PE20010587A1 - Composicion que comprende conjugados de polimeros funcionales como inhibidores de enzimas proteoliticas - Google Patents

Composicion que comprende conjugados de polimeros funcionales como inhibidores de enzimas proteoliticas

Info

Publication number
PE20010587A1
PE20010587A1 PE2000000929A PE0009292000A PE20010587A1 PE 20010587 A1 PE20010587 A1 PE 20010587A1 PE 2000000929 A PE2000000929 A PE 2000000929A PE 0009292000 A PE0009292000 A PE 0009292000A PE 20010587 A1 PE20010587 A1 PE 20010587A1
Authority
PE
Peru
Prior art keywords
alkylene
alkyl
proteolytic enzymes
conjugates
inhibitors
Prior art date
Application number
PE2000000929A
Other languages
English (en)
Inventor
Todd Laurence Underiner
Scott Eduard Osborn
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE20010587A1 publication Critical patent/PE20010587A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A UNA COMPOSICION QUE COMPRENDE: a)DE 0.01% EN PESO DE UNO O MAS CONJUGADOS DE POLIMERO [POLI]-[(L)z-T]i, DE PESO MOLECULAR DE 1000 A 8000 DALTON; T ES UN HETEROCICLICO: GRUPO a, b, L ES UN ENLACE: -(R11)h{(X)j[C(X)]k(X)j(R11)h(X)J[C(X)]j}f(R11)h-, (CH2)p, CO, CXNR10, ENTRE OTROS; R11 ES ALQUILENO C1-C12, ALQUENILENO C1-C12; [POLI] ES UNA UNIDAD POLIMERICA, i ES 1 A 100, z ES 0-1; X ES CH2, NH, O, S, CF2; D, E, F, G SON CH2, N, NH, O, S, CF2, H, ALQUILO C1-C18, CICLOALQUILO C3-C18, ALQUENILO C2-C18, (R1)n-R2, (CH2)mN(R3)2, (CH2)mN+(R3)3Y(-), -R8-R9, ENTRE OTROS; R1 ES ALQUILENO C1-C12, ALQUENILENO C2-C12, R2 ES ARIL C6-C18, n ES 1-16, R3 ES ALQUILO C1-C18, Y ES UN ANION, m ES 0-10, R8 ES (CH2)p, CO, C(X)NR10, ENTRE OTROS; R9 ES H, ALQUIL C1-C18, CICLOALQUIL C3-C18, ALQUENIL C2-C18, R10 ES H, ALQUILO C1-C4; X ES O, S, NR10; p ES 0-12; b)DE 0,01% EN PESO DE VEHICULOS E INGREDIENTES ADJUNTOS SIENDO EL INGREDIENTE ADJUNTO BIOLOGICAMENTE ACTIVO LA HEXAMIDINA Y LOS INGREDIENTES ADJUNTOS TAL COMO EMOLIENTES A BASE DE PETROLEO, ACIDOS GRASOS DEL ESTER DE SUCROSA, POLIETILENGLICOL, ENTRE OTROS. LA COMPOSICION COMPRENDE CONJUGADOS DE POLIMEROS QUE INHIBEN UNA O MAS ENZIMAS PROTEOLITICAS Y PREVIENEN LA IRRITACION DE LA PIEL AL ESTAR EXPUESTA A FLUIDOS CORPORALES COMO HECES Y FLUIDO MESTRUAL
PE2000000929A 1999-09-10 2000-09-08 Composicion que comprende conjugados de polimeros funcionales como inhibidores de enzimas proteoliticas PE20010587A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15341899P 1999-09-10 1999-09-10

Publications (1)

Publication Number Publication Date
PE20010587A1 true PE20010587A1 (es) 2001-07-07

Family

ID=22547144

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2000000929A PE20010587A1 (es) 1999-09-10 2000-09-08 Composicion que comprende conjugados de polimeros funcionales como inhibidores de enzimas proteoliticas
PE2000000928A PE20010586A1 (es) 1999-09-10 2000-09-08 Conjugados de polimeros funcionales que inhiben enzimas lipoliticas y/o proteoliticas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2000000928A PE20010586A1 (es) 1999-09-10 2000-09-08 Conjugados de polimeros funcionales que inhiben enzimas lipoliticas y/o proteoliticas

Country Status (9)

Country Link
US (1) US6541629B1 (es)
EP (2) EP1438073B1 (es)
JP (1) JP5020451B2 (es)
AR (2) AR022655A1 (es)
AT (2) ATE309824T1 (es)
AU (2) AU7125700A (es)
DE (2) DE60024101T2 (es)
PE (2) PE20010587A1 (es)
WO (2) WO2001017564A2 (es)

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US6803496B2 (en) 1997-09-10 2004-10-12 The Procter & Gamble Company Method for maintaining or improving skin health
US8907154B2 (en) 2001-10-01 2014-12-09 The Procter & Gamble Company Sanitary napkins with hydrophobic lotions
US8795716B2 (en) 2001-10-01 2014-08-05 The Procter & Gamble Company Skin care compositions on a thin sanitary napkin
US9035123B2 (en) 2002-10-01 2015-05-19 The Procter & Gamble Company Absorbent article having a lotioned topsheet
US7285570B2 (en) 2003-04-17 2007-10-23 The Procter & Gamble Company Compositions and methods for regulating mammalian keratinous tissue
JP5044214B2 (ja) * 2003-06-06 2012-10-10 アレクシス・アクチボラゲット 皮膚状態または癌の処置のためのｓｃｃｅ阻害剤としての縮合複素環化合物の使用
US7384113B2 (en) * 2004-04-19 2008-06-10 Hewlett-Packard Development Company, L.P. Fluid ejection device with address generator
US7642397B2 (en) * 2004-08-10 2010-01-05 Kimberly-Clark Worldwide, Inc. Absorbent articles comprising a bodily exudate modifying agent and a skin care formulation
US7265257B2 (en) * 2004-08-10 2007-09-04 Kimberly-Clark Worldwide, Inc. Absorbent articles comprising a bodily exudate modifying agent and a film-forming skin care formulation
WO2009102837A2 (en) * 2008-02-15 2009-08-20 The Procter & Gamble Company Absorbent article with lotion comprising a polypropylene glycol material
CN104583228B (zh) * 2012-08-24 2018-09-28 味之素株式会社 酰基二肽衍生物
JP7404031B2 (ja) 2019-10-29 2023-12-25 日本航空電子工業株式会社 アンテナ

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DE2433883C2 (de) * 1973-07-20 1986-03-27 Research Corp., New York, N.Y. Verwendung von physiologisch aktiven Polypeptiden
FR2252351A2 (en) 1973-11-28 1975-06-20 Air Liquide Isolation of enzymes by selective extraction - partition of polyinhibitor-enzyme complex between water and polyethylene glycol
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US5162307A (en) 1988-09-09 1992-11-10 Board Of Trustees Of The University Of Kentucky Polymer bound elastase inhibitors
FR2651125B1 (fr) * 1989-08-23 1992-10-02 Roussel Uclaf Compositions pharmaceutiques de type "pates a l'eau".
DE69120141T2 (de) 1990-03-28 1996-11-28 Nippon Oils & Fats Co Ltd Polymerkombiniertes Arzneimittel zur Magenbehandlung und Verfahren zu dessen Herstellung
JPH04182423A (ja) * 1990-11-16 1992-06-30 Shiseido Co Ltd 清浄・清拭剤組成物
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Also Published As

Publication number Publication date
EP1212097A2 (en) 2002-06-12
DE60024101D1 (de) 2005-12-22
EP1438073B1 (en) 2010-08-11
WO2001017565A3 (en) 2002-01-17
AU7126900A (en) 2001-04-10
JP5020451B2 (ja) 2012-09-05
JP2003508498A (ja) 2003-03-04
ATE476998T1 (de) 2010-08-15
DE60044827D1 (de) 2010-09-23
AR023271A1 (es) 2002-09-04
WO2001017564A2 (en) 2001-03-15
AU7125700A (en) 2001-04-10
WO2001017565A2 (en) 2001-03-15
PE20010586A1 (es) 2001-06-23
ATE309824T1 (de) 2005-12-15
WO2001017564A3 (en) 2002-01-24
DE60024101T2 (de) 2006-07-27
EP1212097B1 (en) 2005-11-16
US6541629B1 (en) 2003-04-01
EP1438073A2 (en) 2004-07-21
AR022655A1 (es) 2002-09-04

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