OA10737A - Substituted azetidin-2-ones for treatment of arth erosclerosis - Google Patents

Substituted azetidin-2-ones for treatment of arth erosclerosis Download PDF

Info

Publication number
OA10737A
OA10737A OA70034A OA70034A OA10737A OA 10737 A OA10737 A OA 10737A OA 70034 A OA70034 A OA 70034A OA 70034 A OA70034 A OA 70034A OA 10737 A OA10737 A OA 10737A
Authority
OA
OAPI
Prior art keywords
oxoazetidin
acetamide
hexyl
azetidin
benzylsulphinyl
Prior art date
Application number
OA70034A
Other languages
English (en)
Inventor
Deirdre Mary Bernadette Hickey
Colin Andrew Leach
Robert John Ife
David Graham Tew
Dashyant Dhanak
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9426020.5A external-priority patent/GB9426020D0/en
Priority claimed from GBGB9426030.4A external-priority patent/GB9426030D0/en
Priority claimed from GBGB9511599.4A external-priority patent/GB9511599D0/en
Priority claimed from GBGB9511600.0A external-priority patent/GB9511600D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of OA10737A publication Critical patent/OA10737A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
OA70034A 1994-12-22 1997-06-20 Substituted azetidin-2-ones for treatment of arth erosclerosis OA10737A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9426020.5A GB9426020D0 (en) 1994-12-22 1994-12-22 Novel compounds
GBGB9426030.4A GB9426030D0 (en) 1994-12-23 1994-12-23 Novel compounds
GBGB9511599.4A GB9511599D0 (en) 1995-06-08 1995-06-08 Novel compounds
GBGB9511600.0A GB9511600D0 (en) 1995-06-08 1995-06-08 Novel compounds

Publications (1)

Publication Number Publication Date
OA10737A true OA10737A (en) 2002-12-10

Family

ID=27451242

Family Applications (1)

Application Number Title Priority Date Filing Date
OA70034A OA10737A (en) 1994-12-22 1997-06-20 Substituted azetidin-2-ones for treatment of arth erosclerosis

Country Status (24)

Country Link
US (1) US5990102A (xx)
EP (1) EP0799200A1 (xx)
JP (1) JPH11500415A (xx)
CN (1) CN1175246A (xx)
AP (1) AP9701007A0 (xx)
AR (1) AR002012A1 (xx)
AU (1) AU704407B2 (xx)
BG (1) BG101687A (xx)
BR (1) BR9510420A (xx)
CA (1) CA2208530A1 (xx)
CZ (1) CZ192297A3 (xx)
DZ (1) DZ1958A1 (xx)
FI (1) FI972584A (xx)
HU (1) HUT77089A (xx)
IL (1) IL116485A0 (xx)
MA (1) MA23834A1 (xx)
MX (1) MX9704736A (xx)
NO (1) NO972909L (xx)
NZ (1) NZ298416A (xx)
OA (1) OA10737A (xx)
PL (1) PL320937A1 (xx)
SK (1) SK80397A3 (xx)
TR (1) TR199501655A2 (xx)
WO (1) WO1996019451A1 (xx)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0840725A1 (en) * 1995-07-01 1998-05-13 Smithkline Beecham Plc Azetidinone derivatives for the treatment of atherosclerosis
EP0865429A1 (en) * 1995-12-08 1998-09-23 Smithkline Beecham Plc Azetidinone compounds for the treatment of atherosclerosis
WO1997021675A1 (en) * 1995-12-08 1997-06-19 Smithkline Beecham Plc Monocyclic beta-lactame derivatives for treatment of atherosclerosis
GB9608649D0 (en) * 1996-04-26 1996-07-03 Smithkline Beecham Plc Novel compounds
IL126696A0 (en) * 1996-04-26 1999-08-17 Smithkline Beecham Plc Azetidinone derivatives for the treatment of atherosclerosis
AU4654199A (en) * 1998-07-23 2000-02-14 Shionogi & Co., Ltd. Monocyclic beta-lactam compounds and chymase inhibitors containing the same
NZ520752A (en) 2000-02-16 2004-03-26 Smithkline Beecham P Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors
GB0024808D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7235543B2 (en) 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7208486B2 (en) 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2517573C (en) * 2003-03-07 2011-12-06 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
CA2565387A1 (en) * 2004-05-03 2005-11-17 Ilypsa, Inc. Modulation of lysophosphatidylcholine and treatment of diet-induced conditions
US8962633B2 (en) 2007-05-11 2015-02-24 Thomas Jefferson University Methods of treatment and prevention of metabolic bone diseases and disorders
WO2008140449A1 (en) 2007-05-11 2008-11-20 Thomas Jefferson University Methods of treatment and prevention of neurodegenerative diseases and disorders
BRPI0810336A2 (pt) 2007-05-11 2019-03-19 The Trustees Of The University Of Pennsylvania "método para tratar e/ou prevenir úlceras de pele em um indivíduo"
ES2559224T3 (es) 2010-12-06 2016-02-11 Glaxo Group Limited Compuestos de pirimidinona para uso en el tratamiento de enfermedades o condiciones mediadas por Lp-PLA2
EP2651403B1 (en) 2010-12-17 2020-12-02 Glaxo Group Limited Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases
WO2013000267A1 (zh) 2011-06-27 2013-01-03 中国科学院上海药物研究所 唑类杂环化合物、其制备方法、药物组合物和用途
JP2014521625A (ja) 2011-07-27 2014-08-28 グラクソ グループ リミテッド 二環式ピリミドン化合物
JP2014521611A (ja) 2011-07-27 2014-08-28 グラクソ グループ リミテッド Ｌｐ−ＰＬＡ２阻害剤としての２，３−ジヒドロイミダゾ［１，２−ｃ］ピリミジン−５（１Ｈ）−オン化合物の使用
CA2899124A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited Compounds
EP2948452B1 (en) 2013-01-25 2017-08-09 GlaxoSmithKline Intellectual Property Development Limited 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors
CA2899143A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited Bicyclic pyrimidone compounds as inhibitors of lp-pla2
WO2015179293A1 (en) * 2014-05-18 2015-11-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Small molecule activators and inhibitors of lecithin: cholesterol acyltransferase
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2021089032A1 (zh) 2019-11-09 2021-05-14 上海赛默罗生物科技有限公司 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5559193A (en) * 1978-09-20 1980-05-02 Glaxo Group Ltd Bblactam compound
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
IL99658A0 (en) * 1990-10-15 1992-08-18 Merck & Co Inc Substituted azetidinones and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AR002012A1 (es) 1998-01-07
HUT77089A (hu) 1998-03-02
AU4389896A (en) 1996-07-10
FI972584A0 (fi) 1997-06-17
NO972909D0 (no) 1997-06-20
CZ192297A3 (en) 1997-11-12
IL116485A0 (en) 1996-08-04
PL320937A1 (en) 1997-11-10
EP0799200A1 (en) 1997-10-08
US5990102A (en) 1999-11-23
WO1996019451A1 (en) 1996-06-27
DZ1958A1 (fr) 2002-02-17
CA2208530A1 (en) 1996-06-27
AP9701007A0 (en) 1997-07-31
BR9510420A (pt) 2004-04-20
CN1175246A (zh) 1998-03-04
MX9704736A (es) 1997-10-31
JPH11500415A (ja) 1999-01-12
NO972909L (no) 1997-08-20
BG101687A (en) 1998-02-27
MA23834A1 (fr) 1996-10-01
NZ298416A (en) 1999-03-29
TR199501655A2 (tr) 1996-07-21
SK80397A3 (en) 1998-01-14
AU704407B2 (en) 1999-04-22
FI972584A (fi) 1997-08-19

Similar Documents

Publication Publication Date Title
OA10737A (en) Substituted azetidin-2-ones for treatment of arth erosclerosis
US6071899A (en) Azetidinone derivatives for the treatment of atherosclerosis
OA10648A (en) Azetidinone derivatives for the treatment of atherosclerosis
EP0051381B1 (en) O-sulfated beta-lactam hydroxamic acids
US5300638A (en) Asymmetric synthesis of taxol side chain
EP0070204A2 (en) Carboxylic beta-lactam compounds and the preparation thereof
EP0336369A1 (en) 3-Acylamino-1-[[[(substituted sulfonyl)amino]carbonyl]amino]2-azetidinones
EP0915843A1 (en) Azetidinone derivatives for the treatment of atheroscleroses
JPH05279367A (ja) β−ラクタム誘導体の製法
SENDAI et al. Chemical modification of sulfazecin synthesis of 4-(substituted methyl)-2-azetidinone-1-sulfonic acid derivatives
KR880002512B1 (ko) 페넴 화합물 및 이의 제조방법
JPS6328063B2 (xx)
US4849419A (en) 7-oxo-4-thia-azabicyclo[3,2,0]hept-2-ene derivatives
JPS61176563A (ja) ４，４‐ジアルキル‐２‐アゼチジノン類の製造法
FI105810B (fi) (3S,4S)-3-[(1R)-1-trialkyylisilyylioksietyyli]-4-[(1R)-(heterosyklyylitiokarbonyyli)-etyyli]atsetidin-2-onijohdannaisten käyttö karbapeneemiantibioottien valmistuksessa
IE75358B1 (en) Process for the preparation of penems
US4694083A (en) Certain carbamate ester derivatives forming salts with pyridinium or picolinium cations which are useful as intermediates
US5466686A (en) Amides of 4-oxo-azetidine-2-sulfonic acids and salts thereof, processes for their preparation and their use
JP3175857B2 (ja) １β−置換カルバペネム合成中間体
US5075439A (en) Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones and intermediates therefor
FI80702C (fi) Foerfarande foer framstaellning av antibakteriella tio-penem-3-karboxylsyror.
GB2149401A (en) Azetidine derivatives
JPH0565291A (ja) （３Ｓ、４Ｒ）−３−［１（Ｒ）−（ｔ−ブチルジメチルシリルオキシ）エチル−４−［１−オキソ−３−チオールアニルチオ（チオカルボニル）チオアゼチジン−２−オンおよびこれらのための中間体の改良された製造方法
JPH045037B2 (xx)
JPS5984886A (ja) フルオロアルキルカルバペネム誘導体