PE20000946A1 - Uso de derivados de tiazolidindiona para el tratamiento o prevencion de cataratas - Google Patents

Uso de derivados de tiazolidindiona para el tratamiento o prevencion de cataratas

Info

Publication number
PE20000946A1
PE20000946A1 PE1999000789A PE00078999A PE20000946A1 PE 20000946 A1 PE20000946 A1 PE 20000946A1 PE 1999000789 A PE1999000789 A PE 1999000789A PE 00078999 A PE00078999 A PE 00078999A PE 20000946 A1 PE20000946 A1 PE 20000946A1
Authority
PE
Peru
Prior art keywords
thiazolidindiona
alkyl
alcoxy
benzyl
rent
Prior art date
Application number
PE1999000789A
Other languages
English (en)
Inventor
John Hardwick Johnson
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PE20000946A1 publication Critical patent/PE20000946A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

SE REFIERE AL USO DE DERIVADOS DE TIAZOLIDINDIONA a)DE FORMULA (I), DONDE: R1 Y R2 SON H o ALQUIL C1-C5; R3 Y R6 SON H, ACILO ALIFATICO C1-C6, ACILO ACICLICO O AROMATICO, HETEROCICLO; R4 Y R5 SON H, ALQUIL C1-C5, ALCOXI C1-C5, O JUNTOS FORMAN ALQUILENDIOXI C1-C4; n ES DE 1 A 3; W ES CH2, CO, CHOR6; Y y Z SON O o NH; b)DE FORMULA (II), DONDE: R11 ES ALQUILO, ALCOXI, CICLOALQUILO, FENILO, ACILO AROMATICO, UN HETEROCICLO DE 5-6 MIEMBROS CON 1-2 N, O o S, NR13R14; R13 Y R14 SON ALQUILO O JUNTO CON N, O o S FORMAN UN ANILLO DE 5-6 MIEMBROS; R12 ES UN ENLACE O ALQUILENO; L1 Y L2 SON H, ALQUILO O FORMAN JUNTOS ALQUILENO; c)DE FORMULA (III), DONDE: R15 Y R16 SON H, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; n ES 0-4. SON COMPUESTOS PREFERIDOS (+)-5-[[4-[(3,4-DIHIDRO-6-HIDROXI-2,5,7,8-TETRAMETIL-2H-BENZOPIRAN-2-IL)METOXI]FENIL]METIL]-2,4-TIAZOLIDINDIONA (TROGLITAZONA); 5-(4-[2-(N-METIL-N-(2-PIRIDIL)AMINO)ETOXI]BENCIL)-2,4-TIAZOLIDINDIONA (ROSIGLITAZONA); 5-[p-[1-METILCICLOHEXIL)METOXI]BENCIL]-2,4-TIAZOLIDINDIONA (CIGLITAZONA) 5-[p-[2-(5-ETIL-2-PIRIDIL)ETOXI]BENCIL]-2,4-TIAZOLIDINDIONA (PIOGLITAZONA); 4-(2-NAFTILMETIL)-1,2,3,4,5-OXATIADIAZOL-2-OXIDO, ENTRE OTROS. LOS COMPUESTOS PUEDEN SER UTIL PARA TRATAR O PREVENIR CATARATAS
PE1999000789A 1998-08-06 1999-08-05 Uso de derivados de tiazolidindiona para el tratamiento o prevencion de cataratas PE20000946A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9551898P 1998-08-06 1998-08-06

Publications (1)

Publication Number Publication Date
PE20000946A1 true PE20000946A1 (es) 2000-10-18

Family

ID=22252372

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000789A PE20000946A1 (es) 1998-08-06 1999-08-05 Uso de derivados de tiazolidindiona para el tratamiento o prevencion de cataratas

Country Status (5)

Country Link
AR (1) AR021749A1 (es)
CO (1) CO5050324A1 (es)
PE (1) PE20000946A1 (es)
UY (1) UY25643A1 (es)
WO (1) WO2000007582A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201934529A (zh) * 2017-12-28 2019-09-01 國立大學法人福井大學 白內障之預防劑及/或治療劑、用於白內障之預防及/或治療之醫藥組合物、用於製造該等之ppar活性化劑之用途以及點眼劑

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
JPS62234085A (ja) * 1985-12-18 1987-10-14 Sankyo Co Ltd チアゾリジン誘導体を有効成分とする糖尿病性合併症治療剤
US4873255A (en) * 1987-02-04 1989-10-10 Sankyo Company Limited Thiazolidinone derivatives, their preparation and their use
CA2265656A1 (en) * 1996-09-12 1998-03-19 Sankyo Company, Limited Glutathione reductase activity potentiator containing troglitazone
CZ96798A3 (cs) * 1997-04-02 1998-10-14 Sankyo Company Limited Deriváty dithiolanu, jejich příprava a jejich terapeutické účinky

Also Published As

Publication number Publication date
WO2000007582A2 (en) 2000-02-17
AR021749A1 (es) 2002-08-07
WO2000007582A3 (en) 2000-06-22
UY25643A1 (es) 1999-11-17
CO5050324A1 (es) 2001-06-27

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal