CU23422B7 - HIDROXI-TETRAHIDRO-NAFTALENILUREA DERIVATIVES - Google Patents
HIDROXI-TETRAHIDRO-NAFTALENILUREA DERIVATIVESInfo
- Publication number
- CU23422B7 CU23422B7 CU20040254A CU20040254A CU23422B7 CU 23422 B7 CU23422 B7 CU 23422B7 CU 20040254 A CU20040254 A CU 20040254A CU 20040254 A CU20040254 A CU 20040254A CU 23422 B7 CU23422 B7 CU 23422B7
- Authority
- CU
- Cuba
- Prior art keywords
- pain
- derivatives
- tetrahydro
- useful
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Esta invención se refiere a derivados de tetrahidro-naftaleno y a sales del mismo que son útiles como ingredientes activo de preparaciones farcéuticas. Los derivados de tetrahidro-naftaleno de la presente invención tienen una excelente actividad como antagonista de VR1 y es útil para la prevención y tratamiento de enfermedades relacianadas con la actividad de VR1, en particular para el tratamiento de incontinencia urinaria de urgencia , vejiga hiperactiva, dolor crónico, dolor neuropático, dolor postoperatorio, dolor por artritis reumatoide, neuralgia, neuropatías, algesia, lesión nerviosa, isquemia, neurodegeneración, apoplejía, incontinencia, trastornos inflamatorios, asma y COPD.This invention relates to tetrahydro-naphthalene derivatives and salts thereof that are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as an antagonist of VR1 and is useful for the prevention and treatment of diseases related to the activity of VR1, in particular for the treatment of urinary incontinence of urgency, overactive bladder, pain Chronic, neuropathic pain, postoperative pain, rheumatoid arthritis pain, neuralgia, neuropathies, algesia, nerve injury, ischemia, neurodegeneration, stroke, incontinence, inflammatory disorders, asthma and COPD.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0210512.0A GB0210512D0 (en) | 2002-05-08 | 2002-05-08 | Tetrahydro-napthalene derivatives |
GBGB0227262.3A GB0227262D0 (en) | 2002-05-08 | 2002-11-21 | Tetrahydro-naphthalene derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CU23422B7 true CU23422B7 (en) | 2009-09-08 |
Family
ID=9936269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20040254A CU23422B7 (en) | 2002-05-08 | 2004-11-04 | HIDROXI-TETRAHIDRO-NAFTALENILUREA DERIVATIVES |
Country Status (13)
Country | Link |
---|---|
KR (1) | KR101000688B1 (en) |
AR (1) | AR039983A1 (en) |
CU (1) | CU23422B7 (en) |
DO (1) | DOP2003000642A (en) |
EC (1) | ECSP045413A (en) |
GB (2) | GB0210512D0 (en) |
GT (1) | GT200300102A (en) |
MA (1) | MA30728B1 (en) |
MY (1) | MY155011A (en) |
PE (1) | PE20040363A1 (en) |
PT (1) | PT1506167E (en) |
UA (1) | UA77301C2 (en) |
ZA (1) | ZA200408993B (en) |
-
2002
- 2002-05-08 GB GBGB0210512.0A patent/GB0210512D0/en not_active Ceased
- 2002-11-21 GB GBGB0227262.3A patent/GB0227262D0/en not_active Ceased
-
2003
- 2003-04-28 PT PT03722554T patent/PT1506167E/en unknown
- 2003-04-28 UA UA20041210079A patent/UA77301C2/en unknown
- 2003-04-28 KR KR1020047017969A patent/KR101000688B1/en not_active IP Right Cessation
- 2003-05-05 GT GT200300102A patent/GT200300102A/en unknown
- 2003-05-06 MY MYPI20031696A patent/MY155011A/en unknown
- 2003-05-07 PE PE2003000445A patent/PE20040363A1/en not_active Application Discontinuation
- 2003-05-07 DO DO2003000642A patent/DOP2003000642A/en unknown
- 2003-05-08 AR ARP030101614A patent/AR039983A1/en active IP Right Grant
-
2004
- 2004-11-04 CU CU20040254A patent/CU23422B7/en unknown
- 2004-11-05 MA MA27935A patent/MA30728B1/en unknown
- 2004-11-05 ZA ZA2004/08993A patent/ZA200408993B/en unknown
- 2004-11-08 EC EC2004005413A patent/ECSP045413A/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200408993B (en) | 2006-01-25 |
DOP2003000642A (en) | 2003-11-15 |
AR039983A1 (en) | 2005-03-09 |
PT1506167E (en) | 2007-12-10 |
ECSP045413A (en) | 2005-01-03 |
GB0227262D0 (en) | 2002-12-31 |
MY155011A (en) | 2015-08-28 |
GT200300102A (en) | 2004-03-17 |
KR101000688B1 (en) | 2010-12-10 |
KR20040108784A (en) | 2004-12-24 |
GB0210512D0 (en) | 2002-06-19 |
MA30728B1 (en) | 2009-10-01 |
UA77301C2 (en) | 2006-11-15 |
PE20040363A1 (en) | 2004-07-03 |
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