PE20010705A1 - Uso de secrecion apo b/inhibidores mtp - Google Patents

Uso de secrecion apo b/inhibidores mtp

Info

Publication number
PE20010705A1
PE20010705A1 PE2000001207A PE0012072000A PE20010705A1 PE 20010705 A1 PE20010705 A1 PE 20010705A1 PE 2000001207 A PE2000001207 A PE 2000001207A PE 0012072000 A PE0012072000 A PE 0012072000A PE 20010705 A1 PE20010705 A1 PE 20010705A1
Authority
PE
Peru
Prior art keywords
butyl
isoindol
fluorene
carboxamide
piperidinyl
Prior art date
Application number
PE2000001207A
Other languages
English (en)
Inventor
Kristin Marie Lundy
Bradley Paul Morgan
Charles Edward Chandler
Mary Anne Hickman
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20010705A1 publication Critical patent/PE20010705A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMPOSICION QUE COMPRENDE APOLIPOPROTEINA B/INHIBIDOR DE PROTEINAS DE TRANSFERENCIA DE TRIGLICERIDOS MICROSOMICOS TAL COMO i)UN COMPUESTO DE FORMULA I DONDE L ES X-Y-Z; X ES CH2, CO, CS, SO2; Y ES UN ENLACE, HIDROCARBILENOS ALIFATICOS; Z ES H, HALOGENO, CIANO, OH, ALCOXI C1-C10, ACILO C1-C10, ALQUILAMINO C1-C10, VINILO, ARILOXI C6-C10, HETEROCICLILO, ENTRE OTROS; SIEMPRE QUE X ES CH2, Y ES UN ENLACE; SON COMPUESTOS PREFERIDOS 4`-TRIFLUOROMETIL-BIFENIL-2-ACIDO CARBOXILICO-(2-BUTIL-1,2,3,4-TETRAHIDROISOQUINOLIN-6-IL)AMIDA, 4'-TRIFLUOROMETIL-BIFENIL-2-ACIDO CARBOXILICO-[2-(2-ACETILAMINOETIL)-1,2,3,4-TETRAHIDROISOQUINOLIN-6-IL AMIDA, 9-[4-[4-(2,3-DIHIDRO-1-OXO-1H-ISOINDOL-2-IL)-1-PIPERIDINIL]BUTIL]-N-PROPIL-9H-FLUORENO-9-CARBOXAMIDA; 2-[1-(3,3-DIFENILPROPIL)-4-PIPERIDINIL]-2,3-DIHIDRO-1H-ISOINDOL-1-ONA; 9-[4-(4-[2-(4-TRIFLUOROMETILFENIL)BENZOILAMINO]PIPERIDIN-1-IL)BUTIL]-N-2,2,2-TRIFLUOROETIL)-9H-FLUORENO-9-CARBOXAMIDA; b)9-[4-[4-(2,3-DIHIDRO-1-OXO-1H-ISOINDOL-2-IL)-1-IL)-1-PIPERIDINIL]-BUTIL]-N-PROPIL-9H-FLUORENO-9-CARBOXAMIDA Y UN AGENTE ANTIOBESIDAD TAL COMO SIBUTRAMINA, ORLISTAT, FENFLURAMINA, DEXFENFLURAMINA, BROMOCRIPTINA, FENTERMINA, EFEDRINA, LEPTINA, FENILPROPANOLAMINA, PSEUDOEFEDRINA, ENTRE OTROS. LA COMPOSICION PUEDE SER UTIL PARA REDUCIR LA ABSORCION DE GRASA INTESTINAL
PE2000001207A 1999-11-10 2000-11-10 Uso de secrecion apo b/inhibidores mtp PE20010705A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16454799P 1999-11-10 1999-11-10

Publications (1)

Publication Number Publication Date
PE20010705A1 true PE20010705A1 (es) 2001-07-11

Family

ID=22595001

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001207A PE20010705A1 (es) 1999-11-10 2000-11-10 Uso de secrecion apo b/inhibidores mtp

Country Status (11)

Country Link
EP (1) EP1099439A3 (es)
JP (1) JP2001172180A (es)
KR (1) KR20010051558A (es)
AU (1) AU6968700A (es)
CA (1) CA2324800A1 (es)
CO (1) CO5261534A1 (es)
HU (1) HUP0004461A3 (es)
IL (1) IL139448A0 (es)
NZ (1) NZ508059A (es)
PE (1) PE20010705A1 (es)
ZA (1) ZA200006419B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101838218A (zh) 2002-02-28 2010-09-22 日本烟草产业株式会社 酯化合物及其医药用途
US6825209B2 (en) 2002-04-15 2004-11-30 Research Triangle Institute Compounds having unique CB1 receptor binding selectivity and methods for their production and use
JP4832897B2 (ja) 2003-08-29 2011-12-07 日本たばこ産業株式会社 エステル誘導体及びその医薬用途
US20060084636A1 (en) * 2004-10-18 2006-04-20 Maria Alemany Methods of using fatty-acid esters of estrogens and serotonin reuptake inhibiting compounds for reducing the body weight of a mammal and compositions containing the same
US8101774B2 (en) 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
KR101129456B1 (ko) * 2004-10-25 2012-03-28 니뽄 다바코 산교 가부시키가이샤 용해성 및 안정성이 개선된 고형 제제 및 그의 제조 방법
KR20070072888A (ko) * 2004-10-25 2007-07-06 니뽄 다바코 산교 가부시키가이샤 용해성 및 안정성이 개선된 고형 제제 및 그의 제조 방법
US9035059B2 (en) * 2011-03-14 2015-05-19 Taisho Pharmaceutical Co., Ltd. Nitrogen-containing condensed heterocyclic compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU218419B (hu) * 1992-03-06 2000-08-28 E.R. Squibb And Sons, Inc. Mikroszomális triglicerid transzfer protein (MTP) nagy molekulatömegű alegységének rekombináns úton történő előállítására és a protein és inhibitorainak kimutatására szolgáló eljárások
US5474993A (en) * 1994-06-14 1995-12-12 Sterling Winthrop, Inc. Lactam inhibitors of cholesterol esterase
EP0832069B1 (en) * 1995-06-07 2003-03-05 Pfizer Inc. BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION
ATE223400T1 (de) * 1996-04-30 2002-09-15 Pfizer Verfahren und zwischenprodukte zur herstellung von 4-trifluoromethylbiphenyl-2-carbonsaüre,(2- (2h-(1,2,4) triazol-3-ylmethyl)-1,2,3,4- tetrahydro-isoquinolin-6-yl)-amide
KR100334567B1 (ko) * 1996-11-27 2002-05-03 디. 제이. 우드, 스피겔 알렌 제이 아포 비-분비/엠티피 억제성 아미드
US5968950A (en) * 1997-06-23 1999-10-19 Pfizer Inc Apo B-secretion/MTP inhibitor hydrochloride salt
IL133201A0 (en) * 1998-12-04 2001-03-19 Pfizer Prod Inc Lowering blood levels of lipoproten (a)

Also Published As

Publication number Publication date
CO5261534A1 (es) 2003-03-31
CA2324800A1 (en) 2001-05-10
EP1099439A2 (en) 2001-05-16
EP1099439A3 (en) 2003-03-26
NZ508059A (en) 2002-11-26
JP2001172180A (ja) 2001-06-26
HUP0004461A2 (hu) 2001-10-28
AU6968700A (en) 2001-05-17
HUP0004461A3 (en) 2004-04-28
IL139448A0 (en) 2001-11-25
KR20010051558A (ko) 2001-06-25
HU0004461D0 (es) 2001-01-29
ZA200006419B (en) 2002-05-08

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