ES2120911A1 - Procedimiento para la preparacion de trihidrato de cefixima. - Google Patents

Procedimiento para la preparacion de trihidrato de cefixima.

Info

Publication number
ES2120911A1
ES2120911A1 ES09650004A ES9650004A ES2120911A1 ES 2120911 A1 ES2120911 A1 ES 2120911A1 ES 09650004 A ES09650004 A ES 09650004A ES 9650004 A ES9650004 A ES 9650004A ES 2120911 A1 ES2120911 A1 ES 2120911A1
Authority
ES
Spain
Prior art keywords
tert
trihydrated
cefixime
preparation
cepheme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09650004A
Other languages
English (en)
Other versions
ES2120911B1 (es
Inventor
Dardes Carlos Picornell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marcham Trading & Investment L
Original Assignee
Marcham Trading & Investment L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marcham Trading & Investment L filed Critical Marcham Trading & Investment L
Publication of ES2120911A1 publication Critical patent/ES2120911A1/es
Application granted granted Critical
Publication of ES2120911B1 publication Critical patent/ES2120911B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE TRIHIDRATO DE CEFIXIMA POR REACCION DE UN DERIVADO REACTIVO DEL ACIDO (Z)-2-(2-AMINOTIAZOL-4-IL)-2-(TERCBUTOXICARBONILMETOXIIMINO)ACETICO N-PROTEGIDO CON LOS 7-AMINO-3-VINIL-3-CEFEM-4-CARBOXILATO DE TERC-BUTILO, O CON UNA DE SUS SALES Y, ANTES DE LA ELIMINACION EVENTUAL DEL GRUPO PROTECTOR DEL PRODUCTO ASI OBTENIDO, A TRAVES DEL TRATAMIENTO DEL PRODUCTO POR LA REACCION CON EL TRICLORURO DE ALUMINIO Y ANISOL. ESTE NUEVO PROCEDIMIENTO SE DESARROLLA A TRAVES DE UN NUEVO COMPUESTO 7B-[(Z)-2-(2-AMINOTIAZOL-4-IL)-2-(TERCBUTOXI-CARBONILMETOXIIMINO) ACETAM IDO]-3-VINIL-3-CEFEM-4-CARBOXILATO DE TERC-BUTILO, EVENTUALMENTE CON EL GRUPO AMINO PROTEGIDO.
ES09650004A 1994-06-03 1996-02-02 Procedimiento para la preparacion de trihidrato de cefixima. Expired - Fee Related ES2120911B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH01751/94A CH688319A5 (fr) 1994-06-03 1994-06-03 Procédé pour la préparation du céfixime trihydraté.

Publications (2)

Publication Number Publication Date
ES2120911A1 true ES2120911A1 (es) 1998-11-01
ES2120911B1 ES2120911B1 (es) 1999-07-01

Family

ID=4217712

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09650004A Expired - Fee Related ES2120911B1 (es) 1994-06-03 1996-02-02 Procedimiento para la preparacion de trihidrato de cefixima.

Country Status (9)

Country Link
EP (1) EP0763043B1 (es)
KR (1) KR100223384B1 (es)
AT (1) ATE171454T1 (es)
AU (1) AU2670295A (es)
CH (1) CH688319A5 (es)
DE (1) DE69504971T2 (es)
ES (1) ES2120911B1 (es)
PE (1) PE13296A1 (es)
WO (1) WO1995033753A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
AT404251B (de) * 1996-08-14 1998-10-27 Biochemie Gmbh Neues kristallines salz von cefixim
PT102061B (pt) * 1997-10-08 2000-06-30 J K Ind Ltd Processo de preparacao de um antibiotico cefalosporina geralmente activo-cefixime
US20040166434A1 (en) 2003-02-21 2004-08-26 Dammel Ralph R. Photoresist composition for deep ultraviolet lithography
DE602005012866D1 (de) * 2004-12-21 2009-04-02 Lupin Ltd Verfahren zur hestellung von cefixim
ES2334685T3 (es) 2005-03-29 2010-03-15 Hetero Drugs Limited Procedimiento mejorado de preparacion de cefixima.
CN1312158C (zh) * 2005-05-20 2007-04-25 天津市医药集团技术发展有限公司 一种头孢克肟的制备方法
WO2016142902A1 (en) * 2015-03-11 2016-09-15 Lupin Limited Cefixime with reduced surface area and high stability
CN111039958B (zh) * 2017-05-31 2022-05-20 郑州大学第一附属医院 头孢地尼的制备方法
JP2023011144A (ja) 2021-07-12 2023-01-24 ウシオ電機株式会社 光源装置、誘電体バリア放電ランプの点灯回路、誘電体バリア放電ランプの点灯方法
CN113968874B (zh) * 2021-10-29 2023-01-31 国药集团威奇达药业有限公司 头孢克肟的精制方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030630A2 (en) * 1979-11-19 1981-06-24 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them; their starting compounds and their preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030630A2 (en) * 1979-11-19 1981-06-24 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them; their starting compounds and their preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEM. ABS., Vol. 109, n‘ 12, 19.09.1988, (Columbus, OH, USA); pßgina 349, columna R; resumen n‘ 98626a; Fed. Regst. Vol. 53, n‘ 124, 28.06.1988, Rockville, pßgina 24256, United States Food and Drug Administration. *
HIDEAKI YAMANAKA et al., Studies on beta-lactam antibiotics. The Journal of Antibiotics, Vol. 38, n‘ 12, Diciembre 1985, Tokyo, pßginas 1738-1751, todo el documento. *

Also Published As

Publication number Publication date
ATE171454T1 (de) 1998-10-15
AU2670295A (en) 1996-01-04
DE69504971T2 (de) 1999-05-20
KR970703348A (ko) 1997-07-03
WO1995033753A1 (fr) 1995-12-14
DE69504971D1 (de) 1998-10-29
EP0763043A1 (fr) 1997-03-19
CH688319A5 (fr) 1997-07-31
PE13296A1 (es) 1996-05-10
ES2120911B1 (es) 1999-07-01
KR100223384B1 (ko) 1999-10-15
EP0763043B1 (fr) 1998-09-23

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