PE13296A1 - Procedimiento para la preparacion de trihidrato de cefixima - Google Patents
Procedimiento para la preparacion de trihidrato de cefiximaInfo
- Publication number
- PE13296A1 PE13296A1 PE1995270369A PE27036995A PE13296A1 PE 13296 A1 PE13296 A1 PE 13296A1 PE 1995270369 A PE1995270369 A PE 1995270369A PE 27036995 A PE27036995 A PE 27036995A PE 13296 A1 PE13296 A1 PE 13296A1
- Authority
- PE
- Peru
- Prior art keywords
- tert
- preparation
- cefixima
- trihydrate
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
SE REFIERE A LA PREPARACION DEL TRIHIDRATO DE CEFIXIMA DE FORMULA A; CARACTERIZADO PORQUE (a) SE HACE REACCIONAR UN DERIVADO FUNCIONAL DEL ACIDO (Z)-2-(2-AMINOTIAZOL-4-IL)-2-(TERC-BUTOXICARBONIL METOXIIMINO)ACETICO N-PROTEGIDO, QUE POSEE UN GRUPO PROTECTOR DE AMINA, DE PREFERENCIA FORMILO, TRITILO, BENCILOXICARBONILO, CON EL 7-AMINO-3 VINIL-3-CEFEM-4-CARBOXILATO DE TERC BUTILO O UNA DE SUS SALES, (b) SE OBTIENE UN PRODUCTO DEL QUE ES ELIMINADO EVENTUALMENTE EL GRUPO PROTECTOR USANDO METODOS TAL COMO HIDROLISIS CON ACIDO CLORHIDRICO EN METANOL LOGRANDOSE UN COMPUESTO ESPECIFICO CON TRICLORURO DE ALUMINIO Y ANISOL, DENOMINADO CEFIXIMA. ESTA CEFIXIMA OBTENIDA ES PRACTICAMENTE EXCENTA DE SU ISOMERO ANTI- CON RENDIMIENTO MUY ELEVADO, SUPERIORES A 80% Y HASTA 90%
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH01751/94A CH688319A5 (fr) | 1994-06-03 | 1994-06-03 | Procédé pour la préparation du céfixime trihydraté. |
Publications (1)
Publication Number | Publication Date |
---|---|
PE13296A1 true PE13296A1 (es) | 1996-05-10 |
Family
ID=4217712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1995270369A PE13296A1 (es) | 1994-06-03 | 1995-06-02 | Procedimiento para la preparacion de trihidrato de cefixima |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0763043B1 (es) |
KR (1) | KR100223384B1 (es) |
AT (1) | ATE171454T1 (es) |
AU (1) | AU2670295A (es) |
CH (1) | CH688319A5 (es) |
DE (1) | DE69504971T2 (es) |
ES (1) | ES2120911B1 (es) |
PE (1) | PE13296A1 (es) |
WO (1) | WO1995033753A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
AT404251B (de) * | 1996-08-14 | 1998-10-27 | Biochemie Gmbh | Neues kristallines salz von cefixim |
PT102061B (pt) * | 1997-10-08 | 2000-06-30 | J K Ind Ltd | Processo de preparacao de um antibiotico cefalosporina geralmente activo-cefixime |
US20040166434A1 (en) | 2003-02-21 | 2004-08-26 | Dammel Ralph R. | Photoresist composition for deep ultraviolet lithography |
US8008478B2 (en) | 2004-12-21 | 2011-08-30 | Lupin Limited | Process for the preparation of cefixime |
ES2334685T3 (es) | 2005-03-29 | 2010-03-15 | Hetero Drugs Limited | Procedimiento mejorado de preparacion de cefixima. |
CN1312158C (zh) * | 2005-05-20 | 2007-04-25 | 天津市医药集团技术发展有限公司 | 一种头孢克肟的制备方法 |
WO2016142902A1 (en) * | 2015-03-11 | 2016-09-15 | Lupin Limited | Cefixime with reduced surface area and high stability |
CN111039958B (zh) * | 2017-05-31 | 2022-05-20 | 郑州大学第一附属医院 | 头孢地尼的制备方法 |
JP2023011144A (ja) | 2021-07-12 | 2023-01-24 | ウシオ電機株式会社 | 光源装置、誘電体バリア放電ランプの点灯回路、誘電体バリア放電ランプの点灯方法 |
CN113968874B (zh) * | 2021-10-29 | 2023-01-31 | 国药集团威奇达药业有限公司 | 头孢克肟的精制方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
-
1994
- 1994-06-03 CH CH01751/94A patent/CH688319A5/fr not_active IP Right Cessation
-
1995
- 1995-05-10 DE DE69504971T patent/DE69504971T2/de not_active Expired - Fee Related
- 1995-05-10 AU AU26702/95A patent/AU2670295A/en not_active Abandoned
- 1995-05-10 EP EP95921739A patent/EP0763043B1/fr not_active Expired - Lifetime
- 1995-05-10 WO PCT/EP1995/001759 patent/WO1995033753A1/fr not_active IP Right Cessation
- 1995-05-10 KR KR1019960706881A patent/KR100223384B1/ko not_active IP Right Cessation
- 1995-05-10 AT AT95921739T patent/ATE171454T1/de not_active IP Right Cessation
- 1995-06-02 PE PE1995270369A patent/PE13296A1/es not_active Application Discontinuation
-
1996
- 1996-02-02 ES ES09650004A patent/ES2120911B1/es not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69504971T2 (de) | 1999-05-20 |
ES2120911A1 (es) | 1998-11-01 |
KR100223384B1 (ko) | 1999-10-15 |
CH688319A5 (fr) | 1997-07-31 |
ES2120911B1 (es) | 1999-07-01 |
DE69504971D1 (de) | 1998-10-29 |
WO1995033753A1 (fr) | 1995-12-14 |
EP0763043B1 (fr) | 1998-09-23 |
EP0763043A1 (fr) | 1997-03-19 |
KR970703348A (ko) | 1997-07-03 |
AU2670295A (en) | 1996-01-04 |
ATE171454T1 (de) | 1998-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |