PA8809701A1 - Derivado de y-lactona del esteroide del ´cido 17-hidroxi-19-nor-21-carboxílico, su uso y el medicamento que lo contiene - Google Patents
Derivado de y-lactona del esteroide del ´cido 17-hidroxi-19-nor-21-carboxílico, su uso y el medicamento que lo contieneInfo
- Publication number
- PA8809701A1 PA8809701A1 PA20088809701A PA8809701A PA8809701A1 PA 8809701 A1 PA8809701 A1 PA 8809701A1 PA 20088809701 A PA20088809701 A PA 20088809701A PA 8809701 A PA8809701 A PA 8809701A PA 8809701 A1 PA8809701 A1 PA 8809701A1
- Authority
- PA
- Panama
- Prior art keywords
- hydrogen
- group
- derivatives
- lactona
- oxygen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Cosmetics (AREA)
Abstract
DERIVADOS DE Y-LACTONA DEL ESTEROIDE DEL ÁCIDO 17-HIDROXI-19-NOR-21-CARBOXÍLICO DE LA FÓRMULA QUÍMICAI,DONDE Z SE SELECCIONA DEL GRUPO QUE COMPRENDE OXÍGENO,DOS ÁTOMOS DE HIDRÓGENO,NOR' Y NNHSO2R',DONDE R' ES HIDRÓGENO,C1-C10-ALQUILO,ARILO O C7-C20-ARALQUILO,R4 SE SELECCIONA DEL GRUPO QUE COMPRENDE HIDRÓGENO Y HALÓGENO,DONDE ADEMÁS R6a,R6b SE SELECCIONAN DE MANERA INDEPENDIENTE DEL GRUPO QUE COMPRENDE HIDRÓGENO,C1-C10-ALQUILO,C2-C10-ALQUENILO Y C2-C10-ALQUINILO,O FORMAN JUNTOS METILENO O 1,2-ETANDIILO,Y R7 SE SELECCIONA DEL GRUPO QUE COMPRENDE HIDRÓGENO,C1-C10-ALQUUILO,C3-C6-CICLOALQUILO,C2-C10-ALQUENILO Y C2-C10-ALQUINILO,R6a,R7 SON JUNTOS UN ÁTOMO DE OXÍGENO O METILENO,O SE SUPRIMEN AL FORMARSE UN ENLACE DOBLE ENTRE C6 Y C7,Y R6b SE SELECCIONA DEL GRUPO QUE COMPRENDE HIDRÓGENO,C1-C10-ALQUILO,C2-C10-ALQUINILO,DONDE ADEMÁS R15 ES HIDRÓGENO,Y R16a,R 16b SE SELECCIONAN DE MANER INDEPENDIENTE DEL GRUPO QUE COMPRENDE HIDRÓGENO Y C1-C10-ALQUILO,O FORMAN JUNTOS METILENO o 1,2-ETANDIILO,o R15,R16a SON JUNTOS UN ÁTOMO DE OXÍGENO,O SE SUPRIMEN AL FORMARCE UN ENLACE DOBLE ENTRE C15 Y C16,Y R16b ES HIDRÓGENO o C1-C10-ALQUIULO,R18 ES HIDRÓGENO o C1-C3-ALQUILO,Y TAMBIÉN SUS SOLVATOS,HIDRATOS,ESTEREOISÓMEROS Y SALES,CON EXCEPCIÓN DE LA y-LACTONA DE 17ALFA-(2-CARBOXIVINIL)-17ß-HIDROXI-19-NOR-ANDROST-4-en-3-ona.USO DE ESTOS DERIVADOS PARA LA PREPARACIÓN DE UN MEDICAMENTO PARA LA CONTRACEPCIÓN ORAL Y PAR EL TRATAMIENTO DE TRASTORNOS PRE,PERI Y POSMENOPÁUSICOS,ASÍ COMO A MEDICAMENTOS QUE CONTIENEN TALES DERIVADOS.LOS DERIVADOS DE LA INVENCIÓN PRESENTAN UN EFECTO GESTAGÉNICO Y EN CASOS PREFERIDOS ADEMÁS UN EFECTO ANTIMINERALCOSTICOIDE Y NEUTRO A LEGERAMENTE ANDROGÉNICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007063503A DE102007063503A1 (de) | 2007-12-29 | 2007-12-29 | 17-Hydroxy-19-nor-21-carbonsäure-Steroid y-Lacton-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8809701A1 true PA8809701A1 (es) | 2009-07-23 |
Family
ID=40481980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20088809701A PA8809701A1 (es) | 2007-12-29 | 2008-12-23 | Derivado de y-lactona del esteroide del ´cido 17-hidroxi-19-nor-21-carboxílico, su uso y el medicamento que lo contiene |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8937058B2 (es) |
| EP (1) | EP2238151A1 (es) |
| JP (1) | JP5600068B2 (es) |
| KR (1) | KR20100102688A (es) |
| CN (1) | CN101910190A (es) |
| AR (1) | AR069966A1 (es) |
| AU (1) | AU2008342910A1 (es) |
| BR (1) | BRPI0821922A2 (es) |
| CA (1) | CA2710491C (es) |
| CL (1) | CL2008003918A1 (es) |
| CO (1) | CO6300845A2 (es) |
| CR (1) | CR11545A (es) |
| DE (1) | DE102007063503A1 (es) |
| DO (1) | DOP2010000198A (es) |
| EC (1) | ECSP10010318A (es) |
| IL (1) | IL206379A0 (es) |
| PA (1) | PA8809701A1 (es) |
| PE (1) | PE20091362A1 (es) |
| TW (1) | TW200940073A (es) |
| UY (1) | UY31584A1 (es) |
| WO (1) | WO2009083266A1 (es) |
| ZA (1) | ZA201005396B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007063503A1 (de) | 2007-12-29 | 2009-07-02 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-19-nor-21-carbonsäure-Steroid y-Lacton-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel |
| WO2012059594A1 (en) | 2010-11-04 | 2012-05-10 | Bayer Pharma Aktiengesellschaft | Mineralcorticoid receptor antagonists for the treatment of corticoid-induced obesity |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2918463A (en) | 1958-06-12 | 1959-12-22 | Searle & Co | 17-carboxyalkylated 17-hydroxy-19-norandrosten-3-ones |
| US3194803A (en) * | 1960-04-28 | 1965-07-13 | Searle & Co | Process and intermediates for the manufacture of 3-keto-delta4, 6 steroids |
| US3254074A (en) * | 1962-04-25 | 1966-05-31 | Merck & Co Inc | Spiroxenones |
| DE1183500B (de) | 1962-10-12 | 1964-12-17 | Schering Ag | Verfahren zur Herstellung von alpha, beta-Methylenketonen der Steroidreihe |
| US3705179A (en) | 1971-03-15 | 1972-12-05 | American Home Prod | Antiandrogenic steroids |
| US3764596A (en) * | 1971-06-22 | 1973-10-09 | Sandoz Ag | 17-dihydrofuranyl-substituted steroids |
| NL7701384A (nl) | 1977-02-10 | 1978-08-14 | Akzo Nv | Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks. |
| DE2922500A1 (de) | 1979-05-31 | 1980-12-04 | Schering Ag | 6 beta .7 beta |
| DE3022337A1 (de) * | 1980-06-11 | 1982-01-07 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen |
| JPS59139400A (ja) * | 1983-01-31 | 1984-08-10 | Shionogi & Co Ltd | 抗アルドステロン活性ステロイド誘導体 |
| DE3402329A1 (de) | 1984-01-20 | 1985-08-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | 6,6-ethylen-15,16-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE3410880A1 (de) * | 1984-03-21 | 1985-10-03 | Schering AG, Berlin und Bergkamen, 1000 Berlin | 17-substituierte estradiene und estratriene |
| DE3426771C2 (de) * | 1984-07-07 | 1997-03-20 | Schering Ag | 13alpha-Methylgonane, deren Herstellung und Verwendung |
| DE4232521A1 (de) * | 1992-09-22 | 1994-03-24 | Schering Ag | Gestagen wirksame 4,5;11,12-Estradiene, Verfahren zu ihrer Herstellung, diese Estradiene enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln |
| DE4447401A1 (de) | 1994-12-23 | 1996-07-04 | Schering Ag | 14,17-C¶2¶-überbrückte Steroide |
| DE19651000A1 (de) | 1996-12-01 | 1998-06-04 | Schering Ag | Oxyiminopregnancarbolactone |
| DE102004063864A1 (de) | 2004-12-30 | 2006-07-13 | Schering Ag | 18-Methyl-19-nor-17-pregn-4-en21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate |
| DE102007063503A1 (de) | 2007-12-29 | 2009-07-02 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-19-nor-21-carbonsäure-Steroid y-Lacton-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel |
-
2007
- 2007-12-29 DE DE102007063503A patent/DE102007063503A1/de not_active Withdrawn
-
2008
- 2008-12-22 TW TW097150069A patent/TW200940073A/zh unknown
- 2008-12-23 CN CN200880123431XA patent/CN101910190A/zh active Pending
- 2008-12-23 CA CA2710491A patent/CA2710491C/en not_active Expired - Fee Related
- 2008-12-23 US US12/810,991 patent/US8937058B2/en not_active Expired - Fee Related
- 2008-12-23 PA PA20088809701A patent/PA8809701A1/es unknown
- 2008-12-23 BR BRPI0821922-2A patent/BRPI0821922A2/pt not_active IP Right Cessation
- 2008-12-23 JP JP2010540078A patent/JP5600068B2/ja not_active Expired - Fee Related
- 2008-12-23 EP EP08868806A patent/EP2238151A1/de not_active Withdrawn
- 2008-12-23 AR ARP080105703A patent/AR069966A1/es unknown
- 2008-12-23 WO PCT/EP2008/011159 patent/WO2009083266A1/de active Application Filing
- 2008-12-23 AU AU2008342910A patent/AU2008342910A1/en not_active Abandoned
- 2008-12-23 KR KR1020107016941A patent/KR20100102688A/ko not_active Application Discontinuation
- 2008-12-26 UY UY31584A patent/UY31584A1/es not_active Application Discontinuation
- 2008-12-29 PE PE2008002191A patent/PE20091362A1/es not_active Application Discontinuation
- 2008-12-29 CL CL2008003918A patent/CL2008003918A1/es unknown
-
2010
- 2010-06-15 IL IL206379A patent/IL206379A0/en unknown
- 2010-06-29 CR CR11545A patent/CR11545A/es not_active Application Discontinuation
- 2010-06-29 CO CO10078679A patent/CO6300845A2/es not_active Application Discontinuation
- 2010-06-29 DO DO2010000198A patent/DOP2010000198A/es unknown
- 2010-06-29 EC EC2010010318A patent/ECSP10010318A/es unknown
- 2010-07-28 ZA ZA2010/05396A patent/ZA201005396B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011507924A (ja) | 2011-03-10 |
| BRPI0821922A2 (pt) | 2015-06-16 |
| JP5600068B2 (ja) | 2014-10-01 |
| AR069966A1 (es) | 2010-03-03 |
| CR11545A (es) | 2010-08-27 |
| DE102007063503A1 (de) | 2009-07-02 |
| CA2710491C (en) | 2015-11-03 |
| CA2710491A1 (en) | 2009-07-09 |
| CL2008003918A1 (es) | 2010-01-15 |
| CN101910190A (zh) | 2010-12-08 |
| ECSP10010318A (es) | 2010-08-31 |
| CO6300845A2 (es) | 2011-07-21 |
| ZA201005396B (en) | 2012-01-25 |
| WO2009083266A1 (de) | 2009-07-09 |
| US8937058B2 (en) | 2015-01-20 |
| DOP2010000198A (es) | 2010-08-31 |
| UY31584A1 (es) | 2009-08-03 |
| TW200940073A (en) | 2009-10-01 |
| PE20091362A1 (es) | 2009-10-15 |
| AU2008342910A1 (en) | 2009-07-09 |
| EP2238151A1 (de) | 2010-10-13 |
| US20110021472A1 (en) | 2011-01-27 |
| IL206379A0 (en) | 2010-12-30 |
| KR20100102688A (ko) | 2010-09-24 |
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