EA201171228A1 - Производные хиназолиндиона, их получение и их различные терапевтические применения - Google Patents
Производные хиназолиндиона, их получение и их различные терапевтические примененияInfo
- Publication number
- EA201171228A1 EA201171228A1 EA201171228A EA201171228A EA201171228A1 EA 201171228 A1 EA201171228 A1 EA 201171228A1 EA 201171228 A EA201171228 A EA 201171228A EA 201171228 A EA201171228 A EA 201171228A EA 201171228 A1 EA201171228 A1 EA 201171228A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- therapeutic applications
- derivatives
- hinazolindion
- receiving
- different therapeutic
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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Abstract
Объектом настоящего изобретения являются производные хиназолиндиона формулы (I), где А означает атом серы или кислорода или сульфоксидную или сульфоновую группу, способы их получения и их терапевтические применения, такие как, среди прочего, в случае рака, диабета, мышечных, костных, сердечно-сосудистых заболеваний, заболеваний центральной нервной системы, заболеваний периферической нервной системы.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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FR0901760A FR2944282B1 (fr) | 2009-04-09 | 2009-04-09 | Derives de quinazolinedione, leur preparation et leurs diverses applications therapeutiques |
PCT/FR2010/050664 WO2010116088A2 (fr) | 2009-04-09 | 2010-04-07 | Dérivés de quinazolinedione, leur préparation et leurs diverses applications thérapeutiques |
Publications (2)
Publication Number | Publication Date |
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EA201171228A1 true EA201171228A1 (ru) | 2012-05-30 |
EA021765B1 EA021765B1 (ru) | 2015-08-31 |
Family
ID=41226702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201171228A EA021765B1 (ru) | 2009-04-09 | 2010-04-07 | Производные хиназолиндиона, их получение и их различные терапевтические применения |
Country Status (22)
Country | Link |
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US (1) | US8722659B2 (ru) |
EP (1) | EP2417130A2 (ru) |
JP (1) | JP5564101B2 (ru) |
KR (1) | KR20120028872A (ru) |
CN (1) | CN102459244B (ru) |
AR (1) | AR076233A1 (ru) |
AU (1) | AU2010233594B2 (ru) |
BR (1) | BRPI1014904A2 (ru) |
CA (1) | CA2758233A1 (ru) |
CL (1) | CL2011002522A1 (ru) |
CO (1) | CO6440583A2 (ru) |
EA (1) | EA021765B1 (ru) |
FR (1) | FR2944282B1 (ru) |
IL (1) | IL215609A0 (ru) |
MA (1) | MA33255B1 (ru) |
MX (1) | MX2011010639A (ru) |
NZ (1) | NZ595768A (ru) |
SG (2) | SG10201401232QA (ru) |
TW (1) | TW201040148A (ru) |
UY (1) | UY32556A (ru) |
WO (1) | WO2010116088A2 (ru) |
ZA (1) | ZA201107363B (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103547267A (zh) | 2010-11-08 | 2014-01-29 | 奥默罗斯公司 | 使用pde7抑制剂治疗成瘾和冲动控制障碍 |
US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
JP2015521177A (ja) * | 2012-05-07 | 2015-07-27 | オメロス コーポレーション | Pde7インヒビターを用いる嗜癖および衝動制御障害の処置 |
ITMI20130646A1 (it) * | 2013-04-19 | 2014-10-20 | Univ Bologna Alma Mater | Composti chinazolindionici con attività inibente sulle sirtuine |
CN106146413B (zh) * | 2015-04-03 | 2019-01-18 | 中南大学 | 2,4-(1h,3h)-喹唑啉二酮衍生物及其合成方法和用途 |
GB201517216D0 (en) * | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
GB201517217D0 (en) * | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
WO2024038089A1 (en) | 2022-08-18 | 2024-02-22 | Mitodicure Gmbh | Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3879393A (en) | 1973-06-18 | 1975-04-22 | Miles Lab | Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones |
DE3172006D1 (en) | 1980-05-22 | 1985-10-03 | Masayuki Ishikawa | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof |
US5264437A (en) | 1992-03-20 | 1993-11-23 | Syntex (U.S.A.) Inc. | Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones |
US5624926A (en) * | 1993-02-18 | 1997-04-29 | Kyowa Hakko Kogyo Co., Ltd. | Piperidinyl-dioxoquinazolines as adenosine reuptake inhibitors |
CN1305454A (zh) * | 1998-04-20 | 2001-07-25 | 藤泽药品工业株式会社 | 作为cgmp-磷酸二酯酶抑制剂的邻氨基苯甲酸衍生物 |
AU2525701A (en) * | 1999-12-14 | 2001-06-25 | Sanofi-Synthelabo | Derivatives of quinazolinedione phthalimide, preparations thereof and their therapeutic uses |
US20090111837A1 (en) | 2005-03-01 | 2009-04-30 | Peter Cox | Use of pde7 inhibitors for the treatment of neuropathic pain |
WO2006092692A1 (en) | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain |
US7846664B2 (en) | 2005-12-07 | 2010-12-07 | The Regents Of The University Of California | Diagnosis and treatment of chronic lymphocytic leukemia (CLL) |
CA2681650C (en) | 2007-03-27 | 2016-11-22 | Omeros Corporation | The use of pde7 inhibitors for the treatment of movement disorders |
EP2138482A4 (en) * | 2007-04-19 | 2011-06-15 | Astellas Pharma Inc | BICYCLIC HETEROCYCLIC COMPOUND |
FR2921926B1 (fr) * | 2007-10-03 | 2009-12-04 | Sanofi Aventis | Derives de quinazolinedione,leur preparation et leurs applications therapeutiques. |
FR2944206B1 (fr) * | 2009-04-09 | 2012-12-28 | Sanofi Aventis | Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione |
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2009
- 2009-04-09 FR FR0901760A patent/FR2944282B1/fr not_active Expired - Fee Related
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2010
- 2010-04-07 CA CA2758233A patent/CA2758233A1/fr not_active Abandoned
- 2010-04-07 BR BRPI1014904A patent/BRPI1014904A2/pt not_active IP Right Cessation
- 2010-04-07 CN CN201080025349.0A patent/CN102459244B/zh not_active Expired - Fee Related
- 2010-04-07 KR KR1020117026561A patent/KR20120028872A/ko not_active Application Discontinuation
- 2010-04-07 MA MA34323A patent/MA33255B1/fr unknown
- 2010-04-07 JP JP2012504055A patent/JP5564101B2/ja not_active Expired - Fee Related
- 2010-04-07 EP EP10723214A patent/EP2417130A2/fr not_active Withdrawn
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- 2010-04-07 AU AU2010233594A patent/AU2010233594B2/en not_active Ceased
- 2010-04-07 WO PCT/FR2010/050664 patent/WO2010116088A2/fr active Application Filing
- 2010-04-07 EA EA201171228A patent/EA021765B1/ru not_active IP Right Cessation
- 2010-04-07 SG SG10201401232QA patent/SG10201401232QA/en unknown
- 2010-04-07 SG SG2011073442A patent/SG175130A1/en unknown
- 2010-04-08 AR ARP100101180A patent/AR076233A1/es unknown
- 2010-04-08 TW TW099110927A patent/TW201040148A/zh unknown
- 2010-04-09 UY UY0001032556A patent/UY32556A/es not_active Application Discontinuation
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- 2011-10-06 CO CO11131880A patent/CO6440583A2/es active IP Right Grant
- 2011-10-07 ZA ZA2011/07363A patent/ZA201107363B/en unknown
- 2011-10-07 CL CL2011002522A patent/CL2011002522A1/es unknown
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Also Published As
Publication number | Publication date |
---|---|
US20120115846A1 (en) | 2012-05-10 |
AU2010233594A1 (en) | 2011-11-03 |
AR076233A1 (es) | 2011-05-26 |
CA2758233A1 (fr) | 2010-10-14 |
TW201040148A (en) | 2010-11-16 |
AU2010233594B2 (en) | 2016-07-07 |
SG175130A1 (en) | 2011-11-28 |
MX2011010639A (es) | 2012-01-19 |
CN102459244B (zh) | 2015-07-08 |
NZ595768A (en) | 2012-12-21 |
SG10201401232QA (en) | 2014-08-28 |
CL2011002522A1 (es) | 2012-02-17 |
KR20120028872A (ko) | 2012-03-23 |
CN102459244A (zh) | 2012-05-16 |
US8722659B2 (en) | 2014-05-13 |
FR2944282B1 (fr) | 2013-05-03 |
FR2944282A1 (fr) | 2010-10-15 |
WO2010116088A3 (fr) | 2010-12-16 |
WO2010116088A2 (fr) | 2010-10-14 |
JP2012523397A (ja) | 2012-10-04 |
MA33255B1 (fr) | 2012-05-02 |
IL215609A0 (en) | 2011-12-29 |
UY32556A (es) | 2010-11-30 |
JP5564101B2 (ja) | 2014-07-30 |
EA021765B1 (ru) | 2015-08-31 |
BRPI1014904A2 (pt) | 2016-04-19 |
ZA201107363B (en) | 2012-12-27 |
EP2417130A2 (fr) | 2012-02-15 |
CO6440583A2 (es) | 2012-05-15 |
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