PA8634301A1 - Derivados de benceno halogenados del ácido aminoisoftálico sustituidos con macrociclos trímeros - Google Patents

Derivados de benceno halogenados del ácido aminoisoftálico sustituidos con macrociclos trímeros

Info

Publication number
PA8634301A1
PA8634301A1 PA20058634301A PA8634301A PA8634301A1 PA 8634301 A1 PA8634301 A1 PA 8634301A1 PA 20058634301 A PA20058634301 A PA 20058634301A PA 8634301 A PA8634301 A PA 8634301A PA 8634301 A1 PA8634301 A1 PA 8634301A1
Authority
PA
Panama
Prior art keywords
macrocicles
bancen
aminoisoftalic
trimmer
halogenated
Prior art date
Application number
PA20058634301A
Other languages
English (en)
Inventor
Juan R Harto
Jose L Martin
Johannes Platzek
Heiko Schirmer
Hanns-Joachim Weinmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PA8634301A1 publication Critical patent/PA8634301A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

COMPLEJO METALICO DE LA FORMULA I (VER ADJUNTO) DONDE HAL ES BROMO O YODO A1 Y A2 TIENEN SIGNIFICADO DIFERENTE, QUE SON APROPIADOS COMO MEDIOS DE CONTRASTE.
PA20058634301A 2004-05-25 2005-05-25 Derivados de benceno halogenados del ácido aminoisoftálico sustituidos con macrociclos trímeros PA8634301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004026103A DE102004026103A1 (de) 2004-05-25 2004-05-25 Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate

Publications (1)

Publication Number Publication Date
PA8634301A1 true PA8634301A1 (es) 2006-07-03

Family

ID=34967416

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058634301A PA8634301A1 (es) 2004-05-25 2005-05-25 Derivados de benceno halogenados del ácido aminoisoftálico sustituidos con macrociclos trímeros

Country Status (12)

Country Link
US (1) US20060120965A1 (es)
EP (1) EP1748992A1 (es)
JP (1) JP2008500293A (es)
AR (1) AR050156A1 (es)
DE (1) DE102004026103A1 (es)
GT (1) GT200500123A (es)
PA (1) PA8634301A1 (es)
PE (1) PE20060365A1 (es)
SV (1) SV2005002124A (es)
TW (1) TW200616982A (es)
UY (1) UY28919A1 (es)
WO (1) WO2005115997A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
KR102464647B1 (ko) 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
AU6996594A (en) * 1993-06-02 1994-12-20 Bracco S.P.A. Iodinated paramagnetic chelates, and their use as contrast agents
US7208140B2 (en) * 2003-02-19 2007-04-24 Schering Aktiengesellschaft Trimeric macrocyclic substituted benzene derivatives
DE10307759B3 (de) * 2003-02-19 2004-11-18 Schering Ag Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel

Also Published As

Publication number Publication date
JP2008500293A (ja) 2008-01-10
DE102004026103A1 (de) 2005-12-22
SV2005002124A (es) 2005-12-06
EP1748992A1 (de) 2007-02-07
GT200500123A (es) 2006-03-17
AR050156A1 (es) 2006-10-04
TW200616982A (en) 2006-06-01
PE20060365A1 (es) 2006-05-27
US20060120965A1 (en) 2006-06-08
UY28919A1 (es) 2005-12-30
WO2005115997A1 (de) 2005-12-08

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PA8634301A1 (es) Derivados de benceno halogenados del ácido aminoisoftálico sustituidos con macrociclos trímeros