OA10167A - Substituted 6-azaandrostenones - Google Patents

Substituted 6-azaandrostenones Download PDF

Info

Publication number
OA10167A
OA10167A OA60676A OA60676A OA10167A OA 10167 A OA10167 A OA 10167A OA 60676 A OA60676 A OA 60676A OA 60676 A OA60676 A OA 60676A OA 10167 A OA10167 A OA 10167A
Authority
OA
OAPI
Prior art keywords
alk1
alk2
carbamoyl
azaandrost
phenyl
Prior art date
Application number
OA60676A
Other languages
English (en)
Inventor
Robert Carl Andrews
Cynthia Cribbs
Stephen Frye
Curt Haffner
Patrick Maloney
Original Assignee
Glaxo Wellcome Inc
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Inc, Glaxo Inc filed Critical Glaxo Wellcome Inc
Publication of OA10167A publication Critical patent/OA10167A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
OA60676A 1992-12-18 1995-06-14 Substituted 6-azaandrostenones OA10167A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99393092A 1992-12-18 1992-12-18
US8066593A 1993-06-18 1993-06-18

Publications (1)

Publication Number Publication Date
OA10167A true OA10167A (en) 1996-12-18

Family

ID=26763785

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60676A OA10167A (en) 1992-12-18 1995-06-14 Substituted 6-azaandrostenones

Country Status (24)

Country Link
EP (1) EP0674651B1 (ja)
JP (1) JPH08504825A (ja)
CN (1) CN1095383A (ja)
AP (1) AP459A (ja)
AT (1) ATE172738T1 (ja)
AU (1) AU673899B2 (ja)
BG (1) BG99729A (ja)
CA (1) CA2152053A1 (ja)
CZ (1) CZ157695A3 (ja)
DE (1) DE69321849D1 (ja)
FI (1) FI953009A (ja)
HU (1) HUT72083A (ja)
IL (1) IL108073A0 (ja)
IS (1) IS4106A (ja)
LV (1) LV10958B (ja)
MX (1) MX9308015A (ja)
NO (1) NO952402L (ja)
NZ (1) NZ261415A (ja)
OA (1) OA10167A (ja)
PL (1) PL314532A1 (ja)
SI (1) SI9300665A (ja)
SK (1) SK79495A3 (ja)
TW (1) TW293824B (ja)
WO (1) WO1994014833A2 (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5516779A (en) * 1994-06-08 1996-05-14 Merck & Co., Inc. 17β-substituted-6-azasteroid derivatives useful as 5α-reductase inhibitors
US5817818A (en) * 1994-09-16 1998-10-06 Glaxo Wellcome Inc. Androstenones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
GB9506678D0 (en) * 1995-03-31 1995-05-24 Glaxo Inc Substituted 6-azacholesten-3-ones
AU704933B2 (en) * 1995-10-19 1999-05-06 Merck & Co., Inc. 16-substituted-6-aza-steroid 5-alpha-reductase inhibitors
US5935968A (en) 1997-03-17 1999-08-10 Merck & Co., Inc. Methods for treating polycystic ovary syndrome
BRPI0409376A (pt) 2003-04-15 2006-04-25 Inflazyme Pharm Ltd derivados de indeno como agentes farmacêuticos
US7790770B2 (en) 2005-11-23 2010-09-07 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
KR20220110337A (ko) 2013-03-14 2022-08-05 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 Ship1 조절제 및 그와 관련된 방법
WO2014143561A1 (en) 2013-03-14 2014-09-18 Aquinox Pharmaceuticals Inc. Ship1 modulators and methods related thereto
CA2986790A1 (en) 2015-06-26 2016-12-29 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
US10053415B2 (en) 2016-01-20 2018-08-21 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
BR112018072255B1 (pt) * 2016-04-29 2024-02-06 The Research Foundation For The State University Of New York Azasteroides para tratamento de tuberculose

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE165368T1 (de) * 1991-12-20 1998-05-15 Glaxo Wellcome Inc Inhibitoren von testosteron-5-alpha reductase.
US5438061A (en) * 1993-07-16 1995-08-01 Merck & Co., Inc. 7-substituted-δ4-6-azasteroid derivatives as 5α-reductase inhibitors

Also Published As

Publication number Publication date
CZ157695A3 (en) 1995-12-13
PL314532A1 (en) 1996-09-16
NO952402D0 (no) 1995-06-16
EP0674651A1 (en) 1995-10-04
AP459A (en) 1996-02-14
MX9308015A (es) 1994-08-31
CN1095383A (zh) 1994-11-23
SI9300665A (en) 1994-06-30
CA2152053A1 (en) 1994-07-07
EP0674651B1 (en) 1998-10-28
NO952402L (no) 1995-08-16
BG99729A (en) 1996-01-31
AP9300599A0 (en) 1994-01-31
WO1994014833A2 (en) 1994-07-07
JPH08504825A (ja) 1996-05-28
FI953009A (fi) 1995-08-15
AU673899B2 (en) 1996-11-28
IL108073A0 (en) 1994-04-12
TW293824B (ja) 1996-12-21
LV10958B (en) 1996-10-20
HUT72083A (en) 1996-03-28
WO1994014833A3 (en) 1994-09-29
NZ261415A (en) 1997-03-24
DE69321849D1 (de) 1998-12-03
FI953009A0 (fi) 1995-06-16
SK79495A3 (en) 1995-11-08
IS4106A (is) 1994-06-19
HU9501775D0 (en) 1995-08-28
ATE172738T1 (de) 1998-11-15
LV10958A (lv) 1995-12-20
AU6015094A (en) 1994-07-19

Similar Documents

Publication Publication Date Title
AP494A (en) Androstenone derivative.
OA10167A (en) Substituted 6-azaandrostenones
EP0641356B1 (en) Inhibitors of 5-alpha-testosterone reductase
WO1993023419A1 (en) NEW 7β-SUBSTITUTED-4-AZA-5α-CHOLESTAN-ONES AS 5α-REDUCTASE INHIBITORS
AU685167B2 (en) Androstenones
AU710208B2 (en) 17-beta-cyclopropyl(amino/oxy) 4-aza steroids as active inhibitors of testosterone 5-alpha-reductase and C17-20-lyase
US5998427A (en) Androstenones
EP0366144B1 (en) 3beta,7beta-hydroxy-substituted steroids and related steroidal compounds
US5708001A (en) Substituted 6-azaandrostenones
US6365597B1 (en) 4-aza steroids
JP3824636B2 (ja) アンドロステノン
US5817818A (en) Androstenones
WO1996030391A1 (en) Substituted 6-azacholesten-3-ones