PE20040363A1 - DERIVATIVES OF HYDROXY TETRAHYDRO-NAPHTHALENYLUREA - Google Patents
DERIVATIVES OF HYDROXY TETRAHYDRO-NAPHTHALENYLUREAInfo
- Publication number
- PE20040363A1 PE20040363A1 PE2003000445A PE2003000445A PE20040363A1 PE 20040363 A1 PE20040363 A1 PE 20040363A1 PE 2003000445 A PE2003000445 A PE 2003000445A PE 2003000445 A PE2003000445 A PE 2003000445A PE 20040363 A1 PE20040363 A1 PE 20040363A1
- Authority
- PE
- Peru
- Prior art keywords
- hydroxy
- tetrahydro
- naphthalenyl
- naphthalenylurea
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UN DERIVADO DE HIDROXI-TETRAHIDRO-NAFTALENILUREA, SUS FORMAS TAUTOMERICAS Y ESTEREOISOMERICA Y SALES DEL MISMO, DE FORMULA I, DONDE X ES (a) O (b); Y ES UN ENLACE DIRECTO; R1, R2 Y R3 SON H, HALOGENO, HIDROXI, ENTRE OTROS; Z1 ES H O ALQUILO C1-C6; Z2 ES H, HALOGENO O ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS N-[4-CLORO-3-(TRIFLUOROMETIL)FENIL]-N'-(7-HIDROXI-5,6,7,8-TETRAHIDRO-1-NAFTALENIL)UREA, N-(3-CLOROFENIL)-N'-(7-HIDROXI-5,6,7,8-TETRAHIDRO-1-NAFTALENIL)UREA Y 3-({[(7-HIDROXI-5,6,7,8-TETRAHIDRO-1-NAFTALENIL)AMINO]CARBONIL}AMINO)BENZOATO DE ETILO; SE REFIERE TAMBIEN A COMPOSICIONES FARMACEUTICAS ANTAGONISTAS DE VR-1 UTILES EN EL TRATAMIENTO Y PROFILAXIS DE ENFERMEDADES ASOCIADAS A TRASTORNOS UROLOGICOS, TRASTORNOS RELACIONADOS A DOLOR, TRASTORNOS INFLAMATORIOS Y TRASTORNOS NEUROLOGICOSREFERS TO A DERIVATIVE OF HYDROXY-TETRAHYDRO-NAPHTHALENYLUREA, ITS TAUTOMERIC AND STEREOISOMERIC FORMS AND SALTS OF THE SAME, OF FORMULA I, WHERE X IS (a) OR (b); AND IT IS A DIRECT LINK; R1, R2 AND R3 ARE H, HALOGEN, HYDROXY, AMONG OTHERS; Z1 IS H O C1-C6 ALKYL; Z2 IS H, HALOGEN OR C1-C6 ALKYL. PREFERRED COMPOUNDS ARE N- [4-CHLORO-3- (TRIFLUORomethyl) PHENYL] -N '- (7-HYDROXY-5,6,7,8-TETRAHYDRO-1-NAPHTHALENYL) UREA, N- (3-CHLOROPHENYL) - N '- (7-HYDROXY-5,6,7,8-TETRAHYDRO-1-NAPHTHALENYL) UREA AND 3 - ({[(7-HYDROXY-5,6,7,8-TETRAHYDRO-1-NAPHTHALENYL) AMINO] CARBONYL} AMINO) ETHYL BENZOATE; IT ALSO REFERS TO ANTAGONISTIC PHARMACEUTICAL COMPOSITIONS OF VR-1 USEFUL IN THE TREATMENT AND PROPHYLAXIS OF DISEASES ASSOCIATED WITH UROLOGIC DISORDERS, PAIN-RELATED DISORDERS, INFLAMMATORY DISORDERS AND NEUROLOGICAL DISORDERS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0210512.0A GB0210512D0 (en) | 2002-05-08 | 2002-05-08 | Tetrahydro-napthalene derivatives |
| GBGB0227262.3A GB0227262D0 (en) | 2002-05-08 | 2002-11-21 | Tetrahydro-naphthalene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040363A1 true PE20040363A1 (en) | 2004-07-03 |
Family
ID=9936269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000445A PE20040363A1 (en) | 2002-05-08 | 2003-05-07 | DERIVATIVES OF HYDROXY TETRAHYDRO-NAPHTHALENYLUREA |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR101000688B1 (en) |
| AR (1) | AR039983A1 (en) |
| CU (1) | CU23422B7 (en) |
| DO (1) | DOP2003000642A (en) |
| EC (1) | ECSP045413A (en) |
| GB (2) | GB0210512D0 (en) |
| GT (1) | GT200300102A (en) |
| MA (1) | MA30728B1 (en) |
| MY (1) | MY155011A (en) |
| PE (1) | PE20040363A1 (en) |
| PT (1) | PT1506167E (en) |
| UA (1) | UA77301C2 (en) |
| ZA (1) | ZA200408993B (en) |
-
2002
- 2002-05-08 GB GBGB0210512.0A patent/GB0210512D0/en not_active Ceased
- 2002-11-21 GB GBGB0227262.3A patent/GB0227262D0/en not_active Ceased
-
2003
- 2003-04-28 PT PT03722554T patent/PT1506167E/en unknown
- 2003-04-28 KR KR1020047017969A patent/KR101000688B1/en not_active IP Right Cessation
- 2003-04-28 UA UA20041210079A patent/UA77301C2/en unknown
- 2003-05-05 GT GT200300102A patent/GT200300102A/en unknown
- 2003-05-06 MY MYPI20031696A patent/MY155011A/en unknown
- 2003-05-07 DO DO2003000642A patent/DOP2003000642A/en unknown
- 2003-05-07 PE PE2003000445A patent/PE20040363A1/en not_active Application Discontinuation
- 2003-05-08 AR ARP030101614A patent/AR039983A1/en active IP Right Grant
-
2004
- 2004-11-04 CU CU20040254A patent/CU23422B7/en unknown
- 2004-11-05 ZA ZA2004/08993A patent/ZA200408993B/en unknown
- 2004-11-05 MA MA27935A patent/MA30728B1/en unknown
- 2004-11-08 EC EC2004005413A patent/ECSP045413A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200408993B (en) | 2006-01-25 |
| KR20040108784A (en) | 2004-12-24 |
| GB0210512D0 (en) | 2002-06-19 |
| CU23422B7 (en) | 2009-09-08 |
| MA30728B1 (en) | 2009-10-01 |
| PT1506167E (en) | 2007-12-10 |
| GB0227262D0 (en) | 2002-12-31 |
| UA77301C2 (en) | 2006-11-15 |
| AR039983A1 (en) | 2005-03-09 |
| DOP2003000642A (en) | 2003-11-15 |
| ECSP045413A (en) | 2005-01-03 |
| MY155011A (en) | 2015-08-28 |
| GT200300102A (en) | 2004-03-17 |
| KR101000688B1 (en) | 2010-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20040775A1 (en) | INDEOL DERIVATIVES AS ß2-ADRENORECEPTOR AGONISTS | |
| NZ539841A (en) | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | |
| FI943948A0 (en) | Heterocyclic carbonic acid derivatives | |
| IS1959B (en) | Benzimidazole compounds, pharmaceutical compositions containing the compounds and their use | |
| ATE275552T1 (en) | 1-SUBSTITUTED-1-AMINOMETHYL-CYCLOALKAN DERIVATIVES (= GABAPENTIN ANALOGUE), THEIR PRODUCTION AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES | |
| MY135841A (en) | Novel benzodioxoles | |
| DK2314582T3 (en) | Heterocyclic compounds as antiviral agents | |
| WO2007071632A3 (en) | 2-pyridin-2-yl-quinazoline derivatives as potassium channel modulating agents for the treatment of respiratory diseases | |
| BR0307060A (en) | n- (phenyl-4-substituted) -anthanilic acid hydroxamate esters | |
| BR0307071A (en) | n- (phenyl-4-substituted) -anthanilic acid hydroxamate esters | |
| DK1725536T3 (en) | Imidazoline derivatives with CB1 antagonistic activity | |
| TNSN04165A1 (en) | Substituted hydroxyethylamines | |
| PE20040728A1 (en) | CASPASE INHIBITORS | |
| ES2421948T3 (en) | Compounds and compositions for delivering active agents | |
| NO20022470D0 (en) | pyrimidine | |
| BRPI0417858A (en) | compound, pharmaceutical composition, and use of a pharmaceutical composition | |
| PA8573501A1 (en) | BENZOXAZINE DERIVATIVES AND THEIR EMPLOYMENT | |
| PE20030726A1 (en) | 4-SUBSTITUTED PHENYLTEHYDROISOQUINOLINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM | |
| SE0201194D0 (en) | New compounds | |
| IS5401A (en) | Composition of monoamine oxidase inhibitor and h5-HT1B antagonist or agonist with partial action | |
| HRP20080544T3 (en) | Benzothiazole formulations and use thereof | |
| ATE388939T1 (en) | N-((PIPERAZINYL)HETARYL)ARYLSULFONAMIDE DERIVATIVES WITH AFFINITY FOR THE DOPAMINE D3 RECEPTOR | |
| CY1108837T1 (en) | New aminopyridine derivatives as mGluR5 antagonists | |
| CA2508845A1 (en) | Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists | |
| ATE469148T1 (en) | 2-(BENZIMIDAZOLE-1YL)-N-(4-PHENYLTHIAZOLE-2-YL)ACETAMIDE DERIVATIVES SUITABLE FOR THE TREATMENT OF TRPV1-RELATED DISEASES |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |