peru
- Prior art keywords
- amine
- pyrimidin
- pyridin
- substituents
- halogen
- Prior art date
Links
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical class NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- -1 -SH Chemical class 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- FHTSIFHJYGMMMD-UHFFFAOYSA-N [C]1=CC=CO1 Chemical class [C]1=CC=CO1 FHTSIFHJYGMMMD-UHFFFAOYSA-N 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200302275A ES2229928B1 (es) | 2003-10-02 | 2003-10-02 | Nuevos derivados de pirimidin-2-amina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050473A1 true PE20050473A1 (es) | 2005-08-24 |
Family
ID=34507890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000948A PE20050473A1 (es) | 2003-10-02 | 2004-09-28 | Nuevos derivados de pirimidin-2-amina |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20070265273A1 (https=) |
| EP (1) | EP1668000A1 (https=) |
| JP (1) | JP2007507443A (https=) |
| KR (1) | KR20060097010A (https=) |
| CN (1) | CN1886402A (https=) |
| AR (1) | AR046170A1 (https=) |
| AU (1) | AU2004283800B8 (https=) |
| BR (1) | BRPI0415324A (https=) |
| CA (1) | CA2540765A1 (https=) |
| CO (1) | CO5690593A2 (https=) |
| EC (1) | ECSP066426A (https=) |
| ES (1) | ES2229928B1 (https=) |
| IL (1) | IL174771A0 (https=) |
| MX (1) | MXPA06003525A (https=) |
| NO (1) | NO20061952L (https=) |
| NZ (1) | NZ546266A (https=) |
| PE (1) | PE20050473A1 (https=) |
| RU (1) | RU2006114746A (https=) |
| SG (1) | SG149077A1 (https=) |
| TW (1) | TW200526645A (https=) |
| UA (1) | UA82563C2 (https=) |
| UY (1) | UY28529A1 (https=) |
| WO (1) | WO2005040155A1 (https=) |
| ZA (1) | ZA200602139B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1799221A1 (en) | 2004-10-15 | 2007-06-27 | Cv Therapeutics, Inc. | Method of preventing and treating airway remodeling and pulmonary inflammation using a2b adenosine receptor antagonists |
| ES2270715B1 (es) * | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| ES2274712B1 (es) * | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| DE102006046410A1 (de) * | 2006-09-20 | 2008-03-27 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Prophylaxe oder Behandlung oder Diagnostik von ischämischen Krankheiten |
| ES2303776B1 (es) * | 2006-12-29 | 2009-08-07 | Laboratorios Almirall S.A. | Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b. |
| ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
| KR20100020454A (ko) * | 2007-06-08 | 2010-02-22 | 바이엘 크롭사이언스 소시에떼아노님 | 살진균제 헤테로사이클릴-피리미디닐-아미노 유도체 |
| ES2394126T3 (es) * | 2007-07-26 | 2013-01-22 | Novartis Ag | Derivados de pirimidina útiles para el tratamiento de estados inflamatorios o alérgicos |
| CA2697077C (en) * | 2007-08-22 | 2012-10-16 | Irm Llc | 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors |
| CA2697081C (en) | 2007-08-22 | 2013-04-23 | Irm Llc | 5-(4-(haloalkoxy)phenyl)pyrimidine-2-amine compounds and compositions as kinase inhibitors |
| EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
| EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
| AR079545A1 (es) | 2009-12-21 | 2012-02-01 | Bayer Cropscience Ag | Tienilpiri(mi)dinilazol |
| SI2531492T1 (sl) * | 2010-02-05 | 2016-08-31 | Heptares Therapeutics Limited | Derivati 1,2,4-triazin-4-amina |
| AU2011346567A1 (en) | 2010-12-21 | 2013-07-25 | Novartis Ag | Bi-heteroaryl compounds as Vps34 inhibitors |
| US20200345725A1 (en) | 2019-01-11 | 2020-11-05 | Omeros Corporation | Methods and Compositions for Treating Cancer |
| CN112592346B (zh) | 2019-07-30 | 2022-04-26 | 厦门宝太生物科技股份有限公司 | 一种a2a和/或a2b抑制剂中间体的制备方法 |
| CN111825698B (zh) | 2019-07-30 | 2021-10-15 | 杭州阿诺生物医药科技有限公司 | 腺苷受体拮抗剂 |
| CN115477653B (zh) * | 2022-10-11 | 2024-04-09 | 安徽省庆云医药股份有限公司 | 一种曲拉西利关键中间体及曲拉西利的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US42891A (en) * | 1864-05-24 | Improvement in water-engines | ||
| US23763A (en) * | 1859-04-26 | Method of adjusting the knives of rotary cutter-heads for planing wood | ||
| US176399A (en) * | 1876-04-18 | Improvement in boxes for packing crackers | ||
| US22106A (en) * | 1858-11-23 | Truss-bridge | ||
| US275038A (en) * | 1883-04-03 | Ors to themselves | ||
| GB9309573D0 (en) * | 1993-05-10 | 1993-06-23 | Merck Sharp & Dohme | Therapeutic agents |
| US5686470A (en) * | 1995-02-10 | 1997-11-11 | Weier; Richard M. | 2, 3-substituted pyridines for the treatment of inflammation |
| KR20070058022A (ko) * | 2000-04-26 | 2007-06-07 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 배변을 촉진하는 의약 조성물 |
| US6641549B2 (en) * | 2001-02-05 | 2003-11-04 | Bsn Medical, Inc. | Custom-moldable support for patellar tendinitis |
| TWI330183B (https=) * | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
| US20050043315A1 (en) * | 2002-01-02 | 2005-02-24 | Hideo Tsutsumi | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them |
-
2003
- 2003-10-02 ES ES200302275A patent/ES2229928B1/es not_active Expired - Fee Related
-
2004
- 2004-09-21 UY UY28529A patent/UY28529A1/es not_active Application Discontinuation
- 2004-09-22 EP EP04765506A patent/EP1668000A1/en not_active Withdrawn
- 2004-09-22 CN CNA2004800346926A patent/CN1886402A/zh active Pending
- 2004-09-22 NZ NZ546266A patent/NZ546266A/en unknown
- 2004-09-22 MX MXPA06003525A patent/MXPA06003525A/es unknown
- 2004-09-22 BR BRPI0415324-3A patent/BRPI0415324A/pt not_active IP Right Cessation
- 2004-09-22 UA UAA200604615A patent/UA82563C2/uk unknown
- 2004-09-22 JP JP2006530007A patent/JP2007507443A/ja active Pending
- 2004-09-22 WO PCT/EP2004/010644 patent/WO2005040155A1/en not_active Ceased
- 2004-09-22 RU RU2006114746/04A patent/RU2006114746A/ru not_active Application Discontinuation
- 2004-09-22 AU AU2004283800A patent/AU2004283800B8/en not_active Ceased
- 2004-09-22 KR KR1020067006384A patent/KR20060097010A/ko not_active Ceased
- 2004-09-22 CA CA002540765A patent/CA2540765A1/en not_active Abandoned
- 2004-09-22 ZA ZA200602139A patent/ZA200602139B/en unknown
- 2004-09-22 US US10/574,101 patent/US20070265273A1/en not_active Abandoned
- 2004-09-22 SG SG200809684-4A patent/SG149077A1/en unknown
- 2004-09-28 PE PE2004000948A patent/PE20050473A1/es not_active Application Discontinuation
- 2004-09-30 AR ARP040103547A patent/AR046170A1/es unknown
- 2004-09-30 TW TW093129574A patent/TW200526645A/zh unknown
-
2006
- 2006-03-16 EC EC2006006426A patent/ECSP066426A/es unknown
- 2006-03-31 CO CO06032147A patent/CO5690593A2/es not_active Application Discontinuation
- 2006-04-03 IL IL174771A patent/IL174771A0/en unknown
- 2006-05-02 NO NO20061952A patent/NO20061952L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UY28529A1 (es) | 2005-04-29 |
| CN1886402A (zh) | 2006-12-27 |
| RU2006114746A (ru) | 2007-11-20 |
| NZ546266A (en) | 2008-10-31 |
| ECSP066426A (es) | 2006-10-17 |
| AU2004283800A1 (en) | 2005-05-06 |
| CA2540765A1 (en) | 2005-05-06 |
| CO5690593A2 (es) | 2006-10-31 |
| AU2004283800B2 (en) | 2009-05-07 |
| EP1668000A1 (en) | 2006-06-14 |
| IL174771A0 (en) | 2006-08-20 |
| KR20060097010A (ko) | 2006-09-13 |
| BRPI0415324A (pt) | 2006-12-05 |
| MXPA06003525A (es) | 2006-06-08 |
| NO20061952L (no) | 2006-06-26 |
| UA82563C2 (uk) | 2008-04-25 |
| AR046170A1 (es) | 2005-11-30 |
| WO2005040155A1 (en) | 2005-05-06 |
| JP2007507443A (ja) | 2007-03-29 |
| TW200526645A (en) | 2005-08-16 |
| US20070265273A1 (en) | 2007-11-15 |
| ES2229928B1 (es) | 2006-07-01 |
| ZA200602139B (en) | 2007-06-27 |
| WO2005040155A8 (en) | 2006-04-20 |
| SG149077A1 (en) | 2009-01-29 |
| ES2229928A1 (es) | 2005-04-16 |
| AU2004283800B8 (en) | 2009-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |