PE20040673A1 - Derivados de la ciclohexilurea - Google Patents

Derivados de la ciclohexilurea

Info

Publication number
PE20040673A1
PE20040673A1 PE2003001137A PE2003001137A PE20040673A1 PE 20040673 A1 PE20040673 A1 PE 20040673A1 PE 2003001137 A PE2003001137 A PE 2003001137A PE 2003001137 A PE2003001137 A PE 2003001137A PE 20040673 A1 PE20040673 A1 PE 20040673A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
substituted
cycloalkyl
heteroaryl
Prior art date
Application number
PE2003001137A
Other languages
English (en)
Inventor
Claudia Hinze
Hans Schick
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20040673A1 publication Critical patent/PE20040673A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/14—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE LA CICLOHEXILUREA DE FORMULA I, DONDE n ES 0 A 3; m ES 0 A 2; X ES O o S (CUANDO m=0); R1 Y R2 SON H, ALQUILO(C1-C8) O CICLOALQUILO(C3-C8), OPCIONALMENTE SATURADOS, RAMIFICADOS Y SUSTITUIDOS, ARILO O HETEROARILO, SUSTITUIDOS O NO, O ARILO, CICLOALQUILO(C3-C8) O HETEROARILO, ENLAZADO A ALQUILENO(C1-C3), O R1 Y R2 JUNTOS FORMAN UN ANILLO Y REPRESENTAN CH2CH2OCH2CH2, CH2CH2NR6CH2CH2 O (CH2)3-6; R3 ES ALQUILO(C1-C8) O CICLOALQUILO(C3-C8), OPCIONALMENTE SATURADOS, RAMIFICADOS Y SUSTITUIDOS; ARILO O HETEROARILO, SUSTITUIDOS NO, ARILO, CICLOALQUILO(C3-C8) O HETEROARILO, ENLAZADO POR ALQUILO(C1-C4); R4 ES H, ALQUILO(C1-C8) OPCIONALMENTE SATURADOS, RAMIFICADOS Y SUSTITUIDOS, O ES (CH2)o-W-(CH2)p-H; R5 CUANDO m ES DIFERENTE DE 0, ES (CH2)qR12, C(Y)ZR12, C(Y)OZR12; O BIEN R5, CUANDO m ES 0, ES CICLOALQUILO(C3-C8), ARILO O HETEROARILO, SUSTITUIDOS O NO; O ES (CH2)qR12. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE 1-(4-DIMETILAMINO-4-FENILCICLOHEXIL)3-(FENILPROPIL)-UREA; CLOHIDRATO DE 1-(4-DIMETILAMINO-4-FENILCICLOHEXIL)3-[2-(1H-INDOL-3-ILO)-ETIL]-UREA; CLORHIDRATO DE N-[(4-DIMETILAMINO-4-FENILCICLOHEXIL-CARBAMOIL)-METIL]-3-(1H-INDOL-3-ILO)-BUTIRAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA OBTENCION DE ESTOS DERIVADOS. ESTOS COMPUESTOS INFLUYEN SOBRE EL SISTEMA NOCICEPTINA/RECEPTOR ORL1 Y SON UTILES PARA EL TRATAMIENTO DEL DOLOR, DOLOR AGUDO, VISCERAL O CRONICO, Y TAMBIEN PARA ESTADOS DE ANGUSTIA, ESTRES Y DE SINDROMES RELACIONADOS
PE2003001137A 2002-11-11 2003-11-11 Derivados de la ciclohexilurea PE20040673A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10252650A DE10252650A1 (de) 2002-11-11 2002-11-11 Cyclohexyl-Harnstoff-Derivate

Publications (1)

Publication Number Publication Date
PE20040673A1 true PE20040673A1 (es) 2004-09-25

Family

ID=32185549

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001137A PE20040673A1 (es) 2002-11-11 2003-11-11 Derivados de la ciclohexilurea

Country Status (9)

Country Link
US (1) US7348354B2 (es)
EP (1) EP1560809B1 (es)
AR (1) AR041931A1 (es)
AT (1) ATE370929T1 (es)
AU (1) AU2003287992A1 (es)
DE (2) DE10252650A1 (es)
ES (1) ES2293053T3 (es)
PE (1) PE20040673A1 (es)
WO (1) WO2004043909A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2860514A1 (fr) * 2003-10-03 2005-04-08 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023508A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Säurederivate substituierter Cyclohexyl-1,4-diamine
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
DE102004023501A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate
AR070398A1 (es) 2008-02-22 2010-03-31 Gruenenthal Chemie Derivados sustituidos de indol
TWI466866B (zh) 2008-03-27 2015-01-01 被取代之環己基二胺
NZ587831A (en) 2008-03-27 2012-03-30 Gruenenthal Chemie Substituted spirocyclic cyclohexane derivatives
DK2257526T3 (da) 2008-03-27 2012-02-06 Gruenenthal Gmbh Spiro(5,5)undecan-derivater
AU2009228637B2 (en) 2008-03-27 2013-12-19 Grunenthal Gmbh (Hetero-)aryl cyclohexane derivatives
CL2009000734A1 (es) 2008-03-27 2009-05-15 Gruenenthal Chemie Compuestos derivados de 4-aminociclohexano sustituido; composicion farmaceutica que comprende a dichos compuestos; y su uso como moduladores del receptor de opioides u y el receptor orl-1 en el tratamiento de la ansiedad, estres, depresion, epilepsia y alzheimer.
MX2010010448A (es) 2008-03-27 2010-11-05 Gruenenthal Gmbh Hidroximetilciclohexil aminas.
BRPI1004176A2 (pt) * 2010-10-25 2015-08-11 Univ Rio De Janeiro Compostos aril e/ou hetero aril uréias funcionalizados; processo de síntese desses composto; composição farmacêutica contendo tais compostos e usos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1179200B (de) * 1960-01-26 1964-10-08 Hoechst Ag Verfahren zur Herstellung von N-Benzolsulfonyl-N'-methyl-cyclohexylharnstoffen
US4656182A (en) * 1983-12-06 1987-04-07 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
DE69515465T2 (de) * 1994-11-04 2000-08-03 Santen Pharmaceutical Co Ltd Neue hydroxy-substituierte 1,3-dialkyl-harnstoffderivate
DE19756036A1 (de) * 1997-12-17 1999-06-24 Merck Patent Gmbh Amid- und Harnstoffderivate
WO2001083452A1 (fr) * 2000-04-28 2001-11-08 Asahi Kasei Kabushiki Kaisha Nouveaux composes tricycliques
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
GB0100623D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds IV
DE10123163A1 (de) * 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate

Also Published As

Publication number Publication date
DE10252650A1 (de) 2004-05-27
DE50308027D1 (en) 2007-10-04
ATE370929T1 (de) 2007-09-15
EP1560809A1 (de) 2005-08-10
EP1560809B1 (de) 2007-08-22
ES2293053T3 (es) 2008-03-16
AU2003287992A1 (en) 2004-06-03
US7348354B2 (en) 2008-03-25
WO2004043909A1 (de) 2004-05-27
US20050261358A1 (en) 2005-11-24
AR041931A1 (es) 2005-06-01

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