NZ631012A - Compositions and methods for live, attenuated alphavirus formulations - Google Patents
Compositions and methods for live, attenuated alphavirus formulationsInfo
- Publication number
- NZ631012A NZ631012A NZ631012A NZ63101214A NZ631012A NZ 631012 A NZ631012 A NZ 631012A NZ 631012 A NZ631012 A NZ 631012A NZ 63101214 A NZ63101214 A NZ 63101214A NZ 631012 A NZ631012 A NZ 631012A
- Authority
- NZ
- New Zealand
- Prior art keywords
- live
- compositions
- composition
- virus
- methods
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 241000710929 Alphavirus Species 0.000 title abstract 5
- 230000002238 attenuated effect Effects 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 abstract 1
- 201000009182 Chikungunya Diseases 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- 208000006825 Eastern Equine Encephalomyelitis Diseases 0.000 abstract 1
- 201000005804 Eastern equine encephalitis Diseases 0.000 abstract 1
- 206010014587 Encephalitis eastern equine Diseases 0.000 abstract 1
- 206010014614 Encephalitis western equine Diseases 0.000 abstract 1
- 206010066919 Epidemic polyarthritis Diseases 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 239000007995 HEPES buffer Substances 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 241000710942 Ross River virus Species 0.000 abstract 1
- 241000710961 Semliki Forest virus Species 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 208000005466 Western Equine Encephalomyelitis Diseases 0.000 abstract 1
- 201000005806 Western equine encephalitis Diseases 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229930182830 galactose Natural products 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361784122P | 2013-03-14 | 2013-03-14 | |
| PCT/US2014/026570 WO2014151855A1 (en) | 2013-03-14 | 2014-03-13 | Compositions and methods for live, attenuated alphavirus formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ631012A true NZ631012A (en) | 2017-08-25 |
Family
ID=50489420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ631012A NZ631012A (en) | 2013-03-14 | 2014-03-13 | Compositions and methods for live, attenuated alphavirus formulations |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10137186B2 (enExample) |
| EP (2) | EP3603667A1 (enExample) |
| JP (3) | JP6426695B2 (enExample) |
| KR (1) | KR20160003662A (enExample) |
| CN (2) | CN105377293B (enExample) |
| AP (1) | AP2015008733A0 (enExample) |
| AU (2) | AU2014236804B2 (enExample) |
| BR (1) | BR112015023205A2 (enExample) |
| CA (1) | CA2903711A1 (enExample) |
| CR (1) | CR20150553A (enExample) |
| DO (1) | DOP2015000226A (enExample) |
| EC (1) | ECSP20007842A (enExample) |
| MX (2) | MX361342B (enExample) |
| MY (1) | MY178476A (enExample) |
| NZ (1) | NZ631012A (enExample) |
| PH (1) | PH12015502115B1 (enExample) |
| SG (3) | SG10201909051QA (enExample) |
| TW (2) | TW201900192A (enExample) |
| WO (1) | WO2014151855A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX361342B (es) | 2013-03-14 | 2018-12-04 | Takeda Vaccines Inc | Composiciones y metodos para formulaciones de alfavirus vivos atenuados. |
| WO2015097650A1 (en) | 2013-12-23 | 2015-07-02 | Theravectys | Lyophilized lentiviral vector particles, compositions and methods |
| PE20190149A1 (es) * | 2016-03-31 | 2019-01-22 | Takeda Vaccines Inc | Composiciones y metodos para estabilizar alfavirus con formulaciones mejoradas |
| NL2022538B1 (en) * | 2019-02-08 | 2020-08-19 | Academisch Ziekenhuis Groningen | Methods for providing purified viral particles of Semliki Forest Virus (SFV), preparations obtainable thereby, and uses thereof. |
| CA3174826A1 (en) * | 2021-01-19 | 2022-07-28 | Katsuro HAGIWARA | Virus stabilizer, gelatin hydrolysate for virus stabilizer, and virus-containing composition |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4338335A (en) * | 1980-02-05 | 1982-07-06 | Merck & Co., Inc. | Vaccine stabilizer containing L-glutamic acid and L-arginine |
| RU2035508C1 (ru) * | 1991-08-16 | 1995-05-20 | Институт органической химии СО РАН | Питательная среда для стабилизации вируса венесуэльского энцефалита лошадей |
| US5545555A (en) * | 1994-07-25 | 1996-08-13 | Microtest, Inc. | Microbial transport media |
| AU4594996A (en) * | 1994-11-30 | 1996-06-19 | Chiron Viagene, Inc. | Recombinant alphavirus vectors |
| US6458560B1 (en) * | 1996-04-05 | 2002-10-01 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
| US6290967B1 (en) * | 1996-12-20 | 2001-09-18 | Merck & Co., Inc. | Stabilizers for lyophilized vaccines |
| US6210683B1 (en) | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
| DE19803453A1 (de) * | 1998-01-30 | 1999-08-12 | Boehringer Ingelheim Int | Vakzine |
| WO2000011201A1 (en) * | 1998-07-30 | 2000-03-02 | Johns Hopkins University School Of Medicine | Targeted alphavirus and alphaviral vectors |
| US6869907B2 (en) * | 2000-05-02 | 2005-03-22 | Pentax Corporation | Color-image-forming medium |
| FR2814957B1 (fr) * | 2000-10-06 | 2002-12-20 | Aventis Pasteur | Composition vaccinale et procede de stabilisation |
| JP4550421B2 (ja) * | 2001-12-12 | 2010-09-22 | メイン・ファ−マ・インタ−ナショナル・プロプライエタリ−・リミテッド | ウイルスの保存のための組成物 |
| AU2003247337B2 (en) * | 2002-04-11 | 2007-09-06 | Medimmune, Llc | Preservation of bioactive materials by freeze dried foam |
| MXPA06006947A (es) * | 2003-12-17 | 2007-01-26 | Wyeth Corp | Metodos para producir virus de almacenamiento estable y composiciones inmunogenicas de estos. |
| EP2073839B1 (en) * | 2006-09-01 | 2016-10-19 | Bharat Biotech International Limited | A vaccine for chikungunya virus infection |
| DK2099485T3 (en) * | 2006-11-03 | 2018-05-22 | Alphavax Inc | Alphavirus and alphavirus replica particle formulations and associated methods |
| CA2668834C (en) | 2006-11-07 | 2016-10-11 | Sanofi Pasteur Biologics Co. | Stabilization of vaccines by lyophilization |
| MX360728B (es) | 2007-04-06 | 2018-11-14 | Takeda Vaccines Inc | Metodos y composiciones para virus vivos atenuados. |
| US8357525B2 (en) * | 2007-09-04 | 2013-01-22 | The United States of America, as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention | Thermal inactivation of rotavirus |
| CN101855336B (zh) | 2007-09-14 | 2019-07-30 | 赛诺菲巴斯德生物制剂有限责任公司 | 含艰难梭菌类毒素a和b的药物组合物 |
| WO2009131604A2 (en) | 2008-01-24 | 2009-10-29 | The Board Of Regents Of The University Of Texas System | Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof |
| CA2745096C (en) * | 2008-12-09 | 2013-11-05 | Coley Pharmaceutical Group, Inc. | Immunostimulatory oligonucleotides |
| EP2519539A4 (en) * | 2009-12-28 | 2013-11-13 | Ligocyte Pharmaceuticals Inc | METHODS FOR STABILIZING VIRUS-LIKE PARTICULATE SOLUTIONS BASED ON INFLUENZA-INFLUENZA-VIRUSED VIRUSES |
| WO2011151726A2 (en) * | 2010-06-01 | 2011-12-08 | Novartis Ag | Concentration of vaccine antigens with lyophilization |
| MX361342B (es) * | 2013-03-14 | 2018-12-04 | Takeda Vaccines Inc | Composiciones y metodos para formulaciones de alfavirus vivos atenuados. |
-
2014
- 2014-03-13 MX MX2015012894A patent/MX361342B/es active IP Right Grant
- 2014-03-13 JP JP2016502179A patent/JP6426695B2/ja not_active Expired - Fee Related
- 2014-03-13 EP EP19172758.5A patent/EP3603667A1/en not_active Withdrawn
- 2014-03-13 TW TW107130863A patent/TW201900192A/zh unknown
- 2014-03-13 WO PCT/US2014/026570 patent/WO2014151855A1/en not_active Ceased
- 2014-03-13 NZ NZ631012A patent/NZ631012A/en not_active IP Right Cessation
- 2014-03-13 MY MYPI2015002316A patent/MY178476A/en unknown
- 2014-03-13 TW TW103109097A patent/TWI649087B/zh not_active IP Right Cessation
- 2014-03-13 US US14/209,921 patent/US10137186B2/en not_active Expired - Fee Related
- 2014-03-13 AU AU2014236804A patent/AU2014236804B2/en not_active Ceased
- 2014-03-13 AP AP2015008733A patent/AP2015008733A0/xx unknown
- 2014-03-13 BR BR112015023205A patent/BR112015023205A2/pt not_active IP Right Cessation
- 2014-03-13 SG SG10201909051Q patent/SG10201909051QA/en unknown
- 2014-03-13 KR KR1020157029550A patent/KR20160003662A/ko not_active Ceased
- 2014-03-13 EP EP14717940.2A patent/EP2968515B1/en active Active
- 2014-03-13 CN CN201480018785.3A patent/CN105377293B/zh not_active Expired - Fee Related
- 2014-03-13 CN CN202010573138.6A patent/CN111729077A/zh active Pending
- 2014-03-13 SG SG10201801459SA patent/SG10201801459SA/en unknown
- 2014-03-13 CA CA2903711A patent/CA2903711A1/en not_active Abandoned
- 2014-03-13 SG SG11201507462QA patent/SG11201507462QA/en unknown
-
2015
- 2015-09-09 DO DO2015000226A patent/DOP2015000226A/es unknown
- 2015-09-14 PH PH12015502115A patent/PH12015502115B1/en unknown
- 2015-09-14 MX MX2018014977A patent/MX2018014977A/es unknown
- 2015-10-14 CR CR20150553A patent/CR20150553A/es unknown
-
2018
- 2018-10-01 AU AU2018236897A patent/AU2018236897B2/en not_active Ceased
- 2018-10-12 US US16/159,221 patent/US10806781B2/en not_active Expired - Fee Related
- 2018-10-25 JP JP2018200754A patent/JP6761015B2/ja not_active Expired - Fee Related
-
2020
- 2020-01-31 EC ECSENADI20207842A patent/ECSP20007842A/es unknown
- 2020-09-03 JP JP2020148154A patent/JP2020193231A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SA520412305B1 (ar) | هيدروكسي سيتيدين ومشتقات واستخدامات مضادة للفيروسات مرتبطة بها n4- | |
| MX367792B (es) | Alfavirus recombinantes atenuados incapaces de replicarse en mosquitos y usos de estos. | |
| EA201800108A1 (ru) | Вакцинные композиции для профилактики абровирусных инфекций | |
| NZ631012A (en) | Compositions and methods for live, attenuated alphavirus formulations | |
| PH12020500080A1 (en) | Senecavirus a immunogenic compositions and methods thereof | |
| MY194449A (en) | Zika vaccines and immunogenic compositions, and methods of using the same | |
| GEP20227374B (en) | Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv) | |
| GEP20227373B (en) | Novel, highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis b virus (hbv) | |
| ZA202403393B (en) | Synthetic chimeric poxviruses | |
| EA201791701A1 (ru) | Диспергируемые композиции | |
| MX2018010958A (es) | Vacuna para virus de zika atenuado vivo. | |
| MX2020005554A (es) | Vacunas y composiciones inmunogenas para zika y metodos para usarlas. | |
| GEP20237539B (en) | Formulations of dengue virus vaccine compositions | |
| PH12018000197A1 (en) | Hand, foot, and mouth vaccines and methods of manufacture and use thereof | |
| ZA202103683B (en) | Substituted arylmethylureas and heteroarylmethylureas, analogues thereof, and methods using same | |
| PH12018502120A1 (en) | Live attenuated alphavirus constructs and methods and uses thereof | |
| PH12015502666B1 (en) | Dengue virus vaccine compositions and methods of use thereof | |
| JP2016513658A5 (enExample) | ||
| JOP20200126A1 (ar) | طرق استخدام وتركيبات تحتوي على دولاجلوتيد | |
| MY190399A (en) | A composition comprising cistanche and ginkgo extracts, the composition useful for improving memory of a subject | |
| PE20190149A1 (es) | Composiciones y metodos para estabilizar alfavirus con formulaciones mejoradas | |
| JOP20190214A1 (ar) | ثنائي هيدرو إيندين-?-كربوكساميدات ونظائر منها بها استبدال، وطرق تستخدمها | |
| WO2015120127A3 (en) | Treating flavivirus infections with amodiaquine and derivatives thereof | |
| EA202191634A1 (ru) | Замещенные арилметилмочевины и гетероарилметилмочевины, их аналоги и способы их применения | |
| PH12019500473A1 (en) | Solid composition for quick ingestion with facilitated swallowing, in the form of solid, non-agglomerated particles, comprising two different types of particles |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 13 MAR 2019 BY AJ PARK Effective date: 20180201 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 13 MAR 2020 BY COMPUTER PACKAGES INC Effective date: 20190219 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 13 MAR 2021 BY COMPUTER PACKAGES INC Effective date: 20200218 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 13 MAR 2022 BY COMPUTER PACKAGES INC Effective date: 20210306 |
|
| LAPS | Patent lapsed |