OA12004A - Heterocyclic compounds inhibiting angiogenesis. - Google Patents
Heterocyclic compounds inhibiting angiogenesis. Download PDFInfo
- Publication number
- OA12004A OA12004A OA1200200042A OA1200200042A OA12004A OA 12004 A OA12004 A OA 12004A OA 1200200042 A OA1200200042 A OA 1200200042A OA 1200200042 A OA1200200042 A OA 1200200042A OA 12004 A OA12004 A OA 12004A
- Authority
- OA
- OAPI
- Prior art keywords
- group
- borrelidin
- atom
- general formula
- nitrogen
- Prior art date
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- 230000002401 inhibitory effect Effects 0.000 title abstract description 17
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- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
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- NGGMYCMLYOUNGM-CSDLUJIJSA-N fumagillin Chemical compound C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 NGGMYCMLYOUNGM-CSDLUJIJSA-N 0.000 description 1
- 229960000936 fumagillin Drugs 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
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- 238000007429 general method Methods 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
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- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 210000004072 lung Anatomy 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- 230000003211 malignant effect Effects 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- OCSMOTCMPXTDND-OUAUKWLOSA-N marimastat Chemical compound CNC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO OCSMOTCMPXTDND-OUAUKWLOSA-N 0.000 description 1
- 229950008959 marimastat Drugs 0.000 description 1
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- 230000009401 metastasis Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940037982 ophthalmologicals Drugs 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
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- 239000003960 organic solvent Substances 0.000 description 1
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- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
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- 229920001282 polysaccharide Polymers 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- HDOUGSFASVGDCS-UHFFFAOYSA-N pyridin-3-ylmethanamine Chemical compound NCC1=CC=CN=C1 HDOUGSFASVGDCS-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 239000012487 rinsing solution Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 229950001248 squalamine Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- OSWULUXZFOQIRU-UHFFFAOYSA-N tert-butyl 2-aminoacetate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)CN OSWULUXZFOQIRU-UHFFFAOYSA-N 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
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- 229960001727 tretinoin Drugs 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9902628A HUP9902628A3 (en) | 1999-08-02 | 1999-08-02 | Angiogenesis inhibiting borrelidin derivatives, their use and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
OA12004A true OA12004A (en) | 2006-04-18 |
Family
ID=89998954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
OA1200200042A OA12004A (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis. |
Country Status (32)
Country | Link |
---|---|
US (1) | US6815465B1 (cs) |
EP (1) | EP1206462B1 (cs) |
JP (1) | JP2003506366A (cs) |
KR (1) | KR20020068495A (cs) |
CN (1) | CN1243746C (cs) |
AP (1) | AP1383A (cs) |
AT (1) | ATE241611T1 (cs) |
AU (1) | AU772206B2 (cs) |
BG (1) | BG106373A (cs) |
BR (1) | BR0012968A (cs) |
CA (1) | CA2378176A1 (cs) |
CZ (1) | CZ2002405A3 (cs) |
DE (1) | DE60003045T2 (cs) |
DK (1) | DK1206462T3 (cs) |
ES (1) | ES2200900T3 (cs) |
HK (1) | HK1048995B (cs) |
HR (1) | HRP20020103B1 (cs) |
HU (1) | HUP9902628A3 (cs) |
IL (1) | IL147904A (cs) |
IS (1) | IS2137B (cs) |
MX (1) | MXPA02001117A (cs) |
NO (1) | NO20020485L (cs) |
NZ (1) | NZ517422A (cs) |
OA (1) | OA12004A (cs) |
PL (1) | PL354281A1 (cs) |
PT (1) | PT1206462E (cs) |
RU (1) | RU2247723C2 (cs) |
SK (1) | SK1822002A3 (cs) |
UA (1) | UA74341C2 (cs) |
WO (1) | WO2001009113A2 (cs) |
YU (1) | YU7302A (cs) |
ZA (1) | ZA200200838B (cs) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
DE60330651D1 (en) | 2002-03-12 | 2010-02-04 | Bristol Myers Squibb Co | C3-cyanoepothilonderivate |
GB0230217D0 (en) * | 2002-12-27 | 2003-02-05 | Biotica Tech Ltd | Borrelidin-producing polyketide synthase and its uses |
US8440217B1 (en) | 2005-06-15 | 2013-05-14 | Mawaheb M. EL-Naggar | Method and system with contact lens product for treating and preventing adverse eye conditions |
GB0609981D0 (en) * | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
GB0713563D0 (en) * | 2007-07-13 | 2007-08-22 | Biotica Tech Ltd | Methods of screening for anti-angiogenic compounds |
EP2197280B1 (en) * | 2007-08-27 | 2013-06-19 | Basf Se | Pyrazole compounds for controlling invertebrate pests |
DE102008014077A1 (de) | 2008-03-13 | 2009-09-17 | Discovery Partner International Gmbh | Borrelidin-Derivate |
WO2009141786A2 (en) * | 2008-05-21 | 2009-11-26 | Piramal Life Sciences Limited | Anti-inflammatory compounds |
EP3034522B1 (en) | 2014-12-15 | 2019-02-06 | Borealis AG | Use of a polypropylene composition |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08173176A (ja) | 1994-12-22 | 1996-07-09 | Mercian Corp | 血管新生阻害剤 |
JP3786461B2 (ja) | 1996-02-22 | 2006-06-14 | メルシャン株式会社 | 新生理活性物質 |
-
1999
- 1999-08-02 HU HU9902628A patent/HUP9902628A3/hu unknown
-
2000
- 2000-08-02 PT PT00949831T patent/PT1206462E/pt unknown
- 2000-08-02 BR BR0012968-2A patent/BR0012968A/pt not_active IP Right Cessation
- 2000-08-02 PL PL00354281A patent/PL354281A1/xx not_active Application Discontinuation
- 2000-08-02 ES ES00949831T patent/ES2200900T3/es not_active Expired - Lifetime
- 2000-08-02 IL IL14790400A patent/IL147904A/xx not_active IP Right Cessation
- 2000-08-02 DE DE60003045T patent/DE60003045T2/de not_active Expired - Fee Related
- 2000-08-02 AP APAP/P/2002/002413A patent/AP1383A/en active
- 2000-08-02 JP JP2001514316A patent/JP2003506366A/ja not_active Withdrawn
- 2000-08-02 NZ NZ517422A patent/NZ517422A/en unknown
- 2000-08-02 YU YU7302A patent/YU7302A/sh unknown
- 2000-08-02 EP EP00949831A patent/EP1206462B1/en not_active Expired - Lifetime
- 2000-08-02 US US10/048,659 patent/US6815465B1/en not_active Expired - Fee Related
- 2000-08-02 AU AU63090/00A patent/AU772206B2/en not_active Ceased
- 2000-08-02 CA CA002378176A patent/CA2378176A1/en not_active Abandoned
- 2000-08-02 SK SK182-2002A patent/SK1822002A3/sk unknown
- 2000-08-02 CZ CZ2002405A patent/CZ2002405A3/cs unknown
- 2000-08-02 UA UA2002010814A patent/UA74341C2/uk unknown
- 2000-08-02 CN CNB008123578A patent/CN1243746C/zh not_active Expired - Fee Related
- 2000-08-02 OA OA1200200042A patent/OA12004A/en unknown
- 2000-08-02 MX MXPA02001117A patent/MXPA02001117A/es active IP Right Grant
- 2000-08-02 RU RU2002105518/04A patent/RU2247723C2/ru not_active IP Right Cessation
- 2000-08-02 AT AT00949831T patent/ATE241611T1/de not_active IP Right Cessation
- 2000-08-02 WO PCT/HU2000/000088 patent/WO2001009113A2/en not_active Application Discontinuation
- 2000-08-02 DK DK00949831T patent/DK1206462T3/da active
- 2000-08-02 KR KR1020027001484A patent/KR20020068495A/ko not_active Application Discontinuation
-
2002
- 2002-01-30 ZA ZA200200838A patent/ZA200200838B/en unknown
- 2002-01-30 NO NO20020485A patent/NO20020485L/no not_active Application Discontinuation
- 2002-01-31 BG BG06373A patent/BG106373A/xx unknown
- 2002-02-01 IS IS6258A patent/IS2137B/xx unknown
- 2002-02-01 HR HR20020103A patent/HRP20020103B1/xx not_active IP Right Cessation
-
2003
- 2003-02-18 HK HK03101165.4A patent/HK1048995B/zh not_active IP Right Cessation
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