PE13296A1 - Procedimiento para la preparacion de trihidrato de cefixima - Google Patents

Procedimiento para la preparacion de trihidrato de cefixima

Info

Publication number
PE13296A1
PE13296A1 PE1995270369A PE27036995A PE13296A1 PE 13296 A1 PE13296 A1 PE 13296A1 PE 1995270369 A PE1995270369 A PE 1995270369A PE 27036995 A PE27036995 A PE 27036995A PE 13296 A1 PE13296 A1 PE 13296A1
Authority
PE
Peru
Prior art keywords
tert
preparation
cefixima
trihydrate
procedure
Prior art date
Application number
PE1995270369A
Other languages
English (en)
Inventor
Carlos Picornell Darder
Original Assignee
Marcham Trading And Invest Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marcham Trading And Invest Ltd filed Critical Marcham Trading And Invest Ltd
Publication of PE13296A1 publication Critical patent/PE13296A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

SE REFIERE A LA PREPARACION DEL TRIHIDRATO DE CEFIXIMA DE FORMULA A; CARACTERIZADO PORQUE (a) SE HACE REACCIONAR UN DERIVADO FUNCIONAL DEL ACIDO (Z)-2-(2-AMINOTIAZOL-4-IL)-2-(TERC-BUTOXICARBONIL METOXIIMINO)ACETICO N-PROTEGIDO, QUE POSEE UN GRUPO PROTECTOR DE AMINA, DE PREFERENCIA FORMILO, TRITILO, BENCILOXICARBONILO, CON EL 7-AMINO-3 VINIL-3-CEFEM-4-CARBOXILATO DE TERC BUTILO O UNA DE SUS SALES, (b) SE OBTIENE UN PRODUCTO DEL QUE ES ELIMINADO EVENTUALMENTE EL GRUPO PROTECTOR USANDO METODOS TAL COMO HIDROLISIS CON ACIDO CLORHIDRICO EN METANOL LOGRANDOSE UN COMPUESTO ESPECIFICO CON TRICLORURO DE ALUMINIO Y ANISOL, DENOMINADO CEFIXIMA. ESTA CEFIXIMA OBTENIDA ES PRACTICAMENTE EXCENTA DE SU ISOMERO ANTI- CON RENDIMIENTO MUY ELEVADO, SUPERIORES A 80% Y HASTA 90%
PE1995270369A 1994-06-03 1995-06-02 Procedimiento para la preparacion de trihidrato de cefixima PE13296A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH01751/94A CH688319A5 (fr) 1994-06-03 1994-06-03 Procédé pour la préparation du céfixime trihydraté.

Publications (1)

Publication Number Publication Date
PE13296A1 true PE13296A1 (es) 1996-05-10

Family

ID=4217712

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995270369A PE13296A1 (es) 1994-06-03 1995-06-02 Procedimiento para la preparacion de trihidrato de cefixima

Country Status (9)

Country Link
EP (1) EP0763043B1 (es)
KR (1) KR100223384B1 (es)
AT (1) ATE171454T1 (es)
AU (1) AU2670295A (es)
CH (1) CH688319A5 (es)
DE (1) DE69504971T2 (es)
ES (1) ES2120911B1 (es)
PE (1) PE13296A1 (es)
WO (1) WO1995033753A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
AT404251B (de) * 1996-08-14 1998-10-27 Biochemie Gmbh Neues kristallines salz von cefixim
PT102061B (pt) * 1997-10-08 2000-06-30 J K Ind Ltd Processo de preparacao de um antibiotico cefalosporina geralmente activo-cefixime
US20040166434A1 (en) 2003-02-21 2004-08-26 Dammel Ralph R. Photoresist composition for deep ultraviolet lithography
DE602005012866D1 (de) * 2004-12-21 2009-04-02 Lupin Ltd Verfahren zur hestellung von cefixim
ES2334685T3 (es) 2005-03-29 2010-03-15 Hetero Drugs Limited Procedimiento mejorado de preparacion de cefixima.
CN1312158C (zh) * 2005-05-20 2007-04-25 天津市医药集团技术发展有限公司 一种头孢克肟的制备方法
WO2016142902A1 (en) * 2015-03-11 2016-09-15 Lupin Limited Cefixime with reduced surface area and high stability
CN111039958B (zh) * 2017-05-31 2022-05-20 郑州大学第一附属医院 头孢地尼的制备方法
JP2023011144A (ja) 2021-07-12 2023-01-24 ウシオ電機株式会社 光源装置、誘電体バリア放電ランプの点灯回路、誘電体バリア放電ランプの点灯方法
CN113968874B (zh) * 2021-10-29 2023-01-31 国药集团威奇达药业有限公司 头孢克肟的精制方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof

Also Published As

Publication number Publication date
ES2120911A1 (es) 1998-11-01
ATE171454T1 (de) 1998-10-15
AU2670295A (en) 1996-01-04
DE69504971T2 (de) 1999-05-20
KR970703348A (ko) 1997-07-03
WO1995033753A1 (fr) 1995-12-14
DE69504971D1 (de) 1998-10-29
EP0763043A1 (fr) 1997-03-19
CH688319A5 (fr) 1997-07-31
ES2120911B1 (es) 1999-07-01
KR100223384B1 (ko) 1999-10-15
EP0763043B1 (fr) 1998-09-23

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed